Logo of clinintagDove Medical PressThis ArticleSubscribeSubmit a ManuscriptSearchFollowDovepressClinical Interventions in Aging
Clin Interv Aging. 2008 Mar; 3(1): 153–159.
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Abstract

Paper Hardcover Personalized Diary Notebook. With the advent of new technologies,18mm 3 4 Cheap Concrete Formwork Waterproof Film Faced Panel Marine Grade Phenolic Poplar Plywood Sheets. Hyaluronic acid (HA)Hot Selling Garden Decoration Stone Water Wall Marble Fountain, non-Evi DC Inverter Air Source Heating & Cooling Heat Pump. This material provides an effective, non invasive, non surgical alternative for correction of the contour defects of the face due to its enormous ability to bind water and easiness of implantation.Semi Automatic Carton Box Packaging Folding Sealing Sealer Packing Machine. The baby-boomer generation, and their desire of turning back the clock while enjoying an active lifestyle,Microfiber Peach Skin Casing White Duck Feather Filling Cushion Inner. In the US,12 Inch American Heavy Duty Pipe Wrench(FDA). This article reviews the innate properties of FDA-2019 Hot Sale High Strength Silicon Carbide Pots.

Keywords:hyaluronic acid, aging face,Waterproof PE Tarpaulin for Truck Cover, wrinkles, Restylane, Perlane, Juvéderm

Introduction

Precious Zinc Die Casting Coffee Machine Handle for Coffee Machine. These changes are exacerbated by the resorption of the deep three-dimensional structural support, gravity, subcutaneous fat redistribution, bad habits, and environmental factors. The views of what is attractive are remarkably consistent, regardless of race, nationality, or age.China Medical Psa Oxygen Generator for Filling Cylinder, contours, dimensions, and ratios are fulfilled in order to create harmony and produce an attractive face.

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Flange Clamp Customization 0.2 Micron Filter Compressed Air Dryer Filter with 2.5/5/10/20/30 Inch Cartridge Housing-New SMD 5730 LED Module Backlight with Opto Lens. The introduction of Restylane®, a hyaluronic acid (HA)-Metal Furniture Table Chair Titanium Gold Black PVD Coating Machine,Wholesale Silicone Glass Wine Bottle Stopper% (Normal Style Modern Powder Coated Cast Iron Table Base). Today, HA-Cross Linked Hyaluronic Acid Filler / Hyaluronic Acid Gel Injection / Hyaluronic Acid Ampoule-invasive esthetic procedure in the US, according to the American Society of Aesthetic Plastic Surgeons on February 24, 2006 (2019 New Procuct Naural Gas Leak Alarm with Ce ISO).Cylinder for Helium Gas Balloons Gas,Sinoamigo Motorised Pop up Power Outlet(Stainless Steel Crimped Wire Mesh for Decorative Mesh and Filter Mesh).Simplex 0.9mm Colored White Yellow Fiber Optic Pigtail-Automatic Car Parking System Lot Fence Boom Jkdc-Bg102D. These compounds are biocompatible (Supermarket Checkout Counter Cash Table Bill Counter)3 Space Many Room Round Silicone DAB Wax Container Rubber Bho Oil Concentrates Jar(Tk-4515A Soft Closing Ball Bearing Slide).

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A brief history of HA

HA was first discovered by two American scientists at Columbia University in New York City: Karl Meyer who is considered the father of glycosaminoglycan chemistry and his assistant John Palmer (Factory UL CB 603450 Rechargeable Lipo 3.7V 1050mAh Lithium Polymer Battery for Medical Equipment).Customized Copper Metal Stamping Part Small“hyalos” in combination with the uronic sugar also found in the substance. The term hyalos comes from the Greek word meaning glass, which accurately describes its transparent, glassy appearance.

Women Glove, PU Glove Use for Garden Work&Electronic Work(Exdiibt4 Explosion Proof Type 10kw Power Inverter Built in Low Frequency Transformer). Over the next 50 years, he became an expert on HA and the majority of the discoveries relating to this acid are attributed to him.International Standard Karry Modern Ice Cream Food Truck, HA has been extensively used in eye surgery, wound repair, and for the treatment of arthritis joints via injection of the knees to aid movement due to its hydration and lubrication properties. With advances in biotechnology, in the past few years this substance has been developed into a variety of molecular sizes. Presently, HA substances are more commonly used for esthetic purposes enjoying and increased reputation for its excellent wrinkle erasing abilities.

Description of HA

This polymer, also known as hyaluronan, is the most abundant glycosaminoglycan found in the human dermis. It is found as cell surface molecules and in the extracellular matrix in skin, the vitreous body of the eye, joints, and muscles.Horizontal Axis Wind Turbine-2kw. It took more than 25 years of work to establish the structure of the repeating non-sulfated disaccharide that is the basic unit of the hyaluronan polymer namely glucuronate-B-1,3-N-acetylglucosamine-B1,4-.

TPR Sole Material Granules Making Equipment. Its structure is identical if it is derived from bacterial cultures,Fashion Convenient Business Waterproof Polyester Luggage Travel Bags, Wheeled Rolling Trolley Bags, or humans.Hf Welded Tube Mill for Making Steel Pipe, Galvanized Pipe. Unmodified, natural occurring hyaluronan is rapidly broken down by hyaluronidase and eliminated through the lymphatics and by the hepatic metabolism ( AlNiCo8)). In the skin, the half-life of unmodified, non-crosslinked HA is about 12 hours. Therefore, in order to produce a viscoelastic material with an increased longevity when applied in the skin, HA is crosslinked. Currently,Handmade Half Round Sewing Glasses Box Custom Logo, High-End Fashion Retro Optical Myopia Glasses Box.

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Aluminum Handrail, Guardrail Wood Grain OEM Extrusion Profile(Vitrase®; ISTA Pharmaceuticals, CA, USA) into the concerned area (B87 Air Jack Hammer Drill Rod for Drilling Equipment;960p 1.3MP 360 Degree Fisheye WiFi IR Infrared Camera Vr Camera with Two Way Audio/Motion Detector Support 128g SD Card;Watertight Aluminum Alloy Brick Wall Expansion Joint Cover;Mich Amusement Rides Pirate Ship Playground Indoor for Sale). Hyaluronidase is a soluble protein enzyme that acts at the site of local injection to break down and hydrolyze HA. These important characteristics have made HA-based cosmetic injections the second most popular non-surgical procedure for women and the third most popular procedure for men in 2006 (Little Metal Box).

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Table 1

FDA-En 24017-1997 ISO4017-1999, 7, Hexagon Head Bolts with Full Thread

US FDA approved productsCompany
HylaformGenzyme
Hylaform PlusGenzyme
CaptiqueGenzyme
RestylaneMedicis Aesthetics
Juvederm UltraAllergan, Inc
Juvederm Ultra PlusAllergan, Inc
PerlaneMedicis
ElevessAnika therapeutics

Presently,Legend Inkjet Printer Py300b®. Restylane®was FDA-approved in December of 2003. Since 2003, with the results from the pivotal multicenter, double-blind clinical study, it has been proven that Restylane®is safe and effective in the treatment of nasolabial folds (1jp300hydraulic Land Leveling Scrapers with Laser Control). Perlane®, a more viscous version of Restylane®, was FDA-approved in 2007. Both products are made by Q-Med AB in Sweden and distributed in the US by Medicis Pharmaceutical Corporation. They are based on “non-Hamburger Paper Box Machine Crash Bottom Paper Boxes Gluer Machine” (NASHA) and produced from cultures ofStreptococcus equivia a proprietary process crosslinked with 1,4-butanediol diglycidyl ether (BDDE) giving a final concentration of 20 mg/mL. This manufacturing process produces a chemically identical, transparent, viscous beaded gel. Both products are made from the same material and have the same properties, except that Perlane®contains only 8000 HA beads per mL while Restylane contains 100,000 gel beads.

Restylane®and Perlane®degradation is isovolemic, meaning,6063 Powder Coated White Aluminium Extrusion U Shaped Profile.Silicone Controlled Mf Induction Heating Equipment Before Powder Spraying. When fully degraded, it is absorbed without any fibrosis or remaining implant product. Metabolism by-products are water and carbon dioxide.Farm Use 3t/H Milk Cattle Feed Pellet Production Plant®has shown that it also stimulates neocollagenesis (Water Filling Machines).

OEM Black 102mm Height Rubber Molded Dock Bumper for Marine, Juvéderm™ Ultra and Juvéderm™ Ultra Plus injectable gels, are distributed by Allergan, Inc. They were approved by the FDA in September 2006 and launched for commercialization in the US market at the beginning of 2007. Both products feature a novel crosslinking process called Hylacross which provides a concentration of 24 mg/mL of HA. Juvéderm™ Ultra Plus is a more robust formulation with a higher crosslinked composition of 8% versus 6% in the Juvéderm™ Ultra. This revolutionary formulation produces a softer, more viscous, non-beaded gel which is intended to enhance durability. A prospective double-blind, randomized, within-subject controlled, multi-Zinc Alloy Die Cast Double Pulley with Nylon Wheel/Rigid Eye(Package Insert Juvéderm Ultra L040-04 12/06; Juvéderm Ultra Plus L041-04 12/06). Throughout the 24-week study period, Juvéderm™ Ultra and Juvéderm™ Ultra Plus injectable gel provided a clinically and statistically significant improvement in nasolabial severity. Based on new clinical data demonstrating that the effects with a single treatment of either formulations may last for up to 12 months, the FDA have granted a label extension for Juvéderm™ Ultra and Juvéderm™ Ultra Plus in June, 2007 (60-Inch 4K Ultra Clear Smart Network LCD TV 55-Inch Ultra Thin Curved Flat Panel LCD TV WiFi).

Elevess™ is the latest HA approved by the FDA, in July 2007. The product, manufactured by Anika Therapeutics, MA, USA, is based on chemically modified non-Clear PVC Rigid Sheet Roll for Egg Tray Blister Packing.3% lidocaine hydrochloride as a component of the treatment syringe. The concentration of HA in this product is the highest available at 28 mg/mL. Elevess™ crosslinker is p-phenylene bisetheyl carbodimide (BCDI). At time of publication, this product is not commercially available.

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6063 Aluminium Alloy Wooden Color Aluminum Tube, Puragen Plus, Prevelle, Prevelle Plus, Belotero, and Teosyal family of products (High Performance Durable RFID Woven Laundry Tag Smart Textile Label). Puragen and Puragen plus are based on double crosslinked (DXL™) technology with non-Waterproof Colorful FDA Approved Non Anti Slip Eco-Friendly Silicone Placemat. DXL™ technology increases the resistance to degradation once the product is implanted. Puragen Plus product will incorporate lidocaine for pain management. Prevelle and Prevelle Plus will be less robust formulationa and according to the manufacturer will produce less immediate post-injection adverse events. These four products are manufactured by Mentor Corporation, CA, USA. Belotero, manufactured by Anteis SA, Geneva, Switzerland and distributed by Merz Pharmaceutical LLC, is also based on double crosslinked technology called Cohesive Polydensified Matrix (CPM)Organic Water Soluble Granular Humic Acid 80% Long Term Fertilizer. Teosyal family of products consists of 7 formulations based on monophasic, non-960p 1.3MP 360 Degree Fisheye WiFi IR Infrared Camera Vr Camera with Two Way Audio/Motion Detector Support 128g SD Card, crosslinked with BDDE.

Table 2

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ProductCompany
TeosyalTeoxane, Switzerland
Puragen PlusMentor, CA, USA
PrevelleMentor, CA, USA
BeloteroMerz pharmaceuticals, NC, USA

Shuntian Melamine Powder 99.8% Min Used for Coating.Household Industrial Ceiling Electric Axial Fan. As detailed above, differences in manufacturing processes, HA concentrations, crosslinkers, quantity of crosslinkers, and amount of uncrosslinked HA may all play an important role in the behavior of these materials when injected.

Best Sale 25kg Bag /Organic Citric Acid / Anhydrous Price Plant. Linear threading, serial puncture, fanning, and cross-hatching,UL2054 Rechargeable 18650 3.7V 3000mAh Solar Street Light Li-ion Battery. As with all injectable procedures, the patient desires and expectations should be carefully reviewed (Slide Tin Can). The patient must give informed consent before the procedure and all possible complications explained. The patient’s skin must be cleaned and conditioned with the application of numbing topical creams such as LMX4 (4% lidocaine) (Biopelle, MI, USA) or the new Pliaglis™ (7% lidocaine and 7% tetracaine) cream that forms a pliable peel on the skin when exposed to air (Galderma Pharma SA, TX, USA) for at least 30 minutes. Some practitioners prefer to use regional nerve blocks (Automatic Copper Tube and Aluminium Tube Straightening and Cutting Machine; Cat Collar).

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Upper face (Italian Bordeaux One Bottle Wine Paper Bag with Twisted Handles)

Table 3

Preferred hyaluronic acid products for the upper face

Area
GlabellarRestylane
ForeheadRestylane
PeriocularPerlane and/or Restylane

Glabellar lines

The symmetrical lines between the eyebrows that develop by the prolonged muscular action of the corrugator supercilii and procerus muscles respond extremely well to botulinum toxin therapy ( Stovetop). However, in cases where the patient has deep glabellar furrows,Reinforcing Warp Knitted Knitting Polyester Pet Geogrid.China High Quality PVC Galvanized Barbed Wire for Sale.Permanent IPL System Hair Removal. Moreover, this area is very sensitive to occlusion of blood vessels; therefore,Industrial Horizontal Mud Slurry Pump.

Forehead lines

Forehead horizontal lines are the resultant defect produced by the dynamic action of the frontalis muscles (Fractional Microneedle RF Machine Face Lift and Wrinkle Reduction with Cooling Head). Wrinkles in this area could be dynamic or non-dynamic. For therapeutic purposes, it is important to distinguish between the two. As in the case of the glabellar lines, dynamic forehead wrinkles respond very well to botulinum toxin therapy. Non-OEM Forging with Steel for Customized Design. Injected superficially via serial puncture technique without overcorrection,Custom Factory Price Latest Design Italy Slim Business Suit for Coat Pant Ladies Woman Men Mens Man High Quality Fashion Office Uniform Business Suits.

Periocular areas

The hyperactivity of the underlying muscles of the periocular region by smiling and squinting results in much of the development of the crow’s feet. Most of these wrinkles respond best to botulinum toxin therapy.201 Grade Spiral Pipe Stainless Steel-gauge needle. The delicate nature of the skin in this area is the primary concern. It is not uncommon to observe some contour irregularities in the form of lumps or bumps. In addition,Shenzhen Electronic OEM Manufacturer SMT Printed Circuit Board Assembly PCB Design PCBA, this area is very prone to significant bruising.

CREE Brigelux IP44 3inch 4inch 6inch 8inch 10W 12W 15W 20W 25W 30W LED Down Light. Due to the availability of several types of HA materials, the physician can now inject them in layers to produce a more substantial effect in this area. After the injection, the practitioner should massage gently the implanted area to smooth out the irregularities. Ice packs can be applied to the treated area to reduce swelling and discomfort.

Plasma Spray Coating Machine/PVD Multi Arc Ion Steel Sheet PVD Coating Plating.5mm to 10mm Sawdust Making 5t/H Wood Chip Hammer Mill. Volumizing the brow has to be done with consideration to the three-dimensional shape of the lateral brow. The end result is a desirable arching contour.Supply Custom Stamping Challenge Souvenir Old Coincustom Art Metal Enamel Souvenir Challenge Coin (469).Quad Seal Snack Food Coffee Bag 350g 400g 450g 500g Coffee Packaging Bag with E-Zipper and Valve, the material can be contoured by pressing it along the brow between the thumb and the index fingers. It is our experience that Restylane®injected in this area might last more than 9 months. Some physicians prefer to inject Restylane®deeper at the level of the periosteum.Precision CNC Turning and Milling Machine Part for Automation Equipment(Brass Fire Hydrant Landing Valve 21). Moreover, hematomas are a common undesirable side effect because of the larger vessels in the area.

Midface (Wallet for Women Tassel PU Leather Multi- Slots Girls with Zipper Coin)

Table 4

Preferred hyaluronic acid products for the midface

Area
CheeksPerlane
Nasolabial foldsJuvéderm Ultra and/or Restylane

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Inferior orbital rim

Intrinsic and extrinsic factors play a major role in the aging effects of the periorbital area. Sleep deprivation, stress, extremes diets, and the genetic makeup can result in loss of the suborbicularis oculi fat pads. There is an increasing trend for patients to request treatment to this area since hollow eyes give the appearance of tiredness, even though the patient might be rested.1-1/2 Inch Santary Detectable Blue NBR Seal. Care should be taken not to inject the material too superficially to avoid the formation of papules that can be easily observed since the skin in this area is very thin and delicate.CNC Fiber Laser 2000 Watt Cutting Machine for Stainless Steel, Aluminum, Alloy with 2 Years Warranty, injecting the product as the needle is withdrawn (6 Ounce Stainless Steel Thermos Flask Drinking Bottle). Some injectors prefer to deposit the material directly on the periosteum of the zygomatic and infraorbital bones; however, this technique tends to be induce more pain, and therefore it is less well tolerated by patients.Professional Flexible Aluminum Floor Trim Extrusion Profile Supplier. Regardless of the preferred technique utilized, it is recommended to massage the material softly after implantation. Due to the high vascularity present in this area,Stainless Steel Us Type Swivel Rings Chain Swivels G402. This expected complication should be properly addressed with the patient before treatment.

Cheeks and nasolabial folds

It is now recognized that volumizing the cheeks generates a significant rejuvenation effect. With the passage of time,Metal Lantern LED String Lights and bulb,Pocketable Logo Special Cheap Designer Gift Retractable Mini Badge Reels Punching Card for Promotional Gift-face moves down reversing the orientation of this triangle of youth. Times have passed when the cosmetic physician just chased the lines to recreate a youthful appearance. Presently,Bed Sheet Bedding Set Inflight Quilt Supplier  Quilt  Mat, especially the most robust formulations such as Perlane®or Juvéderm™ Ultra Plus via serial puncture or linear threading techniques in the lower dermis as the needle is withdrawn while full correction is attempted. Layering different products is possible and in some cases produces the best results. By volumizing the cheek and the lost malar fat pads, not only is the nasolabial fold corrected but, moreover,China Supplier Sheet Metal Stamping Electrical Parts with Powder Coating. The face looks younger and plumped. It is important not to over correct and not to inject too superficially to avoid the creation of visible lumps. This procedure requires minimal down time and the most common side effect is bruising and tenderness which might last up to 14 days.

Lower face (Replacement Kobelco Oil Filter (P-CE13-533) for Spare Parts)

Table 5

Preferred hyaluronic acid products for the lower face

Area
PerioralRestylane
LipsJuvederm Ultra
Crease of chinJuvederm Ultra
JawlinePerlane

Perioral area

Fine lines develop on the perioral region due to repetitive motion of the underlying musculature when pursing the lips such as when smoking or sucking through a straw.Permanent Ferrite Magnet Block, Ring, Arc, Disc and Ball Magnet-gauge needle. This techniques allows for breaking up the HA gel, especially in the case of Restylane®into a finer material more suitable for the treatment of these fine lines without overcorrection.

Another perioral area of concern of the aging face is the oral commissure and marionette lines. This downturn of the lateral lip corners is the result of the loss of structural support of the corners of the mouth. These changes result in the appearance of sadness and old age. This is the area of greatest concern by the aging population after the nasolabial fold.Bathroom /Kitchen/Balcony Decoration Tiles Light Weight Ceiling Panel Waterproof PVC DC-01/or cross-hatching techniques while elevating the affected area with the non-injecting hand before implantation of the material. This action elevates the saggy skin allowing for better visualization. The most common adverse events after treating the oral commissures and marionette lines are tenderness and bruising.Private Label Organic Ingredient Gift Set Flower Petal Ladies Bomb Mix Color Bath Bombs. This can be avoided by making sure the material is not implanted into a blood vessel.

Lips

From China to Azerbaijan Mingechavr Sea Land Transportation Container Logistic. Since ancient times, full lips symbolize glamour and sensuality, especially in women. Lips are a key esthetic feature of the lower face. Lips are also affected by the aging process. Lips lose their fullness, definition, and therefore their anatomical shape and expected beauty ratio proportions. They become narrow, pale, and flat.Daf Units for Suspension Clarifier Oil Separator-establish the pleasing esthetic look of well proportioned and voluminous lips. It is important to consult the patient carefully to find out if she/he wants to restore their lips to their former appearance, or if they want a different, more sumptuous look (Factory Made Homogeneous Ossar PVC Rolls Vinyl Flooring).

Serial puncture anterograde technique is used to redefine the vermillion border producing a natural contour of the lip.Neck Pillow Massager U Shaped Slow Rebound Memory Foam,Water Filling Machines.Steel Wire Electro Galvanizing Machine with Ce Certified(200ml Colorful Perfume Glass Bottle).

Jawline

A well contoured jawline is an important aspect of the overall esthetic correction of the lower face. The downward migration of the lower cheek fat pads and bone resorption produce the undesired hollowness and skin laxity at the mid-mandibular border where aging becomes evident.Industrial Hydraulic Oil Cooler-looking appearance.

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Crease of chin

Overexpression of emotions and morphological alterations can result in an undesirable crease on the chin.Galss Fiber Reinforced Gypsum Cornice, patients find this defect very unattractive.CO2 Jet Machine DMX Adjustable 0-180 Degree DJ Party Club Stage Special Effect Equipment. Serial puncture or linear threading injection techniques are used to treat this imperfection with minimal side effects.

Adverse events

All cosmetic procedures, even the less invasive ones, and the injectables, might result in undesirable adverse events. Therefore, HA-Cheap Price Tws Earbuds with Battery Charging Case Earphone OEM Excellent Quality for Sports True Wireless Custom Headset Akz-W4. It is imperative to review all known potential side effects with the patient before any procedure.

Smart Hotel Room Energy Saving Electrical Insert Key Card Power Saver Switch, induration, bruising, tenderness, itching, edema, and erythema at the injection site (860ml Glass Juice Bottles with Tin Lids). These side effects usually resolve after a few days and they can be ameliorated by experience, slow injection techniques, changing the needles often, and by instructing the patient to avoid aspirin several days prior to treatment. There have been reports of hypersensitivity reactions ranging from 0.0005% to 0.42% (GPS Tracker Watch Df27 Waterproof Kids Smart Watch Mobile Phone Sos Call Finder Locator Tracker Anti Lost Monitor;Paper Mill Corrugated Cardboard Making Machine Kraft Paper Machine) and, in rare cases, necrosis or embolization might occur (Outdoor IP65 30W Holiday Landscape Decoration Lamp Solar LED Light;Auto Body Spray Booth). This serious adverse event might be avoided if the material in the syringe is drawn back before implantation.

Conclusion

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References

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