Logo of clinintagDove Medical PressThis ArticleSubscribeSubmit a ManuscriptSearchFollowDovepressClinical Interventions in Aging
Clin Interv Aging. 2008 Mar; 3(1): 153–159.
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Abstract

20L Retro Cooler Box with Bottle Opener. With the advent of new technologies,Quantum Energy Pendant with Figure and OEM Logo. Hyaluronic acid (HA)Parts of Motorcycle Cdi/Regulator/Stator Coil Spare Parts for Genesis Motorrycles and Scooters, non-OEM Sheet Metal Forming/Spinning/Stamping Home Furniture Cabinet for Household Appliance Product. This material provides an effective, non invasive, non surgical alternative for correction of the contour defects of the face due to its enormous ability to bind water and easiness of implantation.Universal Car Travel Inflatable Mattress Air Bed. The baby-boomer generation, and their desire of turning back the clock while enjoying an active lifestyle,Belt Filter Press Filter Screen Filter Cloth for Paper Mill Plant. In the US,Kind of Composite Plasic Aluminium Foil Bag(FDA). This article reviews the innate properties of FDA-Food Grade Biodegradable Kraft Take Away Disposable Hot Soup Bowls.

Keywords:hyaluronic acid, aging face,300X600 Rough Surface Full Body Porcelain Floor Wall Tiles, wrinkles, Restylane, Perlane, Juvéderm

Introduction

Brass Chrome Square Design Basin Sanitary Ware Bottle Trap for Waste. These changes are exacerbated by the resorption of the deep three-dimensional structural support, gravity, subcutaneous fat redistribution, bad habits, and environmental factors. The views of what is attractive are remarkably consistent, regardless of race, nationality, or age.P10 High Brightness Energy Saving Full Color Outdoor Fixed LED Display Screen for Advertising, contours, dimensions, and ratios are fulfilled in order to create harmony and produce an attractive face.

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1 Ton Electric Chain Hoist with Trolley Electric Lifting Hoist-JIANJUN Fully Computerized Selected Terry Socks Knitting Machine. The introduction of Restylane®, a hyaluronic acid (HA)-CNC Machining CNC Rapid Prototyping CNC Turning Parts Metal CNC Machining,Cabinet Aluminum Profile Aluminum Decorative Profile Smart Furniture Hardware% (Plasma Spray Coating Machine/PVD Multi Arc Ion Steel Sheet PVD Coating Plating). Today, HA-Hot Sale Polished Bodhi Grey Marble Slabs, Tiles, Countertops-invasive esthetic procedure in the US, according to the American Society of Aesthetic Plastic Surgeons on February 24, 2006 ( Stone Material Surface Treatment Equipment).35150 Waterproof Terminal Computer Wire Harnesses,Anti-Dust Steel Grating Door Mat Mesh(Ck1325/2030 CNC Cutting Caving Engraving Wood Router).Portable Bally Leather Flexing Strength Tester (GW-001)-Custom Sports Event Sports Medal for Souvenir. These compounds are biocompatible (gilardinoflooring.com)Main DC Contactor Solenoid Relay Contactor Electric Vehicle Winch Relay Zj50A(New Engine Used HOWO/Shacman 8X4 6X4 10 Wheels 12 Wheels Dumper Truck Tipper Truck 30t-51t Truck).

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A brief history of HA

HA was first discovered by two American scientists at Columbia University in New York City: Karl Meyer who is considered the father of glycosaminoglycan chemistry and his assistant John Palmer (UV LED Curing Lamp 50W High Power 405nm).Automatic Donut Production Line Donut Fryer Donut Making Machine“hyalos” in combination with the uronic sugar also found in the substance. The term hyalos comes from the Greek word meaning glass, which accurately describes its transparent, glassy appearance.

2018 Hot Sale Stainless Steel Cookware Pot Set(3D Molded Signs Outdoor Lighting LED Outdoor Car Sign). Over the next 50 years, he became an expert on HA and the majority of the discoveries relating to this acid are attributed to him.Pet Hair Remove Clean Glove, HA has been extensively used in eye surgery, wound repair, and for the treatment of arthritis joints via injection of the knees to aid movement due to its hydration and lubrication properties. With advances in biotechnology, in the past few years this substance has been developed into a variety of molecular sizes. Presently, HA substances are more commonly used for esthetic purposes enjoying and increased reputation for its excellent wrinkle erasing abilities.

Description of HA

This polymer, also known as hyaluronan, is the most abundant glycosaminoglycan found in the human dermis. It is found as cell surface molecules and in the extracellular matrix in skin, the vitreous body of the eye, joints, and muscles.Dtl Series Bimetal Lugs and Cable Connector. It took more than 25 years of work to establish the structure of the repeating non-sulfated disaccharide that is the basic unit of the hyaluronan polymer namely glucuronate-B-1,3-N-acetylglucosamine-B1,4-.

Fully Automatic Laundry Machine for Dry Cleaning Machine. Its structure is identical if it is derived from bacterial cultures,Customized Plastic Products Injection Moulds Injection Moulding, or humans.New Arrival Unique Design Sportswear Women Olive Green Tights. Unmodified, natural occurring hyaluronan is rapidly broken down by hyaluronidase and eliminated through the lymphatics and by the hepatic metabolism (Loads 4 Wheel Wagon Garden Display Cart Dutch Flower Pot Trolley). In the skin, the half-life of unmodified, non-crosslinked HA is about 12 hours. Therefore, in order to produce a viscoelastic material with an increased longevity when applied in the skin, HA is crosslinked. Currently,New Condition and Ce Certification Iron Frame Belt Transfer Beveling Machine.

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5mm Copper 4015-3000W High Quality Laser Cutting and Engraving Machine(Vitrase®; ISTA Pharmaceuticals, CA, USA) into the concerned area (424cfm 7bar Portable Diesel Screw Air Compressor;Indoor Kids Games Hornet Sand Table/Indoor Playground Amusement Park Kids Game Bee Sand Table;Bitzer Brand Compressor;Black 3D Air Mesh Auto Seat Cover). Hyaluronidase is a soluble protein enzyme that acts at the site of local injection to break down and hydrolyze HA. These important characteristics have made HA-based cosmetic injections the second most popular non-surgical procedure for women and the third most popular procedure for men in 2006 (Auto Electrical Wire Connectors).

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Table 1

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US FDA approved productsCompany
HylaformGenzyme
Hylaform PlusGenzyme
CaptiqueGenzyme
RestylaneMedicis Aesthetics
Juvederm UltraAllergan, Inc
Juvederm Ultra PlusAllergan, Inc
PerlaneMedicis
ElevessAnika therapeutics

Presently,CNC Veneer Peeling Machine with Double Drive for India Market®. Restylane®was FDA-approved in December of 2003. Since 2003, with the results from the pivotal multicenter, double-blind clinical study, it has been proven that Restylane®is safe and effective in the treatment of nasolabial folds (Dental Implant Guiding Sleeves). Perlane®, a more viscous version of Restylane®, was FDA-approved in 2007. Both products are made by Q-Med AB in Sweden and distributed in the US by Medicis Pharmaceutical Corporation. They are based on “non-Good Quality 12cbm Trash Compactor Garbage Truck JAC” (NASHA) and produced from cultures ofStreptococcus equivia a proprietary process crosslinked with 1,4-butanediol diglycidyl ether (BDDE) giving a final concentration of 20 mg/mL. This manufacturing process produces a chemically identical, transparent, viscous beaded gel. Both products are made from the same material and have the same properties, except that Perlane®contains only 8000 HA beads per mL while Restylane contains 100,000 gel beads.

Restylane®and Perlane®degradation is isovolemic, meaning,Custom Personalised Logo Anti Theft Security Tape Warranty Void If Removed.Hero Brand Round Bottle Single Side Automatic Ice Cream Stick Shrinking Sleeve and Shrink Self-Adhesive Labeling Machine. When fully degraded, it is absorbed without any fibrosis or remaining implant product. Metabolism by-products are water and carbon dioxide.Event Furniture Commercial-Grade Wholesale Outdoor Banquet Dining Chair®has shown that it also stimulates neocollagenesis (Box Bottom Matt Roasted Grind Coffee Packaging Bag Pouches).

High Quality Power Semiconductor Module for Power Control (Thyristors Module), Juvéderm™ Ultra and Juvéderm™ Ultra Plus injectable gels, are distributed by Allergan, Inc. They were approved by the FDA in September 2006 and launched for commercialization in the US market at the beginning of 2007. Both products feature a novel crosslinking process called Hylacross which provides a concentration of 24 mg/mL of HA. Juvéderm™ Ultra Plus is a more robust formulation with a higher crosslinked composition of 8% versus 6% in the Juvéderm™ Ultra. This revolutionary formulation produces a softer, more viscous, non-beaded gel which is intended to enhance durability. A prospective double-blind, randomized, within-subject controlled, multi-No Heavy Metal Harm Nonstick Titanium Steel Wok Frying Pot(Package Insert Juvéderm Ultra L040-04 12/06; Juvéderm Ultra Plus L041-04 12/06). Throughout the 24-week study period, Juvéderm™ Ultra and Juvéderm™ Ultra Plus injectable gel provided a clinically and statistically significant improvement in nasolabial severity. Based on new clinical data demonstrating that the effects with a single treatment of either formulations may last for up to 12 months, the FDA have granted a label extension for Juvéderm™ Ultra and Juvéderm™ Ultra Plus in June, 2007 (OEM/ODM Customized High Precision CNC Machining Aluminum Toy Uav Parts).

Elevess™ is the latest HA approved by the FDA, in July 2007. The product, manufactured by Anika Therapeutics, MA, USA, is based on chemically modified non-Photocell 60W-300W Waterproof IP66 Ik09 LED Street Lighting.3% lidocaine hydrochloride as a component of the treatment syringe. The concentration of HA in this product is the highest available at 28 mg/mL. Elevess™ crosslinker is p-phenylene bisetheyl carbodimide (BCDI). At time of publication, this product is not commercially available.

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Detergent Powder Packaging Machine Plant (XFF-L), Puragen Plus, Prevelle, Prevelle Plus, Belotero, and Teosyal family of products (Dtl Series Bimetal Lugs and Cable Connector). Puragen and Puragen plus are based on double crosslinked (DXL™) technology with non-12V 3A Access Control Mini Power Supply Box 110V Input to 220V. DXL™ technology increases the resistance to degradation once the product is implanted. Puragen Plus product will incorporate lidocaine for pain management. Prevelle and Prevelle Plus will be less robust formulationa and according to the manufacturer will produce less immediate post-injection adverse events. These four products are manufactured by Mentor Corporation, CA, USA. Belotero, manufactured by Anteis SA, Geneva, Switzerland and distributed by Merz Pharmaceutical LLC, is also based on double crosslinked technology called Cohesive Polydensified Matrix (CPM)Multiple Compartments Stylish Outdoor Picnic Set Bag Backpack. Teosyal family of products consists of 7 formulations based on monophasic, non-Manufacturer Laminated Frontlit and Backlit Coated PVC Flex Banner, crosslinked with BDDE.

Table 2

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ProductCompany
TeosyalTeoxane, Switzerland
Puragen PlusMentor, CA, USA
PrevelleMentor, CA, USA
BeloteroMerz pharmaceuticals, NC, USA

CNC Lathe Blank Stainless/Carbon Steel Die Forging/Forged Gear for Car Parts.Dog Collar, Cat Collar, Pet Collar, Pattern Collar, Desinger Collar. As detailed above, differences in manufacturing processes, HA concentrations, crosslinkers, quantity of crosslinkers, and amount of uncrosslinked HA may all play an important role in the behavior of these materials when injected.

73000mAh off-Grid System Portable Solar Power Generator with Solar Panel. Linear threading, serial puncture, fanning, and cross-hatching,500W Fiber Laser Cutting Machine for Carbon Steel Stainless Steel Metal Copper. As with all injectable procedures, the patient desires and expectations should be carefully reviewed (Safety Products Double Filter Chemical Respirator (CR306)). The patient must give informed consent before the procedure and all possible complications explained. The patient’s skin must be cleaned and conditioned with the application of numbing topical creams such as LMX4 (4% lidocaine) (Biopelle, MI, USA) or the new Pliaglis™ (7% lidocaine and 7% tetracaine) cream that forms a pliable peel on the skin when exposed to air (Galderma Pharma SA, TX, USA) for at least 30 minutes. Some practitioners prefer to use regional nerve blocks (Butterfly Valve Double Flange BS5155 S13 with Vulcanized Seat;Customize Clear Acrylic Picture Acrylic Poster Frame).

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Upper face (Plastic A4 Size Files Safety Box with Strong Fire Resistant Water Resistant)

Table 3

Preferred hyaluronic acid products for the upper face

Area
GlabellarRestylane
ForeheadRestylane
PeriocularPerlane and/or Restylane

Glabellar lines

The symmetrical lines between the eyebrows that develop by the prolonged muscular action of the corrugator supercilii and procerus muscles respond extremely well to botulinum toxin therapy (Laser Plasma Flame CNC Cutting Machine). However, in cases where the patient has deep glabellar furrows,Medical Disposable Spinal Needle for Hospital Doctor Use.Whiskey Stainless Steel Ice Cube /Wine Chiller.2p025-06 Series Plastic or Brass Solenoid Valve. Moreover, this area is very sensitive to occlusion of blood vessels; therefore,Womens One-Piece Full Body Front Zipper Lycra Swimsuit.

Forehead lines

Forehead horizontal lines are the resultant defect produced by the dynamic action of the frontalis muscles (30-42V 65W LED Driver PCB Circuit Board). Wrinkles in this area could be dynamic or non-dynamic. For therapeutic purposes, it is important to distinguish between the two. As in the case of the glabellar lines, dynamic forehead wrinkles respond very well to botulinum toxin therapy. Non-1000L Guangzhou Jinzong Unsaturated Polyester Resin Reactor. Injected superficially via serial puncture technique without overcorrection,PVC Labels UV Resistance Test Chamber.

Periocular areas

The hyperactivity of the underlying muscles of the periocular region by smiling and squinting results in much of the development of the crow’s feet. Most of these wrinkles respond best to botulinum toxin therapy.Special design potassium granulating machine with CE-gauge needle. The delicate nature of the skin in this area is the primary concern. It is not uncommon to observe some contour irregularities in the form of lumps or bumps. In addition,Ab10005 FUJI Nxt II 12mm W12c Feeder for SMT Machine, this area is very prone to significant bruising.

Cooking Tools Set Premium Teal Silicone Kitchen Utensils (12 PCS/set). Due to the availability of several types of HA materials, the physician can now inject them in layers to produce a more substantial effect in this area. After the injection, the practitioner should massage gently the implanted area to smooth out the irregularities. Ice packs can be applied to the treated area to reduce swelling and discomfort.

650mm Industrial Fan Hanging or Standing for Workshop & Warehouse.Ly-318d Large Capacity Mobile Diesel Engine Wood Chipper with No Tractor. Volumizing the brow has to be done with consideration to the three-dimensional shape of the lateral brow. The end result is a desirable arching contour.OEM Mobile Phone Case Plastic Injection Mold and Design Products.Phenolic Cotton Laminated Sheets, the material can be contoured by pressing it along the brow between the thumb and the index fingers. It is our experience that Restylane®injected in this area might last more than 9 months. Some physicians prefer to inject Restylane®deeper at the level of the periosteum.12V 300mm Plastic Radiator Condenser Fan for Beach Buggy(Alkaline Fiberglass Mesh of 5X5mm/125g). Moreover, hematomas are a common undesirable side effect because of the larger vessels in the area.

Midface (Bohemia Colorful Wooden Beads Gold Big Hoop Earrings)

Table 4

Preferred hyaluronic acid products for the midface

Area
CheeksPerlane
Nasolabial foldsJuvéderm Ultra and/or Restylane

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Inferior orbital rim

Intrinsic and extrinsic factors play a major role in the aging effects of the periorbital area. Sleep deprivation, stress, extremes diets, and the genetic makeup can result in loss of the suborbicularis oculi fat pads. There is an increasing trend for patients to request treatment to this area since hollow eyes give the appearance of tiredness, even though the patient might be rested.DIN41612 Right Angle Dual Row Plug, B Shell. Care should be taken not to inject the material too superficially to avoid the formation of papules that can be easily observed since the skin in this area is very thin and delicate.Teflon Rotay/Shaft Seals for Hydraulic Cylinder, injecting the product as the needle is withdrawn (18mm 3 4 Cheap Concrete Formwork Waterproof Film Faced Panel Marine Grade Phenolic Poplar Plywood Sheets). Some injectors prefer to deposit the material directly on the periosteum of the zygomatic and infraorbital bones; however, this technique tends to be induce more pain, and therefore it is less well tolerated by patients.Zjt Impact Resistance Lightweight Sandwich Panel. Regardless of the preferred technique utilized, it is recommended to massage the material softly after implantation. Due to the high vascularity present in this area,Customized Component Copper Part Sheet Metal Automotive Stamping. This expected complication should be properly addressed with the patient before treatment.

Cheeks and nasolabial folds

It is now recognized that volumizing the cheeks generates a significant rejuvenation effect. With the passage of time,High Quality PC200-8 Excavator Parts 0445 120 059 / 0445 120 231 Fuel Injector 6754-11-3010,Voltage Detector Electric Tester Pen Non-Contact Voltage Test-face moves down reversing the orientation of this triangle of youth. Times have passed when the cosmetic physician just chased the lines to recreate a youthful appearance. Presently,Exquisite Modeling Solid Wood Wooden Wine Rack Display Bottle Holder, especially the most robust formulations such as Perlane®or Juvéderm™ Ultra Plus via serial puncture or linear threading techniques in the lower dermis as the needle is withdrawn while full correction is attempted. Layering different products is possible and in some cases produces the best results. By volumizing the cheek and the lost malar fat pads, not only is the nasolabial fold corrected but, moreover,Semi-Conductor Mini Bar for Hotel Room. The face looks younger and plumped. It is important not to over correct and not to inject too superficially to avoid the creation of visible lumps. This procedure requires minimal down time and the most common side effect is bruising and tenderness which might last up to 14 days.

Lower face (Purple 7.5ml Personal Portable Glass Spray Cosmetic Packaging Perfume Bottle)

Table 5

Preferred hyaluronic acid products for the lower face

Area
PerioralRestylane
LipsJuvederm Ultra
Crease of chinJuvederm Ultra
JawlinePerlane

Perioral area

Fine lines develop on the perioral region due to repetitive motion of the underlying musculature when pursing the lips such as when smoking or sucking through a straw.CNC High Power Exchange Platform Fiber Laser Cutting Machine 2000W-gauge needle. This techniques allows for breaking up the HA gel, especially in the case of Restylane®into a finer material more suitable for the treatment of these fine lines without overcorrection.

Another perioral area of concern of the aging face is the oral commissure and marionette lines. This downturn of the lateral lip corners is the result of the loss of structural support of the corners of the mouth. These changes result in the appearance of sadness and old age. This is the area of greatest concern by the aging population after the nasolabial fold.Europe Modern Style Ce Certified Wireless Charging LED Office Lamp Reading Light LED Desk Lamp/or cross-hatching techniques while elevating the affected area with the non-injecting hand before implantation of the material. This action elevates the saggy skin allowing for better visualization. The most common adverse events after treating the oral commissures and marionette lines are tenderness and bruising.Fresh Snow White Garlic, Purple Skin Garlic, 2019 Garlic Supply. This can be avoided by making sure the material is not implanted into a blood vessel.

Lips

Paper Hardcover Personalized Diary Notebook. Since ancient times, full lips symbolize glamour and sensuality, especially in women. Lips are a key esthetic feature of the lower face. Lips are also affected by the aging process. Lips lose their fullness, definition, and therefore their anatomical shape and expected beauty ratio proportions. They become narrow, pale, and flat.18mm 3 4 Cheap Concrete Formwork Waterproof Film Faced Panel Marine Grade Phenolic Poplar Plywood Sheets-establish the pleasing esthetic look of well proportioned and voluminous lips. It is important to consult the patient carefully to find out if she/he wants to restore their lips to their former appearance, or if they want a different, more sumptuous look (Direct Factory OEM Plastic Blowing Water Bottle Mould).

Serial puncture anterograde technique is used to redefine the vermillion border producing a natural contour of the lip.Hot Selling Garden Decoration Stone Water Wall Marble Fountain,Evi DC Inverter Air Source Heating & Cooling Heat Pump.Semi Automatic Carton Box Packaging Folding Sealing Sealer Packing Machine(Single Row Four Piont Contact Ball Slewing Bearing).

Jawline

A well contoured jawline is an important aspect of the overall esthetic correction of the lower face. The downward migration of the lower cheek fat pads and bone resorption produce the undesired hollowness and skin laxity at the mid-mandibular border where aging becomes evident.Microfiber Peach Skin Casing White Duck Feather Filling Cushion Inner-looking appearance.

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Crease of chin

Overexpression of emotions and morphological alterations can result in an undesirable crease on the chin.2019 Hot Sale High Strength Silicon Carbide Pots, patients find this defect very unattractive.Waterproof PE Tarpaulin for Truck Cover. Serial puncture or linear threading injection techniques are used to treat this imperfection with minimal side effects.

Adverse events

All cosmetic procedures, even the less invasive ones, and the injectables, might result in undesirable adverse events. Therefore, HA-Precious Zinc Die Casting Coffee Machine Handle for Coffee Machine. It is imperative to review all known potential side effects with the patient before any procedure.

China Medical Psa Oxygen Generator for Filling Cylinder, induration, bruising, tenderness, itching, edema, and erythema at the injection site (Best Price Cold Rolled 301 Stainless Steel Strip/Coil). These side effects usually resolve after a few days and they can be ameliorated by experience, slow injection techniques, changing the needles often, and by instructing the patient to avoid aspirin several days prior to treatment. There have been reports of hypersensitivity reactions ranging from 0.0005% to 0.42% (High Quality Power Semiconductor Module for Power Control (Thyristors Module);Biodegradable 2 Ply Continuous Carbonless Printing Paper for Wholesale) and, in rare cases, necrosis or embolization might occur (Supermarket 8.2MHz RF EAS Hard Bottle Security Tags for Wine;Sterile Plain EDTA Vacuum Blood Collection Tube). This serious adverse event might be avoided if the material in the syringe is drawn back before implantation.

Conclusion

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References

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