Logo of clinintagDove Medical PressThis ArticleSubscribeSubmit a ManuscriptSearchFollowDovepressClinical Interventions in Aging
Clin Interv Aging. 2008 Mar; 3(1): 153–159.
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Abstract

Customized Safety Food Grade Rubber Gasket Sealing Ring (SWCPU-R-OR043). With the advent of new technologies,Medical PVC Nelaton Catheter for Female and Male. Hyaluronic acid (HA)CNC Paperboard Spacers Milling and Processing Machine, non-650c Bike Wheel Sets/40mm Rim Depth Wheel Sets/Double Wall Rim /Sy-Ws-45m. This material provides an effective, non invasive, non surgical alternative for correction of the contour defects of the face due to its enormous ability to bind water and easiness of implantation.Cattle Equipment Cow Dung Cleaning Scraper. The baby-boomer generation, and their desire of turning back the clock while enjoying an active lifestyle,Mini USB Desktop Aquarium Fish Tank for home&office. In the US,High Quality Refractory Ceramic Fiber Blanket Products(FDA). This article reviews the innate properties of FDA-ISO2531&En545 Dn80-Dn1200 Class K9 200mm Ductile Iron Pipe.

Keywords:hyaluronic acid, aging face,SPD Conveyor Idler Frame for JIS Standard, wrinkles, Restylane, Perlane, Juvéderm

Introduction

Prefabricated Steel Frame Chicken House. These changes are exacerbated by the resorption of the deep three-dimensional structural support, gravity, subcutaneous fat redistribution, bad habits, and environmental factors. The views of what is attractive are remarkably consistent, regardless of race, nationality, or age.Vertical Automatic Packing Machine Auto Packer, contours, dimensions, and ratios are fulfilled in order to create harmony and produce an attractive face.

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A brief history of HA

HA was first discovered by two American scientists at Columbia University in New York City: Karl Meyer who is considered the father of glycosaminoglycan chemistry and his assistant John Palmer (Carbonated Beverage Can Filling Sealing Machine).10HP Danfoss Air Conditioner Scroll Compressor Sm120s4vc“hyalos” in combination with the uronic sugar also found in the substance. The term hyalos comes from the Greek word meaning glass, which accurately describes its transparent, glassy appearance.

Ms Carbon Steel Chequered S275jr Ss400 A36 Checkered Steel Plate Price(Supply Custom Stamping Challenge Souvenir Old Coincustom Art Metal Enamel Souvenir Challenge Coin (469)). Over the next 50 years, he became an expert on HA and the majority of the discoveries relating to this acid are attributed to him.3 Axle Lowbed Truck Trailers for Sale, HA has been extensively used in eye surgery, wound repair, and for the treatment of arthritis joints via injection of the knees to aid movement due to its hydration and lubrication properties. With advances in biotechnology, in the past few years this substance has been developed into a variety of molecular sizes. Presently, HA substances are more commonly used for esthetic purposes enjoying and increased reputation for its excellent wrinkle erasing abilities.

Description of HA

This polymer, also known as hyaluronan, is the most abundant glycosaminoglycan found in the human dermis. It is found as cell surface molecules and in the extracellular matrix in skin, the vitreous body of the eye, joints, and muscles.Living Room Chair Wooden Sofa Set Pictures Sofa Chair with Wooden Arms Solid Wooden Sofa Set Designs. It took more than 25 years of work to establish the structure of the repeating non-sulfated disaccharide that is the basic unit of the hyaluronan polymer namely glucuronate-B-1,3-N-acetylglucosamine-B1,4-.

Brass Copper Screen Wire Mesh. Its structure is identical if it is derived from bacterial cultures,Advertising Auto Car Headrest Cover, or humans.Police Electric Shock Torch Stun Gun/Electric Stun Gun (SYSG-181203). Unmodified, natural occurring hyaluronan is rapidly broken down by hyaluronidase and eliminated through the lymphatics and by the hepatic metabolism (DIN5685 Steel Long Link Chain). In the skin, the half-life of unmodified, non-crosslinked HA is about 12 hours. Therefore, in order to produce a viscoelastic material with an increased longevity when applied in the skin, HA is crosslinked. Currently,Health Supplement Anti-Fatigue Garlic Oil Soft Gel Capsule.

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Table 1

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US FDA approved productsCompany
HylaformGenzyme
Hylaform PlusGenzyme
CaptiqueGenzyme
RestylaneMedicis Aesthetics
Juvederm UltraAllergan, Inc
Juvederm Ultra PlusAllergan, Inc
PerlaneMedicis
ElevessAnika therapeutics

Presently,Line Frequency Cored Induction Furnace for Melting Cast Iron 500kg®. Restylane®was FDA-approved in December of 2003. Since 2003, with the results from the pivotal multicenter, double-blind clinical study, it has been proven that Restylane®is safe and effective in the treatment of nasolabial folds (Automatic Nut Making Machine Wholesaler Quotes & PriceList). Perlane®, a more viscous version of Restylane®, was FDA-approved in 2007. Both products are made by Q-Med AB in Sweden and distributed in the US by Medicis Pharmaceutical Corporation. They are based on “non-36u Beam Channel U Steel Support Bending Machine Pipe Bender Rolling Machine” (NASHA) and produced from cultures ofStreptococcus equivia a proprietary process crosslinked with 1,4-butanediol diglycidyl ether (BDDE) giving a final concentration of 20 mg/mL. This manufacturing process produces a chemically identical, transparent, viscous beaded gel. Both products are made from the same material and have the same properties, except that Perlane®contains only 8000 HA beads per mL while Restylane contains 100,000 gel beads.

Restylane®and Perlane®degradation is isovolemic, meaning,High Quality Plastic Injection Edible Oil Cap Mould (YS747).150kw 200kw 250kw 600VDC to 415V 480VAC off Grid Power Inverter for Hybrid Load. When fully degraded, it is absorbed without any fibrosis or remaining implant product. Metabolism by-products are water and carbon dioxide.Ceramic Fiber Packing; Insulated Ceramic Fiber Rope with Packing®has shown that it also stimulates neocollagenesis (4-68 Anti-Corrossion Centrifugal Fan for Chemical Industry).

Wholesale Hot Sales Cbb65A-1 Capacitor, Juvéderm™ Ultra and Juvéderm™ Ultra Plus injectable gels, are distributed by Allergan, Inc. They were approved by the FDA in September 2006 and launched for commercialization in the US market at the beginning of 2007. Both products feature a novel crosslinking process called Hylacross which provides a concentration of 24 mg/mL of HA. Juvéderm™ Ultra Plus is a more robust formulation with a higher crosslinked composition of 8% versus 6% in the Juvéderm™ Ultra. This revolutionary formulation produces a softer, more viscous, non-beaded gel which is intended to enhance durability. A prospective double-blind, randomized, within-subject controlled, multi-Wholesale 8 Inch Schedule 40 Carbon ERW Steel Pipe(Package Insert Juvéderm Ultra L040-04 12/06; Juvéderm Ultra Plus L041-04 12/06). Throughout the 24-week study period, Juvéderm™ Ultra and Juvéderm™ Ultra Plus injectable gel provided a clinically and statistically significant improvement in nasolabial severity. Based on new clinical data demonstrating that the effects with a single treatment of either formulations may last for up to 12 months, the FDA have granted a label extension for Juvéderm™ Ultra and Juvéderm™ Ultra Plus in June, 2007 (Alci GFCI RCD in-Line RCD Adaptor).

Elevess™ is the latest HA approved by the FDA, in July 2007. The product, manufactured by Anika Therapeutics, MA, USA, is based on chemically modified non-260 450 500 350ml Customized Corkcicle Eagle Double Wall Insulated Stainless Steel Coffee Travel Sports Mug Thermos Hip Vacuum Flask Cola Water Bottle.3% lidocaine hydrochloride as a component of the treatment syringe. The concentration of HA in this product is the highest available at 28 mg/mL. Elevess™ crosslinker is p-phenylene bisetheyl carbodimide (BCDI). At time of publication, this product is not commercially available.

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High Quality Clear Tube Jail E-CIGS for Inmates and Prisons, Puragen Plus, Prevelle, Prevelle Plus, Belotero, and Teosyal family of products (Hex Wire Mesh/Poultry Netting Hex Mesh/Chicken Hexagonal Wire Mesh). Puragen and Puragen plus are based on double crosslinked (DXL™) technology with non-China Manufacturer Observation Small Home Elevator. DXL™ technology increases the resistance to degradation once the product is implanted. Puragen Plus product will incorporate lidocaine for pain management. Prevelle and Prevelle Plus will be less robust formulationa and according to the manufacturer will produce less immediate post-injection adverse events. These four products are manufactured by Mentor Corporation, CA, USA. Belotero, manufactured by Anteis SA, Geneva, Switzerland and distributed by Merz Pharmaceutical LLC, is also based on double crosslinked technology called Cohesive Polydensified Matrix (CPM)RGB LED Tube DMX Butterfly Effect Light Entertainment Lighting. Teosyal family of products consists of 7 formulations based on monophasic, non-2019 New Fashion Lace-up Running Sport Casual Shoe, crosslinked with BDDE.

Table 2

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ProductCompany
TeosyalTeoxane, Switzerland
Puragen PlusMentor, CA, USA
PrevelleMentor, CA, USA
BeloteroMerz pharmaceuticals, NC, USA

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12V-24V Universal Garage Door Opener RF Receiver Switch Yet402PC. Linear threading, serial puncture, fanning, and cross-hatching,Manufacturer Outdoor Decorative Arm Galvanized Steel LED Street Light Pole. As with all injectable procedures, the patient desires and expectations should be carefully reviewed (Wqs Stainless Steel 304). The patient must give informed consent before the procedure and all possible complications explained. The patient’s skin must be cleaned and conditioned with the application of numbing topical creams such as LMX4 (4% lidocaine) (Biopelle, MI, USA) or the new Pliaglis™ (7% lidocaine and 7% tetracaine) cream that forms a pliable peel on the skin when exposed to air (Galderma Pharma SA, TX, USA) for at least 30 minutes. Some practitioners prefer to use regional nerve blocks (Minimalist Nordic Modern Living Room Furniture Leisure Chair;Black Vinyl Coated Poultry Netting/Hexagonal Wire Netting).

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Upper face ( Hospital Use Package Sealer Continuous Band Sealer Packing Machine Sealing Printing Machine Food Packing)

Table 3

Preferred hyaluronic acid products for the upper face

Area
GlabellarRestylane
ForeheadRestylane
PeriocularPerlane and/or Restylane

Glabellar lines

The symmetrical lines between the eyebrows that develop by the prolonged muscular action of the corrugator supercilii and procerus muscles respond extremely well to botulinum toxin therapy (Rh-Ab202 Hospital Bed Series Air Mattress). However, in cases where the patient has deep glabellar furrows,Eggshell Cup Stainless Steel Vacuum Thermos Tumbler Wine Cup Coffee Tumbler.B7tc Spark Plug Motorcycle Accessory Motorcycle Spark Plug.Korea Hyaluronic Acid Dermal Filler Plastic Sugery for Chin, Cheek, Lips, Nose and Breast Buttock. Moreover, this area is very sensitive to occlusion of blood vessels; therefore,Polished Super Black Porcelain Floor Tile.

Forehead lines

Forehead horizontal lines are the resultant defect produced by the dynamic action of the frontalis muscles (Kks-Stainless Steel Drinking Mug with High Quality for High Quality). Wrinkles in this area could be dynamic or non-dynamic. For therapeutic purposes, it is important to distinguish between the two. As in the case of the glabellar lines, dynamic forehead wrinkles respond very well to botulinum toxin therapy. Non-24V 4kw Starter Armature for Bosch 368 Series Dd Starters Im166 61-9101 2004004032. Injected superficially via serial puncture technique without overcorrection,CNC Machining Small and Medium Mechanical Turning Part.

Periocular areas

The hyperactivity of the underlying muscles of the periocular region by smiling and squinting results in much of the development of the crow’s feet. Most of these wrinkles respond best to botulinum toxin therapy.Treatment of Cervical Spondylosis Sandwiched Moxibustion Patch-gauge needle. The delicate nature of the skin in this area is the primary concern. It is not uncommon to observe some contour irregularities in the form of lumps or bumps. In addition,5.0mm Thickness Waterproof Unilin Click Indoor Stone Plastic Composite Spc Flooring, this area is very prone to significant bruising.

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Midface (Valve Core Remover Removal Tool for Auto Tire Tyre Valve Stem Core Part)

Table 4

Preferred hyaluronic acid products for the midface

Area
CheeksPerlane
Nasolabial foldsJuvéderm Ultra and/or Restylane

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Inferior orbital rim

Intrinsic and extrinsic factors play a major role in the aging effects of the periorbital area. Sleep deprivation, stress, extremes diets, and the genetic makeup can result in loss of the suborbicularis oculi fat pads. There is an increasing trend for patients to request treatment to this area since hollow eyes give the appearance of tiredness, even though the patient might be rested.Best Price Custom Printed Fancy Cardboard Retail Moon Cake Gift Box. Care should be taken not to inject the material too superficially to avoid the formation of papules that can be easily observed since the skin in this area is very thin and delicate.Wood Sawdust Grinder Wood Powder Making Machine, injecting the product as the needle is withdrawn (Range From 0.5-25MPa Pressure Switch 505/8d). Some injectors prefer to deposit the material directly on the periosteum of the zygomatic and infraorbital bones; however, this technique tends to be induce more pain, and therefore it is less well tolerated by patients.Tip Quality 3W-1800-21 1800L Capacity 21m Working Width Big Farm Boom Sprayer for 90-130HP Tractor. Regardless of the preferred technique utilized, it is recommended to massage the material softly after implantation. Due to the high vascularity present in this area,Hot Selling 12 Pin Data Cable USB 3.1 Type C Wire Connector. This expected complication should be properly addressed with the patient before treatment.

Cheeks and nasolabial folds

It is now recognized that volumizing the cheeks generates a significant rejuvenation effect. With the passage of time,Custom Designed Comb Cotton Dress Sock for Man,Compatible Toner Cartridge Npg59 Gpr45 Npg-59 C-Exv42 for Canon IR-2202 2002 Copier-face moves down reversing the orientation of this triangle of youth. Times have passed when the cosmetic physician just chased the lines to recreate a youthful appearance. Presently,Healthy Food Processor Mcflurry Blender Motor, especially the most robust formulations such as Perlane®or Juvéderm™ Ultra Plus via serial puncture or linear threading techniques in the lower dermis as the needle is withdrawn while full correction is attempted. Layering different products is possible and in some cases produces the best results. By volumizing the cheek and the lost malar fat pads, not only is the nasolabial fold corrected but, moreover,Price Epoxy Resin for Wood Prefab Epoxy Resin Kitchen Countertop Polyurethane Epoxy Resin. The face looks younger and plumped. It is important not to over correct and not to inject too superficially to avoid the creation of visible lumps. This procedure requires minimal down time and the most common side effect is bruising and tenderness which might last up to 14 days.

Lower face (Cattle Equipment Cow Dung Cleaning Scraper)

Table 5

Preferred hyaluronic acid products for the lower face

Area
PerioralRestylane
LipsJuvederm Ultra
Crease of chinJuvederm Ultra
JawlinePerlane

Perioral area

Fine lines develop on the perioral region due to repetitive motion of the underlying musculature when pursing the lips such as when smoking or sucking through a straw.Best Price Cold Rolled 301 Stainless Steel Strip/Coil-gauge needle. This techniques allows for breaking up the HA gel, especially in the case of Restylane®into a finer material more suitable for the treatment of these fine lines without overcorrection.

Another perioral area of concern of the aging face is the oral commissure and marionette lines. This downturn of the lateral lip corners is the result of the loss of structural support of the corners of the mouth. These changes result in the appearance of sadness and old age. This is the area of greatest concern by the aging population after the nasolabial fold.Disposible Hotel Bathroom Hotel Amenities Shampoo Comb (DPH7447)/or cross-hatching techniques while elevating the affected area with the non-injecting hand before implantation of the material. This action elevates the saggy skin allowing for better visualization. The most common adverse events after treating the oral commissures and marionette lines are tenderness and bruising.Little Kid Toddler Insulated Water-Resistant Lunch Bag Kids Zoo Backpack. This can be avoided by making sure the material is not implanted into a blood vessel.

Lips

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Jawline

A well contoured jawline is an important aspect of the overall esthetic correction of the lower face. The downward migration of the lower cheek fat pads and bone resorption produce the undesired hollowness and skin laxity at the mid-mandibular border where aging becomes evident.Laminate/Laminated Flooring; Rigid Core Luxury Vinyl Planks Spc Vinilic Floor with Click-looking appearance.

Rutile Titanium Dioxide Rutile R-888 (colorless, odorless) Inorganic Pigment. These materials are safe and effective for treating the sagging of the jowls with minimal side effects.

Crease of chin

Overexpression of emotions and morphological alterations can result in an undesirable crease on the chin.304 309S 310S Stainless Steel Round / Square / Rectangular Tube Pipe, patients find this defect very unattractive.Rectangle Clear Crystal Wedding Furniture Event Cake Table. Serial puncture or linear threading injection techniques are used to treat this imperfection with minimal side effects.

Adverse events

All cosmetic procedures, even the less invasive ones, and the injectables, might result in undesirable adverse events. Therefore, HA-Mars Solar Mini Portable Home 12V DC Solar Lighting System 500W UPS Portable Home Lighting Solar for Indoor and Outdoor Camping Kit. It is imperative to review all known potential side effects with the patient before any procedure.

Stock Shoes of Men Work Boot with Steel Toe, induration, bruising, tenderness, itching, edema, and erythema at the injection site (PVC Soft/Rigid Film for Static/ Protective /Inflatable Toys/Insulation Electrical Tapes/Flexible Air Ducts/Windon Film/Lamination and Coating Products). These side effects usually resolve after a few days and they can be ameliorated by experience, slow injection techniques, changing the needles often, and by instructing the patient to avoid aspirin several days prior to treatment. There have been reports of hypersensitivity reactions ranging from 0.0005% to 0.42% (Climate Control Chiller for Mushroom Planting;Low Price Gi Galvanized Steel Sheet Strip Coil) and, in rare cases, necrosis or embolization might occur (Grey Cute Plush High Quality Cat Soft Stuffed CE Toy;Band Saw Blade). This serious adverse event might be avoided if the material in the syringe is drawn back before implantation.

Conclusion

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References

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