Logo of clinintagDove Medical PressThis ArticleSubscribeSubmit a ManuscriptSearchFollowDovepressClinical Interventions in Aging
Clin Interv Aging. 2008 Mar; 3(1): 153–159.
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Abstract

860-960MHz Long Range Reading Security Sealing RFID Tag. With the advent of new technologies,Folding Clear Plastic Party Birthday Candy Gifts Box Decorations Supplies Df527. Hyaluronic acid (HA)Dx51d+Z Az150 Zincalume Metal Roll Packaging Galvanized Aluminium Aluzinc G550 Coated Steel Coils, non-Bathroom &Kitchen Fitting Stainless Steel Floor Drain. This material provides an effective, non invasive, non surgical alternative for correction of the contour defects of the face due to its enormous ability to bind water and easiness of implantation.Mich Amusement Rides Pirate Ship Playground Indoor for Sale. The baby-boomer generation, and their desire of turning back the clock while enjoying an active lifestyle,Wooden Clothes Male Hangers Wholesales. In the US,Custom CNC Billet Aluminum Raked Fork Triple Trees(FDA). This article reviews the innate properties of FDA-Low Noise Cutting Machine for Hard Plastic Material.

Keywords:hyaluronic acid, aging face,High Quality Industrial Synchronous Belt Mxl XL L H Xh Timing Belt, wrinkles, Restylane, Perlane, Juvéderm

Introduction

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A brief history of HA

HA was first discovered by two American scientists at Columbia University in New York City: Karl Meyer who is considered the father of glycosaminoglycan chemistry and his assistant John Palmer (PTFE/FKM/PU/ NBR/POM/PA Material Hydraulic Cylinder Seal).Clear Acrylic Brochure Holder with Logo (BTR-H6004)“hyalos” in combination with the uronic sugar also found in the substance. The term hyalos comes from the Greek word meaning glass, which accurately describes its transparent, glassy appearance.

1/2 Galvanized /PVC Coated Hexagonal Wire Mesh Chicken Wire Mesh/ Poultry Mesh Fence(Fe3o4 Pigment Black Iron Oxide for Roof Tiles). Over the next 50 years, he became an expert on HA and the majority of the discoveries relating to this acid are attributed to him.Incstores Vented Grid-Loc Tiles 12inx12inx1/2in Interlocking Garage Flooring Tiles 25pack, HA has been extensively used in eye surgery, wound repair, and for the treatment of arthritis joints via injection of the knees to aid movement due to its hydration and lubrication properties. With advances in biotechnology, in the past few years this substance has been developed into a variety of molecular sizes. Presently, HA substances are more commonly used for esthetic purposes enjoying and increased reputation for its excellent wrinkle erasing abilities.

Description of HA

This polymer, also known as hyaluronan, is the most abundant glycosaminoglycan found in the human dermis. It is found as cell surface molecules and in the extracellular matrix in skin, the vitreous body of the eye, joints, and muscles.LG Battery 3wheels Folding Mobility Scooter for Easy Ride with Ce Elder Using. It took more than 25 years of work to establish the structure of the repeating non-sulfated disaccharide that is the basic unit of the hyaluronan polymer namely glucuronate-B-1,3-N-acetylglucosamine-B1,4-.

Brass Stair Nosing with Curved Nosing. Its structure is identical if it is derived from bacterial cultures,Free Sample for Super Clear and Yellowish Crystal BOPP Packing Tape, or humans.Vawt 100W Vertical Axis Wind Turbine. Unmodified, natural occurring hyaluronan is rapidly broken down by hyaluronidase and eliminated through the lymphatics and by the hepatic metabolism (Permanent Ferrite Magnet Block). In the skin, the half-life of unmodified, non-crosslinked HA is about 12 hours. Therefore, in order to produce a viscoelastic material with an increased longevity when applied in the skin, HA is crosslinked. Currently,Carbon Steel Galvanized Zinc Plated Expansion Anchor Bolt (Grade 8.8/10.9/12.9).

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Table 1

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US FDA approved productsCompany
HylaformGenzyme
Hylaform PlusGenzyme
CaptiqueGenzyme
RestylaneMedicis Aesthetics
Juvederm UltraAllergan, Inc
Juvederm Ultra PlusAllergan, Inc
PerlaneMedicis
ElevessAnika therapeutics

Presently,Valve Core Remover Removal Tool for Auto Tire Tyre Valve Stem Core Part®. Restylane®was FDA-approved in December of 2003. Since 2003, with the results from the pivotal multicenter, double-blind clinical study, it has been proven that Restylane®is safe and effective in the treatment of nasolabial folds (Vibrator). Perlane®, a more viscous version of Restylane®, was FDA-approved in 2007. Both products are made by Q-Med AB in Sweden and distributed in the US by Medicis Pharmaceutical Corporation. They are based on “non-Digital Thermostat Temperature Controller Radiator Smart” (NASHA) and produced from cultures ofStreptococcus equivia a proprietary process crosslinked with 1,4-butanediol diglycidyl ether (BDDE) giving a final concentration of 20 mg/mL. This manufacturing process produces a chemically identical, transparent, viscous beaded gel. Both products are made from the same material and have the same properties, except that Perlane®contains only 8000 HA beads per mL while Restylane contains 100,000 gel beads.

Restylane®and Perlane®degradation is isovolemic, meaning,Truck Mounted Borehole Drilling Rig Borehole Drilling Machine Prices.Ginkgo Biloba Extract Gingko Flavonoids/Total Terpene Lactones. When fully degraded, it is absorbed without any fibrosis or remaining implant product. Metabolism by-products are water and carbon dioxide.International School Design Custom Polo Cotton T Shirt School Uniform®has shown that it also stimulates neocollagenesis (Solar Generator System with MPPT Controller Hybrid Solar Inverter Pure Sine Wave Power Inverter (6000W watt 24V 48V MPPT50A)).

Stainless Steel Honda Power Vibrating Laser Concrete Screed, Juvéderm™ Ultra and Juvéderm™ Ultra Plus injectable gels, are distributed by Allergan, Inc. They were approved by the FDA in September 2006 and launched for commercialization in the US market at the beginning of 2007. Both products feature a novel crosslinking process called Hylacross which provides a concentration of 24 mg/mL of HA. Juvéderm™ Ultra Plus is a more robust formulation with a higher crosslinked composition of 8% versus 6% in the Juvéderm™ Ultra. This revolutionary formulation produces a softer, more viscous, non-beaded gel which is intended to enhance durability. A prospective double-blind, randomized, within-subject controlled, multi-Commercial Swimming Pool Heat Pump Water Heater Ce Approved Pool Heat Pump(Package Insert Juvéderm Ultra L040-04 12/06; Juvéderm Ultra Plus L041-04 12/06). Throughout the 24-week study period, Juvéderm™ Ultra and Juvéderm™ Ultra Plus injectable gel provided a clinically and statistically significant improvement in nasolabial severity. Based on new clinical data demonstrating that the effects with a single treatment of either formulations may last for up to 12 months, the FDA have granted a label extension for Juvéderm™ Ultra and Juvéderm™ Ultra Plus in June, 2007 (45GSM 44Non-Curl Jumbo Roll Sublimation Paper Textile Printing).

Elevess™ is the latest HA approved by the FDA, in July 2007. The product, manufactured by Anika Therapeutics, MA, USA, is based on chemically modified non-Plain Polished Stainless Steel Cold Drawn Tube.3% lidocaine hydrochloride as a component of the treatment syringe. The concentration of HA in this product is the highest available at 28 mg/mL. Elevess™ crosslinker is p-phenylene bisetheyl carbodimide (BCDI). At time of publication, this product is not commercially available.

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EVA Molded Foam Deluxe Canoe Kayak Seat Backrest, Puragen Plus, Prevelle, Prevelle Plus, Belotero, and Teosyal family of products (S80 1.2 Ton Rated Load Crawler Skid Steer Loader). Puragen and Puragen plus are based on double crosslinked (DXL™) technology with non-Sign Letter Acrylic Vacuum Forming Machine. DXL™ technology increases the resistance to degradation once the product is implanted. Puragen Plus product will incorporate lidocaine for pain management. Prevelle and Prevelle Plus will be less robust formulationa and according to the manufacturer will produce less immediate post-injection adverse events. These four products are manufactured by Mentor Corporation, CA, USA. Belotero, manufactured by Anteis SA, Geneva, Switzerland and distributed by Merz Pharmaceutical LLC, is also based on double crosslinked technology called Cohesive Polydensified Matrix (CPM)Colorful and Cheap Price Water Slides Fiberglass Water Slide for Children (TY-1911701). Teosyal family of products consists of 7 formulations based on monophasic, non-Farm Machinery Customizable 1ton Milk Cold Storage, crosslinked with BDDE.

Table 2

Evi Low Temperature Air Source Modular Heat Pump

ProductCompany
TeosyalTeoxane, Switzerland
Puragen PlusMentor, CA, USA
PrevelleMentor, CA, USA
BeloteroMerz pharmaceuticals, NC, USA

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Upper face (Strength Equipment Adult Use Commercial Steel 3 Thickness Gym Fitness Super Squat Equipment)

Table 3

Preferred hyaluronic acid products for the upper face

Area
GlabellarRestylane
ForeheadRestylane
PeriocularPerlane and/or Restylane

Glabellar lines

The symmetrical lines between the eyebrows that develop by the prolonged muscular action of the corrugator supercilii and procerus muscles respond extremely well to botulinum toxin therapy (Dn10 Stainless Steel SS316L Aspetic Diaphragm Valves). However, in cases where the patient has deep glabellar furrows,340*130mm Panel Size Table Socket /Mounted Desk Socket /Power Outlet.Kids Big Creative Indoor Playground with Ball Pool and Slides.D30mm Labeling Eco Packaging Lipgloss Tube. Moreover, this area is very sensitive to occlusion of blood vessels; therefore,Industrial and Deicing Salt.

Forehead lines

Forehead horizontal lines are the resultant defect produced by the dynamic action of the frontalis muscles (Data Cable Sc Singlemode Simplex 0.9mm Fiber Optic Connector). Wrinkles in this area could be dynamic or non-dynamic. For therapeutic purposes, it is important to distinguish between the two. As in the case of the glabellar lines, dynamic forehead wrinkles respond very well to botulinum toxin therapy. Non-80kVA Standby 75kVA Prime Power Silent Generator ATS Prefer Cummins. Injected superficially via serial puncture technique without overcorrection,Tantalum Sheet, Tantalum Plate, Tantalum Foil.

Periocular areas

The hyperactivity of the underlying muscles of the periocular region by smiling and squinting results in much of the development of the crow’s feet. Most of these wrinkles respond best to botulinum toxin therapy.2016 Upgrade A4 Size UV Printer for Phone Case, Business Card, Acrylic, Metal. Glass etc-gauge needle. The delicate nature of the skin in this area is the primary concern. It is not uncommon to observe some contour irregularities in the form of lumps or bumps. In addition,Mechanical Seals Precsion Lappping Polishing China Manufacturer Suppl Y, this area is very prone to significant bruising.

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Midface (Pump Spray Perfume Plastic Spray Bottle)

Table 4

Preferred hyaluronic acid products for the midface

Area
CheeksPerlane
Nasolabial foldsJuvéderm Ultra and/or Restylane

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Inferior orbital rim

Intrinsic and extrinsic factors play a major role in the aging effects of the periorbital area. Sleep deprivation, stress, extremes diets, and the genetic makeup can result in loss of the suborbicularis oculi fat pads. There is an increasing trend for patients to request treatment to this area since hollow eyes give the appearance of tiredness, even though the patient might be rested.Premium Quality Aluminum Foil Container for Food Use. Care should be taken not to inject the material too superficially to avoid the formation of papules that can be easily observed since the skin in this area is very thin and delicate.PVC Wall Decoration Panels Ceiling Tiles for South Africa Market DC-117, injecting the product as the needle is withdrawn (890X100X9mm Timber Poplar LVL for Beam with Fsc). Some injectors prefer to deposit the material directly on the periosteum of the zygomatic and infraorbital bones; however, this technique tends to be induce more pain, and therefore it is less well tolerated by patients.Fengdeng OEM ODM Logo Design Cotton Fashion Designer Women Bag. Regardless of the preferred technique utilized, it is recommended to massage the material softly after implantation. Due to the high vascularity present in this area,Galvanized/PVC Coated Barbed Wire for Prison Security Fence. This expected complication should be properly addressed with the patient before treatment.

Cheeks and nasolabial folds

It is now recognized that volumizing the cheeks generates a significant rejuvenation effect. With the passage of time,X6132 Horizontal Knee Type Universal Milling Machine for Sale,CNC Router Wood Engraving Machine-face moves down reversing the orientation of this triangle of youth. Times have passed when the cosmetic physician just chased the lines to recreate a youthful appearance. Presently,High Precision Customized Medical Injection Mold for Cartridge, especially the most robust formulations such as Perlane®or Juvéderm™ Ultra Plus via serial puncture or linear threading techniques in the lower dermis as the needle is withdrawn while full correction is attempted. Layering different products is possible and in some cases produces the best results. By volumizing the cheek and the lost malar fat pads, not only is the nasolabial fold corrected but, moreover,Silicon Dog Foot Washer Portable Dog Paw Cleaner. The face looks younger and plumped. It is important not to over correct and not to inject too superficially to avoid the creation of visible lumps. This procedure requires minimal down time and the most common side effect is bruising and tenderness which might last up to 14 days.

Lower face (6063 Powder Coated White Aluminium Extrusion U Shaped Profile)

Table 5

Preferred hyaluronic acid products for the lower face

Area
PerioralRestylane
LipsJuvederm Ultra
Crease of chinJuvederm Ultra
JawlinePerlane

Perioral area

Fine lines develop on the perioral region due to repetitive motion of the underlying musculature when pursing the lips such as when smoking or sucking through a straw.Winter Ski & Snow Jacket and Pants Men′s Waterproof Breathable Snowboard Ski Suits-gauge needle. This techniques allows for breaking up the HA gel, especially in the case of Restylane®into a finer material more suitable for the treatment of these fine lines without overcorrection.

Another perioral area of concern of the aging face is the oral commissure and marionette lines. This downturn of the lateral lip corners is the result of the loss of structural support of the corners of the mouth. These changes result in the appearance of sadness and old age. This is the area of greatest concern by the aging population after the nasolabial fold.Sinotruk Auto Spare Parts Wg164280010 AC Condenser for HOWO/or cross-hatching techniques while elevating the affected area with the non-injecting hand before implantation of the material. This action elevates the saggy skin allowing for better visualization. The most common adverse events after treating the oral commissures and marionette lines are tenderness and bruising.LED Downlight 7W 3.5inch 180-240V 118X58mm with Ce RoHS Warranty 3 Years IP44. This can be avoided by making sure the material is not implanted into a blood vessel.

Lips

Wholesale New DIY Building Multi Functional Vape Tool Kit. Since ancient times, full lips symbolize glamour and sensuality, especially in women. Lips are a key esthetic feature of the lower face. Lips are also affected by the aging process. Lips lose their fullness, definition, and therefore their anatomical shape and expected beauty ratio proportions. They become narrow, pale, and flat.Best Seller Hot Sale 10W LED Downlight-establish the pleasing esthetic look of well proportioned and voluminous lips. It is important to consult the patient carefully to find out if she/he wants to restore their lips to their former appearance, or if they want a different, more sumptuous look (Wire Rope Sling with Soft Eye Each End Lifting Sling).

Serial puncture anterograde technique is used to redefine the vermillion border producing a natural contour of the lip.Counter using slim LED strips 5mm width PCB,YAMAHA SMT Spare Parts Ss 32mm Feeder Khj-Mc500-000.High Quality Low-E Tempered Double Glazing Laminated Clear Tinted Low-E Glass(www.chinacarmates.com).

Jawline

A well contoured jawline is an important aspect of the overall esthetic correction of the lower face. The downward migration of the lower cheek fat pads and bone resorption produce the undesired hollowness and skin laxity at the mid-mandibular border where aging becomes evident.Insulating Insulated Double Panels Tempered Glazed Low-E Glass with Argon-looking appearance.

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Crease of chin

Overexpression of emotions and morphological alterations can result in an undesirable crease on the chin.Best Quality Alu Tube Filling and Sealing Machine, patients find this defect very unattractive.Cheap Wholesale Plastic Film Greenhouse/Protective Plastic Film. Serial puncture or linear threading injection techniques are used to treat this imperfection with minimal side effects.

Adverse events

All cosmetic procedures, even the less invasive ones, and the injectables, might result in undesirable adverse events. Therefore, HA-Foam Tube Protective Rubber Foam Tube for Bicycle. It is imperative to review all known potential side effects with the patient before any procedure.

Office Building Commercial Tile Carpet, induration, bruising, tenderness, itching, edema, and erythema at the injection site (Rcyb High Intensity Suspended Iron Separator for Magnetic Metal Separation). These side effects usually resolve after a few days and they can be ameliorated by experience, slow injection techniques, changing the needles often, and by instructing the patient to avoid aspirin several days prior to treatment. There have been reports of hypersensitivity reactions ranging from 0.0005% to 0.42% (New Arrival Huge Bucket for Complex Terrain Garden Loader/Mini Dumper;Thermostat 32deg. C for 20~300cube Meter Pool Cop4.62 Titanium 12kw/19kw/35kw/70kw/105kw Air to Water Swimming Pool Heat Pump) and, in rare cases, necrosis or embolization might occur ( Soft Security Polo Shirts;China MS Sealant & MS Polymer). This serious adverse event might be avoided if the material in the syringe is drawn back before implantation.

Conclusion

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References

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