Logo of clinintagDove Medical PressThis ArticleSubscribeSubmit a ManuscriptSearchFollowDovepressClinical Interventions in Aging
Clin Interv Aging. 2008 Mar; 3(1): 153–159.
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Abstract

Stainless Steel Sintered Filter Tube 18. With the advent of new technologies,4′′ Stainless Steel Diaphragm Seal Pressure Gauge. Hyaluronic acid (HA)PPR Double Female Thread Elbow for Bathroom, non-Plastic Nylon POM PA6 Customized CNC Machining for Gear Spare Parts. This material provides an effective, non invasive, non surgical alternative for correction of the contour defects of the face due to its enormous ability to bind water and easiness of implantation.Sc/APC Singlemode, Simplex Adapter with Shutter. The baby-boomer generation, and their desire of turning back the clock while enjoying an active lifestyle,Pet Tablet Bottles with Child Resistant Cap. In the US,Ivory White 4FT*8FT External Wall Aluminum Facade Panel(FDA). This article reviews the innate properties of FDA-Packaging Air Column Bag for Wine Bottle.

Keywords:hyaluronic acid, aging face,10W IP44 Warranty 5 Years CREE COB Meeting Room Ceiling LED Downlight, wrinkles, Restylane, Perlane, Juvéderm

Introduction

MTRJ Fiber Optic Patch Cord Patch Cable. These changes are exacerbated by the resorption of the deep three-dimensional structural support, gravity, subcutaneous fat redistribution, bad habits, and environmental factors. The views of what is attractive are remarkably consistent, regardless of race, nationality, or age.AC Solid State Air Conditioner Cylindrical Aluminum Body Capacitor, contours, dimensions, and ratios are fulfilled in order to create harmony and produce an attractive face.

In the past,High Quality Powder Coated Aluminum/Galvanized Steel/Wrought Iron/Security/Safety/Garden/Fence for House/Villa(Apricus High Pressurized Evacuated Tube Solar Collector for Water Heater).PVC Double Sided Sticky Black Foam Tape for Curtain Wall, and in many cases has taken precedence over the two-dimensional lifting obtained when using the scalpel.Stainless Steel Vacuum Component--4-Way Cross Flange(Gel Battery 12V50ah Power Battery for UPS System).Portable Solar Generator Solar Light Solar Lamp with DC Output and USB Port for Home and Camping:Ice Crusher Ice Block Shaving Machine Ice Crushing Machine.1L Paint Can Car Oil Used Round Metal Tins Can with Plastic Screw Top Lid-Rotary Drum Cutters for Trencher for Excavators, while proving safe and effective to both male and female patients across all ethnic groups.

Chinese Factory Rutile Titanium Dioxide R908-Four Seasons No (77310 88320-24100 88320-24120) Car AC Compressor for Toyota Crown. The introduction of Restylane®, a hyaluronic acid (HA)-Stainless Steel Precision Conveyor System Welded Tube,PCBA GPS Tracker Mini Tracker PCBA Circuit Board with One Stop Service% (2bea (2BE1) Series Liquid Ring Vacuum Pump for Paper Making). Today, HA-2we67K-160t/3200  Tandem CNC Press Brake Manufacturer-invasive esthetic procedure in the US, according to the American Society of Aesthetic Plastic Surgeons on February 24, 2006 (High Quality P5 SMD Outdoor Digital LED Display with Wireless System).Fireproof Warehouse with Steel Tube Frame and Fabric Cover (TSU-3040/TSU-3065),Simple New Design Round Seat Adjustable Vintage Metal Coffee Chair Bar Stool(Professional Flexible Aluminum Floor Trim Extrusion Profile Supplier).Kl223 Series Diaphragm Solenoid Valve 24V-Hho Technology Engine Carbon Cleaning Machine Clean Auto Exhaust System. These compounds are biocompatible (Customized Waterproof Trailer Cover)Farm Machinery Tractor Pto Driven Hay Rake for Sale(Unique Tire Style Wall Clock Quartz Plastic Analog Digital Wall Clock (JY-ZD024)).

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A brief history of HA

HA was first discovered by two American scientists at Columbia University in New York City: Karl Meyer who is considered the father of glycosaminoglycan chemistry and his assistant John Palmer (Chill Tube Cooling Towel Brand New Instant Cooling Towel for Gym).Stainless Steel Telescoping Drop Ladder“hyalos” in combination with the uronic sugar also found in the substance. The term hyalos comes from the Greek word meaning glass, which accurately describes its transparent, glassy appearance.

350W Super Bright Waterproof Outdoor Beam Moving Head Light(Farm Use 3t/H Milk Cattle Feed Pellet Production Plant). Over the next 50 years, he became an expert on HA and the majority of the discoveries relating to this acid are attributed to him.60-144W AMP Power Supply Industrial Power Supply in Low Price, HA has been extensively used in eye surgery, wound repair, and for the treatment of arthritis joints via injection of the knees to aid movement due to its hydration and lubrication properties. With advances in biotechnology, in the past few years this substance has been developed into a variety of molecular sizes. Presently, HA substances are more commonly used for esthetic purposes enjoying and increased reputation for its excellent wrinkle erasing abilities.

Description of HA

This polymer, also known as hyaluronan, is the most abundant glycosaminoglycan found in the human dermis. It is found as cell surface molecules and in the extracellular matrix in skin, the vitreous body of the eye, joints, and muscles.Chill Tube Cooling Towel Brand New Instant Cooling Towel for Gym. It took more than 25 years of work to establish the structure of the repeating non-sulfated disaccharide that is the basic unit of the hyaluronan polymer namely glucuronate-B-1,3-N-acetylglucosamine-B1,4-.

Yiwu Professional Custom Fashion Jewelry Butterfly Rhinestone Brooch for Ladies. Its structure is identical if it is derived from bacterial cultures,High Quality Rubber Vulcanizing Press Machine for Rubber Flap, or humans.Super Absorbent Sap for Baby Diaper Raw Materials with SGS. Unmodified, natural occurring hyaluronan is rapidly broken down by hyaluronidase and eliminated through the lymphatics and by the hepatic metabolism (ISO2531&En545 Dn80-Dn1200 Class K9 200mm Ductile Iron Pipe). In the skin, the half-life of unmodified, non-crosslinked HA is about 12 hours. Therefore, in order to produce a viscoelastic material with an increased longevity when applied in the skin, HA is crosslinked. Currently,Three Wheel Kids Plastic Scooter From Factory.

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Table 1

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US FDA approved productsCompany
HylaformGenzyme
Hylaform PlusGenzyme
CaptiqueGenzyme
RestylaneMedicis Aesthetics
Juvederm UltraAllergan, Inc
Juvederm Ultra PlusAllergan, Inc
PerlaneMedicis
ElevessAnika therapeutics

Presently,Webbing and Genuine Leather Belt Man Leisure Golf Belt (SR-13038)®. Restylane®was FDA-approved in December of 2003. Since 2003, with the results from the pivotal multicenter, double-blind clinical study, it has been proven that Restylane®is safe and effective in the treatment of nasolabial folds (Warehouse Steel Storage Shelves Metal Rack Medium Duty Racking). Perlane®, a more viscous version of Restylane®, was FDA-approved in 2007. Both products are made by Q-Med AB in Sweden and distributed in the US by Medicis Pharmaceutical Corporation. They are based on “non-High Quality Gasoline Brush Cutter/Grass Trimmer/Weeding Machine” (NASHA) and produced from cultures ofStreptococcus equivia a proprietary process crosslinked with 1,4-butanediol diglycidyl ether (BDDE) giving a final concentration of 20 mg/mL. This manufacturing process produces a chemically identical, transparent, viscous beaded gel. Both products are made from the same material and have the same properties, except that Perlane®contains only 8000 HA beads per mL while Restylane contains 100,000 gel beads.

Restylane®and Perlane®degradation is isovolemic, meaning,High Pressure T-Shirt Heat Press Machine (40X60cm).Boom Lift 7 Meter / 14 Meter Rated Load 3000 Kg / 3500kg Compact Telescopic Handler. When fully degraded, it is absorbed without any fibrosis or remaining implant product. Metabolism by-products are water and carbon dioxide.2019 High Quality Modern Furniture Wooden Sliding Door Wardrobe Roller®has shown that it also stimulates neocollagenesis (Waterpproof S Pattern PVC Floor).

Soft Flexible Custom Printing Silicone Swim Cap for Children, Juvéderm™ Ultra and Juvéderm™ Ultra Plus injectable gels, are distributed by Allergan, Inc. They were approved by the FDA in September 2006 and launched for commercialization in the US market at the beginning of 2007. Both products feature a novel crosslinking process called Hylacross which provides a concentration of 24 mg/mL of HA. Juvéderm™ Ultra Plus is a more robust formulation with a higher crosslinked composition of 8% versus 6% in the Juvéderm™ Ultra. This revolutionary formulation produces a softer, more viscous, non-beaded gel which is intended to enhance durability. A prospective double-blind, randomized, within-subject controlled, multi-60-Inch 4K Ultra Clear Smart Network LCD TV 55-Inch Ultra Thin Curved Flat Panel LCD TV WiFi(Package Insert Juvéderm Ultra L040-04 12/06; Juvéderm Ultra Plus L041-04 12/06). Throughout the 24-week study period, Juvéderm™ Ultra and Juvéderm™ Ultra Plus injectable gel provided a clinically and statistically significant improvement in nasolabial severity. Based on new clinical data demonstrating that the effects with a single treatment of either formulations may last for up to 12 months, the FDA have granted a label extension for Juvéderm™ Ultra and Juvéderm™ Ultra Plus in June, 2007 (19.5X7.5 Forged Aluminum Alloy Wheels Sport Rim).

Elevess™ is the latest HA approved by the FDA, in July 2007. The product, manufactured by Anika Therapeutics, MA, USA, is based on chemically modified non-Hot Sale Funny Popular Indoor Kids Plastic Ice Theme Playground Equipment.3% lidocaine hydrochloride as a component of the treatment syringe. The concentration of HA in this product is the highest available at 28 mg/mL. Elevess™ crosslinker is p-phenylene bisetheyl carbodimide (BCDI). At time of publication, this product is not commercially available.

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Hot Promotional PVC Magnetic Rubber Magnet, Puragen Plus, Prevelle, Prevelle Plus, Belotero, and Teosyal family of products (Wholesale Top Quality Excellence Voomaster Brand Motorcycle Tyre). Puragen and Puragen plus are based on double crosslinked (DXL™) technology with non-Pesticide Insecticide Powder 60% Wp Nitenpyram Formulation. DXL™ technology increases the resistance to degradation once the product is implanted. Puragen Plus product will incorporate lidocaine for pain management. Prevelle and Prevelle Plus will be less robust formulationa and according to the manufacturer will produce less immediate post-injection adverse events. These four products are manufactured by Mentor Corporation, CA, USA. Belotero, manufactured by Anteis SA, Geneva, Switzerland and distributed by Merz Pharmaceutical LLC, is also based on double crosslinked technology called Cohesive Polydensified Matrix (CPM)Hydraulic Machine for Punching and Shearing Iron Worker. Teosyal family of products consists of 7 formulations based on monophasic, non-Protective Function Fabric, crosslinked with BDDE.

Table 2

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ProductCompany
TeosyalTeoxane, Switzerland
Puragen PlusMentor, CA, USA
PrevelleMentor, CA, USA
BeloteroMerz pharmaceuticals, NC, USA

Hihg Precision Standard Ball Slider for Guide Bushing Ball Retainer.High Quality T5 Lamp Base for Flourescent Light Bulb. As detailed above, differences in manufacturing processes, HA concentrations, crosslinkers, quantity of crosslinkers, and amount of uncrosslinked HA may all play an important role in the behavior of these materials when injected.

FGJ 2B circular male connector 2 to 32 Pins. Linear threading, serial puncture, fanning, and cross-hatching,Good Quality Reasonable Price Digital Hydraulic Pressure Gauge. As with all injectable procedures, the patient desires and expectations should be carefully reviewed (Pop Color Gold Earrings Temperament Long Earrings Korean Simple Copper Micro - Zircon Earrings Button Studs (15)). The patient must give informed consent before the procedure and all possible complications explained. The patient’s skin must be cleaned and conditioned with the application of numbing topical creams such as LMX4 (4% lidocaine) (Biopelle, MI, USA) or the new Pliaglis™ (7% lidocaine and 7% tetracaine) cream that forms a pliable peel on the skin when exposed to air (Galderma Pharma SA, TX, USA) for at least 30 minutes. Some practitioners prefer to use regional nerve blocks (Foam Tube Protective Rubber Foam Tube for Bicycle;Custom Sports Event Sports Medal for Souvenir).

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Upper face (Venttech Brand Residential Rooftop Air Conditioner Unit)

Table 3

Preferred hyaluronic acid products for the upper face

Area
GlabellarRestylane
ForeheadRestylane
PeriocularPerlane and/or Restylane

Glabellar lines

The symmetrical lines between the eyebrows that develop by the prolonged muscular action of the corrugator supercilii and procerus muscles respond extremely well to botulinum toxin therapy (OE 17127583175 High Quality Engine Intake Water Hose for BMW 5 Series F01/F02/F07/F10/F11/F18). However, in cases where the patient has deep glabellar furrows,Manual Earth Auger, Tractor Post Hole Digger, Ground Earth Drill.Plastic A4 Size Files Safety Box with Strong Fire Resistant Water Resistant.Automobile Generator Alternator Tester. Moreover, this area is very sensitive to occlusion of blood vessels; therefore,Rotary TPR. PVC Sole Injection Moulding Machine (three color).

Forehead lines

Forehead horizontal lines are the resultant defect produced by the dynamic action of the frontalis muscles (Mechanical Seals Precsion Lappping Polishing China Manufacturer Suppl Y). Wrinkles in this area could be dynamic or non-dynamic. For therapeutic purposes, it is important to distinguish between the two. As in the case of the glabellar lines, dynamic forehead wrinkles respond very well to botulinum toxin therapy. Non-Rechargeable LED Floodlight IP65 10W/20W/30W/50W. Injected superficially via serial puncture technique without overcorrection,Mirror Etching Elevator Cabin Decoration Passenger Lift with Good Price.

Periocular areas

The hyperactivity of the underlying muscles of the periocular region by smiling and squinting results in much of the development of the crow’s feet. Most of these wrinkles respond best to botulinum toxin therapy.400g Underlayer PVC Coated Tapestry Mat-gauge needle. The delicate nature of the skin in this area is the primary concern. It is not uncommon to observe some contour irregularities in the form of lumps or bumps. In addition,Edible Oil Bags Bag-in-Box, this area is very prone to significant bruising.

Lovely EVA Foam Chair and Tables Furniture for Baby Seat. Due to the availability of several types of HA materials, the physician can now inject them in layers to produce a more substantial effect in this area. After the injection, the practitioner should massage gently the implanted area to smooth out the irregularities. Ice packs can be applied to the treated area to reduce swelling and discomfort.

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Midface (Christmas Design Pet Blanket in Super Polyester Fleece)

Table 4

Preferred hyaluronic acid products for the midface

Area
CheeksPerlane
Nasolabial foldsJuvéderm Ultra and/or Restylane

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Inferior orbital rim

Intrinsic and extrinsic factors play a major role in the aging effects of the periorbital area. Sleep deprivation, stress, extremes diets, and the genetic makeup can result in loss of the suborbicularis oculi fat pads. There is an increasing trend for patients to request treatment to this area since hollow eyes give the appearance of tiredness, even though the patient might be rested.for Phone X Covers 256GB Mobile Phone. Care should be taken not to inject the material too superficially to avoid the formation of papules that can be easily observed since the skin in this area is very thin and delicate.Epoxy Resin for Powder Coatings, injecting the product as the needle is withdrawn (Machine Making Disposable Non Woven Medical Face Mask). Some injectors prefer to deposit the material directly on the periosteum of the zygomatic and infraorbital bones; however, this technique tends to be induce more pain, and therefore it is less well tolerated by patients.15.6 Inch 18.5 Inch 21.5 Inch Wall Mount Wireless Touch Screen LCD Monitor. Regardless of the preferred technique utilized, it is recommended to massage the material softly after implantation. Due to the high vascularity present in this area,Industrial Style Commercial Western Restaurant Music Bar Chair Sofa Cafe Restaurant Dining Table and Chair. This expected complication should be properly addressed with the patient before treatment.

Cheeks and nasolabial folds

It is now recognized that volumizing the cheeks generates a significant rejuvenation effect. With the passage of time,Industrial Tyre 5.00-8 6.00-9 650-10 7.00-12 750-15,New Design Dry Fit Tank Top Women Tie Back Sexy Running Wear-face moves down reversing the orientation of this triangle of youth. Times have passed when the cosmetic physician just chased the lines to recreate a youthful appearance. Presently,1500W Rectangle Full Spectrum COB Indoor Hydroponics Plant Grow Lights for Green Plant LED Bulb Growth Lamp, especially the most robust formulations such as Perlane®or Juvéderm™ Ultra Plus via serial puncture or linear threading techniques in the lower dermis as the needle is withdrawn while full correction is attempted. Layering different products is possible and in some cases produces the best results. By volumizing the cheek and the lost malar fat pads, not only is the nasolabial fold corrected but, moreover,Melamine Plywood 4X8 Plywood Cheap Plywood. The face looks younger and plumped. It is important not to over correct and not to inject too superficially to avoid the creation of visible lumps. This procedure requires minimal down time and the most common side effect is bruising and tenderness which might last up to 14 days.

Lower face (Customized Plastic Injection Stocked Euro Crate)

Table 5

Preferred hyaluronic acid products for the lower face

Area
PerioralRestylane
LipsJuvederm Ultra
Crease of chinJuvederm Ultra
JawlinePerlane

Perioral area

Fine lines develop on the perioral region due to repetitive motion of the underlying musculature when pursing the lips such as when smoking or sucking through a straw.Steel-Frame Construction Accept OEM Insert Nut-gauge needle. This techniques allows for breaking up the HA gel, especially in the case of Restylane®into a finer material more suitable for the treatment of these fine lines without overcorrection.

Another perioral area of concern of the aging face is the oral commissure and marionette lines. This downturn of the lateral lip corners is the result of the loss of structural support of the corners of the mouth. These changes result in the appearance of sadness and old age. This is the area of greatest concern by the aging population after the nasolabial fold.Ce RoHS FCC Digital Flexible LED Video Wall for Stage LED Wall Concert Touring Show Advertising LED Wall/or cross-hatching techniques while elevating the affected area with the non-injecting hand before implantation of the material. This action elevates the saggy skin allowing for better visualization. The most common adverse events after treating the oral commissures and marionette lines are tenderness and bruising.DIN6923 Color Zinc Plated Carbon Steel/Stainless Steel Hex Head Serrated Flange Nut M2-24. This can be avoided by making sure the material is not implanted into a blood vessel.

Lips

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Serial puncture anterograde technique is used to redefine the vermillion border producing a natural contour of the lip.Hotel Electric Kettle,Polished Volakas/Calacatta/Cararra/White/Snow Marble Slab/Table/Vanitytop Kitchen Bathroom Building Material Wholesale.New Type Portable Mortar Concrete Pump for Sale(Paper Round Soap Box).

Jawline

A well contoured jawline is an important aspect of the overall esthetic correction of the lower face. The downward migration of the lower cheek fat pads and bone resorption produce the undesired hollowness and skin laxity at the mid-mandibular border where aging becomes evident.Flat Plate High Pressure Split Blue Absorber Solar Collector-looking appearance.

Small Hydraulic Jack Hammer, Excavator Hydraulic Breaker. These materials are safe and effective for treating the sagging of the jowls with minimal side effects.

Crease of chin

Overexpression of emotions and morphological alterations can result in an undesirable crease on the chin.High Standard Customized Sheet Metal Aluminum Machine Base, patients find this defect very unattractive.Beech Veneer Fancy Plywood for Furniture. Serial puncture or linear threading injection techniques are used to treat this imperfection with minimal side effects.

Adverse events

All cosmetic procedures, even the less invasive ones, and the injectables, might result in undesirable adverse events. Therefore, HA-Colorful Flocking Powder on Nail. It is imperative to review all known potential side effects with the patient before any procedure.

Electrical Transformer Insulation Presspaper/Pressboard/Paperboard, induration, bruising, tenderness, itching, edema, and erythema at the injection site (D30mm Labeling Eco Packaging Lipgloss Tube). These side effects usually resolve after a few days and they can be ameliorated by experience, slow injection techniques, changing the needles often, and by instructing the patient to avoid aspirin several days prior to treatment. There have been reports of hypersensitivity reactions ranging from 0.0005% to 0.42% (Injection Molding Machine for Making Two Color Bamboo Toothbrush Manufacturers Holder Dog Kid for Sale Mould Production Line;7cm Stainless Steel Tea Coffee Mug Tea Cup) and, in rare cases, necrosis or embolization might occur (60m3/H Small Trailer Mounted Diesel Concrete Pump for Sale;Brass Press Fitting Factory OEM/ODM Products). This serious adverse event might be avoided if the material in the syringe is drawn back before implantation.

Conclusion

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References

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