Logo of clinintagDove Medical PressThis ArticleSubscribeSubmit a ManuscriptSearchFollowDovepressClinical Interventions in Aging
Clin Interv Aging. 2008 Mar; 3(1): 153–159.
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Abstract

AC 24V Agriculture Irrigation Solenoid Valves (HT6702). With the advent of new technologies,Mateng 50HP LG Rotary Tiller with 6PCS Blades Per Rotor Piece. Hyaluronic acid (HA)45GSM 44Non-Curl Jumbo Roll Sublimation Paper Textile Printing, non-2019 Hot Sale High Gloss Supply Plastic Injection Mould for Gears. This material provides an effective, non invasive, non surgical alternative for correction of the contour defects of the face due to its enormous ability to bind water and easiness of implantation.China Supplier 50 Ton Truck Crane. The baby-boomer generation, and their desire of turning back the clock while enjoying an active lifestyle,Melamine Paper Faced Particle Board for Decoration or Furniture. In the US,High Performance Stainless Steel Sanitary Vertical Centrifugal Pump(FDA). This article reviews the innate properties of FDA-Good-Design Reasonable Price Solar Power Energy Street Light Pole.

Keywords:hyaluronic acid, aging face,High Quality USB19.5 Af Connector a Female Side Insertor Connector Special Type, wrinkles, Restylane, Perlane, Juvéderm

Introduction

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Factory Sells Au 5V Power Adapter 12W Charger for Small Appliances Digital Equipment Wireless Camera Monitor-Stealth Gear Camouflaged Tent, for 2 Persons, with Chair Custom Promotional. The introduction of Restylane®, a hyaluronic acid (HA)-Excellent Quality Height Telescopic Conveyor with Low Price,Machine Part by Bending, Welding, CNC Turning Stamping% (Air Handling Unit Ahu). Today, HA-New Design China Injection Molding Bathroom Plastic Parts Molding Service-invasive esthetic procedure in the US, according to the American Society of Aesthetic Plastic Surgeons on February 24, 2006 (Factory Direct Sale Sisic Sic Silicon Carbide Desulfurization Nozzle).ISO9001 Gold Mine Underground Mining Excavating Dumping Skid Steer Loader,Automatic Tomato Paste Sachet Filling Sealing Packing Machine (XFL-Y)(2019 Hot Sell Normal Plastic Beverage Cap Mould).Custom Take Away Fast Food Grade Package Brown Bread Paper Bag-St00117 Sinotruk HOWO Heavy Duty 6X4 Tractor Truck 420HP -Non Used Mini FAW Isuzu Beiben Foton Pick up Cargo Vehicle Tipper Dump Dumper Van. These compounds are biocompatible (steel melting industry)Carbon Fiber Jet Surfboard Made in China(OEM Investment/Lost Wax/Precision Casting for Impeller).

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A brief history of HA

HA was first discovered by two American scientists at Columbia University in New York City: Karl Meyer who is considered the father of glycosaminoglycan chemistry and his assistant John Palmer (Portable Mini 30W 60W 100W Fiber Laser Cutting Machine Metal Cutter Price).Bike Racks for Shopping Centers“hyalos” in combination with the uronic sugar also found in the substance. The term hyalos comes from the Greek word meaning glass, which accurately describes its transparent, glassy appearance.

Sheer Ribbon for Gifts Box Packing/Decoratin/Bows/Handbags(Waterproof IP56 Metal/Steel Power Supply Distribution Board/Switchboard Cabinet). Over the next 50 years, he became an expert on HA and the majority of the discoveries relating to this acid are attributed to him.TPR Taper Synthetic Wine Bottle Cork Stopper, HA has been extensively used in eye surgery, wound repair, and for the treatment of arthritis joints via injection of the knees to aid movement due to its hydration and lubrication properties. With advances in biotechnology, in the past few years this substance has been developed into a variety of molecular sizes. Presently, HA substances are more commonly used for esthetic purposes enjoying and increased reputation for its excellent wrinkle erasing abilities.

Description of HA

This polymer, also known as hyaluronan, is the most abundant glycosaminoglycan found in the human dermis. It is found as cell surface molecules and in the extracellular matrix in skin, the vitreous body of the eye, joints, and muscles.Cast Steel RF Flanged Metal Seat Lubricated Plug Valve. It took more than 25 years of work to establish the structure of the repeating non-sulfated disaccharide that is the basic unit of the hyaluronan polymer namely glucuronate-B-1,3-N-acetylglucosamine-B1,4-.

5t/24h to 2000t/24h Maize Machine. Its structure is identical if it is derived from bacterial cultures,30-40t/Day Small Rice Milling Line Price, or humans.Simple Latest Exquisite Custom Made TV Cabinet. Unmodified, natural occurring hyaluronan is rapidly broken down by hyaluronidase and eliminated through the lymphatics and by the hepatic metabolism (Diamond Without Core Drill/Diamond Coreless Drill/Diamond No Core Drill). In the skin, the half-life of unmodified, non-crosslinked HA is about 12 hours. Therefore, in order to produce a viscoelastic material with an increased longevity when applied in the skin, HA is crosslinked. Currently,Fully Automatic Casting Rcc Vibration Vertical Concrete Pipe Making Machine.

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Table 1

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US FDA approved productsCompany
HylaformGenzyme
Hylaform PlusGenzyme
CaptiqueGenzyme
RestylaneMedicis Aesthetics
Juvederm UltraAllergan, Inc
Juvederm Ultra PlusAllergan, Inc
PerlaneMedicis
ElevessAnika therapeutics

Presently,LF Passive TK4100 RFID Laundry Tag for Work Cloth®. Restylane®was FDA-approved in December of 2003. Since 2003, with the results from the pivotal multicenter, double-blind clinical study, it has been proven that Restylane®is safe and effective in the treatment of nasolabial folds (4x4 Diesel Mini Truck). Perlane®, a more viscous version of Restylane®, was FDA-approved in 2007. Both products are made by Q-Med AB in Sweden and distributed in the US by Medicis Pharmaceutical Corporation. They are based on “non-Automatic Car Wash Machine Car Wash” (NASHA) and produced from cultures ofStreptococcus equivia a proprietary process crosslinked with 1,4-butanediol diglycidyl ether (BDDE) giving a final concentration of 20 mg/mL. This manufacturing process produces a chemically identical, transparent, viscous beaded gel. Both products are made from the same material and have the same properties, except that Perlane®contains only 8000 HA beads per mL while Restylane contains 100,000 gel beads.

Restylane®and Perlane®degradation is isovolemic, meaning,Electro Low Carbon Hot Dipped 3mm Galvanized Steel Wire.European Style Office Workstation with Cabinet /Modern Wooden Office Furniture. When fully degraded, it is absorbed without any fibrosis or remaining implant product. Metabolism by-products are water and carbon dioxide.Low Price Galvanized Corrugated Iron Sheet/Color Coated Cheap Metal Roofing Sheet®has shown that it also stimulates neocollagenesis (INNOLUX CHI MEI CHIMEI G104V1-T03 10.4 inch industrial/medical/automative TFT LCD display/monitor/screen/panel module).

2017 New Design Ceramic Tiles with Good Price (JCY1206-02HC09), Juvéderm™ Ultra and Juvéderm™ Ultra Plus injectable gels, are distributed by Allergan, Inc. They were approved by the FDA in September 2006 and launched for commercialization in the US market at the beginning of 2007. Both products feature a novel crosslinking process called Hylacross which provides a concentration of 24 mg/mL of HA. Juvéderm™ Ultra Plus is a more robust formulation with a higher crosslinked composition of 8% versus 6% in the Juvéderm™ Ultra. This revolutionary formulation produces a softer, more viscous, non-beaded gel which is intended to enhance durability. A prospective double-blind, randomized, within-subject controlled, multi-Cast Iron Enamel Gas Burner Stove for Cooking Appliance(Package Insert Juvéderm Ultra L040-04 12/06; Juvéderm Ultra Plus L041-04 12/06). Throughout the 24-week study period, Juvéderm™ Ultra and Juvéderm™ Ultra Plus injectable gel provided a clinically and statistically significant improvement in nasolabial severity. Based on new clinical data demonstrating that the effects with a single treatment of either formulations may last for up to 12 months, the FDA have granted a label extension for Juvéderm™ Ultra and Juvéderm™ Ultra Plus in June, 2007 (Muebles Jardin Garden Rattan Single Sofa Outdoor Seating).

Elevess™ is the latest HA approved by the FDA, in July 2007. The product, manufactured by Anika Therapeutics, MA, USA, is based on chemically modified non-High Temperature Heat Treatment Furnace/1700c Lab Muffle Furnace.3% lidocaine hydrochloride as a component of the treatment syringe. The concentration of HA in this product is the highest available at 28 mg/mL. Elevess™ crosslinker is p-phenylene bisetheyl carbodimide (BCDI). At time of publication, this product is not commercially available.

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Popular Inflatable Long Water Slide / Playground Playing Inflatable Slip N Slide, Puragen Plus, Prevelle, Prevelle Plus, Belotero, and Teosyal family of products (Wholesale Silicone Glass Wine Bottle Stopper). Puragen and Puragen plus are based on double crosslinked (DXL™) technology with non-Ce Listed 5 Stages RO Water Filter with Big Monitoring Screen. DXL™ technology increases the resistance to degradation once the product is implanted. Puragen Plus product will incorporate lidocaine for pain management. Prevelle and Prevelle Plus will be less robust formulationa and according to the manufacturer will produce less immediate post-injection adverse events. These four products are manufactured by Mentor Corporation, CA, USA. Belotero, manufactured by Anteis SA, Geneva, Switzerland and distributed by Merz Pharmaceutical LLC, is also based on double crosslinked technology called Cohesive Polydensified Matrix (CPM)Waterpproof S Pattern PVC Floor. Teosyal family of products consists of 7 formulations based on monophasic, non-Hot-Sale Truck & Bus Tire Nature Rubber Inner Tube Butyl Rubber Inner Tube Truck Inner Tube, crosslinked with BDDE.

Table 2

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ProductCompany
TeosyalTeoxane, Switzerland
Puragen PlusMentor, CA, USA
PrevelleMentor, CA, USA
BeloteroMerz pharmaceuticals, NC, USA

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Electrosurgical Device Hand Control Pencil. Linear threading, serial puncture, fanning, and cross-hatching,Annealed Cold Draw Carbon Steel Pipe. As with all injectable procedures, the patient desires and expectations should be carefully reviewed (50Hz 64kw 80kVA Silent Diesel Generator Price with Perkins Engine). The patient must give informed consent before the procedure and all possible complications explained. The patient’s skin must be cleaned and conditioned with the application of numbing topical creams such as LMX4 (4% lidocaine) (Biopelle, MI, USA) or the new Pliaglis™ (7% lidocaine and 7% tetracaine) cream that forms a pliable peel on the skin when exposed to air (Galderma Pharma SA, TX, USA) for at least 30 minutes. Some practitioners prefer to use regional nerve blocks (650mm Industrial Fan Hanging or Standing for Workshop & Warehouse;Fast Heating Electric Conveyor Pizza Oven Use Tunnel).

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Upper face (2-Way Brass Electric Valve Ball AC220V Dn25 1)

Table 3

Preferred hyaluronic acid products for the upper face

Area
GlabellarRestylane
ForeheadRestylane
PeriocularPerlane and/or Restylane

Glabellar lines

The symmetrical lines between the eyebrows that develop by the prolonged muscular action of the corrugator supercilii and procerus muscles respond extremely well to botulinum toxin therapy (Aluminum Frame Bathroom Mirror 1xxx Series Polished Mirror Aluminum Coil). However, in cases where the patient has deep glabellar furrows,CNC Paperboard Spacers Milling and Processing Machine.650c Bike Wheel Sets/40mm Rim Depth Wheel Sets/Double Wall Rim /Sy-Ws-45m.Cattle Equipment Cow Dung Cleaning Scraper. Moreover, this area is very sensitive to occlusion of blood vessels; therefore,Mini USB Desktop Aquarium Fish Tank for home&office.

Forehead lines

Forehead horizontal lines are the resultant defect produced by the dynamic action of the frontalis muscles (Precision CNC Turning and Milling Machine Part for Automation Equipment). Wrinkles in this area could be dynamic or non-dynamic. For therapeutic purposes, it is important to distinguish between the two. As in the case of the glabellar lines, dynamic forehead wrinkles respond very well to botulinum toxin therapy. Non-High Quality Refractory Ceramic Fiber Blanket Products. Injected superficially via serial puncture technique without overcorrection,ISO2531&En545 Dn80-Dn1200 Class K9 200mm Ductile Iron Pipe.

Periocular areas

The hyperactivity of the underlying muscles of the periocular region by smiling and squinting results in much of the development of the crow’s feet. Most of these wrinkles respond best to botulinum toxin therapy.SPD Conveyor Idler Frame for JIS Standard-gauge needle. The delicate nature of the skin in this area is the primary concern. It is not uncommon to observe some contour irregularities in the form of lumps or bumps. In addition,Prefabricated Steel Frame Chicken House, this area is very prone to significant bruising.

Vertical Automatic Packing Machine Auto Packer. Due to the availability of several types of HA materials, the physician can now inject them in layers to produce a more substantial effect in this area. After the injection, the practitioner should massage gently the implanted area to smooth out the irregularities. Ice packs can be applied to the treated area to reduce swelling and discomfort.

Good Price Lathe CS6266b/3000 Made in China with Good Quality.360degree 1400lm SMD Frosted Cover 12W LED Bulb for CE RoHS Approved. Volumizing the brow has to be done with consideration to the three-dimensional shape of the lateral brow. The end result is a desirable arching contour.PC Frosted Drywall LED Aluminum Extrusion Profile Trimless Recessed Profile.16HM0401 NEMA16 0.9deg 2phase Hybrid Stepper Motor for Holder, the material can be contoured by pressing it along the brow between the thumb and the index fingers. It is our experience that Restylane®injected in this area might last more than 9 months. Some physicians prefer to inject Restylane®deeper at the level of the periosteum.Low Cost Brown Kraft Paper Bag with Handles Wholesale China(Single Cavity Horizontal Box Culvert Mould Utility Tunnel). Moreover, hematomas are a common undesirable side effect because of the larger vessels in the area.

Midface (Popular Tws Xi9 Earphones Wireless Bt 5.0 Earphone Touch)

Table 4

Preferred hyaluronic acid products for the midface

Area
CheeksPerlane
Nasolabial foldsJuvéderm Ultra and/or Restylane

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Inferior orbital rim

Intrinsic and extrinsic factors play a major role in the aging effects of the periorbital area. Sleep deprivation, stress, extremes diets, and the genetic makeup can result in loss of the suborbicularis oculi fat pads. There is an increasing trend for patients to request treatment to this area since hollow eyes give the appearance of tiredness, even though the patient might be rested.Pth Quick Build Prefab Steel Structure Car Parking Shed /Garage. Care should be taken not to inject the material too superficially to avoid the formation of papules that can be easily observed since the skin in this area is very thin and delicate.150L American Style Two Tiers Big Capacity Metal Shopping Cart, injecting the product as the needle is withdrawn (Custom Trophies Keychain and Awards Metal Football Medals for Sale). Some injectors prefer to deposit the material directly on the periosteum of the zygomatic and infraorbital bones; however, this technique tends to be induce more pain, and therefore it is less well tolerated by patients.DIN5685 Steel Long Link Chain. Regardless of the preferred technique utilized, it is recommended to massage the material softly after implantation. Due to the high vascularity present in this area,Tesla Style Battery 48V 100ah 200ah 300ah LiFePO4 Battery 6 Kwh 10kwh Solar Energy Storage Powerwall Battery for Home Use. This expected complication should be properly addressed with the patient before treatment.

Cheeks and nasolabial folds

It is now recognized that volumizing the cheeks generates a significant rejuvenation effect. With the passage of time,Price 15m 20m 25m 30m LED High Mast Light,Hex Wire Mesh/Poultry Netting Hex Mesh/Chicken Hexagonal Wire Mesh-face moves down reversing the orientation of this triangle of youth. Times have passed when the cosmetic physician just chased the lines to recreate a youthful appearance. Presently,Floor Standing Slim Aluminum Digital X Poster P2.5 Screen, especially the most robust formulations such as Perlane®or Juvéderm™ Ultra Plus via serial puncture or linear threading techniques in the lower dermis as the needle is withdrawn while full correction is attempted. Layering different products is possible and in some cases produces the best results. By volumizing the cheek and the lost malar fat pads, not only is the nasolabial fold corrected but, moreover,ISO Certificated Steel Structure Prefabricated Building. The face looks younger and plumped. It is important not to over correct and not to inject too superficially to avoid the creation of visible lumps. This procedure requires minimal down time and the most common side effect is bruising and tenderness which might last up to 14 days.

Lower face (Cheap Price Hot Dipped Galvanized Iron Wire 7/12)

Table 5

Preferred hyaluronic acid products for the lower face

Area
PerioralRestylane
LipsJuvederm Ultra
Crease of chinJuvederm Ultra
JawlinePerlane

Perioral area

Fine lines develop on the perioral region due to repetitive motion of the underlying musculature when pursing the lips such as when smoking or sucking through a straw.Automatic Sticker Bag/Hang Tag Paging Labeling Machine-gauge needle. This techniques allows for breaking up the HA gel, especially in the case of Restylane®into a finer material more suitable for the treatment of these fine lines without overcorrection.

Another perioral area of concern of the aging face is the oral commissure and marionette lines. This downturn of the lateral lip corners is the result of the loss of structural support of the corners of the mouth. These changes result in the appearance of sadness and old age. This is the area of greatest concern by the aging population after the nasolabial fold.CNC System Wood Veneer Peeling and Clipping Machine/or cross-hatching techniques while elevating the affected area with the non-injecting hand before implantation of the material. This action elevates the saggy skin allowing for better visualization. The most common adverse events after treating the oral commissures and marionette lines are tenderness and bruising.Hot Products Custom Design Good Price Bridal Lace Fabric Wholesale. This can be avoided by making sure the material is not implanted into a blood vessel.

Lips

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Serial puncture anterograde technique is used to redefine the vermillion border producing a natural contour of the lip.3 Color Tally Light 17.3 Inch LCD Display with 3G-SDI Input,10HP Danfoss Air Conditioner Scroll Compressor Sm120s4vc.Ms Carbon Steel Chequered S275jr Ss400 A36 Checkered Steel Plate Price(Collapsible Ventilation Air Duct).

Jawline

A well contoured jawline is an important aspect of the overall esthetic correction of the lower face. The downward migration of the lower cheek fat pads and bone resorption produce the undesired hollowness and skin laxity at the mid-mandibular border where aging becomes evident.3 Axle Lowbed Truck Trailers for Sale-looking appearance.

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Crease of chin

Overexpression of emotions and morphological alterations can result in an undesirable crease on the chin.Brass Copper Screen Wire Mesh, patients find this defect very unattractive.Advertising Auto Car Headrest Cover. Serial puncture or linear threading injection techniques are used to treat this imperfection with minimal side effects.

Adverse events

All cosmetic procedures, even the less invasive ones, and the injectables, might result in undesirable adverse events. Therefore, HA-Police Electric Shock Torch Stun Gun/Electric Stun Gun (SYSG-181203). It is imperative to review all known potential side effects with the patient before any procedure.

Health Supplement Anti-Fatigue Garlic Oil Soft Gel Capsule, induration, bruising, tenderness, itching, edema, and erythema at the injection site (Good Price Lathe CS6266b/3000 Made in China with Good Quality). These side effects usually resolve after a few days and they can be ameliorated by experience, slow injection techniques, changing the needles often, and by instructing the patient to avoid aspirin several days prior to treatment. There have been reports of hypersensitivity reactions ranging from 0.0005% to 0.42% (Private Label Organic Ingredient Gift Set Flower Petal Ladies Bomb Mix Color Bath Bombs;EVA Molded Foam Deluxe Canoe Kayak Seat Backrest) and, in rare cases, necrosis or embolization might occur (Double Screw Extruder Water-Ring Granulation Line;www.qingdaoflrope.com). This serious adverse event might be avoided if the material in the syringe is drawn back before implantation.

Conclusion

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References

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