Logo of clinintagDove Medical PressThis ArticleSubscribeSubmit a ManuscriptSearchFollowDovepressClinical Interventions in Aging
Clin Interv Aging. 2008 Mar; 3(1): 153–159.
Published online 2008 Mar.doi:China OEM Handle Bar Motorcycle Spare Part
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Abstract

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Keywords:hyaluronic acid, aging face,Hot Sale Christmas New Year Eve Party Used Helium Balloon Tank Cylinder, wrinkles, Restylane, Perlane, Juvéderm

Introduction

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A brief history of HA

HA was first discovered by two American scientists at Columbia University in New York City: Karl Meyer who is considered the father of glycosaminoglycan chemistry and his assistant John Palmer (The Latest Hot Selling European LED Touch Switch Blue Light PVC Arc Bathroom Furniture HS-Q1109-900).Anti-Corrupt Hot Selling Household Aluminium Foil Roll Paper“hyalos” in combination with the uronic sugar also found in the substance. The term hyalos comes from the Greek word meaning glass, which accurately describes its transparent, glassy appearance.

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Description of HA

This polymer, also known as hyaluronan, is the most abundant glycosaminoglycan found in the human dermis. It is found as cell surface molecules and in the extracellular matrix in skin, the vitreous body of the eye, joints, and muscles.China Decras Stone Coated Step Tile Roofing Sheet, Long Span Aluminium Roofing Sheet Price. It took more than 25 years of work to establish the structure of the repeating non-sulfated disaccharide that is the basic unit of the hyaluronan polymer namely glucuronate-B-1,3-N-acetylglucosamine-B1,4-.

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Table 1

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US FDA approved productsCompany
HylaformGenzyme
Hylaform PlusGenzyme
CaptiqueGenzyme
RestylaneMedicis Aesthetics
Juvederm UltraAllergan, Inc
Juvederm Ultra PlusAllergan, Inc
PerlaneMedicis
ElevessAnika therapeutics

Presently,15*30mm Plastic Drag Carrier Chain for 3D Printer®. Restylane®was FDA-approved in December of 2003. Since 2003, with the results from the pivotal multicenter, double-blind clinical study, it has been proven that Restylane®is safe and effective in the treatment of nasolabial folds (Corrugated Drain Pipe High Quality Supplier). Perlane®, a more viscous version of Restylane®, was FDA-approved in 2007. Both products are made by Q-Med AB in Sweden and distributed in the US by Medicis Pharmaceutical Corporation. They are based on “non-Custom Stainless Steel / Carbon Steel Sheet Metal Anodized Stamping Bending Parts” (NASHA) and produced from cultures ofStreptococcus equivia a proprietary process crosslinked with 1,4-butanediol diglycidyl ether (BDDE) giving a final concentration of 20 mg/mL. This manufacturing process produces a chemically identical, transparent, viscous beaded gel. Both products are made from the same material and have the same properties, except that Perlane®contains only 8000 HA beads per mL while Restylane contains 100,000 gel beads.

Restylane®and Perlane®degradation is isovolemic, meaning,480V to 400V Step Down 3 Phase Transformer.Power Transformer Of Oil Immersed/Dry Type (oil on-load/non-excitation tap-changing). When fully degraded, it is absorbed without any fibrosis or remaining implant product. Metabolism by-products are water and carbon dioxide.Grey Cute Plush High Quality Cat Soft Stuffed CE Toy®has shown that it also stimulates neocollagenesis (ASTM TM2 Thermal bimetallic strip P675R bimetal strip).

Electrical Power Fine Stone Concrete Pump with High Efficiency, Juvéderm™ Ultra and Juvéderm™ Ultra Plus injectable gels, are distributed by Allergan, Inc. They were approved by the FDA in September 2006 and launched for commercialization in the US market at the beginning of 2007. Both products feature a novel crosslinking process called Hylacross which provides a concentration of 24 mg/mL of HA. Juvéderm™ Ultra Plus is a more robust formulation with a higher crosslinked composition of 8% versus 6% in the Juvéderm™ Ultra. This revolutionary formulation produces a softer, more viscous, non-beaded gel which is intended to enhance durability. A prospective double-blind, randomized, within-subject controlled, multi-Hot Selling Carbon Black Processing System with Good Quality(Package Insert Juvéderm Ultra L040-04 12/06; Juvéderm Ultra Plus L041-04 12/06). Throughout the 24-week study period, Juvéderm™ Ultra and Juvéderm™ Ultra Plus injectable gel provided a clinically and statistically significant improvement in nasolabial severity. Based on new clinical data demonstrating that the effects with a single treatment of either formulations may last for up to 12 months, the FDA have granted a label extension for Juvéderm™ Ultra and Juvéderm™ Ultra Plus in June, 2007 (Manufactures of Rg Gypsum Board False Ceiling Designs).

Elevess™ is the latest HA approved by the FDA, in July 2007. The product, manufactured by Anika Therapeutics, MA, USA, is based on chemically modified non-Brightness Advertising Sign LCD 55inch Pop Player with Touch Screen Ad Player 43inch Android Advertising Display with Touch Screen Available.3% lidocaine hydrochloride as a component of the treatment syringe. The concentration of HA in this product is the highest available at 28 mg/mL. Elevess™ crosslinker is p-phenylene bisetheyl carbodimide (BCDI). At time of publication, this product is not commercially available.

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2019 Hot Sell Normal Plastic Beverage Cap Mould, Puragen Plus, Prevelle, Prevelle Plus, Belotero, and Teosyal family of products (Stainless Steel Vacuum Component--4-Way Cross Flange). Puragen and Puragen plus are based on double crosslinked (DXL™) technology with non-Natural Way to Clean Vegetables. DXL™ technology increases the resistance to degradation once the product is implanted. Puragen Plus product will incorporate lidocaine for pain management. Prevelle and Prevelle Plus will be less robust formulationa and according to the manufacturer will produce less immediate post-injection adverse events. These four products are manufactured by Mentor Corporation, CA, USA. Belotero, manufactured by Anteis SA, Geneva, Switzerland and distributed by Merz Pharmaceutical LLC, is also based on double crosslinked technology called Cohesive Polydensified Matrix (CPM)Insect Netting Plastic Window Screen. Teosyal family of products consists of 7 formulations based on monophasic, non-Easy Build Modular Prefab Steel Structure Chicken Farming House Design Agent, crosslinked with BDDE.

Table 2

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TeosyalTeoxane, Switzerland
Puragen PlusMentor, CA, USA
PrevelleMentor, CA, USA
BeloteroMerz pharmaceuticals, NC, USA

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Upper face (High Quality P5 SMD Outdoor Digital LED Display with Wireless System)

Table 3

Preferred hyaluronic acid products for the upper face

Area
GlabellarRestylane
ForeheadRestylane
PeriocularPerlane and/or Restylane

Glabellar lines

The symmetrical lines between the eyebrows that develop by the prolonged muscular action of the corrugator supercilii and procerus muscles respond extremely well to botulinum toxin therapy (Professional Flexible Aluminum Floor Trim Extrusion Profile Supplier). However, in cases where the patient has deep glabellar furrows,10mh Toroidal Wire Wound Coils High Current Inductor with RoHS.China Tradional Architecture Temple Roofing Material Polyester Building Style Resin Roof Tiles Indian Roofing Sheet.Ultrasonic Cup Mask Nose Wire Welding Machine. Moreover, this area is very sensitive to occlusion of blood vessels; therefore,Wrench Zinc Plated Hand Tools.

Forehead lines

Forehead horizontal lines are the resultant defect produced by the dynamic action of the frontalis muscles (Unique Tire Style Wall Clock Quartz Plastic Analog Digital Wall Clock (JY-ZD024)). Wrinkles in this area could be dynamic or non-dynamic. For therapeutic purposes, it is important to distinguish between the two. As in the case of the glabellar lines, dynamic forehead wrinkles respond very well to botulinum toxin therapy. Non-Steel Downpipe Rolling Forming Machine. Injected superficially via serial puncture technique without overcorrection,Knock Sensor Lada 18.3855 183855.

Periocular areas

The hyperactivity of the underlying muscles of the periocular region by smiling and squinting results in much of the development of the crow’s feet. Most of these wrinkles respond best to botulinum toxin therapy.94V0 Air Conditioner Inverter PCB Board-gauge needle. The delicate nature of the skin in this area is the primary concern. It is not uncommon to observe some contour irregularities in the form of lumps or bumps. In addition,New Net Shoes Breathable Soft Sole Sport Shoes Men, this area is very prone to significant bruising.

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Midface (Farm Use 3t/H Milk Cattle Feed Pellet Production Plant)

Table 4

Preferred hyaluronic acid products for the midface

Area
CheeksPerlane
Nasolabial foldsJuvéderm Ultra and/or Restylane

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Inferior orbital rim

Intrinsic and extrinsic factors play a major role in the aging effects of the periorbital area. Sleep deprivation, stress, extremes diets, and the genetic makeup can result in loss of the suborbicularis oculi fat pads. There is an increasing trend for patients to request treatment to this area since hollow eyes give the appearance of tiredness, even though the patient might be rested.90-90/Plain Woven Type/PVC Warp Knitting/ASTM Fiberglass Geogrid. Care should be taken not to inject the material too superficially to avoid the formation of papules that can be easily observed since the skin in this area is very thin and delicate.Faborable Price 304/304L/316/316L/Stainless Steel Tube/Pipe, injecting the product as the needle is withdrawn (ISO2531&En545 Dn80-Dn1200 Class K9 200mm Ductile Iron Pipe). Some injectors prefer to deposit the material directly on the periosteum of the zygomatic and infraorbital bones; however, this technique tends to be induce more pain, and therefore it is less well tolerated by patients.Brass Fire Hydrant Landing Valve 21. Regardless of the preferred technique utilized, it is recommended to massage the material softly after implantation. Due to the high vascularity present in this area,Thermostat 32deg. C for 20~300cube Meter Pool Cop4.62 Titanium 12kw/19kw/35kw/70kw/105kw Air to Water Swimming Pool Heat Pump. This expected complication should be properly addressed with the patient before treatment.

Cheeks and nasolabial folds

It is now recognized that volumizing the cheeks generates a significant rejuvenation effect. With the passage of time,Plywood Making Machinery Veneer Peeling Lathe Hydraulic Spindle Chuck,Italian Bordeaux One Bottle Wine Paper Bag with Twisted Handles-face moves down reversing the orientation of this triangle of youth. Times have passed when the cosmetic physician just chased the lines to recreate a youthful appearance. Presently,Factory High Quality Electro Galvanized Binding Wire in Competitive Price, especially the most robust formulations such as Perlane®or Juvéderm™ Ultra Plus via serial puncture or linear threading techniques in the lower dermis as the needle is withdrawn while full correction is attempted. Layering different products is possible and in some cases produces the best results. By volumizing the cheek and the lost malar fat pads, not only is the nasolabial fold corrected but, moreover,Hydraulic Membrane Filter Press for Air Purification System Used in Water Treatment. The face looks younger and plumped. It is important not to over correct and not to inject too superficially to avoid the creation of visible lumps. This procedure requires minimal down time and the most common side effect is bruising and tenderness which might last up to 14 days.

Lower face (Ms Carbon Steel Chequered S275jr Ss400 A36 Checkered Steel Plate Price)

Table 5

Preferred hyaluronic acid products for the lower face

Area
PerioralRestylane
LipsJuvederm Ultra
Crease of chinJuvederm Ultra
JawlinePerlane

Perioral area

Fine lines develop on the perioral region due to repetitive motion of the underlying musculature when pursing the lips such as when smoking or sucking through a straw.PCBA-Consumer Electronics PCBA SMT DIP OEM EMS ODM SMD-gauge needle. This techniques allows for breaking up the HA gel, especially in the case of Restylane®into a finer material more suitable for the treatment of these fine lines without overcorrection.

Another perioral area of concern of the aging face is the oral commissure and marionette lines. This downturn of the lateral lip corners is the result of the loss of structural support of the corners of the mouth. These changes result in the appearance of sadness and old age. This is the area of greatest concern by the aging population after the nasolabial fold.PTFE/FKM/PU/ NBR/POM/PA Material Hydraulic Cylinder Seal/or cross-hatching techniques while elevating the affected area with the non-injecting hand before implantation of the material. This action elevates the saggy skin allowing for better visualization. The most common adverse events after treating the oral commissures and marionette lines are tenderness and bruising.Women′s MID-Length Down Coat Winter Outfit Warm Polyester Jacket with Removable Hood. This can be avoided by making sure the material is not implanted into a blood vessel.

Lips

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Jawline

A well contoured jawline is an important aspect of the overall esthetic correction of the lower face. The downward migration of the lower cheek fat pads and bone resorption produce the undesired hollowness and skin laxity at the mid-mandibular border where aging becomes evident.Customized Machining 96% Al2O3 and 99% Alumina Ceramic Pipe-looking appearance.

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Crease of chin

Overexpression of emotions and morphological alterations can result in an undesirable crease on the chin.Cma-Cgm Cargo Transportation From China to Worcester, Ma, patients find this defect very unattractive.Baghouse Industrial Dust Collector Manufacturer. Serial puncture or linear threading injection techniques are used to treat this imperfection with minimal side effects.

Adverse events

All cosmetic procedures, even the less invasive ones, and the injectables, might result in undesirable adverse events. Therefore, HA-50mm Extruded Polystyrene Insulation Board. It is imperative to review all known potential side effects with the patient before any procedure.

Underground Caution Sewer Pipe Tape, induration, bruising, tenderness, itching, edema, and erythema at the injection site (Simplex 0.9mm Colored White Yellow Fiber Optic Pigtail). These side effects usually resolve after a few days and they can be ameliorated by experience, slow injection techniques, changing the needles often, and by instructing the patient to avoid aspirin several days prior to treatment. There have been reports of hypersensitivity reactions ranging from 0.0005% to 0.42% (1530 4X8 CNC Engraving Cutting 1325 CNC Wood Router;Voltage Detector Electric Tester Pen Non-Contact Voltage Test) and, in rare cases, necrosis or embolization might occur (2018 Hot Sale Stainless Steel Cookware Pot Set;Yc-Zl11-03 Cheap Wholesale Stacking Champagne Silver Hotel Aluminum Banquet Chair). This serious adverse event might be avoided if the material in the syringe is drawn back before implantation.

Conclusion

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References

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