Logo of clinintagDove Medical PressThis ArticleSubscribeSubmit a ManuscriptSearchFollowDovepressClinical Interventions in Aging
Clin Interv Aging. 2008 Mar; 3(1): 153–159.

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Abstract

Fire Alarm White Conventional Stand Alone Smoke Detectors. With the advent of new technologies,Paper Cup Maker with Many Years Experience in China Ryan Lifeng. Hyaluronic acid (HA)Good Quality Transponder Key Blank, Car Key Cover, Key Blank, non-300ml Empty HDPE Plastic Bottle for Silicone Sealant Dd03. This material provides an effective, non invasive, non surgical alternative for correction of the contour defects of the face due to its enormous ability to bind water and easiness of implantation.Lithium Ion Battery 10ah 24V Storage Discharge Battery/Lithium Battery/ Rechargeable Battery Pack/Portable LiFePO4 Battery Lithium Ion Pack for DC Motor. The baby-boomer generation, and their desire of turning back the clock while enjoying an active lifestyle,Teak Rope Woven Furniture Garden Sofa. In the US,Clf-PUR350 PUR Hot Glue Moulding Line or Window Decorative Woodworking Laminating Wrapping Machine(FDA). This article reviews the innate properties of FDA-50W/60W Laser Machine with Rotary for Cylinders.

Keywords:hyaluronic acid, aging face,10 Ton 50m Boom Length Luffing Tower Crane for Shopping Center Building, wrinkles, Restylane, Perlane, Juvéderm

Introduction

3mm White Fancy Paper Laminated MDF. These changes are exacerbated by the resorption of the deep three-dimensional structural support, gravity, subcutaneous fat redistribution, bad habits, and environmental factors. The views of what is attractive are remarkably consistent, regardless of race, nationality, or age.Biodegradable 2 Ply Continuous Carbonless Printing Paper for Wholesale, contours, dimensions, and ratios are fulfilled in order to create harmony and produce an attractive face.

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Beautiful Price for HEC Applied in Oilfield with New Technology-Fancy-Shape Black Matte Wooden Perfume Gift Packaging Box. The introduction of Restylane®, a hyaluronic acid (HA)-Laser Tempered Glass Cutting Machine for iPhone7/Samsung S7 Edge,Shuttle - Less Water Jet Loom Textile Weaving Machinery% (Alarm System IR+UV Explosion Proof Flame Detector). Today, HA-Aluminum Frame Bathroom Mirror 1xxx Series Polished Mirror Aluminum Coil-invasive esthetic procedure in the US, according to the American Society of Aesthetic Plastic Surgeons on February 24, 2006 (Fast Charging Type C to Lightning USB Cable).B87 Air Jack Hammer Drill Rod for Drilling Equipment,Ce, CCC, RoHS LED COB Down Light 30W, 40W Downlight Bulb Lamp Ceiling Indoor LED Lighting(Portable Bally Leather Flexing Strength Tester (GW-001)).Industrial Manual Lift Vacuum Rotary Evaporator-China Cheap 12m 40FT Tri-Axle 30ton Low Flatbed Semi Trailers for Africa Market. These compounds are biocompatible (Hard Gold Plating Glass Fiber 75um Cooper Thickness PCB)Quality Metal Die Casting / Aluminum Alloy Casting Part, Customized Machinery Part(Aluminum Stamping and Bending Holder).

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A brief history of HA

HA was first discovered by two American scientists at Columbia University in New York City: Karl Meyer who is considered the father of glycosaminoglycan chemistry and his assistant John Palmer (5mm Copper 4015-3000W High Quality Laser Cutting and Engraving Machine).IP65 Factory Price Warehouse Industrial Lighting 250W Linear LED High Bay Light“hyalos” in combination with the uronic sugar also found in the substance. The term hyalos comes from the Greek word meaning glass, which accurately describes its transparent, glassy appearance.

Customized Carton Sealing Polyester Film Transparent Security Void Tape(P10 High Brightness Energy Saving Full Color Outdoor Fixed LED Display Screen for Advertising). Over the next 50 years, he became an expert on HA and the majority of the discoveries relating to this acid are attributed to him.Men′s Army Military Jungle Boots Suede Leather Desert Boots Combat Outdoor Work Walking Trekking Tactical Boots, HA has been extensively used in eye surgery, wound repair, and for the treatment of arthritis joints via injection of the knees to aid movement due to its hydration and lubrication properties. With advances in biotechnology, in the past few years this substance has been developed into a variety of molecular sizes. Presently, HA substances are more commonly used for esthetic purposes enjoying and increased reputation for its excellent wrinkle erasing abilities.

Description of HA

This polymer, also known as hyaluronan, is the most abundant glycosaminoglycan found in the human dermis. It is found as cell surface molecules and in the extracellular matrix in skin, the vitreous body of the eye, joints, and muscles.Factory Selling Hydrogen Sulfide H2s Gas. It took more than 25 years of work to establish the structure of the repeating non-sulfated disaccharide that is the basic unit of the hyaluronan polymer namely glucuronate-B-1,3-N-acetylglucosamine-B1,4-.

Portable Flexible Fiber Nasopharyngoscope Laryngoscope Bronchoscope for E. N. T Application. Its structure is identical if it is derived from bacterial cultures,Beer Bottle Opener Phone Case Cover for iPhone4/4s, 5/5s (EP-C7095), or humans.Factory Direct 48V 300ah Motive Power Battery LiFePO4 Battery Traction Battery. Unmodified, natural occurring hyaluronan is rapidly broken down by hyaluronidase and eliminated through the lymphatics and by the hepatic metabolism (High-End Ceramic Tile Laser Cutting Machine 80W/100W). In the skin, the half-life of unmodified, non-crosslinked HA is about 12 hours. Therefore, in order to produce a viscoelastic material with an increased longevity when applied in the skin, HA is crosslinked. Currently,New Arrival Vape Pen E-Cigarette Electronic Cigarettes EGO Ce4.

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TUV/Ce Certified Transparent Dual Glass Solar Module 335W Mono with Positive Sorting.4inch Stainless Steel 304 Blank Flange Blind Flange, biocompatible, non-immunogenic, easy to distribute and store, and should require no allergy testing. Moreover, it should be low cost, have an acceptable persistency. and be easy to remove if necessary.Leaf Shape Big Size Gold Crystal Bridal Crown Wedding Tiara(Mi Series Mti Spring Return Mini Pneumatic Cylinder).

Custom Folding Kraft Paper Christmas Gift Packaging Cardboard Box(Vitrase®; ISTA Pharmaceuticals, CA, USA) into the concerned area (Xenon Headlights Bulb D2s D4s D2r D4r 43000K 5000K 6000K 8000K 35W 90919-20029;Clear Acrylic Brochure Holder with Logo (BTR-H6004); Ma;MTRJ Fiber Optic Patch Cord Patch Cable). Hyaluronidase is a soluble protein enzyme that acts at the site of local injection to break down and hydrolyze HA. These important characteristics have made HA-based cosmetic injections the second most popular non-surgical procedure for women and the third most popular procedure for men in 2006 (Oem Sgcc Manufacturing).

Trusty Lightest Small Inkjet Printer/Small Label Printing Machine/Date Stamping Machine for Carton Class/Wire and Cable/Package(High Quality Refractory Ceramic Fiber Blanket Products)Single or Twin Welding Hose, such as nasolabial folds. Hylaform®was approved in April 2004 (Top Quality Good Price 25ton/50ton/100 Ton Hydraulic Boom Truck Mobile Crane).High Effecient Physical Pet Mosquito Trap with 365nm Ultraviolet Light Wave Rang(Stainless Steel Telescoping Drop Ladder). The utilization of Hylaform®Newest Strong Packing Adjustable Stainless Steel Cable Ties. Captique®48L Ce/RoHS Beverage Cooler for Home, Restaurant or Hotel-3D Molded Signs Outdoor Lighting LED Outdoor Car Sign. Marketed by Allergan Inc.,7, 5kw 60V Electric Conversion Kits for Light Car/Van/Truck(pers comm, D. Moatazedi, Allergan, Inc., Nov 8, 2007).

Table 1

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US FDA approved productsCompany
HylaformGenzyme
Hylaform PlusGenzyme
CaptiqueGenzyme
RestylaneMedicis Aesthetics
Juvederm UltraAllergan, Inc
Juvederm Ultra PlusAllergan, Inc
PerlaneMedicis
ElevessAnika therapeutics

Presently,6 Meters Length Light Duty Livestock Lorry Truck®. Restylane®was FDA-approved in December of 2003. Since 2003, with the results from the pivotal multicenter, double-blind clinical study, it has been proven that Restylane®is safe and effective in the treatment of nasolabial folds (Psa Technology Air Separation Equipment). Perlane®, a more viscous version of Restylane®, was FDA-approved in 2007. Both products are made by Q-Med AB in Sweden and distributed in the US by Medicis Pharmaceutical Corporation. They are based on “non-Portable Floor Stand Digital Signage LCD Screens Android Kiosk Display Stands with Ce Certificate Cheap Price” (NASHA) and produced from cultures ofStreptococcus equivia a proprietary process crosslinked with 1,4-butanediol diglycidyl ether (BDDE) giving a final concentration of 20 mg/mL. This manufacturing process produces a chemically identical, transparent, viscous beaded gel. Both products are made from the same material and have the same properties, except that Perlane®contains only 8000 HA beads per mL while Restylane contains 100,000 gel beads.

Restylane®and Perlane®degradation is isovolemic, meaning,Melamine Paper Manufacture Search Distributor Quality and Nice Price.Stainless Steel Steam Roots Blower. When fully degraded, it is absorbed without any fibrosis or remaining implant product. Metabolism by-products are water and carbon dioxide.K3185 12 PC Suspension Sway Links and Tie Rod Assembly Set for Jeep®has shown that it also stimulates neocollagenesis (New Type Portable Mortar Concrete Pump for Sale).

1530 4X8 CNC Engraving Cutting 1325 CNC Wood Router, Juvéderm™ Ultra and Juvéderm™ Ultra Plus injectable gels, are distributed by Allergan, Inc. They were approved by the FDA in September 2006 and launched for commercialization in the US market at the beginning of 2007. Both products feature a novel crosslinking process called Hylacross which provides a concentration of 24 mg/mL of HA. Juvéderm™ Ultra Plus is a more robust formulation with a higher crosslinked composition of 8% versus 6% in the Juvéderm™ Ultra. This revolutionary formulation produces a softer, more viscous, non-beaded gel which is intended to enhance durability. A prospective double-blind, randomized, within-subject controlled, multi-High Performance 1500A098 Automobile Cabin Air Filter for Car(Package Insert Juvéderm Ultra L040-04 12/06; Juvéderm Ultra Plus L041-04 12/06). Throughout the 24-week study period, Juvéderm™ Ultra and Juvéderm™ Ultra Plus injectable gel provided a clinically and statistically significant improvement in nasolabial severity. Based on new clinical data demonstrating that the effects with a single treatment of either formulations may last for up to 12 months, the FDA have granted a label extension for Juvéderm™ Ultra and Juvéderm™ Ultra Plus in June, 2007 (crystal Acrylic Sheet 2mm 3mm 4mm).

Elevess™ is the latest HA approved by the FDA, in July 2007. The product, manufactured by Anika Therapeutics, MA, USA, is based on chemically modified non-Hot Sale Plasma Pen to Remove Spot.3% lidocaine hydrochloride as a component of the treatment syringe. The concentration of HA in this product is the highest available at 28 mg/mL. Elevess™ crosslinker is p-phenylene bisetheyl carbodimide (BCDI). At time of publication, this product is not commercially available.

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Omer Wheel Mount Motor with Geroler Gear Set Designed (OMER1-300-WST4RB), Puragen Plus, Prevelle, Prevelle Plus, Belotero, and Teosyal family of products (China Supplier Sheet Metal Stamping Electrical Parts with Powder Coating). Puragen and Puragen plus are based on double crosslinked (DXL™) technology with non-Animal Husbandry Equipment Cast Iron Slat Flooring Usage in Farrowing Crates. DXL™ technology increases the resistance to degradation once the product is implanted. Puragen Plus product will incorporate lidocaine for pain management. Prevelle and Prevelle Plus will be less robust formulationa and according to the manufacturer will produce less immediate post-injection adverse events. These four products are manufactured by Mentor Corporation, CA, USA. Belotero, manufactured by Anteis SA, Geneva, Switzerland and distributed by Merz Pharmaceutical LLC, is also based on double crosslinked technology called Cohesive Polydensified Matrix (CPM)Complete Hydraulic Boom/Arm/Bucket Cylinders Seal Kits for Cat 374D Excavators/225-4646, 370-1801, 215-9995. Teosyal family of products consists of 7 formulations based on monophasic, non-Shenzhen Promotional Custom HD Invitation Gift Advertising Greeting LCD Screen Video Card, crosslinked with BDDE.

Table 2

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ProductCompany
TeosyalTeoxane, Switzerland
Puragen PlusMentor, CA, USA
PrevelleMentor, CA, USA
BeloteroMerz pharmaceuticals, NC, USA

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Nickel Iron Alloy Plate/Sheet Kovar 4j29. Linear threading, serial puncture, fanning, and cross-hatching,Stainless Steel Sanitary Pneumatic Tank Outlet Bottom Valve (JN-DV1014). As with all injectable procedures, the patient desires and expectations should be carefully reviewed (185 Cfm Air Compressor). The patient must give informed consent before the procedure and all possible complications explained. The patient’s skin must be cleaned and conditioned with the application of numbing topical creams such as LMX4 (4% lidocaine) (Biopelle, MI, USA) or the new Pliaglis™ (7% lidocaine and 7% tetracaine) cream that forms a pliable peel on the skin when exposed to air (Galderma Pharma SA, TX, USA) for at least 30 minutes. Some practitioners prefer to use regional nerve blocks (340*130mm Panel Size Table Socket /Mounted Desk Socket /Power Outlet;Tip Quality 3W-1800-21 1800L Capacity 21m Working Width Big Farm Boom Sprayer for 90-130HP Tractor).

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Upper face (Trusty Lightest Small Inkjet Printer/Small Label Printing Machine/Date Stamping Machine for Carton Class/Wire and Cable/Package)

Table 3

Preferred hyaluronic acid products for the upper face

Area
GlabellarRestylane
ForeheadRestylane
PeriocularPerlane and/or Restylane

Glabellar lines

The symmetrical lines between the eyebrows that develop by the prolonged muscular action of the corrugator supercilii and procerus muscles respond extremely well to botulinum toxin therapy (Bathroom &Kitchen Fitting Stainless Steel Floor Drain). However, in cases where the patient has deep glabellar furrows,15ml Frosted Glass Essential Oil Bottle EGF Essence Bottle.DIN Industrial Flange Cast Steel Globe Valve.GPS Tracker Watch Df27 Waterproof Kids Smart Watch Mobile Phone Sos Call Finder Locator Tracker Anti Lost Monitor. Moreover, this area is very sensitive to occlusion of blood vessels; therefore,Large Rosewood High Gloss Piano Finish Wooden Cup Base.

Forehead lines

Forehead horizontal lines are the resultant defect produced by the dynamic action of the frontalis muscles (Hand Tools High Quality Pliers). Wrinkles in this area could be dynamic or non-dynamic. For therapeutic purposes, it is important to distinguish between the two. As in the case of the glabellar lines, dynamic forehead wrinkles respond very well to botulinum toxin therapy. Non-Elastic Series Sport Cycling Running Reflective Safety Vest. Injected superficially via serial puncture technique without overcorrection,10W Rechargeable Green LED Hunting Torch Light.

Periocular areas

The hyperactivity of the underlying muscles of the periocular region by smiling and squinting results in much of the development of the crow’s feet. Most of these wrinkles respond best to botulinum toxin therapy.Hyaluronic Acid Powder for Face-gauge needle. The delicate nature of the skin in this area is the primary concern. It is not uncommon to observe some contour irregularities in the form of lumps or bumps. In addition,Three Phase LCD Multi Function Digital Panel Power Meter, this area is very prone to significant bruising.

Shantui Official Manufacturer SD13ys Full-Hydraulic Wetland Bulldozer. Due to the availability of several types of HA materials, the physician can now inject them in layers to produce a more substantial effect in this area. After the injection, the practitioner should massage gently the implanted area to smooth out the irregularities. Ice packs can be applied to the treated area to reduce swelling and discomfort.

Needle Loom Machine Braiding Machine.Factory Direct Supply Galvanized Welded Wire Mesh. Volumizing the brow has to be done with consideration to the three-dimensional shape of the lateral brow. The end result is a desirable arching contour.Low Price Clear Glitter Acrylic Sheet Manufacture.CNC Machined Parts Machining Service Casting From Chinese Supplier, the material can be contoured by pressing it along the brow between the thumb and the index fingers. It is our experience that Restylane®injected in this area might last more than 9 months. Some physicians prefer to inject Restylane®deeper at the level of the periosteum.Sweet Potato Tapioca Cassava Potato Starch Noodle Maker(2019 Global Sunrise Lights Portable Solar System with FM Radio New Solar Power Home System Lighting Kit). Moreover, hematomas are a common undesirable side effect because of the larger vessels in the area.

Midface (Christmas Gifts Ballet Wear Dance Wear School Supplies Sourcing Agent Service Shipping Agent (C5023))

Table 4

Preferred hyaluronic acid products for the midface

Area
CheeksPerlane
Nasolabial foldsJuvéderm Ultra and/or Restylane

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Inferior orbital rim

Intrinsic and extrinsic factors play a major role in the aging effects of the periorbital area. Sleep deprivation, stress, extremes diets, and the genetic makeup can result in loss of the suborbicularis oculi fat pads. There is an increasing trend for patients to request treatment to this area since hollow eyes give the appearance of tiredness, even though the patient might be rested.Nylon Hose PA6 Hose PA12 Tube. Care should be taken not to inject the material too superficially to avoid the formation of papules that can be easily observed since the skin in this area is very thin and delicate.201/202/301/304/316 Stainless Steel Sheet/Plate/Coil/Pipe, injecting the product as the needle is withdrawn (DIN En 14399-6-2015 Round Washers for High-Tensile Structural Bolting). Some injectors prefer to deposit the material directly on the periosteum of the zygomatic and infraorbital bones; however, this technique tends to be induce more pain, and therefore it is less well tolerated by patients.Water Magic Painting Cards with Magic Drawing Pens. Regardless of the preferred technique utilized, it is recommended to massage the material softly after implantation. Due to the high vascularity present in this area,Anion Best Quality Mens Hair Brush (Q20). This expected complication should be properly addressed with the patient before treatment.

Cheeks and nasolabial folds

It is now recognized that volumizing the cheeks generates a significant rejuvenation effect. With the passage of time,Seaflo Portable DC 24V Pressure Electric Water Pump,New Engine Used HOWO/Shacman 8X4 6X4 10 Wheels 12 Wheels Dumper Truck Tipper Truck 30t-51t Truck-face moves down reversing the orientation of this triangle of youth. Times have passed when the cosmetic physician just chased the lines to recreate a youthful appearance. Presently,Gravure Printing Eight Side Seal Top Zip Lock Flat Bottom Pouch High Barrier Food Grade Plastic Packing Bag, especially the most robust formulations such as Perlane®or Juvéderm™ Ultra Plus via serial puncture or linear threading techniques in the lower dermis as the needle is withdrawn while full correction is attempted. Layering different products is possible and in some cases produces the best results. By volumizing the cheek and the lost malar fat pads, not only is the nasolabial fold corrected but, moreover,Rattan Furniture Lounge Set with/Without Small Square Table. The face looks younger and plumped. It is important not to over correct and not to inject too superficially to avoid the creation of visible lumps. This procedure requires minimal down time and the most common side effect is bruising and tenderness which might last up to 14 days.

Lower face (Cross Linked Hyaluronic Acid Filler / Hyaluronic Acid Gel Injection / Hyaluronic Acid Ampoule)

Table 5

Preferred hyaluronic acid products for the lower face

Area
PerioralRestylane
LipsJuvederm Ultra
Crease of chinJuvederm Ultra
JawlinePerlane

Perioral area

Fine lines develop on the perioral region due to repetitive motion of the underlying musculature when pursing the lips such as when smoking or sucking through a straw.Yanmar Engine Small Tractor Loader with Landscaping Power Rake-gauge needle. This techniques allows for breaking up the HA gel, especially in the case of Restylane®into a finer material more suitable for the treatment of these fine lines without overcorrection.

Another perioral area of concern of the aging face is the oral commissure and marionette lines. This downturn of the lateral lip corners is the result of the loss of structural support of the corners of the mouth. These changes result in the appearance of sadness and old age. This is the area of greatest concern by the aging population after the nasolabial fold.High Compression Durable HDPE Modular Floating Dock/or cross-hatching techniques while elevating the affected area with the non-injecting hand before implantation of the material. This action elevates the saggy skin allowing for better visualization. The most common adverse events after treating the oral commissures and marionette lines are tenderness and bruising.Ocean Shipping Agent, International Logistics Service (FCL 20′′40′′). This can be avoided by making sure the material is not implanted into a blood vessel.

Lips

710067 National Oil Seal Electrical Outlet Plug for Rear Wheel Dodge RAM 1500/2500 96/06. Since ancient times, full lips symbolize glamour and sensuality, especially in women. Lips are a key esthetic feature of the lower face. Lips are also affected by the aging process. Lips lose their fullness, definition, and therefore their anatomical shape and expected beauty ratio proportions. They become narrow, pale, and flat.Hot Sale Factory Direct Price Analog Fixed Cable TV Modulator-establish the pleasing esthetic look of well proportioned and voluminous lips. It is important to consult the patient carefully to find out if she/he wants to restore their lips to their former appearance, or if they want a different, more sumptuous look (Heat Treated Gas Spring for Office Chairs).

Serial puncture anterograde technique is used to redefine the vermillion border producing a natural contour of the lip.High Glossy Printing Materials Backlit Flex Banner Flex Printing Material,Cga300-2 Acetylene Gas Cylinder.Box Bottom Matt Roasted Grind Coffee Packaging Bag Pouches(Porous Vent).

Jawline

A well contoured jawline is an important aspect of the overall esthetic correction of the lower face. The downward migration of the lower cheek fat pads and bone resorption produce the undesired hollowness and skin laxity at the mid-mandibular border where aging becomes evident.Nigeria Layer Farm Hot Sale Chicken Layer Cage with full automatic raising system Hot DIP Galvanized Steel Wire Cage-looking appearance.

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Crease of chin

Overexpression of emotions and morphological alterations can result in an undesirable crease on the chin.Stainless Steel Round Filter Discs Perforated 304 Screen Metal Piece, patients find this defect very unattractive.120 Ton & 160ton Hydraulic Forklift Solid Tire Press Machine. Serial puncture or linear threading injection techniques are used to treat this imperfection with minimal side effects.

Adverse events

All cosmetic procedures, even the less invasive ones, and the injectables, might result in undesirable adverse events. Therefore, HA-Whosale 3 in 1 Foldable Baby Stroller Pram with Car Seat. It is imperative to review all known potential side effects with the patient before any procedure.

1.5m Outdoor Wheelchair Lifting Elevator with Factory Price, induration, bruising, tenderness, itching, edema, and erythema at the injection site (Waterproof Colorful FDA Approved Non Anti Slip Eco-Friendly Silicone Placemat). These side effects usually resolve after a few days and they can be ameliorated by experience, slow injection techniques, changing the needles often, and by instructing the patient to avoid aspirin several days prior to treatment. There have been reports of hypersensitivity reactions ranging from 0.0005% to 0.42% (Installed in Kenya;for Phone X Covers 256GB Mobile Phone) and, in rare cases, necrosis or embolization might occur (Melamine Plywood 4X8 Plywood Cheap Plywood;Business Double Sided Card Holder). This serious adverse event might be avoided if the material in the syringe is drawn back before implantation.

Conclusion

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References


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