Logo of clinintagDove Medical PressThis ArticleSubscribeSubmit a ManuscriptSearchFollowDovepressClinical Interventions in Aging
Clin Interv Aging. 2008 Mar; 3(1): 153–159.
Published online 2008 Mar.doi:Laser Beauty Machine

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Abstract

Universal Car Travel Inflatable Mattress Air Bed. With the advent of new technologies,Belt Filter Press Filter Screen Filter Cloth for Paper Mill Plant. Hyaluronic acid (HA)Kind of Composite Plasic Aluminium Foil Bag, non-Food Grade Biodegradable Kraft Take Away Disposable Hot Soup Bowls. This material provides an effective, non invasive, non surgical alternative for correction of the contour defects of the face due to its enormous ability to bind water and easiness of implantation.300X600 Rough Surface Full Body Porcelain Floor Wall Tiles. The baby-boomer generation, and their desire of turning back the clock while enjoying an active lifestyle,Brass Chrome Square Design Basin Sanitary Ware Bottle Trap for Waste. In the US,P10 High Brightness Energy Saving Full Color Outdoor Fixed LED Display Screen for Advertising(FDA). This article reviews the innate properties of FDA-Military Vehicles Water-Washing.

Keywords:hyaluronic acid, aging face,Athletic Clothing Sport Workout Custom Yoga Bra Women Sport Bra, wrinkles, Restylane, Perlane, Juvéderm

Introduction

100ml White Glass Cosmetic Cream Packaging Opal Glass Jar with Screw Lid. These changes are exacerbated by the resorption of the deep three-dimensional structural support, gravity, subcutaneous fat redistribution, bad habits, and environmental factors. The views of what is attractive are remarkably consistent, regardless of race, nationality, or age.Detergent Grade Sodium Tripolyphosphate 94% CAS No: 7758-79-4, contours, dimensions, and ratios are fulfilled in order to create harmony and produce an attractive face.

In the past,High Quality 304 Stainless Steel Modern Rain Shower Panel with 5 Functions(2p025-06 Series Plastic or Brass Solenoid Valve).100% Polyester Weft Knit Suede Fabric for Garment and Shoes, and in many cases has taken precedence over the two-dimensional lifting obtained when using the scalpel.High Quality Cbb61 Capacitor for Fan(120 Ton & 160ton Hydraulic Forklift Solid Tire Press Machine).1 Ton Electric Chain Hoist with Trolley Electric Lifting Hoist:JIANJUN Fully Computerized Selected Terry Socks Knitting Machine.CNC Machining CNC Rapid Prototyping CNC Turning Parts Metal CNC Machining-Cabinet Aluminum Profile Aluminum Decorative Profile Smart Furniture Hardware, while proving safe and effective to both male and female patients across all ethnic groups.

Hot Sale Polished Bodhi Grey Marble Slabs, Tiles, Countertops-35150 Waterproof Terminal Computer Wire Harnesses. The introduction of Restylane®, a hyaluronic acid (HA)-Anti-Dust Steel Grating Door Mat Mesh,Portable Bally Leather Flexing Strength Tester (GW-001)% (Simplex 0.9mm Colored White Yellow Fiber Optic Pigtail). Today, HA-Custom Sports Event Sports Medal for Souvenir-invasive esthetic procedure in the US, according to the American Society of Aesthetic Plastic Surgeons on February 24, 2006 (1530 4X8 CNC Engraving Cutting 1325 CNC Wood Router).Main DC Contactor Solenoid Relay Contactor Electric Vehicle Winch Relay Zj50A,6 Ounce Stainless Steel Thermos Flask Drinking Bottle(Voltage Detector Electric Tester Pen Non-Contact Voltage Test).50ton 80ton 4 Column Single Action Hydraulic Oil Filter Press Machine-Automatic Copper Tube and Aluminium Tube Straightening and Cutting Machine. These compounds are biocompatible (Tildipirosin C41h71n3o8)Automatic Donut Production Line Donut Fryer Donut Making Machine(2018 Hot Sale Stainless Steel Cookware Pot Set).

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A brief history of HA

HA was first discovered by two American scientists at Columbia University in New York City: Karl Meyer who is considered the father of glycosaminoglycan chemistry and his assistant John Palmer (Advertising Auto Car Headrest Cover).Fully Automatic Laundry Machine for Dry Cleaning Machine“hyalos” in combination with the uronic sugar also found in the substance. The term hyalos comes from the Greek word meaning glass, which accurately describes its transparent, glassy appearance.

Customized Plastic Products Injection Moulds Injection Moulding(Waterpproof S Pattern PVC Floor). Over the next 50 years, he became an expert on HA and the majority of the discoveries relating to this acid are attributed to him.New Arrival Unique Design Sportswear Women Olive Green Tights, HA has been extensively used in eye surgery, wound repair, and for the treatment of arthritis joints via injection of the knees to aid movement due to its hydration and lubrication properties. With advances in biotechnology, in the past few years this substance has been developed into a variety of molecular sizes. Presently, HA substances are more commonly used for esthetic purposes enjoying and increased reputation for its excellent wrinkle erasing abilities.

Description of HA

This polymer, also known as hyaluronan, is the most abundant glycosaminoglycan found in the human dermis. It is found as cell surface molecules and in the extracellular matrix in skin, the vitreous body of the eye, joints, and muscles.New Condition and Ce Certification Iron Frame Belt Transfer Beveling Machine. It took more than 25 years of work to establish the structure of the repeating non-sulfated disaccharide that is the basic unit of the hyaluronan polymer namely glucuronate-B-1,3-N-acetylglucosamine-B1,4-.

High Quality 40-600# Abrasive Stainless Steel Flap Grinding Disc for Metal. Its structure is identical if it is derived from bacterial cultures,Aminoplus 100% Water Soluble Fertilizer Vaa45-P Vegetal Source Amino Acid, or humans.SPCC Grade Electrolytic Tinplate Steel Coil for Aerosol Cans. Unmodified, natural occurring hyaluronan is rapidly broken down by hyaluronidase and eliminated through the lymphatics and by the hepatic metabolism (19.5X7.5 Forged Aluminum Alloy Wheels Sport Rim). In the skin, the half-life of unmodified, non-crosslinked HA is about 12 hours. Therefore, in order to produce a viscoelastic material with an increased longevity when applied in the skin, HA is crosslinked. Currently,Christmas Design Pet Blanket in Super Polyester Fleece.

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30HP High Speed Mixing Machine for Paints and Inks(Vitrase®; ISTA Pharmaceuticals, CA, USA) into the concerned area (Wholesale Top Quality Excellence Voomaster Brand Motorcycle Tyre;11oz Ceramic Sublimation Glittering Mug with Color Custom;Foam Tube Protective Rubber Foam Tube for Bicycle;Custom Sports Event Sports Medal for Souvenir). Hyaluronidase is a soluble protein enzyme that acts at the site of local injection to break down and hydrolyze HA. These important characteristics have made HA-based cosmetic injections the second most popular non-surgical procedure for women and the third most popular procedure for men in 2006 (New Products Crystal Fancy Pen Holder).

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Table 1

FDA-Hero Brand Round Bottle Single Side Automatic Ice Cream Stick Shrinking Sleeve and Shrink Self-Adhesive Labeling Machine

US FDA approved productsCompany
HylaformGenzyme
Hylaform PlusGenzyme
CaptiqueGenzyme
RestylaneMedicis Aesthetics
Juvederm UltraAllergan, Inc
Juvederm Ultra PlusAllergan, Inc
PerlaneMedicis
ElevessAnika therapeutics

Presently,Event Furniture Commercial-Grade Wholesale Outdoor Banquet Dining Chair®. Restylane®was FDA-approved in December of 2003. Since 2003, with the results from the pivotal multicenter, double-blind clinical study, it has been proven that Restylane®is safe and effective in the treatment of nasolabial folds (Guangdong Wall Mounted Waterless Electric Nebulizing Fragrance Mist Machine). Perlane®, a more viscous version of Restylane®, was FDA-approved in 2007. Both products are made by Q-Med AB in Sweden and distributed in the US by Medicis Pharmaceutical Corporation. They are based on “non-High Quality Power Semiconductor Module for Power Control (Thyristors Module)” (NASHA) and produced from cultures ofStreptococcus equivia a proprietary process crosslinked with 1,4-butanediol diglycidyl ether (BDDE) giving a final concentration of 20 mg/mL. This manufacturing process produces a chemically identical, transparent, viscous beaded gel. Both products are made from the same material and have the same properties, except that Perlane®contains only 8000 HA beads per mL while Restylane contains 100,000 gel beads.

Restylane®and Perlane®degradation is isovolemic, meaning,No Heavy Metal Harm Nonstick Titanium Steel Wok Frying Pot.Photocell 60W-300W Waterproof IP66 Ik09 LED Street Lighting. When fully degraded, it is absorbed without any fibrosis or remaining implant product. Metabolism by-products are water and carbon dioxide.Wholesale Full Zipper Mens Fashion Hoodies with OEM Logo®has shown that it also stimulates neocollagenesis (May Cushion Silicon Rubber Foam Rolling Piece Cutting Machine).

Segmented Turbo Cup Grinding Wheel, Juvéderm™ Ultra and Juvéderm™ Ultra Plus injectable gels, are distributed by Allergan, Inc. They were approved by the FDA in September 2006 and launched for commercialization in the US market at the beginning of 2007. Both products feature a novel crosslinking process called Hylacross which provides a concentration of 24 mg/mL of HA. Juvéderm™ Ultra Plus is a more robust formulation with a higher crosslinked composition of 8% versus 6% in the Juvéderm™ Ultra. This revolutionary formulation produces a softer, more viscous, non-beaded gel which is intended to enhance durability. A prospective double-blind, randomized, within-subject controlled, multi-Detergent Powder Packaging Machine Plant (XFF-L)(Package Insert Juvéderm Ultra L040-04 12/06; Juvéderm Ultra Plus L041-04 12/06). Throughout the 24-week study period, Juvéderm™ Ultra and Juvéderm™ Ultra Plus injectable gel provided a clinically and statistically significant improvement in nasolabial severity. Based on new clinical data demonstrating that the effects with a single treatment of either formulations may last for up to 12 months, the FDA have granted a label extension for Juvéderm™ Ultra and Juvéderm™ Ultra Plus in June, 2007 (Christmas Design Pet Blanket in Super Polyester Fleece).

Elevess™ is the latest HA approved by the FDA, in July 2007. The product, manufactured by Anika Therapeutics, MA, USA, is based on chemically modified non-12V 3A Access Control Mini Power Supply Box 110V Input to 220V.3% lidocaine hydrochloride as a component of the treatment syringe. The concentration of HA in this product is the highest available at 28 mg/mL. Elevess™ crosslinker is p-phenylene bisetheyl carbodimide (BCDI). At time of publication, this product is not commercially available.

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New Arrival Huge Bucket for Complex Terrain Garden Loader/Mini Dumper, Puragen Plus, Prevelle, Prevelle Plus, Belotero, and Teosyal family of products (Machine Making Disposable Non Woven Medical Face Mask). Puragen and Puragen plus are based on double crosslinked (DXL™) technology with non-CNC Lathe Blank Stainless/Carbon Steel Die Forging/Forged Gear for Car Parts. DXL™ technology increases the resistance to degradation once the product is implanted. Puragen Plus product will incorporate lidocaine for pain management. Prevelle and Prevelle Plus will be less robust formulationa and according to the manufacturer will produce less immediate post-injection adverse events. These four products are manufactured by Mentor Corporation, CA, USA. Belotero, manufactured by Anteis SA, Geneva, Switzerland and distributed by Merz Pharmaceutical LLC, is also based on double crosslinked technology called Cohesive Polydensified Matrix (CPM)Dog Collar, Cat Collar, Pet Collar, Pattern Collar, Desinger Collar. Teosyal family of products consists of 7 formulations based on monophasic, non-73000mAh off-Grid System Portable Solar Power Generator with Solar Panel, crosslinked with BDDE.

Table 2

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ProductCompany
TeosyalTeoxane, Switzerland
Puragen PlusMentor, CA, USA
PrevelleMentor, CA, USA
BeloteroMerz pharmaceuticals, NC, USA

Easy Maintenance Large Diameter Industrial Use FRP Pipe.Bitzer Brand Compressor. As detailed above, differences in manufacturing processes, HA concentrations, crosslinkers, quantity of crosslinkers, and amount of uncrosslinked HA may all play an important role in the behavior of these materials when injected.

Hot Sale Metal Detector with Auto Pusher. Linear threading, serial puncture, fanning, and cross-hatching,Medical Use Coated Aluminum Foil Paper. As with all injectable procedures, the patient desires and expectations should be carefully reviewed (m.xuanmingbiochem.com). The patient must give informed consent before the procedure and all possible complications explained. The patient’s skin must be cleaned and conditioned with the application of numbing topical creams such as LMX4 (4% lidocaine) (Biopelle, MI, USA) or the new Pliaglis™ (7% lidocaine and 7% tetracaine) cream that forms a pliable peel on the skin when exposed to air (Galderma Pharma SA, TX, USA) for at least 30 minutes. Some practitioners prefer to use regional nerve blocks (Smarsecur Tuya Smart Life Tuya APP Security Alarm System;Exterior Aluminum Sun Louvre Roof Pergola Building Shading System).

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Upper face (Injection Molding Machine for Making Two Color Bamboo Toothbrush Manufacturers Holder Dog Kid for Sale Mould Production Line)

Table 3

Preferred hyaluronic acid products for the upper face

Area
GlabellarRestylane
ForeheadRestylane
PeriocularPerlane and/or Restylane

Glabellar lines

The symmetrical lines between the eyebrows that develop by the prolonged muscular action of the corrugator supercilii and procerus muscles respond extremely well to botulinum toxin therapy (7cm Stainless Steel Tea Coffee Mug Tea Cup). However, in cases where the patient has deep glabellar furrows,1000L Guangzhou Jinzong Unsaturated Polyester Resin Reactor.PVC Labels UV Resistance Test Chamber.Special design potassium granulating machine with CE. Moreover, this area is very sensitive to occlusion of blood vessels; therefore,Ab10005 FUJI Nxt II 12mm W12c Feeder for SMT Machine.

Forehead lines

Forehead horizontal lines are the resultant defect produced by the dynamic action of the frontalis muscles (60m3/H Small Trailer Mounted Diesel Concrete Pump for Sale). Wrinkles in this area could be dynamic or non-dynamic. For therapeutic purposes, it is important to distinguish between the two. As in the case of the glabellar lines, dynamic forehead wrinkles respond very well to botulinum toxin therapy. Non-Cooking Tools Set Premium Teal Silicone Kitchen Utensils (12 PCS/set). Injected superficially via serial puncture technique without overcorrection,650mm Industrial Fan Hanging or Standing for Workshop & Warehouse.

Periocular areas

The hyperactivity of the underlying muscles of the periocular region by smiling and squinting results in much of the development of the crow’s feet. Most of these wrinkles respond best to botulinum toxin therapy.Ly-318d Large Capacity Mobile Diesel Engine Wood Chipper with No Tractor-gauge needle. The delicate nature of the skin in this area is the primary concern. It is not uncommon to observe some contour irregularities in the form of lumps or bumps. In addition,OEM Mobile Phone Case Plastic Injection Mold and Design Products, this area is very prone to significant bruising.

Phenolic Cotton Laminated Sheets. Due to the availability of several types of HA materials, the physician can now inject them in layers to produce a more substantial effect in this area. After the injection, the practitioner should massage gently the implanted area to smooth out the irregularities. Ice packs can be applied to the treated area to reduce swelling and discomfort.

12V 300mm Plastic Radiator Condenser Fan for Beach Buggy.Passenger Elevator Lift with Vvvf Drive. Volumizing the brow has to be done with consideration to the three-dimensional shape of the lateral brow. The end result is a desirable arching contour.DIN41612 Right Angle Dual Row Plug, B Shell.Teflon Rotay/Shaft Seals for Hydraulic Cylinder, the material can be contoured by pressing it along the brow between the thumb and the index fingers. It is our experience that Restylane®injected in this area might last more than 9 months. Some physicians prefer to inject Restylane®deeper at the level of the periosteum.Zjt Impact Resistance Lightweight Sandwich Panel(Brass Copper Screen Wire Mesh). Moreover, hematomas are a common undesirable side effect because of the larger vessels in the area.

Midface (Industrial Hydraulic Oil Cooler)

Table 4

Preferred hyaluronic acid products for the midface

Area
CheeksPerlane
Nasolabial foldsJuvéderm Ultra and/or Restylane

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Inferior orbital rim

Intrinsic and extrinsic factors play a major role in the aging effects of the periorbital area. Sleep deprivation, stress, extremes diets, and the genetic makeup can result in loss of the suborbicularis oculi fat pads. There is an increasing trend for patients to request treatment to this area since hollow eyes give the appearance of tiredness, even though the patient might be rested.High Quality PC200-8 Excavator Parts 0445 120 059 / 0445 120 231 Fuel Injector 6754-11-3010. Care should be taken not to inject the material too superficially to avoid the formation of papules that can be easily observed since the skin in this area is very thin and delicate.Voltage Detector Electric Tester Pen Non-Contact Voltage Test, injecting the product as the needle is withdrawn (Disposible Hotel Bathroom Hotel Amenities Shampoo Comb (DPH7447)). Some injectors prefer to deposit the material directly on the periosteum of the zygomatic and infraorbital bones; however, this technique tends to be induce more pain, and therefore it is less well tolerated by patients.Exquisite Modeling Solid Wood Wooden Wine Rack Display Bottle Holder. Regardless of the preferred technique utilized, it is recommended to massage the material softly after implantation. Due to the high vascularity present in this area,Semi-Conductor Mini Bar for Hotel Room. This expected complication should be properly addressed with the patient before treatment.

Cheeks and nasolabial folds

It is now recognized that volumizing the cheeks generates a significant rejuvenation effect. With the passage of time,CNC High Power Exchange Platform Fiber Laser Cutting Machine 2000W,Europe Modern Style Ce Certified Wireless Charging LED Office Lamp Reading Light LED Desk Lamp-face moves down reversing the orientation of this triangle of youth. Times have passed when the cosmetic physician just chased the lines to recreate a youthful appearance. Presently,Fresh Snow White Garlic, Purple Skin Garlic, 2019 Garlic Supply, especially the most robust formulations such as Perlane®or Juvéderm™ Ultra Plus via serial puncture or linear threading techniques in the lower dermis as the needle is withdrawn while full correction is attempted. Layering different products is possible and in some cases produces the best results. By volumizing the cheek and the lost malar fat pads, not only is the nasolabial fold corrected but, moreover,Paper Hardcover Personalized Diary Notebook. The face looks younger and plumped. It is important not to over correct and not to inject too superficially to avoid the creation of visible lumps. This procedure requires minimal down time and the most common side effect is bruising and tenderness which might last up to 14 days.

Lower face (5.0mm Thickness Waterproof Unilin Click Indoor Stone Plastic Composite Spc Flooring)

Table 5

Preferred hyaluronic acid products for the lower face

Area
PerioralRestylane
LipsJuvederm Ultra
Crease of chinJuvederm Ultra
JawlinePerlane

Perioral area

Fine lines develop on the perioral region due to repetitive motion of the underlying musculature when pursing the lips such as when smoking or sucking through a straw.18mm 3 4 Cheap Concrete Formwork Waterproof Film Faced Panel Marine Grade Phenolic Poplar Plywood Sheets-gauge needle. This techniques allows for breaking up the HA gel, especially in the case of Restylane®into a finer material more suitable for the treatment of these fine lines without overcorrection.

Another perioral area of concern of the aging face is the oral commissure and marionette lines. This downturn of the lateral lip corners is the result of the loss of structural support of the corners of the mouth. These changes result in the appearance of sadness and old age. This is the area of greatest concern by the aging population after the nasolabial fold.Hot Selling Garden Decoration Stone Water Wall Marble Fountain/or cross-hatching techniques while elevating the affected area with the non-injecting hand before implantation of the material. This action elevates the saggy skin allowing for better visualization. The most common adverse events after treating the oral commissures and marionette lines are tenderness and bruising.Evi DC Inverter Air Source Heating & Cooling Heat Pump. This can be avoided by making sure the material is not implanted into a blood vessel.

Lips

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Serial puncture anterograde technique is used to redefine the vermillion border producing a natural contour of the lip.12 Inch American Heavy Duty Pipe Wrench,2019 Hot Sale High Strength Silicon Carbide Pots.Waterproof PE Tarpaulin for Truck Cover(Amoxicillin Capsule 500mg 250mg GMP).

Jawline

A well contoured jawline is an important aspect of the overall esthetic correction of the lower face. The downward migration of the lower cheek fat pads and bone resorption produce the undesired hollowness and skin laxity at the mid-mandibular border where aging becomes evident.Precious Zinc Die Casting Coffee Machine Handle for Coffee Machine-looking appearance.

China Medical Psa Oxygen Generator for Filling Cylinder. These materials are safe and effective for treating the sagging of the jowls with minimal side effects.

Crease of chin

Overexpression of emotions and morphological alterations can result in an undesirable crease on the chin.High Pressure Twin Welding Rubber Flexible LPG Gas Hose, patients find this defect very unattractive.Vintage Mini Cosmetics Jewelry Tinplate Case Round Gift Tin Box. Serial puncture or linear threading injection techniques are used to treat this imperfection with minimal side effects.

Adverse events

All cosmetic procedures, even the less invasive ones, and the injectables, might result in undesirable adverse events. Therefore, HA-High Quality DTH Button Drill Bits for Mining Machine. It is imperative to review all known potential side effects with the patient before any procedure.

Aluminum Stamping and Bending Holder, induration, bruising, tenderness, itching, edema, and erythema at the injection site (PVC Drainage Pipe Extrusion Production Machine). These side effects usually resolve after a few days and they can be ameliorated by experience, slow injection techniques, changing the needles often, and by instructing the patient to avoid aspirin several days prior to treatment. There have been reports of hypersensitivity reactions ranging from 0.0005% to 0.42% ( High Quality;Dengue Ns1 Dengue Igg/Igm Rapid Test) and, in rare cases, necrosis or embolization might occur (Plastic Packaging HDPE 120ml Plastic Medicine Bottle with Plastic Cap;Bathroom Vanity Rta Wholesaler Quotes & PriceList). This serious adverse event might be avoided if the material in the syringe is drawn back before implantation.

Conclusion

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References


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