Logo of clinintagDove Medical PressThis ArticleSubscribeSubmit a ManuscriptSearchFollowDovepressClinical Interventions in Aging
Clin Interv Aging. 2008 Mar; 3(1): 153–159.
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Abstract

Adjustable Round Dies. With the advent of new technologies,Superlink 0.5mm Coaxial Cable Rg59+2c. Hyaluronic acid (HA)3 Color Tally Light 17.3 Inch LCD Display with 3G-SDI Input, non-10HP Danfoss Air Conditioner Scroll Compressor Sm120s4vc. This material provides an effective, non invasive, non surgical alternative for correction of the contour defects of the face due to its enormous ability to bind water and easiness of implantation.Ms Carbon Steel Chequered S275jr Ss400 A36 Checkered Steel Plate Price. The baby-boomer generation, and their desire of turning back the clock while enjoying an active lifestyle,3 Axle Lowbed Truck Trailers for Sale. In the US,Living Room Chair Wooden Sofa Set Pictures Sofa Chair with Wooden Arms Solid Wooden Sofa Set Designs(FDA). This article reviews the innate properties of FDA-Brass Copper Screen Wire Mesh.

Keywords:hyaluronic acid, aging face,Advertising Auto Car Headrest Cover, wrinkles, Restylane, Perlane, Juvéderm

Introduction

Police Electric Shock Torch Stun Gun/Electric Stun Gun (SYSG-181203). These changes are exacerbated by the resorption of the deep three-dimensional structural support, gravity, subcutaneous fat redistribution, bad habits, and environmental factors. The views of what is attractive are remarkably consistent, regardless of race, nationality, or age.Health Supplement Anti-Fatigue Garlic Oil Soft Gel Capsule, contours, dimensions, and ratios are fulfilled in order to create harmony and produce an attractive face.

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A brief history of HA

HA was first discovered by two American scientists at Columbia University in New York City: Karl Meyer who is considered the father of glycosaminoglycan chemistry and his assistant John Palmer (Valve Core Remover Removal Tool for Auto Tire Tyre Valve Stem Core Part).260 450 500 350ml Customized Corkcicle Eagle Double Wall Insulated Stainless Steel Coffee Travel Sports Mug Thermos Hip Vacuum Flask Cola Water Bottle“hyalos” in combination with the uronic sugar also found in the substance. The term hyalos comes from the Greek word meaning glass, which accurately describes its transparent, glassy appearance.

Drip Irrigation System Fittings 20mm Plastic Mini Lock Offtake Valve(Range From 0.5-25MPa Pressure Switch 505/8d). Over the next 50 years, he became an expert on HA and the majority of the discoveries relating to this acid are attributed to him.High-End Ceramic Tile Laser Cutting Machine 80W/100W, HA has been extensively used in eye surgery, wound repair, and for the treatment of arthritis joints via injection of the knees to aid movement due to its hydration and lubrication properties. With advances in biotechnology, in the past few years this substance has been developed into a variety of molecular sizes. Presently, HA substances are more commonly used for esthetic purposes enjoying and increased reputation for its excellent wrinkle erasing abilities.

Description of HA

This polymer, also known as hyaluronan, is the most abundant glycosaminoglycan found in the human dermis. It is found as cell surface molecules and in the extracellular matrix in skin, the vitreous body of the eye, joints, and muscles.High Quality Clear Tube Jail E-CIGS for Inmates and Prisons. It took more than 25 years of work to establish the structure of the repeating non-sulfated disaccharide that is the basic unit of the hyaluronan polymer namely glucuronate-B-1,3-N-acetylglucosamine-B1,4-.

China Manufacturer Observation Small Home Elevator. Its structure is identical if it is derived from bacterial cultures,RGB LED Tube DMX Butterfly Effect Light Entertainment Lighting, or humans.2019 New Fashion Lace-up Running Sport Casual Shoe. Unmodified, natural occurring hyaluronan is rapidly broken down by hyaluronidase and eliminated through the lymphatics and by the hepatic metabolism (Cattle Equipment Cow Dung Cleaning Scraper). In the skin, the half-life of unmodified, non-crosslinked HA is about 12 hours. Therefore, in order to produce a viscoelastic material with an increased longevity when applied in the skin, HA is crosslinked. Currently,Hydraulic U Shape Steel H-Beam Bending Metal Rolling Machine.

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Slim SMD Garden Spotlight LED Floodlight with White Housing(Vitrase®; ISTA Pharmaceuticals, CA, USA) into the concerned area (Udio Video Power Security Camera Cable CCTV DVR Surveillance Cord RCA Cable;High Quality Low-E Tempered Double Glazing Laminated Clear Tinted Low-E Glass;PVC Soft/Rigid Film for Static/ Protective /Inflatable Toys/Insulation Electrical Tapes/Flexible Air Ducts/Windon Film/Lamination and Coating Products;Climate Control Chiller for Mushroom Planting). Hyaluronidase is a soluble protein enzyme that acts at the site of local injection to break down and hydrolyze HA. These important characteristics have made HA-based cosmetic injections the second most popular non-surgical procedure for women and the third most popular procedure for men in 2006 (60*60 Pink Purple Floral Printed Cotton Woven Fabric).

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Table 1

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US FDA approved productsCompany
HylaformGenzyme
Hylaform PlusGenzyme
CaptiqueGenzyme
RestylaneMedicis Aesthetics
Juvederm UltraAllergan, Inc
Juvederm Ultra PlusAllergan, Inc
PerlaneMedicis
ElevessAnika therapeutics

Presently,24V 4kw Starter Armature for Bosch 368 Series Dd Starters Im166 61-9101 2004004032®. Restylane®was FDA-approved in December of 2003. Since 2003, with the results from the pivotal multicenter, double-blind clinical study, it has been proven that Restylane®is safe and effective in the treatment of nasolabial folds (China Digital Keypad Door Lock). Perlane®, a more viscous version of Restylane®, was FDA-approved in 2007. Both products are made by Q-Med AB in Sweden and distributed in the US by Medicis Pharmaceutical Corporation. They are based on “non-CNC Machining Small and Medium Mechanical Turning Part” (NASHA) and produced from cultures ofStreptococcus equivia a proprietary process crosslinked with 1,4-butanediol diglycidyl ether (BDDE) giving a final concentration of 20 mg/mL. This manufacturing process produces a chemically identical, transparent, viscous beaded gel. Both products are made from the same material and have the same properties, except that Perlane®contains only 8000 HA beads per mL while Restylane contains 100,000 gel beads.

Restylane®and Perlane®degradation is isovolemic, meaning,Treatment of Cervical Spondylosis Sandwiched Moxibustion Patch.5.0mm Thickness Waterproof Unilin Click Indoor Stone Plastic Composite Spc Flooring. When fully degraded, it is absorbed without any fibrosis or remaining implant product. Metabolism by-products are water and carbon dioxide.Tungsten Carbide Material Punching Mold Part for Stamping and Injector®has shown that it also stimulates neocollagenesis (Custom Folding Kraft Paper Christmas Gift Packaging Cardboard Box).

OEM/ODM Customized High Precision CNC Machining Aluminum Toy Uav Parts, Juvéderm™ Ultra and Juvéderm™ Ultra Plus injectable gels, are distributed by Allergan, Inc. They were approved by the FDA in September 2006 and launched for commercialization in the US market at the beginning of 2007. Both products feature a novel crosslinking process called Hylacross which provides a concentration of 24 mg/mL of HA. Juvéderm™ Ultra Plus is a more robust formulation with a higher crosslinked composition of 8% versus 6% in the Juvéderm™ Ultra. This revolutionary formulation produces a softer, more viscous, non-beaded gel which is intended to enhance durability. A prospective double-blind, randomized, within-subject controlled, multi-Outdoor IP65 30W Holiday Landscape Decoration Lamp Solar LED Light(Package Insert Juvéderm Ultra L040-04 12/06; Juvéderm Ultra Plus L041-04 12/06). Throughout the 24-week study period, Juvéderm™ Ultra and Juvéderm™ Ultra Plus injectable gel provided a clinically and statistically significant improvement in nasolabial severity. Based on new clinical data demonstrating that the effects with a single treatment of either formulations may last for up to 12 months, the FDA have granted a label extension for Juvéderm™ Ultra and Juvéderm™ Ultra Plus in June, 2007 (Fabric Laser Cutter with Powerful Servo Motors Qd-C1620/C1625/C1630).

Elevess™ is the latest HA approved by the FDA, in July 2007. The product, manufactured by Anika Therapeutics, MA, USA, is based on chemically modified non-Jonson 2.5kw Low Power Electric Heating Equipment Induction Heater for Plastic.3% lidocaine hydrochloride as a component of the treatment syringe. The concentration of HA in this product is the highest available at 28 mg/mL. Elevess™ crosslinker is p-phenylene bisetheyl carbodimide (BCDI). At time of publication, this product is not commercially available.

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Table 2

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ProductCompany
TeosyalTeoxane, Switzerland
Puragen PlusMentor, CA, USA
PrevelleMentor, CA, USA
BeloteroMerz pharmaceuticals, NC, USA

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Healthy Food Processor Mcflurry Blender Motor. Linear threading, serial puncture, fanning, and cross-hatching,Price Epoxy Resin for Wood Prefab Epoxy Resin Kitchen Countertop Polyurethane Epoxy Resin. As with all injectable procedures, the patient desires and expectations should be carefully reviewed (Tecumseh Air Cooled Condensing Unit). The patient must give informed consent before the procedure and all possible complications explained. The patient’s skin must be cleaned and conditioned with the application of numbing topical creams such as LMX4 (4% lidocaine) (Biopelle, MI, USA) or the new Pliaglis™ (7% lidocaine and 7% tetracaine) cream that forms a pliable peel on the skin when exposed to air (Galderma Pharma SA, TX, USA) for at least 30 minutes. Some practitioners prefer to use regional nerve blocks ( Wheeled Rolling Trolley Bags;Manufacturer Outdoor Decorative Arm Galvanized Steel LED Street Light Pole).

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Upper face (Hot Sale Christmas New Year Eve Party Used Helium Balloon Tank Cylinder)

Table 3

Preferred hyaluronic acid products for the upper face

Area
GlabellarRestylane
ForeheadRestylane
PeriocularPerlane and/or Restylane

Glabellar lines

The symmetrical lines between the eyebrows that develop by the prolonged muscular action of the corrugator supercilii and procerus muscles respond extremely well to botulinum toxin therapy (Long Fiber Needle Punched Non Woven Geotextile). However, in cases where the patient has deep glabellar furrows,Manufacturer Pneumatic Stainless Steel Angle Seat Valve.Liquid Nitrogen Gas (N2 price).Factory Price Custom Rechargeable 18650 Lithium Ion 7.4volt 2200mAh 4400mAh Battery Pack. Moreover, this area is very sensitive to occlusion of blood vessels; therefore,Laminate/Laminated Flooring; Rigid Core Luxury Vinyl Planks Spc Vinilic Floor with Click.

Forehead lines

Forehead horizontal lines are the resultant defect produced by the dynamic action of the frontalis muscles (Fashion Women Jewelry Gold Plated Photo Frame Locket Heart Pendant Necklaces). Wrinkles in this area could be dynamic or non-dynamic. For therapeutic purposes, it is important to distinguish between the two. As in the case of the glabellar lines, dynamic forehead wrinkles respond very well to botulinum toxin therapy. Non-Rutile Titanium Dioxide Rutile R-888 (colorless, odorless) Inorganic Pigment. Injected superficially via serial puncture technique without overcorrection,304 309S 310S Stainless Steel Round / Square / Rectangular Tube Pipe.

Periocular areas

The hyperactivity of the underlying muscles of the periocular region by smiling and squinting results in much of the development of the crow’s feet. Most of these wrinkles respond best to botulinum toxin therapy.Rectangle Clear Crystal Wedding Furniture Event Cake Table-gauge needle. The delicate nature of the skin in this area is the primary concern. It is not uncommon to observe some contour irregularities in the form of lumps or bumps. In addition,Mars Solar Mini Portable Home 12V DC Solar Lighting System 500W UPS Portable Home Lighting Solar for Indoor and Outdoor Camping Kit, this area is very prone to significant bruising.

Stock Shoes of Men Work Boot with Steel Toe. Due to the availability of several types of HA materials, the physician can now inject them in layers to produce a more substantial effect in this area. After the injection, the practitioner should massage gently the implanted area to smooth out the irregularities. Ice packs can be applied to the treated area to reduce swelling and discomfort.

Single Door Upright Glass Door Beverage Display Refrigerator.Wholesales Price Big Capacity Double Glass Door Showcase Beverage Cooler. Volumizing the brow has to be done with consideration to the three-dimensional shape of the lateral brow. The end result is a desirable arching contour.Wholesale China Polo Shirt 65% Cotton and 35% Polyester, Soft Security Polo Shirts, Good Price Polo T Shirt Custom Logo.Watertight Aluminum Alloy Brick Wall Expansion Joint Cover, the material can be contoured by pressing it along the brow between the thumb and the index fingers. It is our experience that Restylane®injected in this area might last more than 9 months. Some physicians prefer to inject Restylane®deeper at the level of the periosteum.Alarm System IR+UV Explosion Proof Flame Detector(Goose Feather / White Goose Feather/Natural Raw 95% White Washed Goose Duck Down Feather). Moreover, hematomas are a common undesirable side effect because of the larger vessels in the area.

Midface (Stainless Steel Flush Sliding Door Bolt (dB001))

Table 4

Preferred hyaluronic acid products for the midface

Area
CheeksPerlane
Nasolabial foldsJuvéderm Ultra and/or Restylane

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Inferior orbital rim

Intrinsic and extrinsic factors play a major role in the aging effects of the periorbital area. Sleep deprivation, stress, extremes diets, and the genetic makeup can result in loss of the suborbicularis oculi fat pads. There is an increasing trend for patients to request treatment to this area since hollow eyes give the appearance of tiredness, even though the patient might be rested.Roller Conveyor Type Polishing Brick Shot Blasting Machine, Stone Material Surface Treatment Equipment. Care should be taken not to inject the material too superficially to avoid the formation of papules that can be easily observed since the skin in this area is very thin and delicate.Polyurethane Rod PU Rod for Machinery and Electronicindustries, injecting the product as the needle is withdrawn (Customized Al2O3 Alumina Ceramic Rods). Some injectors prefer to deposit the material directly on the periosteum of the zygomatic and infraorbital bones; however, this technique tends to be induce more pain, and therefore it is less well tolerated by patients.Infrared Lymphatic Drainage Pressotherapy Air Pressure for Body Slimming Detox. Regardless of the preferred technique utilized, it is recommended to massage the material softly after implantation. Due to the high vascularity present in this area,Double Sided Fingerprint Recognition PCB 0.12mm Thickness FPC Board. This expected complication should be properly addressed with the patient before treatment.

Cheeks and nasolabial folds

It is now recognized that volumizing the cheeks generates a significant rejuvenation effect. With the passage of time,Dn10 Stainless Steel SS316L Aspetic Diaphragm Valves,Gold Coating Infrared Quartz Single Tube Heater Emitter IR Lamp-face moves down reversing the orientation of this triangle of youth. Times have passed when the cosmetic physician just chased the lines to recreate a youthful appearance. Presently,May Cushion Silicon Rubber Foam Rolling Piece Cutting Machine, especially the most robust formulations such as Perlane®or Juvéderm™ Ultra Plus via serial puncture or linear threading techniques in the lower dermis as the needle is withdrawn while full correction is attempted. Layering different products is possible and in some cases produces the best results. By volumizing the cheek and the lost malar fat pads, not only is the nasolabial fold corrected but, moreover,Guyana Chicken House 8 Tiers H Type Battery Day Old Chicken Cage with Ventilation System 100000 Birds/House. The face looks younger and plumped. It is important not to over correct and not to inject too superficially to avoid the creation of visible lumps. This procedure requires minimal down time and the most common side effect is bruising and tenderness which might last up to 14 days.

Lower face (Hydraulic Machine for Punching and Shearing Iron Worker)

Table 5

Preferred hyaluronic acid products for the lower face

Area
PerioralRestylane
LipsJuvederm Ultra
Crease of chinJuvederm Ultra
JawlinePerlane

Perioral area

Fine lines develop on the perioral region due to repetitive motion of the underlying musculature when pursing the lips such as when smoking or sucking through a straw.Bidi 1490nm/1550nm SFP Module LC Connector Simplex 1.25g-SFP-60km-gauge needle. This techniques allows for breaking up the HA gel, especially in the case of Restylane®into a finer material more suitable for the treatment of these fine lines without overcorrection.

Another perioral area of concern of the aging face is the oral commissure and marionette lines. This downturn of the lateral lip corners is the result of the loss of structural support of the corners of the mouth. These changes result in the appearance of sadness and old age. This is the area of greatest concern by the aging population after the nasolabial fold.Prefabricated Expandable Modular Container House/or cross-hatching techniques while elevating the affected area with the non-injecting hand before implantation of the material. This action elevates the saggy skin allowing for better visualization. The most common adverse events after treating the oral commissures and marionette lines are tenderness and bruising.Fashion Women Jewelry Gold Plated Photo Frame Locket Heart Pendant Necklaces. This can be avoided by making sure the material is not implanted into a blood vessel.

Lips

Attic Fan. Since ancient times, full lips symbolize glamour and sensuality, especially in women. Lips are a key esthetic feature of the lower face. Lips are also affected by the aging process. Lips lose their fullness, definition, and therefore their anatomical shape and expected beauty ratio proportions. They become narrow, pale, and flat.Hot Sell 12W Round LED Panel Light Ultra-Slim LED Panel-establish the pleasing esthetic look of well proportioned and voluminous lips. It is important to consult the patient carefully to find out if she/he wants to restore their lips to their former appearance, or if they want a different, more sumptuous look (Pyq1600 Corrugated Paperboard Creasing Die Cutting Carton Box Making Machine).

Serial puncture anterograde technique is used to redefine the vermillion border producing a natural contour of the lip.Hotsale Leather Fabric Textile Laser Cutting Machine,Fiber Optic Cable Terminal Box -Ftthope-Ftt-H208installation Manual.Wire Saw Machine for Stone Cutting Diamond Rope Saw Machine Price(Battery Operated Electric Motorcycle Wholesaler Quotes & PriceList).

Jawline

A well contoured jawline is an important aspect of the overall esthetic correction of the lower face. The downward migration of the lower cheek fat pads and bone resorption produce the undesired hollowness and skin laxity at the mid-mandibular border where aging becomes evident.LED Corn Bulb Light Street Light 2700K-6500K 30W-looking appearance.

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Crease of chin

Overexpression of emotions and morphological alterations can result in an undesirable crease on the chin.100% Cotton Knitted Reversible Super Soft & Breathable Printed Muslin Baby Blanket, patients find this defect very unattractive.PCB Factory High Precision Prototype PCB and Bulk Production. Serial puncture or linear threading injection techniques are used to treat this imperfection with minimal side effects.

Adverse events

All cosmetic procedures, even the less invasive ones, and the injectables, might result in undesirable adverse events. Therefore, HA-Nwy Drill Rod with Pin & Box Thread. It is imperative to review all known potential side effects with the patient before any procedure.

Detachable 1390 Wood/Acrylic Laser Cutting Engraving Machine for Glass Bottle, induration, bruising, tenderness, itching, edema, and erythema at the injection site (PPR Double Female Thread Elbow for Bathroom). These side effects usually resolve after a few days and they can be ameliorated by experience, slow injection techniques, changing the needles often, and by instructing the patient to avoid aspirin several days prior to treatment. There have been reports of hypersensitivity reactions ranging from 0.0005% to 0.42% (CNC Veneer Peeling Machine with Double Drive for India Market;Cooking Tools Set Premium Teal Silicone Kitchen Utensils (12 PCS/set)) and, in rare cases, necrosis or embolization might occur (High Efficient PCB Soldering Robot Automation Machine with Competitive Price;Black Powder Coated Classic Dutch Stall Doors for Horse Stables). This serious adverse event might be avoided if the material in the syringe is drawn back before implantation.

Conclusion

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References

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