Logo of clinintagDove Medical PressThis ArticleSubscribeSubmit a ManuscriptSearchFollowDovepressClinical Interventions in Aging
Clin Interv Aging. 2008 Mar; 3(1): 153–159.
Published online 2008 Mar.doi:Industrial Plate Heat Exchanger Manufacturer
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Abstract

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Keywords:hyaluronic acid, aging face,Qt4-15 Qt5-15 Qt6-15 Automatic Concrete Fly Ash Block Making Machine Pavement Brick Machine, wrinkles, Restylane, Perlane, Juvéderm

Introduction

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A brief history of HA

HA was first discovered by two American scientists at Columbia University in New York City: Karl Meyer who is considered the father of glycosaminoglycan chemistry and his assistant John Palmer (Shenzhen Fr4 94V0 PCB Board Based Multilayer Mobile Phone Motherboard).Fancy-Shape Black Matte Wooden Perfume Gift Packaging Box“hyalos” in combination with the uronic sugar also found in the substance. The term hyalos comes from the Greek word meaning glass, which accurately describes its transparent, glassy appearance.

Laser Tempered Glass Cutting Machine for iPhone7/Samsung S7 Edge(Japan NTN 6316 Radial Deep Groove Ball Bearing Price List). Over the next 50 years, he became an expert on HA and the majority of the discoveries relating to this acid are attributed to him.Shuttle - Less Water Jet Loom Textile Weaving Machinery, HA has been extensively used in eye surgery, wound repair, and for the treatment of arthritis joints via injection of the knees to aid movement due to its hydration and lubrication properties. With advances in biotechnology, in the past few years this substance has been developed into a variety of molecular sizes. Presently, HA substances are more commonly used for esthetic purposes enjoying and increased reputation for its excellent wrinkle erasing abilities.

Description of HA

This polymer, also known as hyaluronan, is the most abundant glycosaminoglycan found in the human dermis. It is found as cell surface molecules and in the extracellular matrix in skin, the vitreous body of the eye, joints, and muscles.Aluminum Frame Bathroom Mirror 1xxx Series Polished Mirror Aluminum Coil. It took more than 25 years of work to establish the structure of the repeating non-sulfated disaccharide that is the basic unit of the hyaluronan polymer namely glucuronate-B-1,3-N-acetylglucosamine-B1,4-.

B87 Air Jack Hammer Drill Rod for Drilling Equipment. Its structure is identical if it is derived from bacterial cultures,Ce, CCC, RoHS LED COB Down Light 30W, 40W Downlight Bulb Lamp Ceiling Indoor LED Lighting, or humans.Industrial Manual Lift Vacuum Rotary Evaporator. Unmodified, natural occurring hyaluronan is rapidly broken down by hyaluronidase and eliminated through the lymphatics and by the hepatic metabolism (Low Cost Brown Kraft Paper Bag with Handles Wholesale China). In the skin, the half-life of unmodified, non-crosslinked HA is about 12 hours. Therefore, in order to produce a viscoelastic material with an increased longevity when applied in the skin, HA is crosslinked. Currently,China Cheap 12m 40FT Tri-Axle 30ton Low Flatbed Semi Trailers for Africa Market.

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Table 1

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US FDA approved productsCompany
HylaformGenzyme
Hylaform PlusGenzyme
CaptiqueGenzyme
RestylaneMedicis Aesthetics
Juvederm UltraAllergan, Inc
Juvederm Ultra PlusAllergan, Inc
PerlaneMedicis
ElevessAnika therapeutics

Presently,TUV/Ce Certified Transparent Dual Glass Solar Module 335W Mono with Positive Sorting®. Restylane®was FDA-approved in December of 2003. Since 2003, with the results from the pivotal multicenter, double-blind clinical study, it has been proven that Restylane®is safe and effective in the treatment of nasolabial folds (Roofing Sheet Roof Panel Curving Crimping Machine). Perlane®, a more viscous version of Restylane®, was FDA-approved in 2007. Both products are made by Q-Med AB in Sweden and distributed in the US by Medicis Pharmaceutical Corporation. They are based on “non-4inch Stainless Steel 304 Blank Flange Blind Flange” (NASHA) and produced from cultures ofStreptococcus equivia a proprietary process crosslinked with 1,4-butanediol diglycidyl ether (BDDE) giving a final concentration of 20 mg/mL. This manufacturing process produces a chemically identical, transparent, viscous beaded gel. Both products are made from the same material and have the same properties, except that Perlane®contains only 8000 HA beads per mL while Restylane contains 100,000 gel beads.

Restylane®and Perlane®degradation is isovolemic, meaning,Leaf Shape Big Size Gold Crystal Bridal Crown Wedding Tiara.Custom Folding Kraft Paper Christmas Gift Packaging Cardboard Box. When fully degraded, it is absorbed without any fibrosis or remaining implant product. Metabolism by-products are water and carbon dioxide.Trusty Lightest Small Inkjet Printer/Small Label Printing Machine/Date Stamping Machine for Carton Class/Wire and Cable/Package®has shown that it also stimulates neocollagenesis (Prefabricated Expandable Modular Container House).

Single or Twin Welding Hose, Juvéderm™ Ultra and Juvéderm™ Ultra Plus injectable gels, are distributed by Allergan, Inc. They were approved by the FDA in September 2006 and launched for commercialization in the US market at the beginning of 2007. Both products feature a novel crosslinking process called Hylacross which provides a concentration of 24 mg/mL of HA. Juvéderm™ Ultra Plus is a more robust formulation with a higher crosslinked composition of 8% versus 6% in the Juvéderm™ Ultra. This revolutionary formulation produces a softer, more viscous, non-beaded gel which is intended to enhance durability. A prospective double-blind, randomized, within-subject controlled, multi-High Effecient Physical Pet Mosquito Trap with 365nm Ultraviolet Light Wave Rang(Package Insert Juvéderm Ultra L040-04 12/06; Juvéderm Ultra Plus L041-04 12/06). Throughout the 24-week study period, Juvéderm™ Ultra and Juvéderm™ Ultra Plus injectable gel provided a clinically and statistically significant improvement in nasolabial severity. Based on new clinical data demonstrating that the effects with a single treatment of either formulations may last for up to 12 months, the FDA have granted a label extension for Juvéderm™ Ultra and Juvéderm™ Ultra Plus in June, 2007 (Compactor File Storage Cabinet Mobile Shelves Metal Locking Shelving).

Elevess™ is the latest HA approved by the FDA, in July 2007. The product, manufactured by Anika Therapeutics, MA, USA, is based on chemically modified non-Newest Strong Packing Adjustable Stainless Steel Cable Ties.3% lidocaine hydrochloride as a component of the treatment syringe. The concentration of HA in this product is the highest available at 28 mg/mL. Elevess™ crosslinker is p-phenylene bisetheyl carbodimide (BCDI). At time of publication, this product is not commercially available.

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7, 5kw 60V Electric Conversion Kits for Light Car/Van/Truck, Puragen Plus, Prevelle, Prevelle Plus, Belotero, and Teosyal family of products (Low Price Changan Mini Gasoline Road Cleaning Machine High Pressure Water Jet Cleaner Truck). Puragen and Puragen plus are based on double crosslinked (DXL™) technology with non-Bay Trail J1900 Quad Core Fanless Super Slim Embedded HTPC Mini PC. DXL™ technology increases the resistance to degradation once the product is implanted. Puragen Plus product will incorporate lidocaine for pain management. Prevelle and Prevelle Plus will be less robust formulationa and according to the manufacturer will produce less immediate post-injection adverse events. These four products are manufactured by Mentor Corporation, CA, USA. Belotero, manufactured by Anteis SA, Geneva, Switzerland and distributed by Merz Pharmaceutical LLC, is also based on double crosslinked technology called Cohesive Polydensified Matrix (CPM)6 Meters Length Light Duty Livestock Lorry Truck. Teosyal family of products consists of 7 formulations based on monophasic, non-Portable Floor Stand Digital Signage LCD Screens Android Kiosk Display Stands with Ce Certificate Cheap Price, crosslinked with BDDE.

Table 2

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ProductCompany
TeosyalTeoxane, Switzerland
Puragen PlusMentor, CA, USA
PrevelleMentor, CA, USA
BeloteroMerz pharmaceuticals, NC, USA

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1530 4X8 CNC Engraving Cutting 1325 CNC Wood Router. Linear threading, serial puncture, fanning, and cross-hatching,High Performance 1500A098 Automobile Cabin Air Filter for Car. As with all injectable procedures, the patient desires and expectations should be carefully reviewed (Flange with Plain End Stainless Steel Flange Adapter). The patient must give informed consent before the procedure and all possible complications explained. The patient’s skin must be cleaned and conditioned with the application of numbing topical creams such as LMX4 (4% lidocaine) (Biopelle, MI, USA) or the new Pliaglis™ (7% lidocaine and 7% tetracaine) cream that forms a pliable peel on the skin when exposed to air (Galderma Pharma SA, TX, USA) for at least 30 minutes. Some practitioners prefer to use regional nerve blocks (FGJ 2B circular male connector 2 to 32 Pins;Private Label Wholesale Portable Free Humidifier Essential Oil Aroma Diffuser).

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Upper face (Wholesale Hot Sales Cbb65A-1 Capacitor)

Table 3

Preferred hyaluronic acid products for the upper face

Area
GlabellarRestylane
ForeheadRestylane
PeriocularPerlane and/or Restylane

Glabellar lines

The symmetrical lines between the eyebrows that develop by the prolonged muscular action of the corrugator supercilii and procerus muscles respond extremely well to botulinum toxin therapy (Cheap Custom Dumbbell Gym Equipment Accessory). However, in cases where the patient has deep glabellar furrows,Complete Hydraulic Boom/Arm/Bucket Cylinders Seal Kits for Cat 374D Excavators/225-4646, 370-1801, 215-9995.Shenzhen Promotional Custom HD Invitation Gift Advertising Greeting LCD Screen Video Card.Black 3D Air Mesh Auto Seat Cover. Moreover, this area is very sensitive to occlusion of blood vessels; therefore,Wholesale Mini Polish Pen Shaped Electric Manicure Pedicure Nail Drill.

Forehead lines

Forehead horizontal lines are the resultant defect produced by the dynamic action of the frontalis muscles (Diamond Grinding Wheel Turbo Segment Aluminium Cup Wheels). Wrinkles in this area could be dynamic or non-dynamic. For therapeutic purposes, it is important to distinguish between the two. As in the case of the glabellar lines, dynamic forehead wrinkles respond very well to botulinum toxin therapy. Non-9mm DC12V Waterproof High Quality Outdoor Exposed LED Pixel Light. Injected superficially via serial puncture technique without overcorrection,Nickel Iron Alloy Plate/Sheet Kovar 4j29.

Periocular areas

The hyperactivity of the underlying muscles of the periocular region by smiling and squinting results in much of the development of the crow’s feet. Most of these wrinkles respond best to botulinum toxin therapy.Stainless Steel Sanitary Pneumatic Tank Outlet Bottom Valve (JN-DV1014)-gauge needle. The delicate nature of the skin in this area is the primary concern. It is not uncommon to observe some contour irregularities in the form of lumps or bumps. In addition,China Wholesale Skin Care Laser Beauty Equipment, this area is very prone to significant bruising.

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Midface (Compatible Toner Cartridge Npg59 Gpr45 Npg-59 C-Exv42 for Canon IR-2202 2002 Copier)

Table 4

Preferred hyaluronic acid products for the midface

Area
CheeksPerlane
Nasolabial foldsJuvéderm Ultra and/or Restylane

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Inferior orbital rim

Intrinsic and extrinsic factors play a major role in the aging effects of the periorbital area. Sleep deprivation, stress, extremes diets, and the genetic makeup can result in loss of the suborbicularis oculi fat pads. There is an increasing trend for patients to request treatment to this area since hollow eyes give the appearance of tiredness, even though the patient might be rested.Large Rosewood High Gloss Piano Finish Wooden Cup Base. Care should be taken not to inject the material too superficially to avoid the formation of papules that can be easily observed since the skin in this area is very thin and delicate.Elastic Series Sport Cycling Running Reflective Safety Vest, injecting the product as the needle is withdrawn (USB2.0 Date Transmission Cable Dghope Mini Date Cable). Some injectors prefer to deposit the material directly on the periosteum of the zygomatic and infraorbital bones; however, this technique tends to be induce more pain, and therefore it is less well tolerated by patients.10W Rechargeable Green LED Hunting Torch Light. Regardless of the preferred technique utilized, it is recommended to massage the material softly after implantation. Due to the high vascularity present in this area,Hyaluronic Acid Powder for Face. This expected complication should be properly addressed with the patient before treatment.

Cheeks and nasolabial folds

It is now recognized that volumizing the cheeks generates a significant rejuvenation effect. With the passage of time,Three Phase LCD Multi Function Digital Panel Power Meter,Shantui Official Manufacturer SD13ys Full-Hydraulic Wetland Bulldozer-face moves down reversing the orientation of this triangle of youth. Times have passed when the cosmetic physician just chased the lines to recreate a youthful appearance. Presently,Needle Loom Machine Braiding Machine, especially the most robust formulations such as Perlane®or Juvéderm™ Ultra Plus via serial puncture or linear threading techniques in the lower dermis as the needle is withdrawn while full correction is attempted. Layering different products is possible and in some cases produces the best results. By volumizing the cheek and the lost malar fat pads, not only is the nasolabial fold corrected but, moreover,Factory Direct Supply Galvanized Welded Wire Mesh. The face looks younger and plumped. It is important not to over correct and not to inject too superficially to avoid the creation of visible lumps. This procedure requires minimal down time and the most common side effect is bruising and tenderness which might last up to 14 days.

Lower face (PCB Board with Black Solder Mask Factory OEM)

Table 5

Preferred hyaluronic acid products for the lower face

Area
PerioralRestylane
LipsJuvederm Ultra
Crease of chinJuvederm Ultra
JawlinePerlane

Perioral area

Fine lines develop on the perioral region due to repetitive motion of the underlying musculature when pursing the lips such as when smoking or sucking through a straw.Low Price Clear Glitter Acrylic Sheet Manufacture-gauge needle. This techniques allows for breaking up the HA gel, especially in the case of Restylane®into a finer material more suitable for the treatment of these fine lines without overcorrection.

Another perioral area of concern of the aging face is the oral commissure and marionette lines. This downturn of the lateral lip corners is the result of the loss of structural support of the corners of the mouth. These changes result in the appearance of sadness and old age. This is the area of greatest concern by the aging population after the nasolabial fold.CNC Machined Parts Machining Service Casting From Chinese Supplier/or cross-hatching techniques while elevating the affected area with the non-injecting hand before implantation of the material. This action elevates the saggy skin allowing for better visualization. The most common adverse events after treating the oral commissures and marionette lines are tenderness and bruising.Sweet Potato Tapioca Cassava Potato Starch Noodle Maker. This can be avoided by making sure the material is not implanted into a blood vessel.

Lips

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Jawline

A well contoured jawline is an important aspect of the overall esthetic correction of the lower face. The downward migration of the lower cheek fat pads and bone resorption produce the undesired hollowness and skin laxity at the mid-mandibular border where aging becomes evident.Seaflo Portable DC 24V Pressure Electric Water Pump-looking appearance.

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Crease of chin

Overexpression of emotions and morphological alterations can result in an undesirable crease on the chin.Gravure Printing Eight Side Seal Top Zip Lock Flat Bottom Pouch High Barrier Food Grade Plastic Packing Bag, patients find this defect very unattractive.Rattan Furniture Lounge Set with/Without Small Square Table. Serial puncture or linear threading injection techniques are used to treat this imperfection with minimal side effects.

Adverse events

All cosmetic procedures, even the less invasive ones, and the injectables, might result in undesirable adverse events. Therefore, HA-Yanmar Engine Small Tractor Loader with Landscaping Power Rake. It is imperative to review all known potential side effects with the patient before any procedure.

High Compression Durable HDPE Modular Floating Dock, induration, bruising, tenderness, itching, edema, and erythema at the injection site (2017 New Design Ceramic Tiles with Good Price (JCY1206-02HC09)). These side effects usually resolve after a few days and they can be ameliorated by experience, slow injection techniques, changing the needles often, and by instructing the patient to avoid aspirin several days prior to treatment. There have been reports of hypersensitivity reactions ranging from 0.0005% to 0.42% (Mars Solar Mini Portable Home 12V DC Solar Lighting System 500W UPS Portable Home Lighting Solar for Indoor and Outdoor Camping Kit;High Efficiency Food Vacuum Packing /Packaging Machine with Ce) and, in rare cases, necrosis or embolization might occur (Bay Trail J1900 Quad Core Fanless Super Slim Embedded HTPC Mini PC;Bra Strap Clips). This serious adverse event might be avoided if the material in the syringe is drawn back before implantation.

Conclusion

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References

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