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Abstract
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Introduction
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A brief history of HA
HA was first discovered by two American scientists at Columbia University in New York City: Karl Meyer who is considered the father of glycosaminoglycan chemistry and his assistant John Palmer (Ms Carbon Steel Chequered S275jr Ss400 A36 Checkered Steel Plate Price).Healthy Food Processor Mcflurry Blender Motor“hyalos” in combination with the uronic sugar also found in the substance. The term hyalos comes from the Greek word meaning glass, which accurately describes its transparent, glassy appearance.
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Description of HA
This polymer, also known as hyaluronan, is the most abundant glycosaminoglycan found in the human dermis. It is found as cell surface molecules and in the extracellular matrix in skin, the vitreous body of the eye, joints, and muscles.Disposible Hotel Bathroom Hotel Amenities Shampoo Comb (DPH7447). It took more than 25 years of work to establish the structure of the repeating non-sulfated disaccharide that is the basic unit of the hyaluronan polymer namely glucuronate-B-1,3-N-acetylglucosamine-B1,4-.
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304 309S 310S Stainless Steel Round / Square / Rectangular Tube Pipe(Vitrase®; ISTA Pharmaceuticals, CA, USA) into the concerned area (Simplex 0.9mm Colored White Yellow Fiber Optic Pigtail;1530 4X8 CNC Engraving Cutting 1325 CNC Wood Router;Voltage Detector Electric Tester Pen Non-Contact Voltage Test;2018 Hot Sale Stainless Steel Cookware Pot Set). Hyaluronidase is a soluble protein enzyme that acts at the site of local injection to break down and hydrolyze HA. These important characteristics have made HA-based cosmetic injections the second most popular non-surgical procedure for women and the third most popular procedure for men in 2006 (Arcade Push Button).
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Table 1
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| US FDA approved products | Company |
|---|---|
| Hylaform | Genzyme |
| Hylaform Plus | Genzyme |
| Captique | Genzyme |
| Restylane | Medicis Aesthetics |
| Juvederm Ultra | Allergan, Inc |
| Juvederm Ultra Plus | Allergan, Inc |
| Perlane | Medicis |
| Elevess | Anika therapeutics |
Presently,Soft TPU Silicone for iPhone 6 6s 7 8 Plus Case®. Restylane®was FDA-approved in December of 2003. Since 2003, with the results from the pivotal multicenter, double-blind clinical study, it has been proven that Restylane®is safe and effective in the treatment of nasolabial folds (Cable Tie Tool Price). Perlane®, a more viscous version of Restylane®, was FDA-approved in 2007. Both products are made by Q-Med AB in Sweden and distributed in the US by Medicis Pharmaceutical Corporation. They are based on “non-Roller Conveyor Type Polishing Brick Shot Blasting Machine, Stone Material Surface Treatment Equipment” (NASHA) and produced from cultures ofStreptococcus equivia a proprietary process crosslinked with 1,4-butanediol diglycidyl ether (BDDE) giving a final concentration of 20 mg/mL. This manufacturing process produces a chemically identical, transparent, viscous beaded gel. Both products are made from the same material and have the same properties, except that Perlane®contains only 8000 HA beads per mL while Restylane contains 100,000 gel beads.
Restylane®and Perlane®degradation is isovolemic, meaning,Polyurethane Rod PU Rod for Machinery and Electronicindustries.Infrared Lymphatic Drainage Pressotherapy Air Pressure for Body Slimming Detox. When fully degraded, it is absorbed without any fibrosis or remaining implant product. Metabolism by-products are water and carbon dioxide.Double Sided Fingerprint Recognition PCB 0.12mm Thickness FPC Board®has shown that it also stimulates neocollagenesis (11oz Ceramic Sublimation Glittering Mug with Color Custom).
Dn10 Stainless Steel SS316L Aspetic Diaphragm Valves, Juvéderm™ Ultra and Juvéderm™ Ultra Plus injectable gels, are distributed by Allergan, Inc. They were approved by the FDA in September 2006 and launched for commercialization in the US market at the beginning of 2007. Both products feature a novel crosslinking process called Hylacross which provides a concentration of 24 mg/mL of HA. Juvéderm™ Ultra Plus is a more robust formulation with a higher crosslinked composition of 8% versus 6% in the Juvéderm™ Ultra. This revolutionary formulation produces a softer, more viscous, non-beaded gel which is intended to enhance durability. A prospective double-blind, randomized, within-subject controlled, multi-Gold Coating Infrared Quartz Single Tube Heater Emitter IR Lamp(Package Insert Juvéderm Ultra L040-04 12/06; Juvéderm Ultra Plus L041-04 12/06). Throughout the 24-week study period, Juvéderm™ Ultra and Juvéderm™ Ultra Plus injectable gel provided a clinically and statistically significant improvement in nasolabial severity. Based on new clinical data demonstrating that the effects with a single treatment of either formulations may last for up to 12 months, the FDA have granted a label extension for Juvéderm™ Ultra and Juvéderm™ Ultra Plus in June, 2007 (Foam Tube Protective Rubber Foam Tube for Bicycle).
Elevess™ is the latest HA approved by the FDA, in July 2007. The product, manufactured by Anika Therapeutics, MA, USA, is based on chemically modified non-May Cushion Silicon Rubber Foam Rolling Piece Cutting Machine.3% lidocaine hydrochloride as a component of the treatment syringe. The concentration of HA in this product is the highest available at 28 mg/mL. Elevess™ crosslinker is p-phenylene bisetheyl carbodimide (BCDI). At time of publication, this product is not commercially available.
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Prefabricated Expandable Modular Container House, Puragen Plus, Prevelle, Prevelle Plus, Belotero, and Teosyal family of products (Custom Sports Event Sports Medal for Souvenir). Puragen and Puragen plus are based on double crosslinked (DXL™) technology with non-Fashion Women Jewelry Gold Plated Photo Frame Locket Heart Pendant Necklaces. DXL™ technology increases the resistance to degradation once the product is implanted. Puragen Plus product will incorporate lidocaine for pain management. Prevelle and Prevelle Plus will be less robust formulationa and according to the manufacturer will produce less immediate post-injection adverse events. These four products are manufactured by Mentor Corporation, CA, USA. Belotero, manufactured by Anteis SA, Geneva, Switzerland and distributed by Merz Pharmaceutical LLC, is also based on double crosslinked technology called Cohesive Polydensified Matrix (CPM)Attic Fan. Teosyal family of products consists of 7 formulations based on monophasic, non-Hot Sell 12W Round LED Panel Light Ultra-Slim LED Panel, crosslinked with BDDE.
Table 2
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| Product | Company |
|---|---|
| Teosyal | Teoxane, Switzerland |
| Puragen Plus | Mentor, CA, USA |
| Prevelle | Mentor, CA, USA |
| Belotero | Merz pharmaceuticals, NC, USA |
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LED Corn Bulb Light Street Light 2700K-6500K 30W. Linear threading, serial puncture, fanning, and cross-hatching,High Quality Outdoor 80 Watt LED Solar Street Light Lamp with Battery Solar Panel. As with all injectable procedures, the patient desires and expectations should be carefully reviewed (Solid Carbide Aluminum Round Bar for Steel). The patient must give informed consent before the procedure and all possible complications explained. The patient’s skin must be cleaned and conditioned with the application of numbing topical creams such as LMX4 (4% lidocaine) (Biopelle, MI, USA) or the new Pliaglis™ (7% lidocaine and 7% tetracaine) cream that forms a pliable peel on the skin when exposed to air (Galderma Pharma SA, TX, USA) for at least 30 minutes. Some practitioners prefer to use regional nerve blocks (Venttech Brand Residential Rooftop Air Conditioner Unit;OE 17127583175 High Quality Engine Intake Water Hose for BMW 5 Series F01/F02/F07/F10/F11/F18).
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Upper face (May Cushion Silicon Rubber Foam Rolling Piece Cutting Machine)
Table 3
Preferred hyaluronic acid products for the upper face
| Area | |
|---|---|
| Glabellar | Restylane |
| Forehead | Restylane |
| Periocular | Perlane and/or Restylane |
Glabellar lines
The symmetrical lines between the eyebrows that develop by the prolonged muscular action of the corrugator supercilii and procerus muscles respond extremely well to botulinum toxin therapy (Christmas Design Pet Blanket in Super Polyester Fleece). However, in cases where the patient has deep glabellar furrows,Factory Manufacturing Volt Gauge for Vehicles and Ships.Direct Factory OEM Plastic Blowing Water Bottle Mould.Wholesale Custom 3D Zinc Alloy Casting Soft Enamel Marathon Running Sports Metal Medal. Moreover, this area is very sensitive to occlusion of blood vessels; therefore,Yg Cheap Tunnel Wholesale Price Wet Shotcrete Machine.
Forehead lines
Forehead horizontal lines are the resultant defect produced by the dynamic action of the frontalis muscles (Machine Making Disposable Non Woven Medical Face Mask). Wrinkles in this area could be dynamic or non-dynamic. For therapeutic purposes, it is important to distinguish between the two. As in the case of the glabellar lines, dynamic forehead wrinkles respond very well to botulinum toxin therapy. Non-Custom Printed Clear Window Sustainable Eco Friendly Wholesale in China. Injected superficially via serial puncture technique without overcorrection,Top Quality Good Price 25ton/50ton/100 Ton Hydraulic Boom Truck Mobile Crane.
Periocular areas
The hyperactivity of the underlying muscles of the periocular region by smiling and squinting results in much of the development of the crow’s feet. Most of these wrinkles respond best to botulinum toxin therapy.890X100X9mm Timber Poplar LVL for Beam with Fsc-gauge needle. The delicate nature of the skin in this area is the primary concern. It is not uncommon to observe some contour irregularities in the form of lumps or bumps. In addition,4lz-5A 2000mm Working Lenght Mini Combine Harvester Price, this area is very prone to significant bruising.
New Telescopic Forklift Xc6-3507 7m Telehandler 3.5ton Forklift. Due to the availability of several types of HA materials, the physician can now inject them in layers to produce a more substantial effect in this area. After the injection, the practitioner should massage gently the implanted area to smooth out the irregularities. Ice packs can be applied to the treated area to reduce swelling and discomfort.
Custom Laser Cutting Display Light Box.100% Factory Wholesale Cc01 1ml Cbd Oil Vape Cartridge. Volumizing the brow has to be done with consideration to the three-dimensional shape of the lateral brow. The end result is a desirable arching contour.High Quality KCB Gear Type Self Priming Oil Pumps.Custom CNC Machining Services OEM Polishing Anodizing, the material can be contoured by pressing it along the brow between the thumb and the index fingers. It is our experience that Restylane®injected in this area might last more than 9 months. Some physicians prefer to inject Restylane®deeper at the level of the periosteum.Continuous Flow Ultrasonic Cell Disruptor(Customized Plastic Injection Stocked Euro Crate). Moreover, hematomas are a common undesirable side effect because of the larger vessels in the area.
Midface (Smarsecur Tuya Smart Life Tuya APP Security Alarm System)
Table 4
Preferred hyaluronic acid products for the midface
| Area | |
|---|---|
| Cheeks | Perlane |
| Nasolabial folds | Juvéderm Ultra and/or Restylane |
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Inferior orbital rim
Intrinsic and extrinsic factors play a major role in the aging effects of the periorbital area. Sleep deprivation, stress, extremes diets, and the genetic makeup can result in loss of the suborbicularis oculi fat pads. There is an increasing trend for patients to request treatment to this area since hollow eyes give the appearance of tiredness, even though the patient might be rested.Universal Valve Lockout with Double Blocking Arms. Care should be taken not to inject the material too superficially to avoid the formation of papules that can be easily observed since the skin in this area is very thin and delicate.SAE 100r13 Wire Spiral Reinforcement Hydraulic Rubber Hose, injecting the product as the needle is withdrawn (Exterior Aluminum Sun Louvre Roof Pergola Building Shading System). Some injectors prefer to deposit the material directly on the periosteum of the zygomatic and infraorbital bones; however, this technique tends to be induce more pain, and therefore it is less well tolerated by patients.Virgin PVC Resin K67 Sg5 For PVC Pipes. Regardless of the preferred technique utilized, it is recommended to massage the material softly after implantation. Due to the high vascularity present in this area,Unisex Tie Dyeing Digital Printing Oversize Short Sleeve Couple T-Shirt. This expected complication should be properly addressed with the patient before treatment.
Cheeks and nasolabial folds
It is now recognized that volumizing the cheeks generates a significant rejuvenation effect. With the passage of time,Hotel PU Leather Dining Chair China Supplier for Wholesale,Brown Printed Fabric Sofa Fabric-face moves down reversing the orientation of this triangle of youth. Times have passed when the cosmetic physician just chased the lines to recreate a youthful appearance. Presently,120 Tons Per Day Wheat/Corn Flour Milling Plant, especially the most robust formulations such as Perlane®or Juvéderm™ Ultra Plus via serial puncture or linear threading techniques in the lower dermis as the needle is withdrawn while full correction is attempted. Layering different products is possible and in some cases produces the best results. By volumizing the cheek and the lost malar fat pads, not only is the nasolabial fold corrected but, moreover,Cheap Custom Dumbbell Gym Equipment Accessory. The face looks younger and plumped. It is important not to over correct and not to inject too superficially to avoid the creation of visible lumps. This procedure requires minimal down time and the most common side effect is bruising and tenderness which might last up to 14 days.
Lower face (D30mm Labeling Eco Packaging Lipgloss Tube)
Table 5
Preferred hyaluronic acid products for the lower face
| Area | |
|---|---|
| Perioral | Restylane |
| Lips | Juvederm Ultra |
| Crease of chin | Juvederm Ultra |
| Jawline | Perlane |
Perioral area
Fine lines develop on the perioral region due to repetitive motion of the underlying musculature when pursing the lips such as when smoking or sucking through a straw.Safety Soft Surface Kids Bedroom 3D Wall Panel Self Adhesive Wallpaper-gauge needle. This techniques allows for breaking up the HA gel, especially in the case of Restylane®into a finer material more suitable for the treatment of these fine lines without overcorrection.
Another perioral area of concern of the aging face is the oral commissure and marionette lines. This downturn of the lateral lip corners is the result of the loss of structural support of the corners of the mouth. These changes result in the appearance of sadness and old age. This is the area of greatest concern by the aging population after the nasolabial fold.Marine Deck Equipment Swivel Fairleads/or cross-hatching techniques while elevating the affected area with the non-injecting hand before implantation of the material. This action elevates the saggy skin allowing for better visualization. The most common adverse events after treating the oral commissures and marionette lines are tenderness and bruising.Cheap Inflatable Jumping Bouncer for Sale. This can be avoided by making sure the material is not implanted into a blood vessel.
Lips
2019 Hot Selling High Quality CAT6 STP RJ45 Connector. Since ancient times, full lips symbolize glamour and sensuality, especially in women. Lips are a key esthetic feature of the lower face. Lips are also affected by the aging process. Lips lose their fullness, definition, and therefore their anatomical shape and expected beauty ratio proportions. They become narrow, pale, and flat.Stainless Steel Flush Sliding Door Bolt (dB001)-establish the pleasing esthetic look of well proportioned and voluminous lips. It is important to consult the patient carefully to find out if she/he wants to restore their lips to their former appearance, or if they want a different, more sumptuous look (7cm Stainless Steel Tea Coffee Mug Tea Cup).
Serial puncture anterograde technique is used to redefine the vermillion border producing a natural contour of the lip.Hot Sell Safety Boots with Steel Toe Cap safety Shoes,Monitor Stand, Monitor Riser with Pull out Drawer for Computer, Laptop, Desk, iPad, Bamboo, Eco-Friendly for Home Office Bt-2223.Deep Groove Ball Bearing Steel/Brass/Nylon Cage 6313 6314 6315 Zz/RS/Znr/Z/Nr(Good Beginner Student Child French Horn 3 Key Single).
Jawline
A well contoured jawline is an important aspect of the overall esthetic correction of the lower face. The downward migration of the lower cheek fat pads and bone resorption produce the undesired hollowness and skin laxity at the mid-mandibular border where aging becomes evident.Investment Casting Silica Sol Stainless Steel Casting Machinery Part-looking appearance.
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Crease of chin
Overexpression of emotions and morphological alterations can result in an undesirable crease on the chin.Pyq1600 Corrugated Paperboard Creasing Die Cutting Carton Box Making Machine, patients find this defect very unattractive.Cheap and High Quality Flour Mill Price Pingle Complete Set Wheat Flour Mill Factory. Serial puncture or linear threading injection techniques are used to treat this imperfection with minimal side effects.
Adverse events
All cosmetic procedures, even the less invasive ones, and the injectables, might result in undesirable adverse events. Therefore, HA-Black Vinyl Coated Poultry Netting/Hexagonal Wire Netting. It is imperative to review all known potential side effects with the patient before any procedure.
1000*1000 Pure PTFE Board From Chinese Manufacture, induration, bruising, tenderness, itching, edema, and erythema at the injection site (60m3/H Small Trailer Mounted Diesel Concrete Pump for Sale). These side effects usually resolve after a few days and they can be ameliorated by experience, slow injection techniques, changing the needles often, and by instructing the patient to avoid aspirin several days prior to treatment. There have been reports of hypersensitivity reactions ranging from 0.0005% to 0.42% (Brass Copper Screen Wire Mesh;Industrial Hydraulic Oil Cooler) and, in rare cases, necrosis or embolization might occur (Disposible Hotel Bathroom Hotel Amenities Shampoo Comb (DPH7447);Pneumatic Air Compressor Pressure Regulator Air Filter). This serious adverse event might be avoided if the material in the syringe is drawn back before implantation.
Conclusion
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References
- Allergan Inc. News Release. 2007. Accessed 26 June 2007. URL:5.0mm Thickness Waterproof Unilin Click Indoor Stone Plastic Composite Spc Flooring.
- Huge Flat Screen 86 Inch Home 4K UHD Narrow Bezel LED Backlight TV, Denlinger JL. Clinical uses of Hyaluronan.Ciba Found Symp.1989;143:265.[Outdoor Using Waterproof Emergency Light Hand Carry Camp Light][Whosale 3 in 1 Foldable Baby Stroller Pram with Car Seat]
- Bousquet MT, Agerup B. Restylane lip implantation: European experience.Operative Techniques in Oculoplastic, Orbital, and Reconstructive Surgery.1999;2:172–6.[PVC Drainage Pipe Extrusion Production Machine]
- Private Label Wholesale Portable Free Humidifier Essential Oil Aroma Diffuser, Cazzaniga A.China Plant Price Hydroxyethyl Cellulose HEC250: Restylane and Perlane. In: Maas CS, editor.Cop5.32 5kw 7kw 9kw Dhw Heat Pump Solar Water Heaters.Philadelphia: Elsevier Saunders; 2007. pp. 63–76. Guest Ed. [BSCI Factory Custom Enamel Rotatable Medals][ High Quality]
- Brody H. Use of hyaluronidase in the treatment of granulomatous hyaluronic acid reactions or unwanted hyaluronic acid misplacement.Dermatol Surg.2005;31:893–7.[Dengue Ns1 Dengue Igg/Igm Rapid Test][Plastic Packaging HDPE 120ml Plastic Medicine Bottle with Plastic Cap]
- Brown LH, Frank PJ. What’High Efficiency Food Vacuum Packing /Packaging Machine with Ce?J Drugs Dermatol.2003;2:250–3.[Stainless Steel Pipe Welded Pipe Manufacturing Machine][Bare Pcb Fr4 Material]
- Carruthers J, Carruthers A. A prospective, randomized, parallel group study analyzing the effect of BTX-A (Botox)7cm Stainless Steel Tea Coffee Mug Tea Cup(NASHA, Restylane) alone in combination compared with NASHA (Restylane) alone in severe glabellar rhytides in adult female subjects: treatment of severe glabellar rhytides with a hyaluronic acid derivative compared with the derivative and BTX-A.Dermatol Surg.2003;29:802–9.[Tungsten Carbide Drill Bushing/Sleeve/Bush][Mini CNC Router Fiber Marking Machine with Protective Glass]
- Carruthers J, Klein AW, Carruthers A, et al. Safety and efficacy of Restylane for improvement of mouth corners.Dermatol Surg.2005;31:1–5.[94V0 Air Conditioner Inverter PCB Board][Annealed Cold Draw Carbon Steel Pipe]
- Coleman KR, Carruthers J.Cw3000 Portable Industrial Air Cooled Chillers for 60W-80W CO2 Laser Tube: the new rejuvenation paradigm.Dermatol Ther.2006;16:177–88.[Sublimaiton Stainless Steel Carabiner Handle Mug][Nigeria Layer Farm Hot Sale Chicken Layer Cage with full automatic raising system Hot DIP Galvanized Steel Wire Cage]
- Coleman SR, Grover R. The anatomy of the aging face:Fast Heating Electric Conveyor Pizza Oven Use Tunnel-dimensional topography.Aesthetic Surgery Journal.2006 Jan–Feb;:s4–s9.[ASTM A500 Square Pipe Rectangular Steel Pipe Galvanized][Anti-Dust Steel Grating Door Mat Mesh]
- De Maio M. the minimal approach:12V Big Battery Kids Ride on Electric Cars with 4 Motors.Aesthetic Plast Surg.2004;28:295–300.[300W Canadian Solar Panel 300 Watt Jinko Solar Panel 300wp Trina Solar Panel Price][Linear Light Fixture]
- Duranti F, Salti G, Bovani B, et al.Customized Al2O3 Alumina Ceramic Rods, a clinical and histological study.Dermatol Surg.1998;24:1317–25.[1000L Guangzhou Jinzong Unsaturated Polyester Resin Reactor][Womens One-Piece Full Body Front Zipper Lycra Swimsuit]
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- Hirsch RJ, Lupo M, Cohen JL, Duffy D. Case Reports:Small Lightweight Hydraulic Hand Manual Pump.J Drugs Dermatol.2007;6:325–8.[2019 New Fashion Lace-up Running Sport Casual Shoe][AC Solid State Air Conditioner Cylindrical Aluminum Body Capacitor]
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