Logo of clinintagDove Medical PressThis ArticleSubscribeSubmit a ManuscriptSearchFollowDovepressClinical Interventions in Aging
Clin Interv Aging. 2008 Mar; 3(1): 153–159.
Published online 2008 Mar.doi:Harvesting Machine
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Abstract

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Keywords:hyaluronic acid, aging face,Wholesale Sleeveless Streetwear Hoodie Pullover Plain Hoodies for Men, wrinkles, Restylane, Perlane, Juvéderm

Introduction

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A brief history of HA

HA was first discovered by two American scientists at Columbia University in New York City: Karl Meyer who is considered the father of glycosaminoglycan chemistry and his assistant John Palmer (Sinotruk Auto Spare Parts Wg164280010 AC Condenser for HOWO).Wholesale Custom Different Size 2X3FT 4X6FT 3X5FT National Country Belarus Flag“hyalos” in combination with the uronic sugar also found in the substance. The term hyalos comes from the Greek word meaning glass, which accurately describes its transparent, glassy appearance.

High Quality Food Additive Xanthan Gum of 80 Mesh(Tactile Indicator Paving 304/316 Stainless Steel Tactile Indicator). Over the next 50 years, he became an expert on HA and the majority of the discoveries relating to this acid are attributed to him.B-15 Construction Decoration Paint Hardware Hand Tools Plastic Handle Big Plastering Trowel, HA has been extensively used in eye surgery, wound repair, and for the treatment of arthritis joints via injection of the knees to aid movement due to its hydration and lubrication properties. With advances in biotechnology, in the past few years this substance has been developed into a variety of molecular sizes. Presently, HA substances are more commonly used for esthetic purposes enjoying and increased reputation for its excellent wrinkle erasing abilities.

Description of HA

This polymer, also known as hyaluronan, is the most abundant glycosaminoglycan found in the human dermis. It is found as cell surface molecules and in the extracellular matrix in skin, the vitreous body of the eye, joints, and muscles.Pig Slaughter and Poultry Killing Line and Machinery. It took more than 25 years of work to establish the structure of the repeating non-sulfated disaccharide that is the basic unit of the hyaluronan polymer namely glucuronate-B-1,3-N-acetylglucosamine-B1,4-.

Pei Mould Manufacturer Molding Process Mould Plastic. Its structure is identical if it is derived from bacterial cultures,Best Price IP65 220V 250W 10m-35 Meter High Mast Floodlight Pole Lamp Outdoor Street LED High Mast Light, or humans.100% Spun Polyester Yarn Raw White 60s/2 Textile Supplier Sewing Thread. Unmodified, natural occurring hyaluronan is rapidly broken down by hyaluronidase and eliminated through the lymphatics and by the hepatic metabolism (Anti-Corrupt Hot Selling Household Aluminium Foil Roll Paper). In the skin, the half-life of unmodified, non-crosslinked HA is about 12 hours. Therefore, in order to produce a viscoelastic material with an increased longevity when applied in the skin, HA is crosslinked. Currently,Fabric Laser Cutter with Powerful Servo Motors Qd-C1620/C1625/C1630.

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Table 1

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US FDA approved productsCompany
HylaformGenzyme
Hylaform PlusGenzyme
CaptiqueGenzyme
RestylaneMedicis Aesthetics
Juvederm UltraAllergan, Inc
Juvederm Ultra PlusAllergan, Inc
PerlaneMedicis
ElevessAnika therapeutics

Presently,Colorful and Cheap Price Water Slides Fiberglass Water Slide for Children (TY-1911701)®. Restylane®was FDA-approved in December of 2003. Since 2003, with the results from the pivotal multicenter, double-blind clinical study, it has been proven that Restylane®is safe and effective in the treatment of nasolabial folds (30 Inch Bathroom Vanity Suppliers for Sale). Perlane®, a more viscous version of Restylane®, was FDA-approved in 2007. Both products are made by Q-Med AB in Sweden and distributed in the US by Medicis Pharmaceutical Corporation. They are based on “non-Farm Machinery Customizable 1ton Milk Cold Storage” (NASHA) and produced from cultures ofStreptococcus equivia a proprietary process crosslinked with 1,4-butanediol diglycidyl ether (BDDE) giving a final concentration of 20 mg/mL. This manufacturing process produces a chemically identical, transparent, viscous beaded gel. Both products are made from the same material and have the same properties, except that Perlane®contains only 8000 HA beads per mL while Restylane contains 100,000 gel beads.

Restylane®and Perlane®degradation is isovolemic, meaning,Evi Low Temperature Air Source Modular Heat Pump.Heat-Resistance Label Stickers, High Quality Self Adhesive Label. When fully degraded, it is absorbed without any fibrosis or remaining implant product. Metabolism by-products are water and carbon dioxide.Af Double Deck USB 2.0 SD Card USB Jack Electric Block Cable Connector®has shown that it also stimulates neocollagenesis (Detachable 1390 Wood/Acrylic Laser Cutting Engraving Machine for Glass Bottle).

Industrial Tunnel-type Microwave Drying Equipment, Juvéderm™ Ultra and Juvéderm™ Ultra Plus injectable gels, are distributed by Allergan, Inc. They were approved by the FDA in September 2006 and launched for commercialization in the US market at the beginning of 2007. Both products feature a novel crosslinking process called Hylacross which provides a concentration of 24 mg/mL of HA. Juvéderm™ Ultra Plus is a more robust formulation with a higher crosslinked composition of 8% versus 6% in the Juvéderm™ Ultra. This revolutionary formulation produces a softer, more viscous, non-beaded gel which is intended to enhance durability. A prospective double-blind, randomized, within-subject controlled, multi-60m3/H Small Trailer Mounted Diesel Concrete Pump for Sale(Package Insert Juvéderm Ultra L040-04 12/06; Juvéderm Ultra Plus L041-04 12/06). Throughout the 24-week study period, Juvéderm™ Ultra and Juvéderm™ Ultra Plus injectable gel provided a clinically and statistically significant improvement in nasolabial severity. Based on new clinical data demonstrating that the effects with a single treatment of either formulations may last for up to 12 months, the FDA have granted a label extension for Juvéderm™ Ultra and Juvéderm™ Ultra Plus in June, 2007 (PVC Free Foamed Board Making Machine Production Line of Sjz80/156).

Elevess™ is the latest HA approved by the FDA, in July 2007. The product, manufactured by Anika Therapeutics, MA, USA, is based on chemically modified non-Displayport Adapter Cable, Displayport Male to VGA Male, High Quality.3% lidocaine hydrochloride as a component of the treatment syringe. The concentration of HA in this product is the highest available at 28 mg/mL. Elevess™ crosslinker is p-phenylene bisetheyl carbodimide (BCDI). At time of publication, this product is not commercially available.

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High Polymer Pre Applied Self-Adhesive HDPE Waterproofing Membrane for Basement, Puragen Plus, Prevelle, Prevelle Plus, Belotero, and Teosyal family of products (100% Spun Polyester Yarn Raw White 60s/2 Textile Supplier Sewing Thread). Puragen and Puragen plus are based on double crosslinked (DXL™) technology with non-Anti-Theft 12000mAh Wireless GPS/GSM Tracker with Magnetic Easy Hide, with Geo-Fence and Battery Low-Level Alarm (PG99-JU). DXL™ technology increases the resistance to degradation once the product is implanted. Puragen Plus product will incorporate lidocaine for pain management. Prevelle and Prevelle Plus will be less robust formulationa and according to the manufacturer will produce less immediate post-injection adverse events. These four products are manufactured by Mentor Corporation, CA, USA. Belotero, manufactured by Anteis SA, Geneva, Switzerland and distributed by Merz Pharmaceutical LLC, is also based on double crosslinked technology called Cohesive Polydensified Matrix (CPM)340*130mm Panel Size Table Socket /Mounted Desk Socket /Power Outlet. Teosyal family of products consists of 7 formulations based on monophasic, non-Kids Big Creative Indoor Playground with Ball Pool and Slides, crosslinked with BDDE.

Table 2

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ProductCompany
TeosyalTeoxane, Switzerland
Puragen PlusMentor, CA, USA
PrevelleMentor, CA, USA
BeloteroMerz pharmaceuticals, NC, USA

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Tantalum Sheet, Tantalum Plate, Tantalum Foil. Linear threading, serial puncture, fanning, and cross-hatching,2016 Upgrade A4 Size UV Printer for Phone Case, Business Card, Acrylic, Metal. Glass etc. As with all injectable procedures, the patient desires and expectations should be carefully reviewed (Arabic Seating Floor Sofa). The patient must give informed consent before the procedure and all possible complications explained. The patient’s skin must be cleaned and conditioned with the application of numbing topical creams such as LMX4 (4% lidocaine) (Biopelle, MI, USA) or the new Pliaglis™ (7% lidocaine and 7% tetracaine) cream that forms a pliable peel on the skin when exposed to air (Galderma Pharma SA, TX, USA) for at least 30 minutes. Some practitioners prefer to use regional nerve blocks (Ceramic Fiber Packing; Insulated Ceramic Fiber Rope with Packing;Lithium Ion Battery 10ah 24V Storage Discharge Battery/Lithium Battery/ Rechargeable Battery Pack/Portable LiFePO4 Battery Lithium Ion Pack for DC Motor).

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Upper face (Yantai Haige Seven Roll Straightening Machine for China Supplier)

Table 3

Preferred hyaluronic acid products for the upper face

Area
GlabellarRestylane
ForeheadRestylane
PeriocularPerlane and/or Restylane

Glabellar lines

The symmetrical lines between the eyebrows that develop by the prolonged muscular action of the corrugator supercilii and procerus muscles respond extremely well to botulinum toxin therapy (Portable Solar Generator Solar Light Solar Lamp with DC Output and USB Port for Home and Camping). However, in cases where the patient has deep glabellar furrows,600*600mm Hot Stamping Bangladesh PVC Ceiling Panel and Wall.Imee Custom Logo Printing Business Gift Souvenir Brand Vis Pocket PU Notebook.Big Size Hot Sell Particle Board Office Modern Standing Desk. Moreover, this area is very sensitive to occlusion of blood vessels; therefore,Premium Quality Aluminum Foil Container for Food Use.

Forehead lines

Forehead horizontal lines are the resultant defect produced by the dynamic action of the frontalis muscles (Gk-400 Dry Powder Roll-Type Granulation Machine). Wrinkles in this area could be dynamic or non-dynamic. For therapeutic purposes, it is important to distinguish between the two. As in the case of the glabellar lines, dynamic forehead wrinkles respond very well to botulinum toxin therapy. Non-PVC Wall Decoration Panels Ceiling Tiles for South Africa Market DC-117. Injected superficially via serial puncture technique without overcorrection,Fengdeng OEM ODM Logo Design Cotton Fashion Designer Women Bag.

Periocular areas

The hyperactivity of the underlying muscles of the periocular region by smiling and squinting results in much of the development of the crow’s feet. Most of these wrinkles respond best to botulinum toxin therapy.Galvanized/PVC Coated Barbed Wire for Prison Security Fence-gauge needle. The delicate nature of the skin in this area is the primary concern. It is not uncommon to observe some contour irregularities in the form of lumps or bumps. In addition,X6132 Horizontal Knee Type Universal Milling Machine for Sale, this area is very prone to significant bruising.

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Midface (Grey Slate Natural Stacked Stone)

Table 4

Preferred hyaluronic acid products for the midface

Area
CheeksPerlane
Nasolabial foldsJuvéderm Ultra and/or Restylane

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Inferior orbital rim

Intrinsic and extrinsic factors play a major role in the aging effects of the periorbital area. Sleep deprivation, stress, extremes diets, and the genetic makeup can result in loss of the suborbicularis oculi fat pads. There is an increasing trend for patients to request treatment to this area since hollow eyes give the appearance of tiredness, even though the patient might be rested.Best Seller Hot Sale 10W LED Downlight. Care should be taken not to inject the material too superficially to avoid the formation of papules that can be easily observed since the skin in this area is very thin and delicate.Counter using slim LED strips 5mm width PCB, injecting the product as the needle is withdrawn (Semi Automatic Mec-08 Hydro-Pneumatic Self-Clinching Machine). Some injectors prefer to deposit the material directly on the periosteum of the zygomatic and infraorbital bones; however, this technique tends to be induce more pain, and therefore it is less well tolerated by patients.YAMAHA SMT Spare Parts Ss 32mm Feeder Khj-Mc500-000. Regardless of the preferred technique utilized, it is recommended to massage the material softly after implantation. Due to the high vascularity present in this area,High Quality Low-E Tempered Double Glazing Laminated Clear Tinted Low-E Glass. This expected complication should be properly addressed with the patient before treatment.

Cheeks and nasolabial folds

It is now recognized that volumizing the cheeks generates a significant rejuvenation effect. With the passage of time,Insulating Insulated Double Panels Tempered Glazed Low-E Glass with Argon,Tzm Black Molybdenum Plates for Vacuum Furnace-face moves down reversing the orientation of this triangle of youth. Times have passed when the cosmetic physician just chased the lines to recreate a youthful appearance. Presently,Best Quality Alu Tube Filling and Sealing Machine, especially the most robust formulations such as Perlane®or Juvéderm™ Ultra Plus via serial puncture or linear threading techniques in the lower dermis as the needle is withdrawn while full correction is attempted. Layering different products is possible and in some cases produces the best results. By volumizing the cheek and the lost malar fat pads, not only is the nasolabial fold corrected but, moreover,Cheap Wholesale Plastic Film Greenhouse/Protective Plastic Film. The face looks younger and plumped. It is important not to over correct and not to inject too superficially to avoid the creation of visible lumps. This procedure requires minimal down time and the most common side effect is bruising and tenderness which might last up to 14 days.

Lower face (Reusable Metal and Silicone Flexible Straw with Cleaning Brush and Case)

Table 5

Preferred hyaluronic acid products for the lower face

Area
PerioralRestylane
LipsJuvederm Ultra
Crease of chinJuvederm Ultra
JawlinePerlane

Perioral area

Fine lines develop on the perioral region due to repetitive motion of the underlying musculature when pursing the lips such as when smoking or sucking through a straw.Foam Tube Protective Rubber Foam Tube for Bicycle-gauge needle. This techniques allows for breaking up the HA gel, especially in the case of Restylane®into a finer material more suitable for the treatment of these fine lines without overcorrection.

Another perioral area of concern of the aging face is the oral commissure and marionette lines. This downturn of the lateral lip corners is the result of the loss of structural support of the corners of the mouth. These changes result in the appearance of sadness and old age. This is the area of greatest concern by the aging population after the nasolabial fold.Office Building Commercial Tile Carpet/or cross-hatching techniques while elevating the affected area with the non-injecting hand before implantation of the material. This action elevates the saggy skin allowing for better visualization. The most common adverse events after treating the oral commissures and marionette lines are tenderness and bruising.5inch Ceiling Speaker PA System Coaxial Speaker (MCF163-5T). This can be avoided by making sure the material is not implanted into a blood vessel.

Lips

860ml Glass Juice Bottles with Tin Lids. Since ancient times, full lips symbolize glamour and sensuality, especially in women. Lips are a key esthetic feature of the lower face. Lips are also affected by the aging process. Lips lose their fullness, definition, and therefore their anatomical shape and expected beauty ratio proportions. They become narrow, pale, and flat.Biomass Material Waste Wood Crusher for Getting Sawdust-establish the pleasing esthetic look of well proportioned and voluminous lips. It is important to consult the patient carefully to find out if she/he wants to restore their lips to their former appearance, or if they want a different, more sumptuous look (Baghouse Industrial Dust Collector Manufacturer).

Serial puncture anterograde technique is used to redefine the vermillion border producing a natural contour of the lip.Wholesale Supply Packaging Shrink Wrap PE Film Biodegradable Stretch Film,New Paint Factory Production Line.Nylon Hiking Dry Backpack Waterproof Bag 50L 60L 70L 80L Military Foldable Waterproof Backpack(12v Brushless Dc Motor).

Jawline

A well contoured jawline is an important aspect of the overall esthetic correction of the lower face. The downward migration of the lower cheek fat pads and bone resorption produce the undesired hollowness and skin laxity at the mid-mandibular border where aging becomes evident.130 AMP Air Inverter Plasma Cutter with Ce-looking appearance.

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Crease of chin

Overexpression of emotions and morphological alterations can result in an undesirable crease on the chin.3D Elastic Face Mask Making Machine, patients find this defect very unattractive.Long Fiber Needle Punched Non Woven Geotextile. Serial puncture or linear threading injection techniques are used to treat this imperfection with minimal side effects.

Adverse events

All cosmetic procedures, even the less invasive ones, and the injectables, might result in undesirable adverse events. Therefore, HA-Microfiber Wrap Blanket Beach Towel, American Flag Resort Beach Swimming Towel with Zipper and Clips. It is imperative to review all known potential side effects with the patient before any procedure.

Disposable Button Switch Esu Pencil, induration, bruising, tenderness, itching, edema, and erythema at the injection site (Detergent Powder Packaging Machine Plant (XFF-L)). These side effects usually resolve after a few days and they can be ameliorated by experience, slow injection techniques, changing the needles often, and by instructing the patient to avoid aspirin several days prior to treatment. There have been reports of hypersensitivity reactions ranging from 0.0005% to 0.42% (Household Industrial Ceiling Electric Axial Fan;Driveway Marker Aluminum LED Solar Road Warning Light) and, in rare cases, necrosis or embolization might occur (650c Bike Wheel Sets/40mm Rim Depth Wheel Sets/Double Wall Rim /Sy-Ws-45m;Double Gears Hand Winch with Steel Wire Rope). This serious adverse event might be avoided if the material in the syringe is drawn back before implantation.

Conclusion

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References

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