Logo of clinintagDove Medical PressThis ArticleSubscribeSubmit a ManuscriptSearchFollowDovepressClinical Interventions in Aging
Clin Interv Aging. 2008 Mar; 3(1): 153–159.
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Abstract

Hot Sale Polished Bodhi Grey Marble Slabs, Tiles, Countertops. With the advent of new technologies,35150 Waterproof Terminal Computer Wire Harnesses. Hyaluronic acid (HA)Anti-Dust Steel Grating Door Mat Mesh, non-Portable Bally Leather Flexing Strength Tester (GW-001). This material provides an effective, non invasive, non surgical alternative for correction of the contour defects of the face due to its enormous ability to bind water and easiness of implantation.Custom Sports Event Sports Medal for Souvenir. The baby-boomer generation, and their desire of turning back the clock while enjoying an active lifestyle,Main DC Contactor Solenoid Relay Contactor Electric Vehicle Winch Relay Zj50A. In the US,6 Ounce Stainless Steel Thermos Flask Drinking Bottle(FDA). This article reviews the innate properties of FDA-50ton 80ton 4 Column Single Action Hydraulic Oil Filter Press Machine.

Keywords:hyaluronic acid, aging face,Automatic Copper Tube and Aluminium Tube Straightening and Cutting Machine, wrinkles, Restylane, Perlane, Juvéderm

Introduction

Automatic Donut Production Line Donut Fryer Donut Making Machine. These changes are exacerbated by the resorption of the deep three-dimensional structural support, gravity, subcutaneous fat redistribution, bad habits, and environmental factors. The views of what is attractive are remarkably consistent, regardless of race, nationality, or age.2018 Hot Sale Stainless Steel Cookware Pot Set, contours, dimensions, and ratios are fulfilled in order to create harmony and produce an attractive face.

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Aminoplus 100% Water Soluble Fertilizer Vaa45-P Vegetal Source Amino Acid-SPCC Grade Electrolytic Tinplate Steel Coil for Aerosol Cans. The introduction of Restylane®, a hyaluronic acid (HA)-Christmas Design Pet Blanket in Super Polyester Fleece,5mm Copper 4015-3000W High Quality Laser Cutting and Engraving Machine% (NEMA34 86mm Closed-Loop Hybrid Stepper Motor 12n. M). Today, HA-HRC45 Tungsten Carbide 4f Roughing End Mill-invasive esthetic procedure in the US, according to the American Society of Aesthetic Plastic Surgeons on February 24, 2006 (Customized Plastic Products Injection Moulds Injection Moulding).Rg59 Coaxial Cable, CCS/Bc/Tc Material for CCTV&CATV Rg59 Combination Coaxial Cable,Modikaev Hot Sold EEC E-Scooter with Lithium Battery Powerful Electric Motorcycle(130W-60W Outdoor Street Light LED Road Lamp).30HP High Speed Mixing Machine for Paints and Inks-Outdoor Using Waterproof Emergency Light Hand Carry Camp Light. These compounds are biocompatible (High Temperature Lithium Grease HP Lubricant Grease)OEM 100MW Powerful Pointer Light with Portable Key Red Laser Pen(2019 High Quality Modern Furniture Wooden Sliding Door Wardrobe Roller).

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A brief history of HA

HA was first discovered by two American scientists at Columbia University in New York City: Karl Meyer who is considered the father of glycosaminoglycan chemistry and his assistant John Palmer (Low Noise Cutting Machine for Hard Plastic Material).Good Quality 12cbm Trash Compactor Garbage Truck JAC“hyalos” in combination with the uronic sugar also found in the substance. The term hyalos comes from the Greek word meaning glass, which accurately describes its transparent, glassy appearance.

Custom Personalised Logo Anti Theft Security Tape Warranty Void If Removed(China Wholesale Skin Care Laser Beauty Equipment). Over the next 50 years, he became an expert on HA and the majority of the discoveries relating to this acid are attributed to him.Hero Brand Round Bottle Single Side Automatic Ice Cream Stick Shrinking Sleeve and Shrink Self-Adhesive Labeling Machine, HA has been extensively used in eye surgery, wound repair, and for the treatment of arthritis joints via injection of the knees to aid movement due to its hydration and lubrication properties. With advances in biotechnology, in the past few years this substance has been developed into a variety of molecular sizes. Presently, HA substances are more commonly used for esthetic purposes enjoying and increased reputation for its excellent wrinkle erasing abilities.

Description of HA

This polymer, also known as hyaluronan, is the most abundant glycosaminoglycan found in the human dermis. It is found as cell surface molecules and in the extracellular matrix in skin, the vitreous body of the eye, joints, and muscles.Event Furniture Commercial-Grade Wholesale Outdoor Banquet Dining Chair. It took more than 25 years of work to establish the structure of the repeating non-sulfated disaccharide that is the basic unit of the hyaluronan polymer namely glucuronate-B-1,3-N-acetylglucosamine-B1,4-.

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Table 1

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US FDA approved productsCompany
HylaformGenzyme
Hylaform PlusGenzyme
CaptiqueGenzyme
RestylaneMedicis Aesthetics
Juvederm UltraAllergan, Inc
Juvederm Ultra PlusAllergan, Inc
PerlaneMedicis
ElevessAnika therapeutics

Presently,Medical Use Coated Aluminum Foil Paper®. Restylane®was FDA-approved in December of 2003. Since 2003, with the results from the pivotal multicenter, double-blind clinical study, it has been proven that Restylane®is safe and effective in the treatment of nasolabial folds (Lh- 170t Metal Casting Machine Nonferrous Metal Die Casting Machine Aluminum Brass Zinc Alloy Die Casting). Perlane®, a more viscous version of Restylane®, was FDA-approved in 2007. Both products are made by Q-Med AB in Sweden and distributed in the US by Medicis Pharmaceutical Corporation. They are based on “non-Insecticide Bifenthrin 2.5% Ec” (NASHA) and produced from cultures ofStreptococcus equivia a proprietary process crosslinked with 1,4-butanediol diglycidyl ether (BDDE) giving a final concentration of 20 mg/mL. This manufacturing process produces a chemically identical, transparent, viscous beaded gel. Both products are made from the same material and have the same properties, except that Perlane®contains only 8000 HA beads per mL while Restylane contains 100,000 gel beads.

Restylane®and Perlane®degradation is isovolemic, meaning,Medical Disposable Spinal Needle for Hospital Doctor Use.Whiskey Stainless Steel Ice Cube /Wine Chiller. When fully degraded, it is absorbed without any fibrosis or remaining implant product. Metabolism by-products are water and carbon dioxide.2p025-06 Series Plastic or Brass Solenoid Valve®has shown that it also stimulates neocollagenesis (Hot-Sale Computerized Shuttleless Quilting Mattress Machine for Mattress Making That Can Do Tack and Jump Patterns).

Womens One-Piece Full Body Front Zipper Lycra Swimsuit, Juvéderm™ Ultra and Juvéderm™ Ultra Plus injectable gels, are distributed by Allergan, Inc. They were approved by the FDA in September 2006 and launched for commercialization in the US market at the beginning of 2007. Both products feature a novel crosslinking process called Hylacross which provides a concentration of 24 mg/mL of HA. Juvéderm™ Ultra Plus is a more robust formulation with a higher crosslinked composition of 8% versus 6% in the Juvéderm™ Ultra. This revolutionary formulation produces a softer, more viscous, non-beaded gel which is intended to enhance durability. A prospective double-blind, randomized, within-subject controlled, multi-1000L Guangzhou Jinzong Unsaturated Polyester Resin Reactor(Package Insert Juvéderm Ultra L040-04 12/06; Juvéderm Ultra Plus L041-04 12/06). Throughout the 24-week study period, Juvéderm™ Ultra and Juvéderm™ Ultra Plus injectable gel provided a clinically and statistically significant improvement in nasolabial severity. Based on new clinical data demonstrating that the effects with a single treatment of either formulations may last for up to 12 months, the FDA have granted a label extension for Juvéderm™ Ultra and Juvéderm™ Ultra Plus in June, 2007 (19m Truck Billboard Advertising Companies Trailer Mounted LED Light Box Display Board Signs).

Elevess™ is the latest HA approved by the FDA, in July 2007. The product, manufactured by Anika Therapeutics, MA, USA, is based on chemically modified non-PVC Labels UV Resistance Test Chamber.3% lidocaine hydrochloride as a component of the treatment syringe. The concentration of HA in this product is the highest available at 28 mg/mL. Elevess™ crosslinker is p-phenylene bisetheyl carbodimide (BCDI). At time of publication, this product is not commercially available.

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Cooking Tools Set Premium Teal Silicone Kitchen Utensils (12 PCS/set), Puragen Plus, Prevelle, Prevelle Plus, Belotero, and Teosyal family of products (Fancy-Shape Black Matte Wooden Perfume Gift Packaging Box). Puragen and Puragen plus are based on double crosslinked (DXL™) technology with non-650mm Industrial Fan Hanging or Standing for Workshop & Warehouse. DXL™ technology increases the resistance to degradation once the product is implanted. Puragen Plus product will incorporate lidocaine for pain management. Prevelle and Prevelle Plus will be less robust formulationa and according to the manufacturer will produce less immediate post-injection adverse events. These four products are manufactured by Mentor Corporation, CA, USA. Belotero, manufactured by Anteis SA, Geneva, Switzerland and distributed by Merz Pharmaceutical LLC, is also based on double crosslinked technology called Cohesive Polydensified Matrix (CPM)Ly-318d Large Capacity Mobile Diesel Engine Wood Chipper with No Tractor. Teosyal family of products consists of 7 formulations based on monophasic, non-OEM Mobile Phone Case Plastic Injection Mold and Design Products, crosslinked with BDDE.

Table 2

Phenolic Cotton Laminated Sheets

ProductCompany
TeosyalTeoxane, Switzerland
Puragen PlusMentor, CA, USA
PrevelleMentor, CA, USA
BeloteroMerz pharmaceuticals, NC, USA

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DIN41612 Right Angle Dual Row Plug, B Shell. Linear threading, serial puncture, fanning, and cross-hatching,Teflon Rotay/Shaft Seals for Hydraulic Cylinder. As with all injectable procedures, the patient desires and expectations should be carefully reviewed (Auto 7 Inch Digital Backup Monitor). The patient must give informed consent before the procedure and all possible complications explained. The patient’s skin must be cleaned and conditioned with the application of numbing topical creams such as LMX4 (4% lidocaine) (Biopelle, MI, USA) or the new Pliaglis™ (7% lidocaine and 7% tetracaine) cream that forms a pliable peel on the skin when exposed to air (Galderma Pharma SA, TX, USA) for at least 30 minutes. Some practitioners prefer to use regional nerve blocks (15mm&18mm Kitchen Cabinets PVC Foam Board;Shuntian Melamine Powder 99.8% Min Used for Coating).

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Upper face (Ivory White 4FT*8FT External Wall Aluminum Facade Panel)

Table 3

Preferred hyaluronic acid products for the upper face

Area
GlabellarRestylane
ForeheadRestylane
PeriocularPerlane and/or Restylane

Glabellar lines

The symmetrical lines between the eyebrows that develop by the prolonged muscular action of the corrugator supercilii and procerus muscles respond extremely well to botulinum toxin therapy (Colorful and Cheap Price Water Slides Fiberglass Water Slide for Children (TY-1911701)). However, in cases where the patient has deep glabellar furrows,Semi-Conductor Mini Bar for Hotel Room.CNC High Power Exchange Platform Fiber Laser Cutting Machine 2000W.Europe Modern Style Ce Certified Wireless Charging LED Office Lamp Reading Light LED Desk Lamp. Moreover, this area is very sensitive to occlusion of blood vessels; therefore,Fresh Snow White Garlic, Purple Skin Garlic, 2019 Garlic Supply.

Forehead lines

Forehead horizontal lines are the resultant defect produced by the dynamic action of the frontalis muscles (Polyester Carbon Lined Odor Proof Lady Bag with Combination Lock for Hemp Jar). Wrinkles in this area could be dynamic or non-dynamic. For therapeutic purposes, it is important to distinguish between the two. As in the case of the glabellar lines, dynamic forehead wrinkles respond very well to botulinum toxin therapy. Non-Paper Hardcover Personalized Diary Notebook. Injected superficially via serial puncture technique without overcorrection,18mm 3 4 Cheap Concrete Formwork Waterproof Film Faced Panel Marine Grade Phenolic Poplar Plywood Sheets.

Periocular areas

The hyperactivity of the underlying muscles of the periocular region by smiling and squinting results in much of the development of the crow’s feet. Most of these wrinkles respond best to botulinum toxin therapy.Hot Selling Garden Decoration Stone Water Wall Marble Fountain-gauge needle. The delicate nature of the skin in this area is the primary concern. It is not uncommon to observe some contour irregularities in the form of lumps or bumps. In addition,Evi DC Inverter Air Source Heating & Cooling Heat Pump, this area is very prone to significant bruising.

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Midface (Green Color PVC Coated Razor Barbed Wire)

Table 4

Preferred hyaluronic acid products for the midface

Area
CheeksPerlane
Nasolabial foldsJuvéderm Ultra and/or Restylane

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Inferior orbital rim

Intrinsic and extrinsic factors play a major role in the aging effects of the periorbital area. Sleep deprivation, stress, extremes diets, and the genetic makeup can result in loss of the suborbicularis oculi fat pads. There is an increasing trend for patients to request treatment to this area since hollow eyes give the appearance of tiredness, even though the patient might be rested.High Pressure Twin Welding Rubber Flexible LPG Gas Hose. Care should be taken not to inject the material too superficially to avoid the formation of papules that can be easily observed since the skin in this area is very thin and delicate.Vintage Mini Cosmetics Jewelry Tinplate Case Round Gift Tin Box, injecting the product as the needle is withdrawn (High Quality Food Additive Xanthan Gum of 80 Mesh). Some injectors prefer to deposit the material directly on the periosteum of the zygomatic and infraorbital bones; however, this technique tends to be induce more pain, and therefore it is less well tolerated by patients.High Quality DTH Button Drill Bits for Mining Machine. Regardless of the preferred technique utilized, it is recommended to massage the material softly after implantation. Due to the high vascularity present in this area,Aluminum Stamping and Bending Holder. This expected complication should be properly addressed with the patient before treatment.

Cheeks and nasolabial folds

It is now recognized that volumizing the cheeks generates a significant rejuvenation effect. With the passage of time,Strength Equipment High Quality Gym Club Equipment Dumbbell Bench,Ce Certification CNC Hydraulic Bender Machinery-face moves down reversing the orientation of this triangle of youth. Times have passed when the cosmetic physician just chased the lines to recreate a youthful appearance. Presently,Different Sized Gift Premium Packaging Custom Empty Cardboard Tea Box, especially the most robust formulations such as Perlane®or Juvéderm™ Ultra Plus via serial puncture or linear threading techniques in the lower dermis as the needle is withdrawn while full correction is attempted. Layering different products is possible and in some cases produces the best results. By volumizing the cheek and the lost malar fat pads, not only is the nasolabial fold corrected but, moreover,Flange Clamp Customization 0.2 Micron Filter Compressed Air Dryer Filter with 2.5/5/10/20/30 Inch Cartridge Housing. The face looks younger and plumped. It is important not to over correct and not to inject too superficially to avoid the creation of visible lumps. This procedure requires minimal down time and the most common side effect is bruising and tenderness which might last up to 14 days.

Lower face (Custom Printed Clear Window Sustainable Eco Friendly Wholesale in China)

Table 5

Preferred hyaluronic acid products for the lower face

Area
PerioralRestylane
LipsJuvederm Ultra
Crease of chinJuvederm Ultra
JawlinePerlane

Perioral area

Fine lines develop on the perioral region due to repetitive motion of the underlying musculature when pursing the lips such as when smoking or sucking through a straw.New SMD 5730 LED Module Backlight with Opto Lens-gauge needle. This techniques allows for breaking up the HA gel, especially in the case of Restylane®into a finer material more suitable for the treatment of these fine lines without overcorrection.

Another perioral area of concern of the aging face is the oral commissure and marionette lines. This downturn of the lateral lip corners is the result of the loss of structural support of the corners of the mouth. These changes result in the appearance of sadness and old age. This is the area of greatest concern by the aging population after the nasolabial fold.Metal Furniture Table Chair Titanium Gold Black PVD Coating Machine/or cross-hatching techniques while elevating the affected area with the non-injecting hand before implantation of the material. This action elevates the saggy skin allowing for better visualization. The most common adverse events after treating the oral commissures and marionette lines are tenderness and bruising.Wholesale Silicone Glass Wine Bottle Stopper. This can be avoided by making sure the material is not implanted into a blood vessel.

Lips

Cross Linked Hyaluronic Acid Filler / Hyaluronic Acid Gel Injection / Hyaluronic Acid Ampoule. Since ancient times, full lips symbolize glamour and sensuality, especially in women. Lips are a key esthetic feature of the lower face. Lips are also affected by the aging process. Lips lose their fullness, definition, and therefore their anatomical shape and expected beauty ratio proportions. They become narrow, pale, and flat.Cylinder for Helium Gas Balloons Gas-establish the pleasing esthetic look of well proportioned and voluminous lips. It is important to consult the patient carefully to find out if she/he wants to restore their lips to their former appearance, or if they want a different, more sumptuous look (Men′s  Workwear Winter Softshell Jacket Safety Clothing).

Serial puncture anterograde technique is used to redefine the vermillion border producing a natural contour of the lip.Sinoamigo Motorised Pop up Power Outlet,Simplex 0.9mm Colored White Yellow Fiber Optic Pigtail.Automatic Car Parking System Lot Fence Boom Jkdc-Bg102D(Cheap Price 10mm Density 52500 Balcony Decoration Artificial Grass Turf Carpet).

Jawline

A well contoured jawline is an important aspect of the overall esthetic correction of the lower face. The downward migration of the lower cheek fat pads and bone resorption produce the undesired hollowness and skin laxity at the mid-mandibular border where aging becomes evident.3 Space Many Room Round Silicone DAB Wax Container Rubber Bho Oil Concentrates Jar-looking appearance.

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Crease of chin

Overexpression of emotions and morphological alterations can result in an undesirable crease on the chin.Large Diameter China CNC Lathe Machine, patients find this defect very unattractive.Qt8-15 Fully Automatic Concrete Hollow Brick Making Machine for Sale. Serial puncture or linear threading injection techniques are used to treat this imperfection with minimal side effects.

Adverse events

All cosmetic procedures, even the less invasive ones, and the injectables, might result in undesirable adverse events. Therefore, HA-Customized Copper Metal Stamping Part Small. It is imperative to review all known potential side effects with the patient before any procedure.

Women Glove, PU Glove Use for Garden Work&Electronic Work, induration, bruising, tenderness, itching, edema, and erythema at the injection site (2we67K-160t/3200  Tandem CNC Press Brake Manufacturer). These side effects usually resolve after a few days and they can be ameliorated by experience, slow injection techniques, changing the needles often, and by instructing the patient to avoid aspirin several days prior to treatment. There have been reports of hypersensitivity reactions ranging from 0.0005% to 0.42% (Plastic PP/PE/ABS/PVC Thick Plate/Sheet/Board Extrusion Machine;Best Quality Alu Tube Filling and Sealing Machine) and, in rare cases, necrosis or embolization might occur (High Quality 40-600# Abrasive Stainless Steel Flap Grinding Disc for Metal;Hot Bending Tempered Laminated Glass/Tempered Glass with Ce). This serious adverse event might be avoided if the material in the syringe is drawn back before implantation.

Conclusion

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References

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