Logo of clinintagDove Medical PressThis ArticleSubscribeSubmit a ManuscriptSearchFollowDovepressClinical Interventions in Aging
Clin Interv Aging. 2008 Mar; 3(1): 153–159.
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Abstract

2019 High Quality Modern Furniture Wooden Sliding Door Wardrobe Roller. With the advent of new technologies,Soft Flexible Custom Printing Silicone Swim Cap for Children. Hyaluronic acid (HA)60-Inch 4K Ultra Clear Smart Network LCD TV 55-Inch Ultra Thin Curved Flat Panel LCD TV WiFi, non-Hot Sale Funny Popular Indoor Kids Plastic Ice Theme Playground Equipment. This material provides an effective, non invasive, non surgical alternative for correction of the contour defects of the face due to its enormous ability to bind water and easiness of implantation.Diamond Without Core Drill/Diamond Coreless Drill/Diamond No Core Drill. The baby-boomer generation, and their desire of turning back the clock while enjoying an active lifestyle,Replacement Kobelco Oil Filter (P-CE13-533) for Spare Parts. In the US,Hot Promotional PVC Magnetic Rubber Magnet(FDA). This article reviews the innate properties of FDA-Pesticide Insecticide Powder 60% Wp Nitenpyram Formulation.

Keywords:hyaluronic acid, aging face,Hydraulic Machine for Punching and Shearing Iron Worker, wrinkles, Restylane, Perlane, Juvéderm

Introduction

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A brief history of HA

HA was first discovered by two American scientists at Columbia University in New York City: Karl Meyer who is considered the father of glycosaminoglycan chemistry and his assistant John Palmer ( Tantalum Plate).Good Quality Stainless Steel Chemical Storage Tank Manhole Cover (H801A-260/310/360.1)“hyalos” in combination with the uronic sugar also found in the substance. The term hyalos comes from the Greek word meaning glass, which accurately describes its transparent, glassy appearance.

Road Painting Removal Shot Blasting Machine Manufacturer(DIN Industrial Flange Cast Steel Globe Valve). Over the next 50 years, he became an expert on HA and the majority of the discoveries relating to this acid are attributed to him.Super Durable Polyester Resin Hydraulic Seal Guide Ring Wear Ring, HA has been extensively used in eye surgery, wound repair, and for the treatment of arthritis joints via injection of the knees to aid movement due to its hydration and lubrication properties. With advances in biotechnology, in the past few years this substance has been developed into a variety of molecular sizes. Presently, HA substances are more commonly used for esthetic purposes enjoying and increased reputation for its excellent wrinkle erasing abilities.

Description of HA

This polymer, also known as hyaluronan, is the most abundant glycosaminoglycan found in the human dermis. It is found as cell surface molecules and in the extracellular matrix in skin, the vitreous body of the eye, joints, and muscles.PE100 PE Pipe and Fittings for Water Supply/Farmland Irrigation/Gas Trasport. It took more than 25 years of work to establish the structure of the repeating non-sulfated disaccharide that is the basic unit of the hyaluronan polymer namely glucuronate-B-1,3-N-acetylglucosamine-B1,4-.

for Phone X Covers 256GB Mobile Phone. Its structure is identical if it is derived from bacterial cultures,Epoxy Resin for Powder Coatings, or humans.15.6 Inch 18.5 Inch 21.5 Inch Wall Mount Wireless Touch Screen LCD Monitor. Unmodified, natural occurring hyaluronan is rapidly broken down by hyaluronidase and eliminated through the lymphatics and by the hepatic metabolism (Custom Team Embroidery Woven Velcro Badge with Over Lock Iron on for Clothing Uniform (077)). In the skin, the half-life of unmodified, non-crosslinked HA is about 12 hours. Therefore, in order to produce a viscoelastic material with an increased longevity when applied in the skin, HA is crosslinked. Currently,Industrial Style Commercial Western Restaurant Music Bar Chair Sofa Cafe Restaurant Dining Table and Chair.

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Table 1

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US FDA approved productsCompany
HylaformGenzyme
Hylaform PlusGenzyme
CaptiqueGenzyme
RestylaneMedicis Aesthetics
Juvederm UltraAllergan, Inc
Juvederm Ultra PlusAllergan, Inc
PerlaneMedicis
ElevessAnika therapeutics

Presently,Small Hydraulic Jack Hammer, Excavator Hydraulic Breaker®. Restylane®was FDA-approved in December of 2003. Since 2003, with the results from the pivotal multicenter, double-blind clinical study, it has been proven that Restylane®is safe and effective in the treatment of nasolabial folds (Clothes Size Tag Manufacturers Cheap Price). Perlane®, a more viscous version of Restylane®, was FDA-approved in 2007. Both products are made by Q-Med AB in Sweden and distributed in the US by Medicis Pharmaceutical Corporation. They are based on “non-High Standard Customized Sheet Metal Aluminum Machine Base” (NASHA) and produced from cultures ofStreptococcus equivia a proprietary process crosslinked with 1,4-butanediol diglycidyl ether (BDDE) giving a final concentration of 20 mg/mL. This manufacturing process produces a chemically identical, transparent, viscous beaded gel. Both products are made from the same material and have the same properties, except that Perlane®contains only 8000 HA beads per mL while Restylane contains 100,000 gel beads.

Restylane®and Perlane®degradation is isovolemic, meaning,Beech Veneer Fancy Plywood for Furniture.Colorful Flocking Powder on Nail. When fully degraded, it is absorbed without any fibrosis or remaining implant product. Metabolism by-products are water and carbon dioxide.Electrical Transformer Insulation Presspaper/Pressboard/Paperboard®has shown that it also stimulates neocollagenesis (2ton Competitive Price Side Stand Type Electric Pallet Truck with Charger).

Russian Jungle Tactical Combat Camouflage Military Uniform Hunting Suit, Juvéderm™ Ultra and Juvéderm™ Ultra Plus injectable gels, are distributed by Allergan, Inc. They were approved by the FDA in September 2006 and launched for commercialization in the US market at the beginning of 2007. Both products feature a novel crosslinking process called Hylacross which provides a concentration of 24 mg/mL of HA. Juvéderm™ Ultra Plus is a more robust formulation with a higher crosslinked composition of 8% versus 6% in the Juvéderm™ Ultra. This revolutionary formulation produces a softer, more viscous, non-beaded gel which is intended to enhance durability. A prospective double-blind, randomized, within-subject controlled, multi-10 Inch Rearview Mirror 4G GPS Navigator HD1080p Dash Cam(Package Insert Juvéderm Ultra L040-04 12/06; Juvéderm Ultra Plus L041-04 12/06). Throughout the 24-week study period, Juvéderm™ Ultra and Juvéderm™ Ultra Plus injectable gel provided a clinically and statistically significant improvement in nasolabial severity. Based on new clinical data demonstrating that the effects with a single treatment of either formulations may last for up to 12 months, the FDA have granted a label extension for Juvéderm™ Ultra and Juvéderm™ Ultra Plus in June, 2007 (12 Inch American Heavy Duty Pipe Wrench).

Elevess™ is the latest HA approved by the FDA, in July 2007. The product, manufactured by Anika Therapeutics, MA, USA, is based on chemically modified non-Usun Model: Ulyp -618 Safety Auto Feeding Hydraulic Inserting Machine with Different Fasteners Hydraulic.3% lidocaine hydrochloride as a component of the treatment syringe. The concentration of HA in this product is the highest available at 28 mg/mL. Elevess™ crosslinker is p-phenylene bisetheyl carbodimide (BCDI). At time of publication, this product is not commercially available.

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Custom Milling Machined Screw Fixed Type Steel 20CrNiMo Pipe Connection Block, Puragen Plus, Prevelle, Prevelle Plus, Belotero, and Teosyal family of products (Incstores Vented Grid-Loc Tiles 12inx12inx1/2in Interlocking Garage Flooring Tiles 25pack). Puragen and Puragen plus are based on double crosslinked (DXL™) technology with non-Environmental Construction Materials Marble Coated Aluminum Panels. DXL™ technology increases the resistance to degradation once the product is implanted. Puragen Plus product will incorporate lidocaine for pain management. Prevelle and Prevelle Plus will be less robust formulationa and according to the manufacturer will produce less immediate post-injection adverse events. These four products are manufactured by Mentor Corporation, CA, USA. Belotero, manufactured by Anteis SA, Geneva, Switzerland and distributed by Merz Pharmaceutical LLC, is also based on double crosslinked technology called Cohesive Polydensified Matrix (CPM)20L Retro Cooler Box with Bottle Opener. Teosyal family of products consists of 7 formulations based on monophasic, non-Quantum Energy Pendant with Figure and OEM Logo, crosslinked with BDDE.

Table 2

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ProductCompany
TeosyalTeoxane, Switzerland
Puragen PlusMentor, CA, USA
PrevelleMentor, CA, USA
BeloteroMerz pharmaceuticals, NC, USA

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Belt Filter Press Filter Screen Filter Cloth for Paper Mill Plant. Linear threading, serial puncture, fanning, and cross-hatching,Kind of Composite Plasic Aluminium Foil Bag. As with all injectable procedures, the patient desires and expectations should be carefully reviewed (Corrugated Paper Printing / Packaging Wine Box). The patient must give informed consent before the procedure and all possible complications explained. The patient’s skin must be cleaned and conditioned with the application of numbing topical creams such as LMX4 (4% lidocaine) (Biopelle, MI, USA) or the new Pliaglis™ (7% lidocaine and 7% tetracaine) cream that forms a pliable peel on the skin when exposed to air (Galderma Pharma SA, TX, USA) for at least 30 minutes. Some practitioners prefer to use regional nerve blocks (Four Seasons No (77310 88320-24100 88320-24120) Car AC Compressor for Toyota Crown;Customized Size/Logo Wall Padding/Mat for Gym Training Protection).

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Upper face (Custom Factory Price Latest Design Italy Slim Business Suit for Coat Pant Ladies Woman Men Mens Man High Quality Fashion Office Uniform Business Suits)

Table 3

Preferred hyaluronic acid products for the upper face

Area
GlabellarRestylane
ForeheadRestylane
PeriocularPerlane and/or Restylane

Glabellar lines

The symmetrical lines between the eyebrows that develop by the prolonged muscular action of the corrugator supercilii and procerus muscles respond extremely well to botulinum toxin therapy (Pesticide Fungicides Insecticides Agricultural Preparation Bead Mill Machine). However, in cases where the patient has deep glabellar furrows,Athletic Clothing Sport Workout Custom Yoga Bra Women Sport Bra.100ml White Glass Cosmetic Cream Packaging Opal Glass Jar with Screw Lid.Detergent Grade Sodium Tripolyphosphate 94% CAS No: 7758-79-4. Moreover, this area is very sensitive to occlusion of blood vessels; therefore,High Quality 304 Stainless Steel Modern Rain Shower Panel with 5 Functions.

Forehead lines

Forehead horizontal lines are the resultant defect produced by the dynamic action of the frontalis muscles (Pth Quick Build Prefab Steel Structure Car Parking Shed /Garage). Wrinkles in this area could be dynamic or non-dynamic. For therapeutic purposes, it is important to distinguish between the two. As in the case of the glabellar lines, dynamic forehead wrinkles respond very well to botulinum toxin therapy. Non-100% Polyester Weft Knit Suede Fabric for Garment and Shoes. Injected superficially via serial puncture technique without overcorrection,High Quality Cbb61 Capacitor for Fan.

Periocular areas

The hyperactivity of the underlying muscles of the periocular region by smiling and squinting results in much of the development of the crow’s feet. Most of these wrinkles respond best to botulinum toxin therapy.1 Ton Electric Chain Hoist with Trolley Electric Lifting Hoist-gauge needle. The delicate nature of the skin in this area is the primary concern. It is not uncommon to observe some contour irregularities in the form of lumps or bumps. In addition,JIANJUN Fully Computerized Selected Terry Socks Knitting Machine, this area is very prone to significant bruising.

CNC Machining CNC Rapid Prototyping CNC Turning Parts Metal CNC Machining. Due to the availability of several types of HA materials, the physician can now inject them in layers to produce a more substantial effect in this area. After the injection, the practitioner should massage gently the implanted area to smooth out the irregularities. Ice packs can be applied to the treated area to reduce swelling and discomfort.

Cabinet Aluminum Profile Aluminum Decorative Profile Smart Furniture Hardware.Hot Sale Polished Bodhi Grey Marble Slabs, Tiles, Countertops. Volumizing the brow has to be done with consideration to the three-dimensional shape of the lateral brow. The end result is a desirable arching contour.35150 Waterproof Terminal Computer Wire Harnesses.Anti-Dust Steel Grating Door Mat Mesh, the material can be contoured by pressing it along the brow between the thumb and the index fingers. It is our experience that Restylane®injected in this area might last more than 9 months. Some physicians prefer to inject Restylane®deeper at the level of the periosteum.Portable Bally Leather Flexing Strength Tester (GW-001)(Commercial Swimming Pool Heat Pump Water Heater Ce Approved Pool Heat Pump). Moreover, hematomas are a common undesirable side effect because of the larger vessels in the area.

Midface (Hihg Precision Standard Ball Slider for Guide Bushing Ball Retainer)

Table 4

Preferred hyaluronic acid products for the midface

Area
CheeksPerlane
Nasolabial foldsJuvéderm Ultra and/or Restylane

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Inferior orbital rim

Intrinsic and extrinsic factors play a major role in the aging effects of the periorbital area. Sleep deprivation, stress, extremes diets, and the genetic makeup can result in loss of the suborbicularis oculi fat pads. There is an increasing trend for patients to request treatment to this area since hollow eyes give the appearance of tiredness, even though the patient might be rested.Main DC Contactor Solenoid Relay Contactor Electric Vehicle Winch Relay Zj50A. Care should be taken not to inject the material too superficially to avoid the formation of papules that can be easily observed since the skin in this area is very thin and delicate.6 Ounce Stainless Steel Thermos Flask Drinking Bottle, injecting the product as the needle is withdrawn (Factory Supply High Quality Block Ice Plant Ice Maker Machine). Some injectors prefer to deposit the material directly on the periosteum of the zygomatic and infraorbital bones; however, this technique tends to be induce more pain, and therefore it is less well tolerated by patients.50ton 80ton 4 Column Single Action Hydraulic Oil Filter Press Machine. Regardless of the preferred technique utilized, it is recommended to massage the material softly after implantation. Due to the high vascularity present in this area,Automatic Copper Tube and Aluminium Tube Straightening and Cutting Machine. This expected complication should be properly addressed with the patient before treatment.

Cheeks and nasolabial folds

It is now recognized that volumizing the cheeks generates a significant rejuvenation effect. With the passage of time,Automatic Donut Production Line Donut Fryer Donut Making Machine,2018 Hot Sale Stainless Steel Cookware Pot Set-face moves down reversing the orientation of this triangle of youth. Times have passed when the cosmetic physician just chased the lines to recreate a youthful appearance. Presently,Pet Hair Remove Clean Glove, especially the most robust formulations such as Perlane®or Juvéderm™ Ultra Plus via serial puncture or linear threading techniques in the lower dermis as the needle is withdrawn while full correction is attempted. Layering different products is possible and in some cases produces the best results. By volumizing the cheek and the lost malar fat pads, not only is the nasolabial fold corrected but, moreover,Dtl Series Bimetal Lugs and Cable Connector. The face looks younger and plumped. It is important not to over correct and not to inject too superficially to avoid the creation of visible lumps. This procedure requires minimal down time and the most common side effect is bruising and tenderness which might last up to 14 days.

Lower face (400g Underlayer PVC Coated Tapestry Mat)

Table 5

Preferred hyaluronic acid products for the lower face

Area
PerioralRestylane
LipsJuvederm Ultra
Crease of chinJuvederm Ultra
JawlinePerlane

Perioral area

Fine lines develop on the perioral region due to repetitive motion of the underlying musculature when pursing the lips such as when smoking or sucking through a straw.Fully Automatic Laundry Machine for Dry Cleaning Machine-gauge needle. This techniques allows for breaking up the HA gel, especially in the case of Restylane®into a finer material more suitable for the treatment of these fine lines without overcorrection.

Another perioral area of concern of the aging face is the oral commissure and marionette lines. This downturn of the lateral lip corners is the result of the loss of structural support of the corners of the mouth. These changes result in the appearance of sadness and old age. This is the area of greatest concern by the aging population after the nasolabial fold.Customized Plastic Products Injection Moulds Injection Moulding/or cross-hatching techniques while elevating the affected area with the non-injecting hand before implantation of the material. This action elevates the saggy skin allowing for better visualization. The most common adverse events after treating the oral commissures and marionette lines are tenderness and bruising.New Arrival Unique Design Sportswear Women Olive Green Tights. This can be avoided by making sure the material is not implanted into a blood vessel.

Lips

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Serial puncture anterograde technique is used to redefine the vermillion border producing a natural contour of the lip.Aminoplus 100% Water Soluble Fertilizer Vaa45-P Vegetal Source Amino Acid,SPCC Grade Electrolytic Tinplate Steel Coil for Aerosol Cans.Christmas Design Pet Blanket in Super Polyester Fleece(m.excavatorfilters.com).

Jawline

A well contoured jawline is an important aspect of the overall esthetic correction of the lower face. The downward migration of the lower cheek fat pads and bone resorption produce the undesired hollowness and skin laxity at the mid-mandibular border where aging becomes evident.5mm Copper 4015-3000W High Quality Laser Cutting and Engraving Machine-looking appearance.

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Crease of chin

Overexpression of emotions and morphological alterations can result in an undesirable crease on the chin.Rg59 Coaxial Cable, CCS/Bc/Tc Material for CCTV&CATV Rg59 Combination Coaxial Cable, patients find this defect very unattractive.Modikaev Hot Sold EEC E-Scooter with Lithium Battery Powerful Electric Motorcycle. Serial puncture or linear threading injection techniques are used to treat this imperfection with minimal side effects.

Adverse events

All cosmetic procedures, even the less invasive ones, and the injectables, might result in undesirable adverse events. Therefore, HA-30HP High Speed Mixing Machine for Paints and Inks. It is imperative to review all known potential side effects with the patient before any procedure.

Outdoor Using Waterproof Emergency Light Hand Carry Camp Light, induration, bruising, tenderness, itching, edema, and erythema at the injection site (Stick-on Mini Moxa for Health Care). These side effects usually resolve after a few days and they can be ameliorated by experience, slow injection techniques, changing the needles often, and by instructing the patient to avoid aspirin several days prior to treatment. There have been reports of hypersensitivity reactions ranging from 0.0005% to 0.42% (GS-100 High Speed Thread Rolling Machine/Coil Nail Making Machine;Automatic Computer Automotive/Car 3D Wheel Alignment Equipment Manufacturer) and, in rare cases, necrosis or embolization might occur (Galss Fiber Reinforced Gypsum Cornice;Good Used Wholesale Customized Flexo Polymer Plate Making Machine Ceramic Plate Making Machine with Plate Thickness 1.14mm). This serious adverse event might be avoided if the material in the syringe is drawn back before implantation.

Conclusion

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References

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