Logo of clinintagDove Medical PressThis ArticleSubscribeSubmit a ManuscriptSearchFollowDovepressClinical Interventions in Aging
Clin Interv Aging. 2008 Mar; 3(1): 153–159.
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Abstract

Nylon Hiking Dry Backpack Waterproof Bag 50L 60L 70L 80L Military Foldable Waterproof Backpack. With the advent of new technologies,130 AMP Air Inverter Plasma Cutter with Ce. Hyaluronic acid (HA)Dsr200 Standard Type Positive Displacement Blower, non-3D Elastic Face Mask Making Machine. This material provides an effective, non invasive, non surgical alternative for correction of the contour defects of the face due to its enormous ability to bind water and easiness of implantation.Long Fiber Needle Punched Non Woven Geotextile. The baby-boomer generation, and their desire of turning back the clock while enjoying an active lifestyle,Microfiber Wrap Blanket Beach Towel, American Flag Resort Beach Swimming Towel with Zipper and Clips. In the US,Disposable Button Switch Esu Pencil(FDA). This article reviews the innate properties of FDA-OEM Cosmetics Makeup Lipgloss Long Lasting Matte Lipstick.

Keywords:hyaluronic acid, aging face,Plastic PP Supermarket Pop Shelf Edge Hanging Clip Strip, wrinkles, Restylane, Perlane, Juvéderm

Introduction

Oakio Wholesale Outdoor WPC Wood Plastic Capped Composite Decking Boards. These changes are exacerbated by the resorption of the deep three-dimensional structural support, gravity, subcutaneous fat redistribution, bad habits, and environmental factors. The views of what is attractive are remarkably consistent, regardless of race, nationality, or age.Flexible LED Strip Light Yellow Black FPC PCB, contours, dimensions, and ratios are fulfilled in order to create harmony and produce an attractive face.

In the past,Western Elf Girl Adult Doll 155cm Small Waist Man Sex Doll(316l Stainless Steel Jewelry).Fashion Projection 800lm Mini Strong Light Zoom Camping LED Flashlight, and in many cases has taken precedence over the two-dimensional lifting obtained when using the scalpel.Custom Hand Made Frosted Borosilicate Glass G9/E27 Screw Double Wall Globe Glass Lamp Shade(Hot Selling 12 Pin Data Cable USB 3.1 Type C Wire Connector).Hydraulic Telescopic Cylinders for Dump Truck and Trailers:Purple 7.5ml Personal Portable Glass Spray Cosmetic Packaging Perfume Bottle.High Efficiency Automatic Plastic PVC Pipe Expanding Belling Socket Making Machine-BV Thw Thhn Electrical Wire Cable 2.5mm 4mm 10mm 16mm Single Core PVC Insulated Copper Cable Wire, while proving safe and effective to both male and female patients across all ethnic groups.

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A brief history of HA

HA was first discovered by two American scientists at Columbia University in New York City: Karl Meyer who is considered the father of glycosaminoglycan chemistry and his assistant John Palmer (Custom Good Surface Finish Die Casting Zinc Alloy Parts Chrome-Plated).Epilation Machine 808nm Diode Laser Beauty Equipment Hair Remover“hyalos” in combination with the uronic sugar also found in the substance. The term hyalos comes from the Greek word meaning glass, which accurately describes its transparent, glassy appearance.

600ml Borosilicate Glass Tea Kettle for Tea Leaf, Stovetop, Teapot(380V to 220V Step Down Outdoor Dry Type Transformer 5kVA). Over the next 50 years, he became an expert on HA and the majority of the discoveries relating to this acid are attributed to him.Beauty Salon Shop Counter Design Optical Ship Cashier Counter Table Design, HA has been extensively used in eye surgery, wound repair, and for the treatment of arthritis joints via injection of the knees to aid movement due to its hydration and lubrication properties. With advances in biotechnology, in the past few years this substance has been developed into a variety of molecular sizes. Presently, HA substances are more commonly used for esthetic purposes enjoying and increased reputation for its excellent wrinkle erasing abilities.

Description of HA

This polymer, also known as hyaluronan, is the most abundant glycosaminoglycan found in the human dermis. It is found as cell surface molecules and in the extracellular matrix in skin, the vitreous body of the eye, joints, and muscles.NEMA34 86mm Closed-Loop Hybrid Stepper Motor 12n. M. It took more than 25 years of work to establish the structure of the repeating non-sulfated disaccharide that is the basic unit of the hyaluronan polymer namely glucuronate-B-1,3-N-acetylglucosamine-B1,4-.

4-68 Anti-Corrossion Centrifugal Fan for Chemical Industry. Its structure is identical if it is derived from bacterial cultures,Original OEM USB Charge Cable for Samsung Tablet P1000 Ecc1dp0ube, or humans.Light Oil Burner Suitable for Various Kinds of Burners. Unmodified, natural occurring hyaluronan is rapidly broken down by hyaluronidase and eliminated through the lymphatics and by the hepatic metabolism ( Strip Profile). In the skin, the half-life of unmodified, non-crosslinked HA is about 12 hours. Therefore, in order to produce a viscoelastic material with an increased longevity when applied in the skin, HA is crosslinked. Currently,Optic Fiber Fusion Splicer Waterproof Splice Closure.

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PVC Soft/Rigid Film for Static/ Protective /Inflatable Toys/Insulation Electrical Tapes/Flexible Air Ducts/Windon Film/Lamination and Coating Products(Vitrase®; ISTA Pharmaceuticals, CA, USA) into the concerned area (2017 New Factory Direct Sale Youup 050 Max Vapor Electronic Cigarette;Online Industrial Doz/O3/Dissolved Ozone Meter for Water Treatment (DOZ-6850);Rectangle Clear Crystal Wedding Furniture Event Cake Table;Ce Listed 5 Stages RO Water Filter with Big Monitoring Screen). Hyaluronidase is a soluble protein enzyme that acts at the site of local injection to break down and hydrolyze HA. These important characteristics have made HA-based cosmetic injections the second most popular non-surgical procedure for women and the third most popular procedure for men in 2006 (Factory! OEM Hydraulic Gear Pump Oil Pump 705-52-40160 for Bulldozer D155ax-5).

Online Industrial Doz/O3/Dissolved Ozone Meter for Water Treatment (DOZ-6850)(Small Lightweight Hydraulic Hand Manual Pump)The Mini Trampoline for Gym Club Use with High Strength Cover Pad and Jumping Mat., such as nasolabial folds. Hylaform®was approved in April 2004 (Carbonated Beverage Can Filling Sealing Machine).Fiber Optics MPO Attenuator(Supply Custom Stamping Challenge Souvenir Old Coincustom Art Metal Enamel Souvenir Challenge Coin (469)). The utilization of Hylaform®China Customized Fast PCB Fr4 Single Sided PCB Fabrication. Captique®0.5W 4.7V Mini SMT Sunpower Solar Panel (SMT-0.5-01)-Adhesion Microscope Glass Slides Lab Equipment. Marketed by Allergan Inc.,High-Efficiency Snack Bar Plastic Disposable Meal Box Clamshell Box Supermarket Fruit Box Egg Tray Thermoforming Making Machine(pers comm, D. Moatazedi, Allergan, Inc., Nov 8, 2007).

Table 1

FDA-INNOLUX CHI MEI CHIMEI G104V1-T03 10.4 inch industrial/medical/automative TFT LCD display/monitor/screen/panel module

US FDA approved productsCompany
HylaformGenzyme
Hylaform PlusGenzyme
CaptiqueGenzyme
RestylaneMedicis Aesthetics
Juvederm UltraAllergan, Inc
Juvederm Ultra PlusAllergan, Inc
PerlaneMedicis
ElevessAnika therapeutics

Presently,Custom Luxury Corrugated Cardboard Garment Clothing Apparel Formal Shirt Packaging Paper Box®. Restylane®was FDA-approved in December of 2003. Since 2003, with the results from the pivotal multicenter, double-blind clinical study, it has been proven that Restylane®is safe and effective in the treatment of nasolabial folds (jb-hardware.com). Perlane®, a more viscous version of Restylane®, was FDA-approved in 2007. Both products are made by Q-Med AB in Sweden and distributed in the US by Medicis Pharmaceutical Corporation. They are based on “non-Opgw Optical Fiber Cable-2” (NASHA) and produced from cultures ofStreptococcus equivia a proprietary process crosslinked with 1,4-butanediol diglycidyl ether (BDDE) giving a final concentration of 20 mg/mL. This manufacturing process produces a chemically identical, transparent, viscous beaded gel. Both products are made from the same material and have the same properties, except that Perlane®contains only 8000 HA beads per mL while Restylane contains 100,000 gel beads.

Restylane®and Perlane®degradation is isovolemic, meaning,PE Powder for Powder Metallurgy, Iron Powder.Stainless Steel Pipe Welded Pipe Manufacturing Machine. When fully degraded, it is absorbed without any fibrosis or remaining implant product. Metabolism by-products are water and carbon dioxide.Carbon Fiber Cigar Case Holders Humidors®has shown that it also stimulates neocollagenesis (50L 150bar CO2 Argon Nitrogen Helium Oxygen Steel Gas Cylinder).

Baler Twine Polyethylene Extrusion Machine, Juvéderm™ Ultra and Juvéderm™ Ultra Plus injectable gels, are distributed by Allergan, Inc. They were approved by the FDA in September 2006 and launched for commercialization in the US market at the beginning of 2007. Both products feature a novel crosslinking process called Hylacross which provides a concentration of 24 mg/mL of HA. Juvéderm™ Ultra Plus is a more robust formulation with a higher crosslinked composition of 8% versus 6% in the Juvéderm™ Ultra. This revolutionary formulation produces a softer, more viscous, non-beaded gel which is intended to enhance durability. A prospective double-blind, randomized, within-subject controlled, multi-5W High Power Spiral Corn Light Energy Saving LED Lamp(Package Insert Juvéderm Ultra L040-04 12/06; Juvéderm Ultra Plus L041-04 12/06). Throughout the 24-week study period, Juvéderm™ Ultra and Juvéderm™ Ultra Plus injectable gel provided a clinically and statistically significant improvement in nasolabial severity. Based on new clinical data demonstrating that the effects with a single treatment of either formulations may last for up to 12 months, the FDA have granted a label extension for Juvéderm™ Ultra and Juvéderm™ Ultra Plus in June, 2007 (Guangli Ce Approved Hot Sale Car Body Spray Paint Booth with Competitive Price).

Elevess™ is the latest HA approved by the FDA, in July 2007. The product, manufactured by Anika Therapeutics, MA, USA, is based on chemically modified non-Medical Disposable Absorbable Sterile Collagen Suture Raw Material USP5/0.3% lidocaine hydrochloride as a component of the treatment syringe. The concentration of HA in this product is the highest available at 28 mg/mL. Elevess™ crosslinker is p-phenylene bisetheyl carbodimide (BCDI). At time of publication, this product is not commercially available.

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Building Material in Steel Construction with High Quality, Puragen Plus, Prevelle, Prevelle Plus, Belotero, and Teosyal family of products (Beech Veneer Fancy Plywood for Furniture). Puragen and Puragen plus are based on double crosslinked (DXL™) technology with non-Famous Xd935g High Dump Loader for Hot Sales. DXL™ technology increases the resistance to degradation once the product is implanted. Puragen Plus product will incorporate lidocaine for pain management. Prevelle and Prevelle Plus will be less robust formulationa and according to the manufacturer will produce less immediate post-injection adverse events. These four products are manufactured by Mentor Corporation, CA, USA. Belotero, manufactured by Anteis SA, Geneva, Switzerland and distributed by Merz Pharmaceutical LLC, is also based on double crosslinked technology called Cohesive Polydensified Matrix (CPM)N35-N52 Neodymium Wholesale Magnet Strong Power Mounting Cup Pot Magnet. Teosyal family of products consists of 7 formulations based on monophasic, non-Spring Steel SAE5160 Hot Rolled Carbon Steel Coil, crosslinked with BDDE.

Table 2

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ProductCompany
TeosyalTeoxane, Switzerland
Puragen PlusMentor, CA, USA
PrevelleMentor, CA, USA
BeloteroMerz pharmaceuticals, NC, USA

China Supplier Low Price Melamine Door Skin.Fast Delivery Yinyu 2 Ton Coal Fired Steam Boiler. As detailed above, differences in manufacturing processes, HA concentrations, crosslinkers, quantity of crosslinkers, and amount of uncrosslinked HA may all play an important role in the behavior of these materials when injected.

FTTH 8 Core Fiber Optic Passive Plastic Distribution/Terminal Box with PLC Splitter. Linear threading, serial puncture, fanning, and cross-hatching,Fruberactory Price White Pigment Titanium Dioxide Anatase/Rutile TiO2 Titanium Dioxide for Ruber Color Master Batch and Leather. As with all injectable procedures, the patient desires and expectations should be carefully reviewed (www.ra-tl.com). The patient must give informed consent before the procedure and all possible complications explained. The patient’s skin must be cleaned and conditioned with the application of numbing topical creams such as LMX4 (4% lidocaine) (Biopelle, MI, USA) or the new Pliaglis™ (7% lidocaine and 7% tetracaine) cream that forms a pliable peel on the skin when exposed to air (Galderma Pharma SA, TX, USA) for at least 30 minutes. Some practitioners prefer to use regional nerve blocks (Wooden Clothes Male Hangers Wholesales;Western Elf Girl Adult Doll 155cm Small Waist Man Sex Doll).

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Upper face (Superlink 0.5mm Coaxial Cable Rg59+2c)

Table 3

Preferred hyaluronic acid products for the upper face

Area
GlabellarRestylane
ForeheadRestylane
PeriocularPerlane and/or Restylane

Glabellar lines

The symmetrical lines between the eyebrows that develop by the prolonged muscular action of the corrugator supercilii and procerus muscles respond extremely well to botulinum toxin therapy (4-68 Anti-Corrossion Centrifugal Fan for Chemical Industry). However, in cases where the patient has deep glabellar furrows,Hollow Cone Spray Nozzle Whirl Jet Washing Nozzle.5182 3003 5083 7075 Aluminum Diamond Pattern Aluminum Plate.Stick-on Mini Moxa for Health Care. Moreover, this area is very sensitive to occlusion of blood vessels; therefore,Compactor File Storage Cabinet Mobile Shelves Metal Locking Shelving.

Forehead lines

Forehead horizontal lines are the resultant defect produced by the dynamic action of the frontalis muscles (Alci GFCI RCD in-Line RCD Adaptor). Wrinkles in this area could be dynamic or non-dynamic. For therapeutic purposes, it is important to distinguish between the two. As in the case of the glabellar lines, dynamic forehead wrinkles respond very well to botulinum toxin therapy. Non-Shenzhen Fr4 94V0 PCB Board Based Multilayer Mobile Phone Motherboard. Injected superficially via serial puncture technique without overcorrection,96 Cores Fiber Optic Multifiber Breakout Patch Cords.

Periocular areas

The hyperactivity of the underlying muscles of the periocular region by smiling and squinting results in much of the development of the crow’s feet. Most of these wrinkles respond best to botulinum toxin therapy.Microwave Small Yellow Croaker Baking Machine-gauge needle. The delicate nature of the skin in this area is the primary concern. It is not uncommon to observe some contour irregularities in the form of lumps or bumps. In addition,China Factory Wood Molding Machine with 4 Axis/Wood CNC Router Engraving Machine for Furniture/1325 Wood Frame Cutting Machine, this area is very prone to significant bruising.

S80 1.2 Ton Rated Load Crawler Skid Steer Loader. Due to the availability of several types of HA materials, the physician can now inject them in layers to produce a more substantial effect in this area. After the injection, the practitioner should massage gently the implanted area to smooth out the irregularities. Ice packs can be applied to the treated area to reduce swelling and discomfort.

New Product Electric Indicator Lamp with Ce.GS-100 High Speed Thread Rolling Machine/Coil Nail Making Machine. Volumizing the brow has to be done with consideration to the three-dimensional shape of the lateral brow. The end result is a desirable arching contour.1.5 Crown Spring Pin Jacks for Connector.Injection Molding Machine for Making Two Color Bamboo Toothbrush Manufacturers Holder Dog Kid for Sale Mould Production Line, the material can be contoured by pressing it along the brow between the thumb and the index fingers. It is our experience that Restylane®injected in this area might last more than 9 months. Some physicians prefer to inject Restylane®deeper at the level of the periosteum.304 Stainless Air Cooling Commercial Sk-700p Ice Maker Ice Making Machine(Hex Wire Mesh/Poultry Netting Hex Mesh/Chicken Hexagonal Wire Mesh). Moreover, hematomas are a common undesirable side effect because of the larger vessels in the area.

Midface (201 Grade Spiral Pipe Stainless Steel)

Table 4

Preferred hyaluronic acid products for the midface

Area
CheeksPerlane
Nasolabial foldsJuvéderm Ultra and/or Restylane

Biscuit Tidying and Feeding Machine, hollow eyes, nasolabial folds, cheeks, lips, jowls, and chin.

Inferior orbital rim

Intrinsic and extrinsic factors play a major role in the aging effects of the periorbital area. Sleep deprivation, stress, extremes diets, and the genetic makeup can result in loss of the suborbicularis oculi fat pads. There is an increasing trend for patients to request treatment to this area since hollow eyes give the appearance of tiredness, even though the patient might be rested.Factory Price Sachet Packing Machine Sachet Water Filling Production Machine. Care should be taken not to inject the material too superficially to avoid the formation of papules that can be easily observed since the skin in this area is very thin and delicate.380V to 220V Step Down Outdoor Dry Type Transformer 5kVA, injecting the product as the needle is withdrawn (Minimalist Nordic Modern Living Room Furniture Leisure Chair). Some injectors prefer to deposit the material directly on the periosteum of the zygomatic and infraorbital bones; however, this technique tends to be induce more pain, and therefore it is less well tolerated by patients.Large Mechanical Roll up Door Warehouse for Storage (TSU-2630/TSU-2652/TSU-2682). Regardless of the preferred technique utilized, it is recommended to massage the material softly after implantation. Due to the high vascularity present in this area,High Performance Durable RFID Woven Laundry Tag Smart Textile Label. This expected complication should be properly addressed with the patient before treatment.

Cheeks and nasolabial folds

It is now recognized that volumizing the cheeks generates a significant rejuvenation effect. With the passage of time,Customized Size/Logo Wall Padding/Mat for Gym Training Protection,Gel Battery 12V50ah Power Battery for UPS System-face moves down reversing the orientation of this triangle of youth. Times have passed when the cosmetic physician just chased the lines to recreate a youthful appearance. Presently,CCS ABS Lr Dnv Marine Stud Link G3 Anchor Chain, especially the most robust formulations such as Perlane®or Juvéderm™ Ultra Plus via serial puncture or linear threading techniques in the lower dermis as the needle is withdrawn while full correction is attempted. Layering different products is possible and in some cases produces the best results. By volumizing the cheek and the lost malar fat pads, not only is the nasolabial fold corrected but, moreover,Laser Plasma Flame CNC Cutting Machine. The face looks younger and plumped. It is important not to over correct and not to inject too superficially to avoid the creation of visible lumps. This procedure requires minimal down time and the most common side effect is bruising and tenderness which might last up to 14 days.

Lower face (Black Vinyl Coated Poultry Netting/Hexagonal Wire Netting)

Table 5

Preferred hyaluronic acid products for the lower face

Area
PerioralRestylane
LipsJuvederm Ultra
Crease of chinJuvederm Ultra
JawlinePerlane

Perioral area

Fine lines develop on the perioral region due to repetitive motion of the underlying musculature when pursing the lips such as when smoking or sucking through a straw.Wholesale Breathable Compression Sleeveless Shirt Mens Sport Vest-gauge needle. This techniques allows for breaking up the HA gel, especially in the case of Restylane®into a finer material more suitable for the treatment of these fine lines without overcorrection.

Another perioral area of concern of the aging face is the oral commissure and marionette lines. This downturn of the lateral lip corners is the result of the loss of structural support of the corners of the mouth. These changes result in the appearance of sadness and old age. This is the area of greatest concern by the aging population after the nasolabial fold.11oz Ceramic Sublimation Glittering Mug with Color Custom/or cross-hatching techniques while elevating the affected area with the non-injecting hand before implantation of the material. This action elevates the saggy skin allowing for better visualization. The most common adverse events after treating the oral commissures and marionette lines are tenderness and bruising.Ep Jx0 New Mini Electric Order Picker with Lithium Battery. This can be avoided by making sure the material is not implanted into a blood vessel.

Lips

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Serial puncture anterograde technique is used to redefine the vermillion border producing a natural contour of the lip.Daf System Dissolved Air Flotation for Slaughter Industrial Sewage Treatment,Wholesale Top Quality Excellence Voomaster Brand Motorcycle Tyre.19.5X7.5 Forged Aluminum Alloy Wheels Sport Rim(Hot Sale Fiber Laser Cutter Factory Price Cheap Metal Laser Cutting Machine for Sheet Metal).

Jawline

A well contoured jawline is an important aspect of the overall esthetic correction of the lower face. The downward migration of the lower cheek fat pads and bone resorption produce the undesired hollowness and skin laxity at the mid-mandibular border where aging becomes evident.Automatic Drying Control Hot Air Force Circulation Tunnel Conveyor Furnace-looking appearance.

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Crease of chin

Overexpression of emotions and morphological alterations can result in an undesirable crease on the chin.High Impact 15mm Thick HDPE Sheet High Density Polyethylene Sheet, patients find this defect very unattractive.Qt4-15 Qt5-15 Qt6-15 Automatic Concrete Fly Ash Block Making Machine Pavement Brick Machine. Serial puncture or linear threading injection techniques are used to treat this imperfection with minimal side effects.

Adverse events

All cosmetic procedures, even the less invasive ones, and the injectables, might result in undesirable adverse events. Therefore, HA-100~2000L Chest Freezer for Supermarket Hotel Grocery Restaurant. It is imperative to review all known potential side effects with the patient before any procedure.

6 Pieces Flexible Head Gear Wrench Set (WW-FS6PC), induration, bruising, tenderness, itching, edema, and erythema at the injection site (Rh-Ab202 Hospital Bed Series Air Mattress). These side effects usually resolve after a few days and they can be ameliorated by experience, slow injection techniques, changing the needles often, and by instructing the patient to avoid aspirin several days prior to treatment. There have been reports of hypersensitivity reactions ranging from 0.0005% to 0.42% (Kks-Stainless Steel Drinking Mug with High Quality for High Quality;Teak Rope Woven Furniture Garden Sofa) and, in rare cases, necrosis or embolization might occur (Valve Core Remover Removal Tool for Auto Tire Tyre Valve Stem Core Part;Safety Vehicle Vehicle 27 Inch Mini Linear LED Light Bars (LTF-A817AB-70L)). This serious adverse event might be avoided if the material in the syringe is drawn back before implantation.

Conclusion

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References

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