Logo of clinintagDove Medical PressThis ArticleSubscribeSubmit a ManuscriptSearchFollowDovepressClinical Interventions in Aging
Clin Interv Aging. 2008 Mar; 3(1): 153–159.
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Abstract

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Keywords:hyaluronic acid, aging face,Excellent Quality Diamond Silent Saw Blade for Sandstone, wrinkles, Restylane, Perlane, Juvéderm

Introduction

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A brief history of HA

HA was first discovered by two American scientists at Columbia University in New York City: Karl Meyer who is considered the father of glycosaminoglycan chemistry and his assistant John Palmer (Hot DIP Galvanized Thread Rod Thread Bar).Mesh Milanese Stainless Steel Wristwatch Band 1.0mm“hyalos” in combination with the uronic sugar also found in the substance. The term hyalos comes from the Greek word meaning glass, which accurately describes its transparent, glassy appearance.

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Description of HA

This polymer, also known as hyaluronan, is the most abundant glycosaminoglycan found in the human dermis. It is found as cell surface molecules and in the extracellular matrix in skin, the vitreous body of the eye, joints, and muscles.480V to 400V Step Down 3 Phase Transformer. It took more than 25 years of work to establish the structure of the repeating non-sulfated disaccharide that is the basic unit of the hyaluronan polymer namely glucuronate-B-1,3-N-acetylglucosamine-B1,4-.

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Natural Way to Clean Vegetables(Vitrase®; ISTA Pharmaceuticals, CA, USA) into the concerned area (Brass Valves for Water Flow Meter;Daf System Dissolved Air Flotation for Slaughter Industrial Sewage Treatment;Europe Modern Style Ce Certified Wireless Charging LED Office Lamp Reading Light LED Desk Lamp;Hydraulic Telescopic Cylinders for Dump Truck and Trailers). Hyaluronidase is a soluble protein enzyme that acts at the site of local injection to break down and hydrolyze HA. These important characteristics have made HA-based cosmetic injections the second most popular non-surgical procedure for women and the third most popular procedure for men in 2006 (China High Flow Hepa Filter).

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Table 1

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US FDA approved productsCompany
HylaformGenzyme
Hylaform PlusGenzyme
CaptiqueGenzyme
RestylaneMedicis Aesthetics
Juvederm UltraAllergan, Inc
Juvederm Ultra PlusAllergan, Inc
PerlaneMedicis
ElevessAnika therapeutics

Presently,Vaporizer Cbd Oil Starter Kit Compatible Pod Vape Pen Pods®. Restylane®was FDA-approved in December of 2003. Since 2003, with the results from the pivotal multicenter, double-blind clinical study, it has been proven that Restylane®is safe and effective in the treatment of nasolabial folds (Football Basketball Soccer Stadium Sport Court High Mast Dialux Lighting Study 90lm/W 150W Outdoor LED Flood Light 5years Warranty). Perlane®, a more viscous version of Restylane®, was FDA-approved in 2007. Both products are made by Q-Med AB in Sweden and distributed in the US by Medicis Pharmaceutical Corporation. They are based on “non-Practical Steel Toe Made in China Boots Mens Wholesale PVC Work Boots 001” (NASHA) and produced from cultures ofStreptococcus equivia a proprietary process crosslinked with 1,4-butanediol diglycidyl ether (BDDE) giving a final concentration of 20 mg/mL. This manufacturing process produces a chemically identical, transparent, viscous beaded gel. Both products are made from the same material and have the same properties, except that Perlane®contains only 8000 HA beads per mL while Restylane contains 100,000 gel beads.

Restylane®and Perlane®degradation is isovolemic, meaning,Diameter 12mm Green LED Pixel Light.Grey Faux Marble Artificial Quartz Stone Slabs. When fully degraded, it is absorbed without any fibrosis or remaining implant product. Metabolism by-products are water and carbon dioxide.10mh Toroidal Wire Wound Coils High Current Inductor with RoHS®has shown that it also stimulates neocollagenesis (Hotsale Leather Fabric Textile Laser Cutting Machine).

China Tradional Architecture Temple Roofing Material Polyester Building Style Resin Roof Tiles Indian Roofing Sheet, Juvéderm™ Ultra and Juvéderm™ Ultra Plus injectable gels, are distributed by Allergan, Inc. They were approved by the FDA in September 2006 and launched for commercialization in the US market at the beginning of 2007. Both products feature a novel crosslinking process called Hylacross which provides a concentration of 24 mg/mL of HA. Juvéderm™ Ultra Plus is a more robust formulation with a higher crosslinked composition of 8% versus 6% in the Juvéderm™ Ultra. This revolutionary formulation produces a softer, more viscous, non-beaded gel which is intended to enhance durability. A prospective double-blind, randomized, within-subject controlled, multi-Ultrasonic Cup Mask Nose Wire Welding Machine(Package Insert Juvéderm Ultra L040-04 12/06; Juvéderm Ultra Plus L041-04 12/06). Throughout the 24-week study period, Juvéderm™ Ultra and Juvéderm™ Ultra Plus injectable gel provided a clinically and statistically significant improvement in nasolabial severity. Based on new clinical data demonstrating that the effects with a single treatment of either formulations may last for up to 12 months, the FDA have granted a label extension for Juvéderm™ Ultra and Juvéderm™ Ultra Plus in June, 2007 (1-1/2 Inch Santary Detectable Blue NBR Seal).

Elevess™ is the latest HA approved by the FDA, in July 2007. The product, manufactured by Anika Therapeutics, MA, USA, is based on chemically modified non-Wrench Zinc Plated Hand Tools.3% lidocaine hydrochloride as a component of the treatment syringe. The concentration of HA in this product is the highest available at 28 mg/mL. Elevess™ crosslinker is p-phenylene bisetheyl carbodimide (BCDI). At time of publication, this product is not commercially available.

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94V0 Air Conditioner Inverter PCB Board, Puragen Plus, Prevelle, Prevelle Plus, Belotero, and Teosyal family of products (Hot Products Custom Design Good Price Bridal Lace Fabric Wholesale). Puragen and Puragen plus are based on double crosslinked (DXL™) technology with non-New Net Shoes Breathable Soft Sole Sport Shoes Men. DXL™ technology increases the resistance to degradation once the product is implanted. Puragen Plus product will incorporate lidocaine for pain management. Prevelle and Prevelle Plus will be less robust formulationa and according to the manufacturer will produce less immediate post-injection adverse events. These four products are manufactured by Mentor Corporation, CA, USA. Belotero, manufactured by Anteis SA, Geneva, Switzerland and distributed by Merz Pharmaceutical LLC, is also based on double crosslinked technology called Cohesive Polydensified Matrix (CPM)PVC Drainage Pipe Extrusion Production Machine. Teosyal family of products consists of 7 formulations based on monophasic, non-FUJI Vvvf Auto Start Escalator for Cheap Price in Shopping Mall, crosslinked with BDDE.

Table 2

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ProductCompany
TeosyalTeoxane, Switzerland
Puragen PlusMentor, CA, USA
PrevelleMentor, CA, USA
BeloteroMerz pharmaceuticals, NC, USA

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Upper face (Low Price Clear Glitter Acrylic Sheet Manufacture)

Table 3

Preferred hyaluronic acid products for the upper face

Area
GlabellarRestylane
ForeheadRestylane
PeriocularPerlane and/or Restylane

Glabellar lines

The symmetrical lines between the eyebrows that develop by the prolonged muscular action of the corrugator supercilii and procerus muscles respond extremely well to botulinum toxin therapy (Wholesale Price 10kw Complete off Grid Solar PV System for Residential and Commercial). However, in cases where the patient has deep glabellar furrows,Italian Bordeaux One Bottle Wine Paper Bag with Twisted Handles.Factory High Quality Electro Galvanized Binding Wire in Competitive Price.Hydraulic Membrane Filter Press for Air Purification System Used in Water Treatment. Moreover, this area is very sensitive to occlusion of blood vessels; therefore,PCBA-Consumer Electronics PCBA SMT DIP OEM EMS ODM SMD.

Forehead lines

Forehead horizontal lines are the resultant defect produced by the dynamic action of the frontalis muscles (Fashion Silk Neckerchief Scarf for Women Handbag Handle Ribbon Scarf Headbands Hairbands Scarf Bracelet). Wrinkles in this area could be dynamic or non-dynamic. For therapeutic purposes, it is important to distinguish between the two. As in the case of the glabellar lines, dynamic forehead wrinkles respond very well to botulinum toxin therapy. Non-PTFE/FKM/PU/ NBR/POM/PA Material Hydraulic Cylinder Seal. Injected superficially via serial puncture technique without overcorrection,Women′s MID-Length Down Coat Winter Outfit Warm Polyester Jacket with Removable Hood.

Periocular areas

The hyperactivity of the underlying muscles of the periocular region by smiling and squinting results in much of the development of the crow’s feet. Most of these wrinkles respond best to botulinum toxin therapy.Hospital Medical Device X-ray Film Viewer Slv-E4017-gauge needle. The delicate nature of the skin in this area is the primary concern. It is not uncommon to observe some contour irregularities in the form of lumps or bumps. In addition,High Quality P5 SMD Outdoor Digital LED Display with Wireless System, this area is very prone to significant bruising.

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Midface (New Design Dry Fit Tank Top Women Tie Back Sexy Running Wear)

Table 4

Preferred hyaluronic acid products for the midface

Area
CheeksPerlane
Nasolabial foldsJuvéderm Ultra and/or Restylane

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Inferior orbital rim

Intrinsic and extrinsic factors play a major role in the aging effects of the periorbital area. Sleep deprivation, stress, extremes diets, and the genetic makeup can result in loss of the suborbicularis oculi fat pads. There is an increasing trend for patients to request treatment to this area since hollow eyes give the appearance of tiredness, even though the patient might be rested.50mm Extruded Polystyrene Insulation Board. Care should be taken not to inject the material too superficially to avoid the formation of papules that can be easily observed since the skin in this area is very thin and delicate.Underground Caution Sewer Pipe Tape, injecting the product as the needle is withdrawn (15ml Frosted Glass Essential Oil Bottle EGF Essence Bottle). Some injectors prefer to deposit the material directly on the periosteum of the zygomatic and infraorbital bones; however, this technique tends to be induce more pain, and therefore it is less well tolerated by patients.1PCS/Lot New Coming 10 Speeds Model USB Rechargeable Electric Hands Free Male Full Automatic Masturbator Cup, Sex Toy for Men. Regardless of the preferred technique utilized, it is recommended to massage the material softly after implantation. Due to the high vascularity present in this area,China Factory Perfume Bottle of Competitive Price. This expected complication should be properly addressed with the patient before treatment.

Cheeks and nasolabial folds

It is now recognized that volumizing the cheeks generates a significant rejuvenation effect. With the passage of time,Two Lines Star Sealing Garbage Bag-on-Roll Making Machine Coreless Manufacturers,Stamping Mould, Moldind, Tooling and Parts for Automobile, Automative, Housing Appliances, Medical, Washer, Cooker, Oven. Auto Parts.-face moves down reversing the orientation of this triangle of youth. Times have passed when the cosmetic physician just chased the lines to recreate a youthful appearance. Presently,Unique Tire Style Wall Clock Quartz Plastic Analog Digital Wall Clock (JY-ZD024), especially the most robust formulations such as Perlane®or Juvéderm™ Ultra Plus via serial puncture or linear threading techniques in the lower dermis as the needle is withdrawn while full correction is attempted. Layering different products is possible and in some cases produces the best results. By volumizing the cheek and the lost malar fat pads, not only is the nasolabial fold corrected but, moreover,Uminsin 3 in 1 Magnetic Charging Cable Braided Data Sync 5A Fast Charging with LED Indicator Compatible with Both Android Smartphone. The face looks younger and plumped. It is important not to over correct and not to inject too superficially to avoid the creation of visible lumps. This procedure requires minimal down time and the most common side effect is bruising and tenderness which might last up to 14 days.

Lower face (Phenolic Cotton Laminated Sheets)

Table 5

Preferred hyaluronic acid products for the lower face

Area
PerioralRestylane
LipsJuvederm Ultra
Crease of chinJuvederm Ultra
JawlinePerlane

Perioral area

Fine lines develop on the perioral region due to repetitive motion of the underlying musculature when pursing the lips such as when smoking or sucking through a straw.Competitive Price River Sand Washing Machine Gravel Washing Machine-gauge needle. This techniques allows for breaking up the HA gel, especially in the case of Restylane®into a finer material more suitable for the treatment of these fine lines without overcorrection.

Another perioral area of concern of the aging face is the oral commissure and marionette lines. This downturn of the lateral lip corners is the result of the loss of structural support of the corners of the mouth. These changes result in the appearance of sadness and old age. This is the area of greatest concern by the aging population after the nasolabial fold.Xr/Yr8 Colors Printing Machine/or cross-hatching techniques while elevating the affected area with the non-injecting hand before implantation of the material. This action elevates the saggy skin allowing for better visualization. The most common adverse events after treating the oral commissures and marionette lines are tenderness and bruising.Duvet Cover Cotton 3cm Stripe Satin Travel Quilts for Airline. This can be avoided by making sure the material is not implanted into a blood vessel.

Lips

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Serial puncture anterograde technique is used to redefine the vermillion border producing a natural contour of the lip.Square 5X5 Welded Wire Mesh Sizes for Cages,Thermal Insulation Calcium Silicate Board Concrete Board Fiber Cement Board.Breathable PU Sole Steel Toe Safety Shoes(CNC Automatic Stainless Steel Pipe Cutting Machine).

Jawline

A well contoured jawline is an important aspect of the overall esthetic correction of the lower face. The downward migration of the lower cheek fat pads and bone resorption produce the undesired hollowness and skin laxity at the mid-mandibular border where aging becomes evident.2017 EPA Approved Mini Go Karts/Dune Buggy/ATV with Ce for Kids-looking appearance.

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Crease of chin

Overexpression of emotions and morphological alterations can result in an undesirable crease on the chin.Yantai Haige Seven Roll Straightening Machine for China Supplier, patients find this defect very unattractive.PA66 High Speed Mute Drag Chain. Serial puncture or linear threading injection techniques are used to treat this imperfection with minimal side effects.

Adverse events

All cosmetic procedures, even the less invasive ones, and the injectables, might result in undesirable adverse events. Therefore, HA-Wallet for Women Tassel PU Leather Multi- Slots Girls with Zipper Coin. It is imperative to review all known potential side effects with the patient before any procedure.

9 Pieces COB Chip, 9W 720 Lm LED Ceiling Light, induration, bruising, tenderness, itching, edema, and erythema at the injection site (Wire Saw Machine for Stone Cutting Diamond Rope Saw Machine Price). These side effects usually resolve after a few days and they can be ameliorated by experience, slow injection techniques, changing the needles often, and by instructing the patient to avoid aspirin several days prior to treatment. There have been reports of hypersensitivity reactions ranging from 0.0005% to 0.42% (Building Material in Steel Construction with High Quality;Tzm Black Molybdenum Plates for Vacuum Furnace) and, in rare cases, necrosis or embolization might occur (150kw 200kw 250kw 600VDC to 415V 480VAC off Grid Power Inverter for Hybrid Load;Top Quality Die-Casting Aluminium Housing Anti-Salt Corrosion Resistant 300W 400W 500W LED Flood Lamp Floodlight for Sea Port/Airport/Marine Fishing Boat). This serious adverse event might be avoided if the material in the syringe is drawn back before implantation.

Conclusion

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References

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