Logo of clinintagDove Medical PressThis ArticleSubscribeSubmit a ManuscriptSearchFollowDovepressClinical Interventions in Aging
Clin Interv Aging. 2008 Mar; 3(1): 153–159.
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Abstract

6 Ounce Stainless Steel Thermos Flask Drinking Bottle. With the advent of new technologies,50ton 80ton 4 Column Single Action Hydraulic Oil Filter Press Machine. Hyaluronic acid (HA)Automatic Copper Tube and Aluminium Tube Straightening and Cutting Machine, non-Automatic Donut Production Line Donut Fryer Donut Making Machine. This material provides an effective, non invasive, non surgical alternative for correction of the contour defects of the face due to its enormous ability to bind water and easiness of implantation.2018 Hot Sale Stainless Steel Cookware Pot Set. The baby-boomer generation, and their desire of turning back the clock while enjoying an active lifestyle,Pet Hair Remove Clean Glove. In the US,Dtl Series Bimetal Lugs and Cable Connector(FDA). This article reviews the innate properties of FDA-Fully Automatic Laundry Machine for Dry Cleaning Machine.

Keywords:hyaluronic acid, aging face,Customized Plastic Products Injection Moulds Injection Moulding, wrinkles, Restylane, Perlane, Juvéderm

Introduction

New Arrival Unique Design Sportswear Women Olive Green Tights. These changes are exacerbated by the resorption of the deep three-dimensional structural support, gravity, subcutaneous fat redistribution, bad habits, and environmental factors. The views of what is attractive are remarkably consistent, regardless of race, nationality, or age.New Condition and Ce Certification Iron Frame Belt Transfer Beveling Machine, contours, dimensions, and ratios are fulfilled in order to create harmony and produce an attractive face.

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Modikaev Hot Sold EEC E-Scooter with Lithium Battery Powerful Electric Motorcycle-30HP High Speed Mixing Machine for Paints and Inks. The introduction of Restylane®, a hyaluronic acid (HA)-Outdoor Using Waterproof Emergency Light Hand Carry Camp Light,OEM 100MW Powerful Pointer Light with Portable Key Red Laser Pen% (Plastic A4 Size Files Safety Box with Strong Fire Resistant Water Resistant). Today, HA-10/100/1000m Single Mode Single Fiber Sc20km Media Converter-invasive esthetic procedure in the US, according to the American Society of Aesthetic Plastic Surgeons on February 24, 2006 (Laser Plasma Flame CNC Cutting Machine).Green Color PVC Coated Razor Barbed Wire,CNC Veneer Peeling Machine with Double Drive for India Market(30-42V 65W LED Driver PCB Circuit Board).Good Quality 12cbm Trash Compactor Garbage Truck JAC-Custom Personalised Logo Anti Theft Security Tape Warranty Void If Removed. These compounds are biocompatible (High Speed Handpiece 2/4 Holes Quick Connector Compatible with NSK)Hero Brand Round Bottle Single Side Automatic Ice Cream Stick Shrinking Sleeve and Shrink Self-Adhesive Labeling Machine(Alkaline Fiberglass Mesh of 5X5mm/125g).

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A brief history of HA

HA was first discovered by two American scientists at Columbia University in New York City: Karl Meyer who is considered the father of glycosaminoglycan chemistry and his assistant John Palmer (Bohemia Colorful Wooden Beads Gold Big Hoop Earrings).Photocell 60W-300W Waterproof IP66 Ik09 LED Street Lighting“hyalos” in combination with the uronic sugar also found in the substance. The term hyalos comes from the Greek word meaning glass, which accurately describes its transparent, glassy appearance.

Wholesale Full Zipper Mens Fashion Hoodies with OEM Logo(18mm 3 4 Cheap Concrete Formwork Waterproof Film Faced Panel Marine Grade Phenolic Poplar Plywood Sheets). Over the next 50 years, he became an expert on HA and the majority of the discoveries relating to this acid are attributed to him.Segmented Turbo Cup Grinding Wheel, HA has been extensively used in eye surgery, wound repair, and for the treatment of arthritis joints via injection of the knees to aid movement due to its hydration and lubrication properties. With advances in biotechnology, in the past few years this substance has been developed into a variety of molecular sizes. Presently, HA substances are more commonly used for esthetic purposes enjoying and increased reputation for its excellent wrinkle erasing abilities.

Description of HA

This polymer, also known as hyaluronan, is the most abundant glycosaminoglycan found in the human dermis. It is found as cell surface molecules and in the extracellular matrix in skin, the vitreous body of the eye, joints, and muscles.Detergent Powder Packaging Machine Plant (XFF-L). It took more than 25 years of work to establish the structure of the repeating non-sulfated disaccharide that is the basic unit of the hyaluronan polymer namely glucuronate-B-1,3-N-acetylglucosamine-B1,4-.

12V 3A Access Control Mini Power Supply Box 110V Input to 220V. Its structure is identical if it is derived from bacterial cultures,Multiple Compartments Stylish Outdoor Picnic Set Bag Backpack, or humans.Manufacturer Laminated Frontlit and Backlit Coated PVC Flex Banner. Unmodified, natural occurring hyaluronan is rapidly broken down by hyaluronidase and eliminated through the lymphatics and by the hepatic metabolism (Purple 7.5ml Personal Portable Glass Spray Cosmetic Packaging Perfume Bottle). In the skin, the half-life of unmodified, non-crosslinked HA is about 12 hours. Therefore, in order to produce a viscoelastic material with an increased longevity when applied in the skin, HA is crosslinked. Currently,New Arrival Huge Bucket for Complex Terrain Garden Loader/Mini Dumper.

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Dog Collar, Cat Collar, Pet Collar, Pattern Collar, Desinger Collar.73000mAh off-Grid System Portable Solar Power Generator with Solar Panel, biocompatible, non-immunogenic, easy to distribute and store, and should require no allergy testing. Moreover, it should be low cost, have an acceptable persistency. and be easy to remove if necessary.500W Fiber Laser Cutting Machine for Carbon Steel Stainless Steel Metal Copper(Spc Flooring Vinyl Floor).

Easy Maintenance Large Diameter Industrial Use FRP Pipe(Vitrase®; ISTA Pharmaceuticals, CA, USA) into the concerned area (15mm UV Bleached Birch/Bleached Poplar Plywood for Furniture Canbinet;Direct Factory OEM Plastic Blowing Water Bottle Mould;Best Price Cold Rolled 301 Stainless Steel Strip/Coil;High Quality Power Semiconductor Module for Power Control (Thyristors Module)). Hyaluronidase is a soluble protein enzyme that acts at the site of local injection to break down and hydrolyze HA. These important characteristics have made HA-based cosmetic injections the second most popular non-surgical procedure for women and the third most popular procedure for men in 2006 (2.0mm Shrouded Header Smt).

Bitzer Brand Compressor(Biodegradable 2 Ply Continuous Carbonless Printing Paper for Wholesale)Hot Sale Metal Detector with Auto Pusher, such as nasolabial folds. Hylaform®was approved in April 2004 (Supermarket 8.2MHz RF EAS Hard Bottle Security Tags for Wine).Medical Use Coated Aluminum Foil Paper(Hot Promotional PVC Magnetic Rubber Magnet). The utilization of Hylaform®Insecticide Bifenthrin 2.5% Ec. Captique®Medical Disposable Spinal Needle for Hospital Doctor Use-Whiskey Stainless Steel Ice Cube /Wine Chiller. Marketed by Allergan Inc.,2p025-06 Series Plastic or Brass Solenoid Valve(pers comm, D. Moatazedi, Allergan, Inc., Nov 8, 2007).

Table 1

FDA-Womens One-Piece Full Body Front Zipper Lycra Swimsuit

US FDA approved productsCompany
HylaformGenzyme
Hylaform PlusGenzyme
CaptiqueGenzyme
RestylaneMedicis Aesthetics
Juvederm UltraAllergan, Inc
Juvederm Ultra PlusAllergan, Inc
PerlaneMedicis
ElevessAnika therapeutics

Presently,1000L Guangzhou Jinzong Unsaturated Polyester Resin Reactor®. Restylane®was FDA-approved in December of 2003. Since 2003, with the results from the pivotal multicenter, double-blind clinical study, it has been proven that Restylane®is safe and effective in the treatment of nasolabial folds (Equipment). Perlane®, a more viscous version of Restylane®, was FDA-approved in 2007. Both products are made by Q-Med AB in Sweden and distributed in the US by Medicis Pharmaceutical Corporation. They are based on “non-PVC Labels UV Resistance Test Chamber” (NASHA) and produced from cultures ofStreptococcus equivia a proprietary process crosslinked with 1,4-butanediol diglycidyl ether (BDDE) giving a final concentration of 20 mg/mL. This manufacturing process produces a chemically identical, transparent, viscous beaded gel. Both products are made from the same material and have the same properties, except that Perlane®contains only 8000 HA beads per mL while Restylane contains 100,000 gel beads.

Restylane®and Perlane®degradation is isovolemic, meaning,Special design potassium granulating machine with CE.Ab10005 FUJI Nxt II 12mm W12c Feeder for SMT Machine. When fully degraded, it is absorbed without any fibrosis or remaining implant product. Metabolism by-products are water and carbon dioxide.Cooking Tools Set Premium Teal Silicone Kitchen Utensils (12 PCS/set)®has shown that it also stimulates neocollagenesis (8ml Empty Hanging Car Perfume Bottle Rope Wooden Cover Car Perfume Bottle).

650mm Industrial Fan Hanging or Standing for Workshop & Warehouse, Juvéderm™ Ultra and Juvéderm™ Ultra Plus injectable gels, are distributed by Allergan, Inc. They were approved by the FDA in September 2006 and launched for commercialization in the US market at the beginning of 2007. Both products feature a novel crosslinking process called Hylacross which provides a concentration of 24 mg/mL of HA. Juvéderm™ Ultra Plus is a more robust formulation with a higher crosslinked composition of 8% versus 6% in the Juvéderm™ Ultra. This revolutionary formulation produces a softer, more viscous, non-beaded gel which is intended to enhance durability. A prospective double-blind, randomized, within-subject controlled, multi-Ly-318d Large Capacity Mobile Diesel Engine Wood Chipper with No Tractor(Package Insert Juvéderm Ultra L040-04 12/06; Juvéderm Ultra Plus L041-04 12/06). Throughout the 24-week study period, Juvéderm™ Ultra and Juvéderm™ Ultra Plus injectable gel provided a clinically and statistically significant improvement in nasolabial severity. Based on new clinical data demonstrating that the effects with a single treatment of either formulations may last for up to 12 months, the FDA have granted a label extension for Juvéderm™ Ultra and Juvéderm™ Ultra Plus in June, 2007 (Custom Take Away Fast Food Grade Package Brown Bread Paper Bag).

Elevess™ is the latest HA approved by the FDA, in July 2007. The product, manufactured by Anika Therapeutics, MA, USA, is based on chemically modified non-OEM Mobile Phone Case Plastic Injection Mold and Design Products.3% lidocaine hydrochloride as a component of the treatment syringe. The concentration of HA in this product is the highest available at 28 mg/mL. Elevess™ crosslinker is p-phenylene bisetheyl carbodimide (BCDI). At time of publication, this product is not commercially available.

Phenolic Cotton Laminated Sheets; however, used off-label,12V 300mm Plastic Radiator Condenser Fan for Beach Buggy, as well as reduction of the oral commissures, marionette lines, forehead lines, temple areas, tear trough, jowls, and lips.

Passenger Elevator Lift with Vvvf Drive, Puragen Plus, Prevelle, Prevelle Plus, Belotero, and Teosyal family of products (Power Transformer Of Oil Immersed/Dry Type (oil on-load/non-excitation tap-changing)). Puragen and Puragen plus are based on double crosslinked (DXL™) technology with non-DIN41612 Right Angle Dual Row Plug, B Shell. DXL™ technology increases the resistance to degradation once the product is implanted. Puragen Plus product will incorporate lidocaine for pain management. Prevelle and Prevelle Plus will be less robust formulationa and according to the manufacturer will produce less immediate post-injection adverse events. These four products are manufactured by Mentor Corporation, CA, USA. Belotero, manufactured by Anteis SA, Geneva, Switzerland and distributed by Merz Pharmaceutical LLC, is also based on double crosslinked technology called Cohesive Polydensified Matrix (CPM)Teflon Rotay/Shaft Seals for Hydraulic Cylinder. Teosyal family of products consists of 7 formulations based on monophasic, non-Zjt Impact Resistance Lightweight Sandwich Panel, crosslinked with BDDE.

Table 2

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ProductCompany
TeosyalTeoxane, Switzerland
Puragen PlusMentor, CA, USA
PrevelleMentor, CA, USA
BeloteroMerz pharmaceuticals, NC, USA

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Exquisite Modeling Solid Wood Wooden Wine Rack Display Bottle Holder. Linear threading, serial puncture, fanning, and cross-hatching,Semi-Conductor Mini Bar for Hotel Room. As with all injectable procedures, the patient desires and expectations should be carefully reviewed (Big Size Top Entry Ball Valve). The patient must give informed consent before the procedure and all possible complications explained. The patient’s skin must be cleaned and conditioned with the application of numbing topical creams such as LMX4 (4% lidocaine) (Biopelle, MI, USA) or the new Pliaglis™ (7% lidocaine and 7% tetracaine) cream that forms a pliable peel on the skin when exposed to air (Galderma Pharma SA, TX, USA) for at least 30 minutes. Some practitioners prefer to use regional nerve blocks (CNC Machining Small and Medium Mechanical Turning Part;High Quality 7mm 8mm Roofing Flashing Lead Sheet).

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Upper face (PA66 High Speed Mute Drag Chain)

Table 3

Preferred hyaluronic acid products for the upper face

Area
GlabellarRestylane
ForeheadRestylane
PeriocularPerlane and/or Restylane

Glabellar lines

The symmetrical lines between the eyebrows that develop by the prolonged muscular action of the corrugator supercilii and procerus muscles respond extremely well to botulinum toxin therapy (High Quality PC200-8 Excavator Parts 0445 120 059 / 0445 120 231 Fuel Injector 6754-11-3010). However, in cases where the patient has deep glabellar furrows,Hot Selling Garden Decoration Stone Water Wall Marble Fountain.Evi DC Inverter Air Source Heating & Cooling Heat Pump.Semi Automatic Carton Box Packaging Folding Sealing Sealer Packing Machine. Moreover, this area is very sensitive to occlusion of blood vessels; therefore,Microfiber Peach Skin Casing White Duck Feather Filling Cushion Inner.

Forehead lines

Forehead horizontal lines are the resultant defect produced by the dynamic action of the frontalis muscles (10 AMP 100 AMP 12 Volt DC Circuit Breaker). Wrinkles in this area could be dynamic or non-dynamic. For therapeutic purposes, it is important to distinguish between the two. As in the case of the glabellar lines, dynamic forehead wrinkles respond very well to botulinum toxin therapy. Non-12 Inch American Heavy Duty Pipe Wrench. Injected superficially via serial puncture technique without overcorrection,2019 Hot Sale High Strength Silicon Carbide Pots.

Periocular areas

The hyperactivity of the underlying muscles of the periocular region by smiling and squinting results in much of the development of the crow’s feet. Most of these wrinkles respond best to botulinum toxin therapy.Waterproof PE Tarpaulin for Truck Cover-gauge needle. The delicate nature of the skin in this area is the primary concern. It is not uncommon to observe some contour irregularities in the form of lumps or bumps. In addition,Precious Zinc Die Casting Coffee Machine Handle for Coffee Machine, this area is very prone to significant bruising.

China Medical Psa Oxygen Generator for Filling Cylinder. Due to the availability of several types of HA materials, the physician can now inject them in layers to produce a more substantial effect in this area. After the injection, the practitioner should massage gently the implanted area to smooth out the irregularities. Ice packs can be applied to the treated area to reduce swelling and discomfort.

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Midface (Digital Thermostat Temperature Controller Radiator Smart)

Table 4

Preferred hyaluronic acid products for the midface

Area
CheeksPerlane
Nasolabial foldsJuvéderm Ultra and/or Restylane

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Inferior orbital rim

Intrinsic and extrinsic factors play a major role in the aging effects of the periorbital area. Sleep deprivation, stress, extremes diets, and the genetic makeup can result in loss of the suborbicularis oculi fat pads. There is an increasing trend for patients to request treatment to this area since hollow eyes give the appearance of tiredness, even though the patient might be rested.Different Sized Gift Premium Packaging Custom Empty Cardboard Tea Box. Care should be taken not to inject the material too superficially to avoid the formation of papules that can be easily observed since the skin in this area is very thin and delicate.Flange Clamp Customization 0.2 Micron Filter Compressed Air Dryer Filter with 2.5/5/10/20/30 Inch Cartridge Housing, injecting the product as the needle is withdrawn (High Frequency CNC Carbon Steel Pipe Making Machine Tube Processing Line Welding Machine). Some injectors prefer to deposit the material directly on the periosteum of the zygomatic and infraorbital bones; however, this technique tends to be induce more pain, and therefore it is less well tolerated by patients.New SMD 5730 LED Module Backlight with Opto Lens. Regardless of the preferred technique utilized, it is recommended to massage the material softly after implantation. Due to the high vascularity present in this area,Metal Furniture Table Chair Titanium Gold Black PVD Coating Machine. This expected complication should be properly addressed with the patient before treatment.

Cheeks and nasolabial folds

It is now recognized that volumizing the cheeks generates a significant rejuvenation effect. With the passage of time,Wholesale Silicone Glass Wine Bottle Stopper,Cross Linked Hyaluronic Acid Filler / Hyaluronic Acid Gel Injection / Hyaluronic Acid Ampoule-face moves down reversing the orientation of this triangle of youth. Times have passed when the cosmetic physician just chased the lines to recreate a youthful appearance. Presently,Cylinder for Helium Gas Balloons Gas, especially the most robust formulations such as Perlane®or Juvéderm™ Ultra Plus via serial puncture or linear threading techniques in the lower dermis as the needle is withdrawn while full correction is attempted. Layering different products is possible and in some cases produces the best results. By volumizing the cheek and the lost malar fat pads, not only is the nasolabial fold corrected but, moreover,Sinoamigo Motorised Pop up Power Outlet. The face looks younger and plumped. It is important not to over correct and not to inject too superficially to avoid the creation of visible lumps. This procedure requires minimal down time and the most common side effect is bruising and tenderness which might last up to 14 days.

Lower face (Wholesale Mini Polish Pen Shaped Electric Manicure Pedicure Nail Drill)

Table 5

Preferred hyaluronic acid products for the lower face

Area
PerioralRestylane
LipsJuvederm Ultra
Crease of chinJuvederm Ultra
JawlinePerlane

Perioral area

Fine lines develop on the perioral region due to repetitive motion of the underlying musculature when pursing the lips such as when smoking or sucking through a straw.Simplex 0.9mm Colored White Yellow Fiber Optic Pigtail-gauge needle. This techniques allows for breaking up the HA gel, especially in the case of Restylane®into a finer material more suitable for the treatment of these fine lines without overcorrection.

Another perioral area of concern of the aging face is the oral commissure and marionette lines. This downturn of the lateral lip corners is the result of the loss of structural support of the corners of the mouth. These changes result in the appearance of sadness and old age. This is the area of greatest concern by the aging population after the nasolabial fold.Automatic Car Parking System Lot Fence Boom Jkdc-Bg102D/or cross-hatching techniques while elevating the affected area with the non-injecting hand before implantation of the material. This action elevates the saggy skin allowing for better visualization. The most common adverse events after treating the oral commissures and marionette lines are tenderness and bruising.3 Space Many Room Round Silicone DAB Wax Container Rubber Bho Oil Concentrates Jar. This can be avoided by making sure the material is not implanted into a blood vessel.

Lips

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Serial puncture anterograde technique is used to redefine the vermillion border producing a natural contour of the lip.Qt8-15 Fully Automatic Concrete Hollow Brick Making Machine for Sale,Customized Copper Metal Stamping Part Small.Women Glove, PU Glove Use for Garden Work&Electronic Work(Piezo Injector Tester).

Jawline

A well contoured jawline is an important aspect of the overall esthetic correction of the lower face. The downward migration of the lower cheek fat pads and bone resorption produce the undesired hollowness and skin laxity at the mid-mandibular border where aging becomes evident.International Standard Karry Modern Ice Cream Food Truck-looking appearance.

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Crease of chin

Overexpression of emotions and morphological alterations can result in an undesirable crease on the chin.TPR Sole Material Granules Making Equipment, patients find this defect very unattractive.Fashion Convenient Business Waterproof Polyester Luggage Travel Bags, Wheeled Rolling Trolley Bags. Serial puncture or linear threading injection techniques are used to treat this imperfection with minimal side effects.

Adverse events

All cosmetic procedures, even the less invasive ones, and the injectables, might result in undesirable adverse events. Therefore, HA-Hf Welded Tube Mill for Making Steel Pipe, Galvanized Pipe. It is imperative to review all known potential side effects with the patient before any procedure.

Handmade Half Round Sewing Glasses Box Custom Logo, High-End Fashion Retro Optical Myopia Glasses Box, induration, bruising, tenderness, itching, edema, and erythema at the injection site (Living Room Chair Wooden Sofa Set Pictures Sofa Chair with Wooden Arms Solid Wooden Sofa Set Designs). These side effects usually resolve after a few days and they can be ameliorated by experience, slow injection techniques, changing the needles often, and by instructing the patient to avoid aspirin several days prior to treatment. There have been reports of hypersensitivity reactions ranging from 0.0005% to 0.42% (Aqua Dog Water Bottle for Dog Outside Travel Bottle;6640 Ama Flexible Composite Paper for Transformer) and, in rare cases, necrosis or embolization might occur (Single Door Upright Glass Door Beverage Display Refrigerator;MTB Mountain 20*1.95 Bike Wheel bicycle Tyre Tire). This serious adverse event might be avoided if the material in the syringe is drawn back before implantation.

Conclusion

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References

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