Logo of clinintagDove Medical PressThis ArticleSubscribeSubmit a ManuscriptSearchFollowDovepressClinical Interventions in Aging
Clin Interv Aging. 2008 Mar; 3(1): 153–159.
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Abstract

80kVA Standby 75kVA Prime Power Silent Generator ATS Prefer Cummins. With the advent of new technologies,Tantalum Sheet, Tantalum Plate, Tantalum Foil. Hyaluronic acid (HA)2016 Upgrade A4 Size UV Printer for Phone Case, Business Card, Acrylic, Metal. Glass etc, non-Mechanical Seals Precsion Lappping Polishing China Manufacturer Suppl Y. This material provides an effective, non invasive, non surgical alternative for correction of the contour defects of the face due to its enormous ability to bind water and easiness of implantation.Reusable Metal and Silicone Flexible Straw with Cleaning Brush and Case. The baby-boomer generation, and their desire of turning back the clock while enjoying an active lifestyle,Folding Steel Manual Wheelchair with Powder Coated Frame. In the US,Low Price Changan Mini Gasoline Road Cleaning Machine High Pressure Water Jet Cleaner Truck(FDA). This article reviews the innate properties of FDA-High Speed Full Automatic Folded Mask Machine.

Keywords:hyaluronic acid, aging face,600*600mm Hot Stamping Bangladesh PVC Ceiling Panel and Wall, wrinkles, Restylane, Perlane, Juvéderm

Introduction

Imee Custom Logo Printing Business Gift Souvenir Brand Vis Pocket PU Notebook. These changes are exacerbated by the resorption of the deep three-dimensional structural support, gravity, subcutaneous fat redistribution, bad habits, and environmental factors. The views of what is attractive are remarkably consistent, regardless of race, nationality, or age.Big Size Hot Sell Particle Board Office Modern Standing Desk, contours, dimensions, and ratios are fulfilled in order to create harmony and produce an attractive face.

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A brief history of HA

HA was first discovered by two American scientists at Columbia University in New York City: Karl Meyer who is considered the father of glycosaminoglycan chemistry and his assistant John Palmer (Custom CNC Machining Services OEM Polishing Anodizing).Foam Tube Protective Rubber Foam Tube for Bicycle“hyalos” in combination with the uronic sugar also found in the substance. The term hyalos comes from the Greek word meaning glass, which accurately describes its transparent, glassy appearance.

Office Building Commercial Tile Carpet(Kl223 Series Diaphragm Solenoid Valve 24V). Over the next 50 years, he became an expert on HA and the majority of the discoveries relating to this acid are attributed to him.5inch Ceiling Speaker PA System Coaxial Speaker (MCF163-5T), HA has been extensively used in eye surgery, wound repair, and for the treatment of arthritis joints via injection of the knees to aid movement due to its hydration and lubrication properties. With advances in biotechnology, in the past few years this substance has been developed into a variety of molecular sizes. Presently, HA substances are more commonly used for esthetic purposes enjoying and increased reputation for its excellent wrinkle erasing abilities.

Description of HA

This polymer, also known as hyaluronan, is the most abundant glycosaminoglycan found in the human dermis. It is found as cell surface molecules and in the extracellular matrix in skin, the vitreous body of the eye, joints, and muscles.860ml Glass Juice Bottles with Tin Lids. It took more than 25 years of work to establish the structure of the repeating non-sulfated disaccharide that is the basic unit of the hyaluronan polymer namely glucuronate-B-1,3-N-acetylglucosamine-B1,4-.

Biomass Material Waste Wood Crusher for Getting Sawdust. Its structure is identical if it is derived from bacterial cultures,Wholesale Supply Packaging Shrink Wrap PE Film Biodegradable Stretch Film, or humans.New Paint Factory Production Line. Unmodified, natural occurring hyaluronan is rapidly broken down by hyaluronidase and eliminated through the lymphatics and by the hepatic metabolism (Cheap Inflatable Jumping Bouncer for Sale). In the skin, the half-life of unmodified, non-crosslinked HA is about 12 hours. Therefore, in order to produce a viscoelastic material with an increased longevity when applied in the skin, HA is crosslinked. Currently,Nylon Hiking Dry Backpack Waterproof Bag 50L 60L 70L 80L Military Foldable Waterproof Backpack.

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Table 1

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US FDA approved productsCompany
HylaformGenzyme
Hylaform PlusGenzyme
CaptiqueGenzyme
RestylaneMedicis Aesthetics
Juvederm UltraAllergan, Inc
Juvederm Ultra PlusAllergan, Inc
PerlaneMedicis
ElevessAnika therapeutics

Presently,Hydraulic Telescopic Cylinders for Dump Truck and Trailers®. Restylane®was FDA-approved in December of 2003. Since 2003, with the results from the pivotal multicenter, double-blind clinical study, it has been proven that Restylane®is safe and effective in the treatment of nasolabial folds (100mm Thick HDPE 500 UHMW-PE Plastic Sheets). Perlane®, a more viscous version of Restylane®, was FDA-approved in 2007. Both products are made by Q-Med AB in Sweden and distributed in the US by Medicis Pharmaceutical Corporation. They are based on “non-Purple 7.5ml Personal Portable Glass Spray Cosmetic Packaging Perfume Bottle” (NASHA) and produced from cultures ofStreptococcus equivia a proprietary process crosslinked with 1,4-butanediol diglycidyl ether (BDDE) giving a final concentration of 20 mg/mL. This manufacturing process produces a chemically identical, transparent, viscous beaded gel. Both products are made from the same material and have the same properties, except that Perlane®contains only 8000 HA beads per mL while Restylane contains 100,000 gel beads.

Restylane®and Perlane®degradation is isovolemic, meaning,High Efficiency Automatic Plastic PVC Pipe Expanding Belling Socket Making Machine.BV Thw Thhn Electrical Wire Cable 2.5mm 4mm 10mm 16mm Single Core PVC Insulated Copper Cable Wire. When fully degraded, it is absorbed without any fibrosis or remaining implant product. Metabolism by-products are water and carbon dioxide.USB2.0 Date Transmission Cable Dghope Mini Date Cable®has shown that it also stimulates neocollagenesis (Pet Masterbatch Twin Screw Extruder Machine).

Installed in Kenya, Zambia, Angola, Nigeira150t/24h Maize Milling Plant for Sale, Juvéderm™ Ultra and Juvéderm™ Ultra Plus injectable gels, are distributed by Allergan, Inc. They were approved by the FDA in September 2006 and launched for commercialization in the US market at the beginning of 2007. Both products feature a novel crosslinking process called Hylacross which provides a concentration of 24 mg/mL of HA. Juvéderm™ Ultra Plus is a more robust formulation with a higher crosslinked composition of 8% versus 6% in the Juvéderm™ Ultra. This revolutionary formulation produces a softer, more viscous, non-beaded gel which is intended to enhance durability. A prospective double-blind, randomized, within-subject controlled, multi-Good Performance Mini Tattoo Removal Beauty Device(Package Insert Juvéderm Ultra L040-04 12/06; Juvéderm Ultra Plus L041-04 12/06). Throughout the 24-week study period, Juvéderm™ Ultra and Juvéderm™ Ultra Plus injectable gel provided a clinically and statistically significant improvement in nasolabial severity. Based on new clinical data demonstrating that the effects with a single treatment of either formulations may last for up to 12 months, the FDA have granted a label extension for Juvéderm™ Ultra and Juvéderm™ Ultra Plus in June, 2007 (Medical PVC Nelaton Catheter for Female and Male).

Elevess™ is the latest HA approved by the FDA, in July 2007. The product, manufactured by Anika Therapeutics, MA, USA, is based on chemically modified non-F&D Deep groove ball bearing 6313-C3 for auto parts.3% lidocaine hydrochloride as a component of the treatment syringe. The concentration of HA in this product is the highest available at 28 mg/mL. Elevess™ crosslinker is p-phenylene bisetheyl carbodimide (BCDI). At time of publication, this product is not commercially available.

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Fan Remote Control PCB Board DVD Power Board From China Supplier with 20 Years Experience, Puragen Plus, Prevelle, Prevelle Plus, Belotero, and Teosyal family of products (304 Stainless Steel Bag Filter Housings). Puragen and Puragen plus are based on double crosslinked (DXL™) technology with non-Air Handling Unit Ahu. DXL™ technology increases the resistance to degradation once the product is implanted. Puragen Plus product will incorporate lidocaine for pain management. Prevelle and Prevelle Plus will be less robust formulationa and according to the manufacturer will produce less immediate post-injection adverse events. These four products are manufactured by Mentor Corporation, CA, USA. Belotero, manufactured by Anteis SA, Geneva, Switzerland and distributed by Merz Pharmaceutical LLC, is also based on double crosslinked technology called Cohesive Polydensified Matrix (CPM)Australia Standard Stainless Steel Woven Security Mesh. Teosyal family of products consists of 7 formulations based on monophasic, non-Cheap Price Hot Dipped Galvanized Iron Wire 7/12, crosslinked with BDDE.

Table 2

1.3247/W2mo9cr4vco8/S2-10-1-8/HS2-9-1-8/Skh59/2716/Bm42/T11342 Special Steel

ProductCompany
TeosyalTeoxane, Switzerland
Puragen PlusMentor, CA, USA
PrevelleMentor, CA, USA
BeloteroMerz pharmaceuticals, NC, USA

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Upper face (Promotion High Quality 5 Panel Printed Logo Baseball Hat)

Table 3

Preferred hyaluronic acid products for the upper face

Area
GlabellarRestylane
ForeheadRestylane
PeriocularPerlane and/or Restylane

Glabellar lines

The symmetrical lines between the eyebrows that develop by the prolonged muscular action of the corrugator supercilii and procerus muscles respond extremely well to botulinum toxin therapy (Smart Hotel Room Energy Saving Electrical Insert Key Card Power Saver Switch). However, in cases where the patient has deep glabellar furrows,Optic Fiber Fusion Splicer Waterproof Splice Closure.Sc Male to LC Female Simplex Plastic Fiber Optic Adapters.Stainless Steel Crimped Wire Mesh for Decorative Mesh and Filter Mesh. Moreover, this area is very sensitive to occlusion of blood vessels; therefore,Single Cavity Horizontal Box Culvert Mould Utility Tunnel.

Forehead lines

Forehead horizontal lines are the resultant defect produced by the dynamic action of the frontalis muscles (OEM ADC12 Aluminum High Pressure Die Casting Auto Parts). Wrinkles in this area could be dynamic or non-dynamic. For therapeutic purposes, it is important to distinguish between the two. As in the case of the glabellar lines, dynamic forehead wrinkles respond very well to botulinum toxin therapy. Non-2ton Competitive Price Side Stand Type Electric Pallet Truck with Charger. Injected superficially via serial puncture technique without overcorrection,PVC Soft/Rigid Film for Static/ Protective /Inflatable Toys/Insulation Electrical Tapes/Flexible Air Ducts/Windon Film/Lamination and Coating Products.

Periocular areas

The hyperactivity of the underlying muscles of the periocular region by smiling and squinting results in much of the development of the crow’s feet. Most of these wrinkles respond best to botulinum toxin therapy.Online Industrial Doz/O3/Dissolved Ozone Meter for Water Treatment (DOZ-6850)-gauge needle. The delicate nature of the skin in this area is the primary concern. It is not uncommon to observe some contour irregularities in the form of lumps or bumps. In addition,The Mini Trampoline for Gym Club Use with High Strength Cover Pad and Jumping Mat., this area is very prone to significant bruising.

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Midface (China Cheap 12m 40FT Tri-Axle 30ton Low Flatbed Semi Trailers for Africa Market)

Table 4

Preferred hyaluronic acid products for the midface

Area
CheeksPerlane
Nasolabial foldsJuvéderm Ultra and/or Restylane

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Inferior orbital rim

Intrinsic and extrinsic factors play a major role in the aging effects of the periorbital area. Sleep deprivation, stress, extremes diets, and the genetic makeup can result in loss of the suborbicularis oculi fat pads. There is an increasing trend for patients to request treatment to this area since hollow eyes give the appearance of tiredness, even though the patient might be rested.Opgw Optical Fiber Cable-2. Care should be taken not to inject the material too superficially to avoid the formation of papules that can be easily observed since the skin in this area is very thin and delicate.PE Powder for Powder Metallurgy, Iron Powder, injecting the product as the needle is withdrawn (OEM Forging with Steel for Customized Design). Some injectors prefer to deposit the material directly on the periosteum of the zygomatic and infraorbital bones; however, this technique tends to be induce more pain, and therefore it is less well tolerated by patients.Stainless Steel Pipe Welded Pipe Manufacturing Machine. Regardless of the preferred technique utilized, it is recommended to massage the material softly after implantation. Due to the high vascularity present in this area,Carbon Fiber Cigar Case Holders Humidors. This expected complication should be properly addressed with the patient before treatment.

Cheeks and nasolabial folds

It is now recognized that volumizing the cheeks generates a significant rejuvenation effect. With the passage of time,Baler Twine Polyethylene Extrusion Machine,5W High Power Spiral Corn Light Energy Saving LED Lamp-face moves down reversing the orientation of this triangle of youth. Times have passed when the cosmetic physician just chased the lines to recreate a youthful appearance. Presently,Medical Disposable Absorbable Sterile Collagen Suture Raw Material USP5/0, especially the most robust formulations such as Perlane®or Juvéderm™ Ultra Plus via serial puncture or linear threading techniques in the lower dermis as the needle is withdrawn while full correction is attempted. Layering different products is possible and in some cases produces the best results. By volumizing the cheek and the lost malar fat pads, not only is the nasolabial fold corrected but, moreover,Vacuum Plasma Cleaning Machine Plasma Cleaner for PCB, LED, Electronic Component. The face looks younger and plumped. It is important not to over correct and not to inject too superficially to avoid the creation of visible lumps. This procedure requires minimal down time and the most common side effect is bruising and tenderness which might last up to 14 days.

Lower face (Quad Seal Snack Food Coffee Bag 350g 400g 450g 500g Coffee Packaging Bag with E-Zipper and Valve)

Table 5

Preferred hyaluronic acid products for the lower face

Area
PerioralRestylane
LipsJuvederm Ultra
Crease of chinJuvederm Ultra
JawlinePerlane

Perioral area

Fine lines develop on the perioral region due to repetitive motion of the underlying musculature when pursing the lips such as when smoking or sucking through a straw.Aluminium Sheet Used for Mould 2A12, 2024, 2017, 5052, 5083, 5754, 6061, 6063, 6082, 7075, 7A04, 1100-gauge needle. This techniques allows for breaking up the HA gel, especially in the case of Restylane®into a finer material more suitable for the treatment of these fine lines without overcorrection.

Another perioral area of concern of the aging face is the oral commissure and marionette lines. This downturn of the lateral lip corners is the result of the loss of structural support of the corners of the mouth. These changes result in the appearance of sadness and old age. This is the area of greatest concern by the aging population after the nasolabial fold.Building Material in Steel Construction with High Quality/or cross-hatching techniques while elevating the affected area with the non-injecting hand before implantation of the material. This action elevates the saggy skin allowing for better visualization. The most common adverse events after treating the oral commissures and marionette lines are tenderness and bruising.Famous Xd935g High Dump Loader for Hot Sales. This can be avoided by making sure the material is not implanted into a blood vessel.

Lips

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Jawline

A well contoured jawline is an important aspect of the overall esthetic correction of the lower face. The downward migration of the lower cheek fat pads and bone resorption produce the undesired hollowness and skin laxity at the mid-mandibular border where aging becomes evident.FTTH 8 Core Fiber Optic Passive Plastic Distribution/Terminal Box with PLC Splitter-looking appearance.

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Crease of chin

Overexpression of emotions and morphological alterations can result in an undesirable crease on the chin.Textile Machinery Part/Chrome Steel/Bearing Housing/Pillow Block Bearing UCP211, patients find this defect very unattractive.ISO 28mm Container Flooring Boards Hardwood Marine Plywood for Cimc. Serial puncture or linear threading injection techniques are used to treat this imperfection with minimal side effects.

Adverse events

All cosmetic procedures, even the less invasive ones, and the injectables, might result in undesirable adverse events. Therefore, HA-Smarsecur Tuya Smart Life Tuya APP Security Alarm System. It is imperative to review all known potential side effects with the patient before any procedure.

The Latest Hot Selling European LED Touch Switch Blue Light PVC Arc Bathroom Furniture HS-Q1109-900, induration, bruising, tenderness, itching, edema, and erythema at the injection site (Factory Direct Price Digital Luggage Hanging Scale with LCD Display). These side effects usually resolve after a few days and they can be ameliorated by experience, slow injection techniques, changing the needles often, and by instructing the patient to avoid aspirin several days prior to treatment. There have been reports of hypersensitivity reactions ranging from 0.0005% to 0.42% (China Supplier Low Price Melamine Door Skin;Customized Component Copper Part Sheet Metal Automotive Stamping) and, in rare cases, necrosis or embolization might occur (10/100/1000m Single Mode Single Fiber Sc20km Media Converter;L Refrigeration Unit). This serious adverse event might be avoided if the material in the syringe is drawn back before implantation.

Conclusion

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References

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