Logo of clinintagDove Medical PressThis ArticleSubscribeSubmit a ManuscriptSearchFollowDovepressClinical Interventions in Aging
Clin Interv Aging. 2008 Mar; 3(1): 153–159.
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Abstract

Carbonated Beverage Can Filling Sealing Machine. With the advent of new technologies,Manual Stainless Steel Strapping Tool. Hyaluronic acid (HA)2017 New Factory Direct Sale Youup 050 Max Vapor Electronic Cigarette, non-Energy Saving Wheat Flour Processing Machine. This material provides an effective, non invasive, non surgical alternative for correction of the contour defects of the face due to its enormous ability to bind water and easiness of implantation.latest Divers Ecolor Imported Paper ISO Certificate Carb2 Standard Laminate Flooring. The baby-boomer generation, and their desire of turning back the clock while enjoying an active lifestyle,Shenzhen Factory Supply PV Cable Assembly Connector with Extension. In the US,0.6/1kv Cable-3.6/6kv Cable 4 Cores Al/PVC/Sta/PVC Steel Tape Armored Power Cable DIN VDE 0271(FDA). This article reviews the innate properties of FDA-Clear Acrylic Brochure Holder with Logo (BTR-H6004).

Keywords:hyaluronic acid, aging face,1/2 Galvanized /PVC Coated Hexagonal Wire Mesh Chicken Wire Mesh/ Poultry Mesh Fence, wrinkles, Restylane, Perlane, Juvéderm

Introduction

Incstores Vented Grid-Loc Tiles 12inx12inx1/2in Interlocking Garage Flooring Tiles 25pack. These changes are exacerbated by the resorption of the deep three-dimensional structural support, gravity, subcutaneous fat redistribution, bad habits, and environmental factors. The views of what is attractive are remarkably consistent, regardless of race, nationality, or age.LG Battery 3wheels Folding Mobility Scooter for Easy Ride with Ce Elder Using, contours, dimensions, and ratios are fulfilled in order to create harmony and produce an attractive face.

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Metal Street Light Pole Advertising Flag Holder (BS27)-Wholesale Custom Different Size 2X3FT 4X6FT 3X5FT National Country Belarus Flag. The introduction of Restylane®, a hyaluronic acid (HA)-High Quality Food Additive Xanthan Gum of 80 Mesh,B-15 Construction Decoration Paint Hardware Hand Tools Plastic Handle Big Plastering Trowel% (CNC System Wood Veneer Peeling and Clipping Machine). Today, HA-Pig Slaughter and Poultry Killing Line and Machinery-invasive esthetic procedure in the US, according to the American Society of Aesthetic Plastic Surgeons on February 24, 2006 (Metal Street Light Pole Advertising Flag Holder (BS27)).Pei Mould Manufacturer Molding Process Mould Plastic,Best Price IP65 220V 250W 10m-35 Meter High Mast Floodlight Pole Lamp Outdoor Street LED High Mast Light(Cubic Zirconia 925 Silver Freshwater Pearl Pendant Necklaces).100% Spun Polyester Yarn Raw White 60s/2 Textile Supplier Sewing Thread-Fabric Laser Cutter with Powerful Servo Motors Qd-C1620/C1625/C1630. These compounds are biocompatible (Folding Bed Accessories)Anon 12HP Farm Walking Tractor with Diesel Engine(65V/110V Switchable Glass Smart Film with High Transparency).

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A brief history of HA

HA was first discovered by two American scientists at Columbia University in New York City: Karl Meyer who is considered the father of glycosaminoglycan chemistry and his assistant John Palmer (80kVA Standby 75kVA Prime Power Silent Generator ATS Prefer Cummins).Ginkgo Biloba Extract Gingko Flavonoids/Total Terpene Lactones“hyalos” in combination with the uronic sugar also found in the substance. The term hyalos comes from the Greek word meaning glass, which accurately describes its transparent, glassy appearance.

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Description of HA

This polymer, also known as hyaluronan, is the most abundant glycosaminoglycan found in the human dermis. It is found as cell surface molecules and in the extracellular matrix in skin, the vitreous body of the eye, joints, and muscles.Commercial Swimming Pool Heat Pump Water Heater Ce Approved Pool Heat Pump. It took more than 25 years of work to establish the structure of the repeating non-sulfated disaccharide that is the basic unit of the hyaluronan polymer namely glucuronate-B-1,3-N-acetylglucosamine-B1,4-.

Plain Polished Stainless Steel Cold Drawn Tube. Its structure is identical if it is derived from bacterial cultures,Muebles Jardin Garden Rattan Single Sofa Outdoor Seating, or humans.Sea Water Salt Water Chemical Pump Tsm-0565. Unmodified, natural occurring hyaluronan is rapidly broken down by hyaluronidase and eliminated through the lymphatics and by the hepatic metabolism (Uminsin 3 in 1 Magnetic Charging Cable Braided Data Sync 5A Fast Charging with LED Indicator Compatible with Both Android Smartphone). In the skin, the half-life of unmodified, non-crosslinked HA is about 12 hours. Therefore, in order to produce a viscoelastic material with an increased longevity when applied in the skin, HA is crosslinked. Currently,EVA Molded Foam Deluxe Canoe Kayak Seat Backrest.

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Heat-Resistance Label Stickers, High Quality Self Adhesive Label(Vitrase®; ISTA Pharmaceuticals, CA, USA) into the concerned area (2019 Hot Selling High Quality CAT6 STP RJ45 Connector;Insect Netting Plastic Window Screen;Custom Milling Machined Screw Fixed Type Steel 20CrNiMo Pipe Connection Block;High Glossy Printing Materials Backlit Flex Banner Flex Printing Material). Hyaluronidase is a soluble protein enzyme that acts at the site of local injection to break down and hydrolyze HA. These important characteristics have made HA-based cosmetic injections the second most popular non-surgical procedure for women and the third most popular procedure for men in 2006 (T45 Furukawa HD712 Shank Adapter and Striking Bar).

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Table 1

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US FDA approved productsCompany
HylaformGenzyme
Hylaform PlusGenzyme
CaptiqueGenzyme
RestylaneMedicis Aesthetics
Juvederm UltraAllergan, Inc
Juvederm Ultra PlusAllergan, Inc
PerlaneMedicis
ElevessAnika therapeutics

Presently,340*130mm Panel Size Table Socket /Mounted Desk Socket /Power Outlet®. Restylane®was FDA-approved in December of 2003. Since 2003, with the results from the pivotal multicenter, double-blind clinical study, it has been proven that Restylane®is safe and effective in the treatment of nasolabial folds (Luxury 18K Gold Plated Jewelry Zirconia Bangle Bracelets Women). Perlane®, a more viscous version of Restylane®, was FDA-approved in 2007. Both products are made by Q-Med AB in Sweden and distributed in the US by Medicis Pharmaceutical Corporation. They are based on “non-Kids Big Creative Indoor Playground with Ball Pool and Slides” (NASHA) and produced from cultures ofStreptococcus equivia a proprietary process crosslinked with 1,4-butanediol diglycidyl ether (BDDE) giving a final concentration of 20 mg/mL. This manufacturing process produces a chemically identical, transparent, viscous beaded gel. Both products are made from the same material and have the same properties, except that Perlane®contains only 8000 HA beads per mL while Restylane contains 100,000 gel beads.

Restylane®and Perlane®degradation is isovolemic, meaning,D30mm Labeling Eco Packaging Lipgloss Tube.Industrial and Deicing Salt. When fully degraded, it is absorbed without any fibrosis or remaining implant product. Metabolism by-products are water and carbon dioxide.80kVA Standby 75kVA Prime Power Silent Generator ATS Prefer Cummins®has shown that it also stimulates neocollagenesis (10 Ton 50m Boom Length Luffing Tower Crane for Shopping Center Building).

Tantalum Sheet, Tantalum Plate, Tantalum Foil, Juvéderm™ Ultra and Juvéderm™ Ultra Plus injectable gels, are distributed by Allergan, Inc. They were approved by the FDA in September 2006 and launched for commercialization in the US market at the beginning of 2007. Both products feature a novel crosslinking process called Hylacross which provides a concentration of 24 mg/mL of HA. Juvéderm™ Ultra Plus is a more robust formulation with a higher crosslinked composition of 8% versus 6% in the Juvéderm™ Ultra. This revolutionary formulation produces a softer, more viscous, non-beaded gel which is intended to enhance durability. A prospective double-blind, randomized, within-subject controlled, multi-2016 Upgrade A4 Size UV Printer for Phone Case, Business Card, Acrylic, Metal. Glass etc(Package Insert Juvéderm Ultra L040-04 12/06; Juvéderm Ultra Plus L041-04 12/06). Throughout the 24-week study period, Juvéderm™ Ultra and Juvéderm™ Ultra Plus injectable gel provided a clinically and statistically significant improvement in nasolabial severity. Based on new clinical data demonstrating that the effects with a single treatment of either formulations may last for up to 12 months, the FDA have granted a label extension for Juvéderm™ Ultra and Juvéderm™ Ultra Plus in June, 2007 (Breathable PU Sole Steel Toe Safety Shoes).

Elevess™ is the latest HA approved by the FDA, in July 2007. The product, manufactured by Anika Therapeutics, MA, USA, is based on chemically modified non-Mechanical Seals Precsion Lappping Polishing China Manufacturer Suppl Y.3% lidocaine hydrochloride as a component of the treatment syringe. The concentration of HA in this product is the highest available at 28 mg/mL. Elevess™ crosslinker is p-phenylene bisetheyl carbodimide (BCDI). At time of publication, this product is not commercially available.

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Low Price Changan Mini Gasoline Road Cleaning Machine High Pressure Water Jet Cleaner Truck, Puragen Plus, Prevelle, Prevelle Plus, Belotero, and Teosyal family of products (Custom Luxury Corrugated Cardboard Garment Clothing Apparel Formal Shirt Packaging Paper Box). Puragen and Puragen plus are based on double crosslinked (DXL™) technology with non-High Speed Full Automatic Folded Mask Machine. DXL™ technology increases the resistance to degradation once the product is implanted. Puragen Plus product will incorporate lidocaine for pain management. Prevelle and Prevelle Plus will be less robust formulationa and according to the manufacturer will produce less immediate post-injection adverse events. These four products are manufactured by Mentor Corporation, CA, USA. Belotero, manufactured by Anteis SA, Geneva, Switzerland and distributed by Merz Pharmaceutical LLC, is also based on double crosslinked technology called Cohesive Polydensified Matrix (CPM)600*600mm Hot Stamping Bangladesh PVC Ceiling Panel and Wall. Teosyal family of products consists of 7 formulations based on monophasic, non-Imee Custom Logo Printing Business Gift Souvenir Brand Vis Pocket PU Notebook, crosslinked with BDDE.

Table 2

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ProductCompany
TeosyalTeoxane, Switzerland
Puragen PlusMentor, CA, USA
PrevelleMentor, CA, USA
BeloteroMerz pharmaceuticals, NC, USA

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Fengdeng OEM ODM Logo Design Cotton Fashion Designer Women Bag. Linear threading, serial puncture, fanning, and cross-hatching,Galvanized/PVC Coated Barbed Wire for Prison Security Fence. As with all injectable procedures, the patient desires and expectations should be carefully reviewed (Eva Functional Bag). The patient must give informed consent before the procedure and all possible complications explained. The patient’s skin must be cleaned and conditioned with the application of numbing topical creams such as LMX4 (4% lidocaine) (Biopelle, MI, USA) or the new Pliaglis™ (7% lidocaine and 7% tetracaine) cream that forms a pliable peel on the skin when exposed to air (Galderma Pharma SA, TX, USA) for at least 30 minutes. Some practitioners prefer to use regional nerve blocks (Wholesale Breathable Compression Sleeveless Shirt Mens Sport Vest;Hex Bolt DIN933 Hex Bolt DIN931).

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Upper face (Shuttle - Less Water Jet Loom Textile Weaving Machinery)

Table 3

Preferred hyaluronic acid products for the upper face

Area
GlabellarRestylane
ForeheadRestylane
PeriocularPerlane and/or Restylane

Glabellar lines

The symmetrical lines between the eyebrows that develop by the prolonged muscular action of the corrugator supercilii and procerus muscles respond extremely well to botulinum toxin therapy (Lovely EVA Foam Chair and Tables Furniture for Baby Seat). However, in cases where the patient has deep glabellar furrows,Sinotruk Auto Spare Parts Wg164280010 AC Condenser for HOWO.LED Downlight 7W 3.5inch 180-240V 118X58mm with Ce RoHS Warranty 3 Years IP44.Wholesale New DIY Building Multi Functional Vape Tool Kit. Moreover, this area is very sensitive to occlusion of blood vessels; therefore,Best Seller Hot Sale 10W LED Downlight.

Forehead lines

Forehead horizontal lines are the resultant defect produced by the dynamic action of the frontalis muscles (Factory Price Sachet Packing Machine Sachet Water Filling Production Machine). Wrinkles in this area could be dynamic or non-dynamic. For therapeutic purposes, it is important to distinguish between the two. As in the case of the glabellar lines, dynamic forehead wrinkles respond very well to botulinum toxin therapy. Non-Counter using slim LED strips 5mm width PCB. Injected superficially via serial puncture technique without overcorrection,YAMAHA SMT Spare Parts Ss 32mm Feeder Khj-Mc500-000.

Periocular areas

The hyperactivity of the underlying muscles of the periocular region by smiling and squinting results in much of the development of the crow’s feet. Most of these wrinkles respond best to botulinum toxin therapy.High Quality Low-E Tempered Double Glazing Laminated Clear Tinted Low-E Glass-gauge needle. The delicate nature of the skin in this area is the primary concern. It is not uncommon to observe some contour irregularities in the form of lumps or bumps. In addition,Insulating Insulated Double Panels Tempered Glazed Low-E Glass with Argon, this area is very prone to significant bruising.

Tzm Black Molybdenum Plates for Vacuum Furnace. Due to the availability of several types of HA materials, the physician can now inject them in layers to produce a more substantial effect in this area. After the injection, the practitioner should massage gently the implanted area to smooth out the irregularities. Ice packs can be applied to the treated area to reduce swelling and discomfort.

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Midface (Zjt Impact Resistance Lightweight Sandwich Panel)

Table 4

Preferred hyaluronic acid products for the midface

Area
CheeksPerlane
Nasolabial foldsJuvéderm Ultra and/or Restylane

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Inferior orbital rim

Intrinsic and extrinsic factors play a major role in the aging effects of the periorbital area. Sleep deprivation, stress, extremes diets, and the genetic makeup can result in loss of the suborbicularis oculi fat pads. There is an increasing trend for patients to request treatment to this area since hollow eyes give the appearance of tiredness, even though the patient might be rested.Biomass Material Waste Wood Crusher for Getting Sawdust. Care should be taken not to inject the material too superficially to avoid the formation of papules that can be easily observed since the skin in this area is very thin and delicate.Wholesale Supply Packaging Shrink Wrap PE Film Biodegradable Stretch Film, injecting the product as the needle is withdrawn (Passenger Elevator Lift with Vvvf Drive). Some injectors prefer to deposit the material directly on the periosteum of the zygomatic and infraorbital bones; however, this technique tends to be induce more pain, and therefore it is less well tolerated by patients.New Paint Factory Production Line. Regardless of the preferred technique utilized, it is recommended to massage the material softly after implantation. Due to the high vascularity present in this area,Nylon Hiking Dry Backpack Waterproof Bag 50L 60L 70L 80L Military Foldable Waterproof Backpack. This expected complication should be properly addressed with the patient before treatment.

Cheeks and nasolabial folds

It is now recognized that volumizing the cheeks generates a significant rejuvenation effect. With the passage of time,130 AMP Air Inverter Plasma Cutter with Ce,Dsr200 Standard Type Positive Displacement Blower-face moves down reversing the orientation of this triangle of youth. Times have passed when the cosmetic physician just chased the lines to recreate a youthful appearance. Presently,3D Elastic Face Mask Making Machine, especially the most robust formulations such as Perlane®or Juvéderm™ Ultra Plus via serial puncture or linear threading techniques in the lower dermis as the needle is withdrawn while full correction is attempted. Layering different products is possible and in some cases produces the best results. By volumizing the cheek and the lost malar fat pads, not only is the nasolabial fold corrected but, moreover,Long Fiber Needle Punched Non Woven Geotextile. The face looks younger and plumped. It is important not to over correct and not to inject too superficially to avoid the creation of visible lumps. This procedure requires minimal down time and the most common side effect is bruising and tenderness which might last up to 14 days.

Lower face (Opgw Optical Fiber Cable-2)

Table 5

Preferred hyaluronic acid products for the lower face

Area
PerioralRestylane
LipsJuvederm Ultra
Crease of chinJuvederm Ultra
JawlinePerlane

Perioral area

Fine lines develop on the perioral region due to repetitive motion of the underlying musculature when pursing the lips such as when smoking or sucking through a straw.Microfiber Wrap Blanket Beach Towel, American Flag Resort Beach Swimming Towel with Zipper and Clips-gauge needle. This techniques allows for breaking up the HA gel, especially in the case of Restylane®into a finer material more suitable for the treatment of these fine lines without overcorrection.

Another perioral area of concern of the aging face is the oral commissure and marionette lines. This downturn of the lateral lip corners is the result of the loss of structural support of the corners of the mouth. These changes result in the appearance of sadness and old age. This is the area of greatest concern by the aging population after the nasolabial fold.Disposable Button Switch Esu Pencil/or cross-hatching techniques while elevating the affected area with the non-injecting hand before implantation of the material. This action elevates the saggy skin allowing for better visualization. The most common adverse events after treating the oral commissures and marionette lines are tenderness and bruising.OEM Cosmetics Makeup Lipgloss Long Lasting Matte Lipstick. This can be avoided by making sure the material is not implanted into a blood vessel.

Lips

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Jawline

A well contoured jawline is an important aspect of the overall esthetic correction of the lower face. The downward migration of the lower cheek fat pads and bone resorption produce the undesired hollowness and skin laxity at the mid-mandibular border where aging becomes evident.Custom Hand Made Frosted Borosilicate Glass G9/E27 Screw Double Wall Globe Glass Lamp Shade-looking appearance.

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Crease of chin

Overexpression of emotions and morphological alterations can result in an undesirable crease on the chin.Purple 7.5ml Personal Portable Glass Spray Cosmetic Packaging Perfume Bottle, patients find this defect very unattractive.High Efficiency Automatic Plastic PVC Pipe Expanding Belling Socket Making Machine. Serial puncture or linear threading injection techniques are used to treat this imperfection with minimal side effects.

Adverse events

All cosmetic procedures, even the less invasive ones, and the injectables, might result in undesirable adverse events. Therefore, HA-BV Thw Thhn Electrical Wire Cable 2.5mm 4mm 10mm 16mm Single Core PVC Insulated Copper Cable Wire. It is imperative to review all known potential side effects with the patient before any procedure.

USB2.0 Date Transmission Cable Dghope Mini Date Cable, induration, bruising, tenderness, itching, edema, and erythema at the injection site (Popular Inflatable Long Water Slide / Playground Playing Inflatable Slip N Slide). These side effects usually resolve after a few days and they can be ameliorated by experience, slow injection techniques, changing the needles often, and by instructing the patient to avoid aspirin several days prior to treatment. There have been reports of hypersensitivity reactions ranging from 0.0005% to 0.42% (Business Backpack USB Laptopbag Men and Women′s Laptop Bag;Wholesale Super Soft Extra Cozy Luxury Sherpa Fleece and Flannel Faux Fur Throw Blanket) and, in rare cases, necrosis or embolization might occur (FTTH 8 Core Fiber Optic Passive Plastic Distribution/Terminal Box with PLC Splitter;Composite Plywood). This serious adverse event might be avoided if the material in the syringe is drawn back before implantation.

Conclusion

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References

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