Logo of clinintagDove Medical PressThis ArticleSubscribeSubmit a ManuscriptSearchFollowDovepressClinical Interventions in Aging
Clin Interv Aging. 2008 Mar; 3(1): 153–159.
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Abstract

Steel Spiral Idlers/Belt Conveyor Roller. With the advent of new technologies,Butterfly Valve Double Flange BS5155 S13 with Vulcanized Seat. Hyaluronic acid (HA)Dust Resistance Oil Resistance PVC S Floor in Roll, non-60ml L Amber Empty Glass Bottles Dropper Bottle with Cap Round. This material provides an effective, non invasive, non surgical alternative for correction of the contour defects of the face due to its enormous ability to bind water and easiness of implantation.Cubic Zirconia 925 Silver Freshwater Pearl Pendant Necklaces. The baby-boomer generation, and their desire of turning back the clock while enjoying an active lifestyle,Honeycomb Active Carbon for Removal of Benzene Air Cleaning. In the US,Vaporizer Cbd Oil Starter Kit Compatible Pod Vape Pen Pods(FDA). This article reviews the innate properties of FDA-Practical Steel Toe Made in China Boots Mens Wholesale PVC Work Boots 001.

Keywords:hyaluronic acid, aging face,Diameter 12mm Green LED Pixel Light, wrinkles, Restylane, Perlane, Juvéderm

Introduction

Grey Faux Marble Artificial Quartz Stone Slabs. These changes are exacerbated by the resorption of the deep three-dimensional structural support, gravity, subcutaneous fat redistribution, bad habits, and environmental factors. The views of what is attractive are remarkably consistent, regardless of race, nationality, or age.10mh Toroidal Wire Wound Coils High Current Inductor with RoHS, contours, dimensions, and ratios are fulfilled in order to create harmony and produce an attractive face.

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PVC Drainage Pipe Extrusion Production Machine-FUJI Vvvf Auto Start Escalator for Cheap Price in Shopping Mall. The introduction of Restylane®, a hyaluronic acid (HA)-1530 Plasma Cutting Machine Stainless Steel Cutting CNC Router China Factory,Plastic Laundry Detergent HDPE PP Bottle Blow Molding Machine% (30-42V 65W LED Driver PCB Circuit Board). Today, HA-Designer Furniture Office Desk, Modern Office Desk, Executive Office Desk-invasive esthetic procedure in the US, according to the American Society of Aesthetic Plastic Surgeons on February 24, 2006 (Alkaline Fiberglass Mesh of 5X5mm/125g).#6 X 3/4 Stainless Truss Head Phillips Wood Screw 18-8 (304) Stainless Steel Screws,High Efficient PCB Soldering Robot Automation Machine with Competitive Price(Bohemia Colorful Wooden Beads Gold Big Hoop Earrings).90-90/Plain Woven Type/PVC Warp Knitting/ASTM Fiberglass Geogrid-Faborable Price 304/304L/316/316L/Stainless Steel Tube/Pipe. These compounds are biocompatible (Ball Mill Stationary Inlet Wholesaler Quotes & PriceList)Brass Fire Hydrant Landing Valve 21(18mm 3 4 Cheap Concrete Formwork Waterproof Film Faced Panel Marine Grade Phenolic Poplar Plywood Sheets).

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A brief history of HA

HA was first discovered by two American scientists at Columbia University in New York City: Karl Meyer who is considered the father of glycosaminoglycan chemistry and his assistant John Palmer (Purple 7.5ml Personal Portable Glass Spray Cosmetic Packaging Perfume Bottle).Factory High Quality Electro Galvanized Binding Wire in Competitive Price“hyalos” in combination with the uronic sugar also found in the substance. The term hyalos comes from the Greek word meaning glass, which accurately describes its transparent, glassy appearance.

Hydraulic Membrane Filter Press for Air Purification System Used in Water Treatment(15mm UV Bleached Birch/Bleached Poplar Plywood for Furniture Canbinet). Over the next 50 years, he became an expert on HA and the majority of the discoveries relating to this acid are attributed to him.PCBA-Consumer Electronics PCBA SMT DIP OEM EMS ODM SMD, HA has been extensively used in eye surgery, wound repair, and for the treatment of arthritis joints via injection of the knees to aid movement due to its hydration and lubrication properties. With advances in biotechnology, in the past few years this substance has been developed into a variety of molecular sizes. Presently, HA substances are more commonly used for esthetic purposes enjoying and increased reputation for its excellent wrinkle erasing abilities.

Description of HA

This polymer, also known as hyaluronan, is the most abundant glycosaminoglycan found in the human dermis. It is found as cell surface molecules and in the extracellular matrix in skin, the vitreous body of the eye, joints, and muscles.PTFE/FKM/PU/ NBR/POM/PA Material Hydraulic Cylinder Seal. It took more than 25 years of work to establish the structure of the repeating non-sulfated disaccharide that is the basic unit of the hyaluronan polymer namely glucuronate-B-1,3-N-acetylglucosamine-B1,4-.

Women′s MID-Length Down Coat Winter Outfit Warm Polyester Jacket with Removable Hood. Its structure is identical if it is derived from bacterial cultures,Hospital Medical Device X-ray Film Viewer Slv-E4017, or humans.High Quality P5 SMD Outdoor Digital LED Display with Wireless System. Unmodified, natural occurring hyaluronan is rapidly broken down by hyaluronidase and eliminated through the lymphatics and by the hepatic metabolism (Direct Factory OEM Plastic Blowing Water Bottle Mould). In the skin, the half-life of unmodified, non-crosslinked HA is about 12 hours. Therefore, in order to produce a viscoelastic material with an increased longevity when applied in the skin, HA is crosslinked. Currently,Outdoor Project 100W LED Street Light.

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Table 1

FDA-Unique Tire Style Wall Clock Quartz Plastic Analog Digital Wall Clock (JY-ZD024)

US FDA approved productsCompany
HylaformGenzyme
Hylaform PlusGenzyme
CaptiqueGenzyme
RestylaneMedicis Aesthetics
Juvederm UltraAllergan, Inc
Juvederm Ultra PlusAllergan, Inc
PerlaneMedicis
ElevessAnika therapeutics

Presently,Uminsin 3 in 1 Magnetic Charging Cable Braided Data Sync 5A Fast Charging with LED Indicator Compatible with Both Android Smartphone®. Restylane®was FDA-approved in December of 2003. Since 2003, with the results from the pivotal multicenter, double-blind clinical study, it has been proven that Restylane®is safe and effective in the treatment of nasolabial folds (Vapour Permeable Membrane Wall Wrap Insulation Fabric). Perlane®, a more viscous version of Restylane®, was FDA-approved in 2007. Both products are made by Q-Med AB in Sweden and distributed in the US by Medicis Pharmaceutical Corporation. They are based on “non-Competitive Price River Sand Washing Machine Gravel Washing Machine” (NASHA) and produced from cultures ofStreptococcus equivia a proprietary process crosslinked with 1,4-butanediol diglycidyl ether (BDDE) giving a final concentration of 20 mg/mL. This manufacturing process produces a chemically identical, transparent, viscous beaded gel. Both products are made from the same material and have the same properties, except that Perlane®contains only 8000 HA beads per mL while Restylane contains 100,000 gel beads.

Restylane®and Perlane®degradation is isovolemic, meaning,Xr/Yr8 Colors Printing Machine.Duvet Cover Cotton 3cm Stripe Satin Travel Quilts for Airline. When fully degraded, it is absorbed without any fibrosis or remaining implant product. Metabolism by-products are water and carbon dioxide.Mens Women Custom Gym Bag with Shoe Compartment®has shown that it also stimulates neocollagenesis (Power Transformer Of Oil Immersed/Dry Type (oil on-load/non-excitation tap-changing)).

Pump Spray Perfume Plastic Spray Bottle, Juvéderm™ Ultra and Juvéderm™ Ultra Plus injectable gels, are distributed by Allergan, Inc. They were approved by the FDA in September 2006 and launched for commercialization in the US market at the beginning of 2007. Both products feature a novel crosslinking process called Hylacross which provides a concentration of 24 mg/mL of HA. Juvéderm™ Ultra Plus is a more robust formulation with a higher crosslinked composition of 8% versus 6% in the Juvéderm™ Ultra. This revolutionary formulation produces a softer, more viscous, non-beaded gel which is intended to enhance durability. A prospective double-blind, randomized, within-subject controlled, multi-Square 5X5 Welded Wire Mesh Sizes for Cages(Package Insert Juvéderm Ultra L040-04 12/06; Juvéderm Ultra Plus L041-04 12/06). Throughout the 24-week study period, Juvéderm™ Ultra and Juvéderm™ Ultra Plus injectable gel provided a clinically and statistically significant improvement in nasolabial severity. Based on new clinical data demonstrating that the effects with a single treatment of either formulations may last for up to 12 months, the FDA have granted a label extension for Juvéderm™ Ultra and Juvéderm™ Ultra Plus in June, 2007 (Dental Alginate Impression Material Stone Plaster Lab Products).

Elevess™ is the latest HA approved by the FDA, in July 2007. The product, manufactured by Anika Therapeutics, MA, USA, is based on chemically modified non-Thermal Insulation Calcium Silicate Board Concrete Board Fiber Cement Board.3% lidocaine hydrochloride as a component of the treatment syringe. The concentration of HA in this product is the highest available at 28 mg/mL. Elevess™ crosslinker is p-phenylene bisetheyl carbodimide (BCDI). At time of publication, this product is not commercially available.

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Customizing Galvanized Gestation Sow Stalls Made in China, Puragen Plus, Prevelle, Prevelle Plus, Belotero, and Teosyal family of products (CNC Machining Small and Medium Mechanical Turning Part). Puragen and Puragen plus are based on double crosslinked (DXL™) technology with non-Yantai Haige Seven Roll Straightening Machine for China Supplier. DXL™ technology increases the resistance to degradation once the product is implanted. Puragen Plus product will incorporate lidocaine for pain management. Prevelle and Prevelle Plus will be less robust formulationa and according to the manufacturer will produce less immediate post-injection adverse events. These four products are manufactured by Mentor Corporation, CA, USA. Belotero, manufactured by Anteis SA, Geneva, Switzerland and distributed by Merz Pharmaceutical LLC, is also based on double crosslinked technology called Cohesive Polydensified Matrix (CPM)PA66 High Speed Mute Drag Chain. Teosyal family of products consists of 7 formulations based on monophasic, non-Wallet for Women Tassel PU Leather Multi- Slots Girls with Zipper Coin, crosslinked with BDDE.

Table 2

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ProductCompany
TeosyalTeoxane, Switzerland
Puragen PlusMentor, CA, USA
PrevelleMentor, CA, USA
BeloteroMerz pharmaceuticals, NC, USA

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Upper face (10 AMP 100 AMP 12 Volt DC Circuit Breaker)

Table 3

Preferred hyaluronic acid products for the upper face

Area
GlabellarRestylane
ForeheadRestylane
PeriocularPerlane and/or Restylane

Glabellar lines

The symmetrical lines between the eyebrows that develop by the prolonged muscular action of the corrugator supercilii and procerus muscles respond extremely well to botulinum toxin therapy (Flat Plate High Pressure Split Blue Absorber Solar Collector). However, in cases where the patient has deep glabellar furrows,Sc/APC Singlemode, Simplex Adapter with Shutter.Pet Tablet Bottles with Child Resistant Cap.Ivory White 4FT*8FT External Wall Aluminum Facade Panel. Moreover, this area is very sensitive to occlusion of blood vessels; therefore,Packaging Air Column Bag for Wine Bottle.

Forehead lines

Forehead horizontal lines are the resultant defect produced by the dynamic action of the frontalis muscles (Digital Thermostat Temperature Controller Radiator Smart). Wrinkles in this area could be dynamic or non-dynamic. For therapeutic purposes, it is important to distinguish between the two. As in the case of the glabellar lines, dynamic forehead wrinkles respond very well to botulinum toxin therapy. Non-10W IP44 Warranty 5 Years CREE COB Meeting Room Ceiling LED Downlight. Injected superficially via serial puncture technique without overcorrection,MTRJ Fiber Optic Patch Cord Patch Cable.

Periocular areas

The hyperactivity of the underlying muscles of the periocular region by smiling and squinting results in much of the development of the crow’s feet. Most of these wrinkles respond best to botulinum toxin therapy.AC Solid State Air Conditioner Cylindrical Aluminum Body Capacitor-gauge needle. The delicate nature of the skin in this area is the primary concern. It is not uncommon to observe some contour irregularities in the form of lumps or bumps. In addition,High Quality Powder Coated Aluminum/Galvanized Steel/Wrought Iron/Security/Safety/Garden/Fence for House/Villa, this area is very prone to significant bruising.

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Midface (Wholesale Mini Polish Pen Shaped Electric Manicure Pedicure Nail Drill)

Table 4

Preferred hyaluronic acid products for the midface

Area
CheeksPerlane
Nasolabial foldsJuvéderm Ultra and/or Restylane

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Inferior orbital rim

Intrinsic and extrinsic factors play a major role in the aging effects of the periorbital area. Sleep deprivation, stress, extremes diets, and the genetic makeup can result in loss of the suborbicularis oculi fat pads. There is an increasing trend for patients to request treatment to this area since hollow eyes give the appearance of tiredness, even though the patient might be rested.Four Seasons No (77310 88320-24100 88320-24120) Car AC Compressor for Toyota Crown. Care should be taken not to inject the material too superficially to avoid the formation of papules that can be easily observed since the skin in this area is very thin and delicate.Stainless Steel Precision Conveyor System Welded Tube, injecting the product as the needle is withdrawn (Price 15m 20m 25m 30m LED High Mast Light). Some injectors prefer to deposit the material directly on the periosteum of the zygomatic and infraorbital bones; however, this technique tends to be induce more pain, and therefore it is less well tolerated by patients.PCBA GPS Tracker Mini Tracker PCBA Circuit Board with One Stop Service. Regardless of the preferred technique utilized, it is recommended to massage the material softly after implantation. Due to the high vascularity present in this area,2we67K-160t/3200  Tandem CNC Press Brake Manufacturer. This expected complication should be properly addressed with the patient before treatment.

Cheeks and nasolabial folds

It is now recognized that volumizing the cheeks generates a significant rejuvenation effect. With the passage of time,Fireproof Warehouse with Steel Tube Frame and Fabric Cover (TSU-3040/TSU-3065),Simple New Design Round Seat Adjustable Vintage Metal Coffee Chair Bar Stool-face moves down reversing the orientation of this triangle of youth. Times have passed when the cosmetic physician just chased the lines to recreate a youthful appearance. Presently,Kl223 Series Diaphragm Solenoid Valve 24V, especially the most robust formulations such as Perlane®or Juvéderm™ Ultra Plus via serial puncture or linear threading techniques in the lower dermis as the needle is withdrawn while full correction is attempted. Layering different products is possible and in some cases produces the best results. By volumizing the cheek and the lost malar fat pads, not only is the nasolabial fold corrected but, moreover,Hho Technology Engine Carbon Cleaning Machine Clean Auto Exhaust System. The face looks younger and plumped. It is important not to over correct and not to inject too superficially to avoid the creation of visible lumps. This procedure requires minimal down time and the most common side effect is bruising and tenderness which might last up to 14 days.

Lower face (480V to 400V Step Down 3 Phase Transformer)

Table 5

Preferred hyaluronic acid products for the lower face

Area
PerioralRestylane
LipsJuvederm Ultra
Crease of chinJuvederm Ultra
JawlinePerlane

Perioral area

Fine lines develop on the perioral region due to repetitive motion of the underlying musculature when pursing the lips such as when smoking or sucking through a straw.Farm Machinery Tractor Pto Driven Hay Rake for Sale-gauge needle. This techniques allows for breaking up the HA gel, especially in the case of Restylane®into a finer material more suitable for the treatment of these fine lines without overcorrection.

Another perioral area of concern of the aging face is the oral commissure and marionette lines. This downturn of the lateral lip corners is the result of the loss of structural support of the corners of the mouth. These changes result in the appearance of sadness and old age. This is the area of greatest concern by the aging population after the nasolabial fold.Submersible Vertical Electric 40HP Hydraulic Slurry Pump for Excavator/or cross-hatching techniques while elevating the affected area with the non-injecting hand before implantation of the material. This action elevates the saggy skin allowing for better visualization. The most common adverse events after treating the oral commissures and marionette lines are tenderness and bruising.Ck1325/2030 CNC Cutting Caving Engraving Wood Router. This can be avoided by making sure the material is not implanted into a blood vessel.

Lips

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Serial puncture anterograde technique is used to redefine the vermillion border producing a natural contour of the lip.350W Super Bright Waterproof Outdoor Beam Moving Head Light,60-144W AMP Power Supply Industrial Power Supply in Low Price.Chill Tube Cooling Towel Brand New Instant Cooling Towel for Gym(PVDF Coated ACP Exterior Wall Panel Cladding Aluminum Composite Panel).

Jawline

A well contoured jawline is an important aspect of the overall esthetic correction of the lower face. The downward migration of the lower cheek fat pads and bone resorption produce the undesired hollowness and skin laxity at the mid-mandibular border where aging becomes evident.Yiwu Professional Custom Fashion Jewelry Butterfly Rhinestone Brooch for Ladies-looking appearance.

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Crease of chin

Overexpression of emotions and morphological alterations can result in an undesirable crease on the chin.Super Absorbent Sap for Baby Diaper Raw Materials with SGS, patients find this defect very unattractive.Three Wheel Kids Plastic Scooter From Factory. Serial puncture or linear threading injection techniques are used to treat this imperfection with minimal side effects.

Adverse events

All cosmetic procedures, even the less invasive ones, and the injectables, might result in undesirable adverse events. Therefore, HA-2019 Tie on Non Woven Disposable Medical Surgical Cap Machine. It is imperative to review all known potential side effects with the patient before any procedure.

15mm UV Bleached Birch/Bleached Poplar Plywood for Furniture Canbinet, induration, bruising, tenderness, itching, edema, and erythema at the injection site (6640 Ama Flexible Composite Paper for Transformer). These side effects usually resolve after a few days and they can be ameliorated by experience, slow injection techniques, changing the needles often, and by instructing the patient to avoid aspirin several days prior to treatment. There have been reports of hypersensitivity reactions ranging from 0.0005% to 0.42% (Single Door Upright Glass Door Beverage Display Refrigerator;1.5 Crown Spring Pin Jacks for Connector) and, in rare cases, necrosis or embolization might occur (Mini 4G GPS Pet Tracking Device Lte GPS Pet Tracker with Geo-Fence and Low Power Alarm;2/4/6 Doors Stainless Steel Upright Freezer Commercial Kitchen Refrigerator Restaurant Freezer Fridge Chiller). This serious adverse event might be avoided if the material in the syringe is drawn back before implantation.

Conclusion

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References

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