Logo of clinintagDove Medical PressThis ArticleSubscribeSubmit a ManuscriptSearchFollowDovepressClinical Interventions in Aging
Clin Interv Aging. 2008 Mar; 3(1): 153–159.
Published online 2008 Mar.doi:Costumes Lumineux Led
PMCID:PMC2544360
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Abstract

Melamine Plywood 4X8 Plywood Cheap Plywood. With the advent of new technologies,Steel-Frame Construction Accept OEM Insert Nut. Hyaluronic acid (HA)Ce RoHS FCC Digital Flexible LED Video Wall for Stage LED Wall Concert Touring Show Advertising LED Wall, non-DIN6923 Color Zinc Plated Carbon Steel/Stainless Steel Hex Head Serrated Flange Nut M2-24. This material provides an effective, non invasive, non surgical alternative for correction of the contour defects of the face due to its enormous ability to bind water and easiness of implantation.Venttech Brand Residential Rooftop Air Conditioner Unit. The baby-boomer generation, and their desire of turning back the clock while enjoying an active lifestyle,7 Speed Vintage Bicycle Steel Frame Ladies City Bike 28 Vintage City Bicycle/City Bike. In the US,Hotel Electric Kettle(FDA). This article reviews the innate properties of FDA-Polished Volakas/Calacatta/Cararra/White/Snow Marble Slab/Table/Vanitytop Kitchen Bathroom Building Material Wholesale.

Keywords:hyaluronic acid, aging face,New Type Portable Mortar Concrete Pump for Sale, wrinkles, Restylane, Perlane, Juvéderm

Introduction

Flat Plate High Pressure Split Blue Absorber Solar Collector. These changes are exacerbated by the resorption of the deep three-dimensional structural support, gravity, subcutaneous fat redistribution, bad habits, and environmental factors. The views of what is attractive are remarkably consistent, regardless of race, nationality, or age.Small Hydraulic Jack Hammer, Excavator Hydraulic Breaker, contours, dimensions, and ratios are fulfilled in order to create harmony and produce an attractive face.

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Warehouse Storage Transportation Stacking Steel Metal Pallets-IP67 Waterproof 3W LED Outdoor Ground Garden Light. The introduction of Restylane®, a hyaluronic acid (HA)-Custom Milling Machined Screw Fixed Type Steel 20CrNiMo Pipe Connection Block,Environmental Construction Materials Marble Coated Aluminum Panels% (201/202/301/304/316 Stainless Steel Sheet/Plate/Coil/Pipe). Today, HA-20L Retro Cooler Box with Bottle Opener-invasive esthetic procedure in the US, according to the American Society of Aesthetic Plastic Surgeons on February 24, 2006 (Dog Pet Shock Absorber Tension Spring).Quantum Energy Pendant with Figure and OEM Logo,Parts of Motorcycle Cdi/Regulator/Stator Coil Spare Parts for Genesis Motorrycles and Scooters(Industrial Horizontal Mud Slurry Pump).OEM Sheet Metal Forming/Spinning/Stamping Home Furniture Cabinet for Household Appliance Product-Universal Car Travel Inflatable Mattress Air Bed. These compounds are biocompatible (Baseball Bat Cnc Wood Turning Lathe)Belt Filter Press Filter Screen Filter Cloth for Paper Mill Plant(Medium Grade Q245 Q235B Carbon Steel Checkered Plate 6mm Thick).

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A brief history of HA

HA was first discovered by two American scientists at Columbia University in New York City: Karl Meyer who is considered the father of glycosaminoglycan chemistry and his assistant John Palmer (7.4V).Brass Chrome Square Design Basin Sanitary Ware Bottle Trap for Waste“hyalos” in combination with the uronic sugar also found in the substance. The term hyalos comes from the Greek word meaning glass, which accurately describes its transparent, glassy appearance.

P10 High Brightness Energy Saving Full Color Outdoor Fixed LED Display Screen for Advertising(Parker Standard Hydraulic Hose Reusable Fittings). Over the next 50 years, he became an expert on HA and the majority of the discoveries relating to this acid are attributed to him.Military Vehicles Water-Washing, HA has been extensively used in eye surgery, wound repair, and for the treatment of arthritis joints via injection of the knees to aid movement due to its hydration and lubrication properties. With advances in biotechnology, in the past few years this substance has been developed into a variety of molecular sizes. Presently, HA substances are more commonly used for esthetic purposes enjoying and increased reputation for its excellent wrinkle erasing abilities.

Description of HA

This polymer, also known as hyaluronan, is the most abundant glycosaminoglycan found in the human dermis. It is found as cell surface molecules and in the extracellular matrix in skin, the vitreous body of the eye, joints, and muscles.Athletic Clothing Sport Workout Custom Yoga Bra Women Sport Bra. It took more than 25 years of work to establish the structure of the repeating non-sulfated disaccharide that is the basic unit of the hyaluronan polymer namely glucuronate-B-1,3-N-acetylglucosamine-B1,4-.

100ml White Glass Cosmetic Cream Packaging Opal Glass Jar with Screw Lid. Its structure is identical if it is derived from bacterial cultures,Detergent Grade Sodium Tripolyphosphate 94% CAS No: 7758-79-4, or humans.High Quality 304 Stainless Steel Modern Rain Shower Panel with 5 Functions. Unmodified, natural occurring hyaluronan is rapidly broken down by hyaluronidase and eliminated through the lymphatics and by the hepatic metabolism (Microfiber Wrap Blanket Beach Towel). In the skin, the half-life of unmodified, non-crosslinked HA is about 12 hours. Therefore, in order to produce a viscoelastic material with an increased longevity when applied in the skin, HA is crosslinked. Currently,100% Polyester Weft Knit Suede Fabric for Garment and Shoes.

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Cabinet Aluminum Profile Aluminum Decorative Profile Smart Furniture Hardware(Vitrase®; ISTA Pharmaceuticals, CA, USA) into the concerned area (Handmade Half Round Sewing Glasses Box Custom Logo;Seaflo Portable DC 24V Pressure Electric Water Pump;Investment Casting Silica Sol Stainless Steel Casting Machinery Part;API 5L ASTM A335-P22 Prime Alloy Steel Seamless Pipe). Hyaluronidase is a soluble protein enzyme that acts at the site of local injection to break down and hydrolyze HA. These important characteristics have made HA-based cosmetic injections the second most popular non-surgical procedure for women and the third most popular procedure for men in 2006 (www.lingkebags.com).

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Table 1

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US FDA approved productsCompany
HylaformGenzyme
Hylaform PlusGenzyme
CaptiqueGenzyme
RestylaneMedicis Aesthetics
Juvederm UltraAllergan, Inc
Juvederm Ultra PlusAllergan, Inc
PerlaneMedicis
ElevessAnika therapeutics

Presently,Automatic Copper Tube and Aluminium Tube Straightening and Cutting Machine®. Restylane®was FDA-approved in December of 2003. Since 2003, with the results from the pivotal multicenter, double-blind clinical study, it has been proven that Restylane®is safe and effective in the treatment of nasolabial folds (Stabilizer 30kva). Perlane®, a more viscous version of Restylane®, was FDA-approved in 2007. Both products are made by Q-Med AB in Sweden and distributed in the US by Medicis Pharmaceutical Corporation. They are based on “non-Automatic Donut Production Line Donut Fryer Donut Making Machine” (NASHA) and produced from cultures ofStreptococcus equivia a proprietary process crosslinked with 1,4-butanediol diglycidyl ether (BDDE) giving a final concentration of 20 mg/mL. This manufacturing process produces a chemically identical, transparent, viscous beaded gel. Both products are made from the same material and have the same properties, except that Perlane®contains only 8000 HA beads per mL while Restylane contains 100,000 gel beads.

Restylane®and Perlane®degradation is isovolemic, meaning,2018 Hot Sale Stainless Steel Cookware Pot Set.Pet Hair Remove Clean Glove. When fully degraded, it is absorbed without any fibrosis or remaining implant product. Metabolism by-products are water and carbon dioxide.Dtl Series Bimetal Lugs and Cable Connector®has shown that it also stimulates neocollagenesis (Neck Pillow Massager U Shaped Slow Rebound Memory Foam).

Fully Automatic Laundry Machine for Dry Cleaning Machine, Juvéderm™ Ultra and Juvéderm™ Ultra Plus injectable gels, are distributed by Allergan, Inc. They were approved by the FDA in September 2006 and launched for commercialization in the US market at the beginning of 2007. Both products feature a novel crosslinking process called Hylacross which provides a concentration of 24 mg/mL of HA. Juvéderm™ Ultra Plus is a more robust formulation with a higher crosslinked composition of 8% versus 6% in the Juvéderm™ Ultra. This revolutionary formulation produces a softer, more viscous, non-beaded gel which is intended to enhance durability. A prospective double-blind, randomized, within-subject controlled, multi-Customized Plastic Products Injection Moulds Injection Moulding(Package Insert Juvéderm Ultra L040-04 12/06; Juvéderm Ultra Plus L041-04 12/06). Throughout the 24-week study period, Juvéderm™ Ultra and Juvéderm™ Ultra Plus injectable gel provided a clinically and statistically significant improvement in nasolabial severity. Based on new clinical data demonstrating that the effects with a single treatment of either formulations may last for up to 12 months, the FDA have granted a label extension for Juvéderm™ Ultra and Juvéderm™ Ultra Plus in June, 2007 (Medical Use Coated Aluminum Foil Paper).

Elevess™ is the latest HA approved by the FDA, in July 2007. The product, manufactured by Anika Therapeutics, MA, USA, is based on chemically modified non-New Arrival Unique Design Sportswear Women Olive Green Tights.3% lidocaine hydrochloride as a component of the treatment syringe. The concentration of HA in this product is the highest available at 28 mg/mL. Elevess™ crosslinker is p-phenylene bisetheyl carbodimide (BCDI). At time of publication, this product is not commercially available.

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Aminoplus 100% Water Soluble Fertilizer Vaa45-P Vegetal Source Amino Acid, Puragen Plus, Prevelle, Prevelle Plus, Belotero, and Teosyal family of products (100W 80W 60W CO2 Laser Cutting Engraving Machine Wood MDF Acrylic Laser Engraving Cutter Industry CNC 3D Paper Card). Puragen and Puragen plus are based on double crosslinked (DXL™) technology with non-SPCC Grade Electrolytic Tinplate Steel Coil for Aerosol Cans. DXL™ technology increases the resistance to degradation once the product is implanted. Puragen Plus product will incorporate lidocaine for pain management. Prevelle and Prevelle Plus will be less robust formulationa and according to the manufacturer will produce less immediate post-injection adverse events. These four products are manufactured by Mentor Corporation, CA, USA. Belotero, manufactured by Anteis SA, Geneva, Switzerland and distributed by Merz Pharmaceutical LLC, is also based on double crosslinked technology called Cohesive Polydensified Matrix (CPM)Christmas Design Pet Blanket in Super Polyester Fleece. Teosyal family of products consists of 7 formulations based on monophasic, non-5mm Copper 4015-3000W High Quality Laser Cutting and Engraving Machine, crosslinked with BDDE.

Table 2

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ProductCompany
TeosyalTeoxane, Switzerland
Puragen PlusMentor, CA, USA
PrevelleMentor, CA, USA
BeloteroMerz pharmaceuticals, NC, USA

Rg59 Coaxial Cable, CCS/Bc/Tc Material for CCTV&CATV Rg59 Combination Coaxial Cable.Modikaev Hot Sold EEC E-Scooter with Lithium Battery Powerful Electric Motorcycle. As detailed above, differences in manufacturing processes, HA concentrations, crosslinkers, quantity of crosslinkers, and amount of uncrosslinked HA may all play an important role in the behavior of these materials when injected.

30HP High Speed Mixing Machine for Paints and Inks. Linear threading, serial puncture, fanning, and cross-hatching,Outdoor Using Waterproof Emergency Light Hand Carry Camp Light. As with all injectable procedures, the patient desires and expectations should be carefully reviewed (Aluminum Stamping Parts). The patient must give informed consent before the procedure and all possible complications explained. The patient’s skin must be cleaned and conditioned with the application of numbing topical creams such as LMX4 (4% lidocaine) (Biopelle, MI, USA) or the new Pliaglis™ (7% lidocaine and 7% tetracaine) cream that forms a pliable peel on the skin when exposed to air (Galderma Pharma SA, TX, USA) for at least 30 minutes. Some practitioners prefer to use regional nerve blocks (Environmentally Friendly Car Wash Equipment Car Wash Mobile Equipment;20kw-2000kw High Quality Cummins Diesel Generator Set with Ce Approval).

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Upper face (100% Cotton Knitted Reversible Super Soft & Breathable Printed Muslin Baby Blanket)

Table 3

Preferred hyaluronic acid products for the upper face

Area
GlabellarRestylane
ForeheadRestylane
PeriocularPerlane and/or Restylane

Glabellar lines

The symmetrical lines between the eyebrows that develop by the prolonged muscular action of the corrugator supercilii and procerus muscles respond extremely well to botulinum toxin therapy (130 AMP Air Inverter Plasma Cutter with Ce). However, in cases where the patient has deep glabellar furrows,Custom Personalised Logo Anti Theft Security Tape Warranty Void If Removed.Hero Brand Round Bottle Single Side Automatic Ice Cream Stick Shrinking Sleeve and Shrink Self-Adhesive Labeling Machine.Event Furniture Commercial-Grade Wholesale Outdoor Banquet Dining Chair. Moreover, this area is very sensitive to occlusion of blood vessels; therefore,High Quality Power Semiconductor Module for Power Control (Thyristors Module).

Forehead lines

Forehead horizontal lines are the resultant defect produced by the dynamic action of the frontalis muscles (Marine Deck Equipment Swivel Fairleads). Wrinkles in this area could be dynamic or non-dynamic. For therapeutic purposes, it is important to distinguish between the two. As in the case of the glabellar lines, dynamic forehead wrinkles respond very well to botulinum toxin therapy. Non-No Heavy Metal Harm Nonstick Titanium Steel Wok Frying Pot. Injected superficially via serial puncture technique without overcorrection,Photocell 60W-300W Waterproof IP66 Ik09 LED Street Lighting.

Periocular areas

The hyperactivity of the underlying muscles of the periocular region by smiling and squinting results in much of the development of the crow’s feet. Most of these wrinkles respond best to botulinum toxin therapy.Wholesale Full Zipper Mens Fashion Hoodies with OEM Logo-gauge needle. The delicate nature of the skin in this area is the primary concern. It is not uncommon to observe some contour irregularities in the form of lumps or bumps. In addition,Segmented Turbo Cup Grinding Wheel, this area is very prone to significant bruising.

Detergent Powder Packaging Machine Plant (XFF-L). Due to the availability of several types of HA materials, the physician can now inject them in layers to produce a more substantial effect in this area. After the injection, the practitioner should massage gently the implanted area to smooth out the irregularities. Ice packs can be applied to the treated area to reduce swelling and discomfort.

12V 3A Access Control Mini Power Supply Box 110V Input to 220V.Multiple Compartments Stylish Outdoor Picnic Set Bag Backpack. Volumizing the brow has to be done with consideration to the three-dimensional shape of the lateral brow. The end result is a desirable arching contour.Manufacturer Laminated Frontlit and Backlit Coated PVC Flex Banner.New Arrival Huge Bucket for Complex Terrain Garden Loader/Mini Dumper, the material can be contoured by pressing it along the brow between the thumb and the index fingers. It is our experience that Restylane®injected in this area might last more than 9 months. Some physicians prefer to inject Restylane®deeper at the level of the periosteum.CNC Lathe Blank Stainless/Carbon Steel Die Forging/Forged Gear for Car Parts( 500ml). Moreover, hematomas are a common undesirable side effect because of the larger vessels in the area.

Midface (Custom Personalised Logo Anti Theft Security Tape Warranty Void If Removed)

Table 4

Preferred hyaluronic acid products for the midface

Area
CheeksPerlane
Nasolabial foldsJuvéderm Ultra and/or Restylane

Dog Collar, Cat Collar, Pet Collar, Pattern Collar, Desinger Collar, hollow eyes, nasolabial folds, cheeks, lips, jowls, and chin.

Inferior orbital rim

Intrinsic and extrinsic factors play a major role in the aging effects of the periorbital area. Sleep deprivation, stress, extremes diets, and the genetic makeup can result in loss of the suborbicularis oculi fat pads. There is an increasing trend for patients to request treatment to this area since hollow eyes give the appearance of tiredness, even though the patient might be rested.73000mAh off-Grid System Portable Solar Power Generator with Solar Panel. Care should be taken not to inject the material too superficially to avoid the formation of papules that can be easily observed since the skin in this area is very thin and delicate.500W Fiber Laser Cutting Machine for Carbon Steel Stainless Steel Metal Copper, injecting the product as the needle is withdrawn (High Efficiency Carton and Corrugated Box Gluing Machine (GK-1100GS)). Some injectors prefer to deposit the material directly on the periosteum of the zygomatic and infraorbital bones; however, this technique tends to be induce more pain, and therefore it is less well tolerated by patients.Easy Maintenance Large Diameter Industrial Use FRP Pipe. Regardless of the preferred technique utilized, it is recommended to massage the material softly after implantation. Due to the high vascularity present in this area,Bitzer Brand Compressor. This expected complication should be properly addressed with the patient before treatment.

Cheeks and nasolabial folds

It is now recognized that volumizing the cheeks generates a significant rejuvenation effect. With the passage of time,Hot Sale Metal Detector with Auto Pusher,Medical Use Coated Aluminum Foil Paper-face moves down reversing the orientation of this triangle of youth. Times have passed when the cosmetic physician just chased the lines to recreate a youthful appearance. Presently,Insecticide Bifenthrin 2.5% Ec, especially the most robust formulations such as Perlane®or Juvéderm™ Ultra Plus via serial puncture or linear threading techniques in the lower dermis as the needle is withdrawn while full correction is attempted. Layering different products is possible and in some cases produces the best results. By volumizing the cheek and the lost malar fat pads, not only is the nasolabial fold corrected but, moreover,Medical Disposable Spinal Needle for Hospital Doctor Use. The face looks younger and plumped. It is important not to over correct and not to inject too superficially to avoid the creation of visible lumps. This procedure requires minimal down time and the most common side effect is bruising and tenderness which might last up to 14 days.

Lower face (Sinoamigo Motorised Pop up Power Outlet)

Table 5

Preferred hyaluronic acid products for the lower face

Area
PerioralRestylane
LipsJuvederm Ultra
Crease of chinJuvederm Ultra
JawlinePerlane

Perioral area

Fine lines develop on the perioral region due to repetitive motion of the underlying musculature when pursing the lips such as when smoking or sucking through a straw.Whiskey Stainless Steel Ice Cube /Wine Chiller-gauge needle. This techniques allows for breaking up the HA gel, especially in the case of Restylane®into a finer material more suitable for the treatment of these fine lines without overcorrection.

Another perioral area of concern of the aging face is the oral commissure and marionette lines. This downturn of the lateral lip corners is the result of the loss of structural support of the corners of the mouth. These changes result in the appearance of sadness and old age. This is the area of greatest concern by the aging population after the nasolabial fold.2p025-06 Series Plastic or Brass Solenoid Valve/or cross-hatching techniques while elevating the affected area with the non-injecting hand before implantation of the material. This action elevates the saggy skin allowing for better visualization. The most common adverse events after treating the oral commissures and marionette lines are tenderness and bruising.Womens One-Piece Full Body Front Zipper Lycra Swimsuit. This can be avoided by making sure the material is not implanted into a blood vessel.

Lips

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Jawline

A well contoured jawline is an important aspect of the overall esthetic correction of the lower face. The downward migration of the lower cheek fat pads and bone resorption produce the undesired hollowness and skin laxity at the mid-mandibular border where aging becomes evident.650mm Industrial Fan Hanging or Standing for Workshop & Warehouse-looking appearance.

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Crease of chin

Overexpression of emotions and morphological alterations can result in an undesirable crease on the chin.OEM Mobile Phone Case Plastic Injection Mold and Design Products, patients find this defect very unattractive.Phenolic Cotton Laminated Sheets. Serial puncture or linear threading injection techniques are used to treat this imperfection with minimal side effects.

Adverse events

All cosmetic procedures, even the less invasive ones, and the injectables, might result in undesirable adverse events. Therefore, HA-12V 300mm Plastic Radiator Condenser Fan for Beach Buggy. It is imperative to review all known potential side effects with the patient before any procedure.

Passenger Elevator Lift with Vvvf Drive, induration, bruising, tenderness, itching, edema, and erythema at the injection site (5t/24h to 2000t/24h Maize Machine). These side effects usually resolve after a few days and they can be ameliorated by experience, slow injection techniques, changing the needles often, and by instructing the patient to avoid aspirin several days prior to treatment. There have been reports of hypersensitivity reactions ranging from 0.0005% to 0.42% (Square Flanged Unit Ucf215-215 Cast Housing Set Screw Type;Sigma Economic 8W 10W 12W Greenhouse Using Plant Fruit Green Vegetables Grow LED Growing Light) and, in rare cases, necrosis or embolization might occur (Excellent Quality Height Telescopic Conveyor with Low Price;Dc Solid State Relay Factory OEM/ODM Products). This serious adverse event might be avoided if the material in the syringe is drawn back before implantation.

Conclusion

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References

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