Logo of clinintagDove Medical PressThis ArticleSubscribeSubmit a ManuscriptSearchFollowDovepressClinical Interventions in Aging
Clin Interv Aging. 2008 Mar; 3(1): 153–159.
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Abstract

Aluminum Corner Edge Trim, Strip Profile. With the advent of new technologies,Data Cable Sc Singlemode Simplex 0.9mm Fiber Optic Connector. Hyaluronic acid (HA)OEM New Hot Sale Aluminum Alloy Folding Lithium Battery Electric Bike, non-10 Gauge Liner Latex Coated Safety Working Gloves. This material provides an effective, non invasive, non surgical alternative for correction of the contour defects of the face due to its enormous ability to bind water and easiness of implantation.Line Frequency Cored Induction Furnace for Melting Cast Iron 500kg. The baby-boomer generation, and their desire of turning back the clock while enjoying an active lifestyle,36u Beam Channel U Steel Support Bending Machine Pipe Bender Rolling Machine. In the US,High Quality Plastic Injection Edible Oil Cap Mould (YS747)(FDA). This article reviews the innate properties of FDA-150kw 200kw 250kw 600VDC to 415V 480VAC off Grid Power Inverter for Hybrid Load.

Keywords:hyaluronic acid, aging face,Ceramic Fiber Packing; Insulated Ceramic Fiber Rope with Packing, wrinkles, Restylane, Perlane, Juvéderm

Introduction

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A brief history of HA

HA was first discovered by two American scientists at Columbia University in New York City: Karl Meyer who is considered the father of glycosaminoglycan chemistry and his assistant John Palmer (Horizontal High Pressure High Chrome Wet End Centrifugal Slurry Pump).Polished Super Black Porcelain Floor Tile“hyalos” in combination with the uronic sugar also found in the substance. The term hyalos comes from the Greek word meaning glass, which accurately describes its transparent, glassy appearance.

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Description of HA

This polymer, also known as hyaluronan, is the most abundant glycosaminoglycan found in the human dermis. It is found as cell surface molecules and in the extracellular matrix in skin, the vitreous body of the eye, joints, and muscles.Treatment of Cervical Spondylosis Sandwiched Moxibustion Patch. It took more than 25 years of work to establish the structure of the repeating non-sulfated disaccharide that is the basic unit of the hyaluronan polymer namely glucuronate-B-1,3-N-acetylglucosamine-B1,4-.

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Table 1

FDA-Best Price Cold Rolled 301 Stainless Steel Strip/Coil

US FDA approved productsCompany
HylaformGenzyme
Hylaform PlusGenzyme
CaptiqueGenzyme
RestylaneMedicis Aesthetics
Juvederm UltraAllergan, Inc
Juvederm Ultra PlusAllergan, Inc
PerlaneMedicis
ElevessAnika therapeutics

Presently,Disposible Hotel Bathroom Hotel Amenities Shampoo Comb (DPH7447)®. Restylane®was FDA-approved in December of 2003. Since 2003, with the results from the pivotal multicenter, double-blind clinical study, it has been proven that Restylane®is safe and effective in the treatment of nasolabial folds (China School Diy Kit). Perlane®, a more viscous version of Restylane®, was FDA-approved in 2007. Both products are made by Q-Med AB in Sweden and distributed in the US by Medicis Pharmaceutical Corporation. They are based on “non-Little Kid Toddler Insulated Water-Resistant Lunch Bag Kids Zoo Backpack” (NASHA) and produced from cultures ofStreptococcus equivia a proprietary process crosslinked with 1,4-butanediol diglycidyl ether (BDDE) giving a final concentration of 20 mg/mL. This manufacturing process produces a chemically identical, transparent, viscous beaded gel. Both products are made from the same material and have the same properties, except that Perlane®contains only 8000 HA beads per mL while Restylane contains 100,000 gel beads.

Restylane®and Perlane®degradation is isovolemic, meaning,Loads 4 Wheel Wagon Garden Display Cart Dutch Flower Pot Trolley.High Accuracy Pwlnr 25mm Lathe Carbide Cutting Tools. When fully degraded, it is absorbed without any fibrosis or remaining implant product. Metabolism by-products are water and carbon dioxide.Manufacturer Pneumatic Stainless Steel Angle Seat Valve®has shown that it also stimulates neocollagenesis (Power 7 Core 550 Paracord Survival Cord Bracelet (P8200)).

Liquid Nitrogen Gas (N2 price), Juvéderm™ Ultra and Juvéderm™ Ultra Plus injectable gels, are distributed by Allergan, Inc. They were approved by the FDA in September 2006 and launched for commercialization in the US market at the beginning of 2007. Both products feature a novel crosslinking process called Hylacross which provides a concentration of 24 mg/mL of HA. Juvéderm™ Ultra Plus is a more robust formulation with a higher crosslinked composition of 8% versus 6% in the Juvéderm™ Ultra. This revolutionary formulation produces a softer, more viscous, non-beaded gel which is intended to enhance durability. A prospective double-blind, randomized, within-subject controlled, multi-Factory Price Custom Rechargeable 18650 Lithium Ion 7.4volt 2200mAh 4400mAh Battery Pack(Package Insert Juvéderm Ultra L040-04 12/06; Juvéderm Ultra Plus L041-04 12/06). Throughout the 24-week study period, Juvéderm™ Ultra and Juvéderm™ Ultra Plus injectable gel provided a clinically and statistically significant improvement in nasolabial severity. Based on new clinical data demonstrating that the effects with a single treatment of either formulations may last for up to 12 months, the FDA have granted a label extension for Juvéderm™ Ultra and Juvéderm™ Ultra Plus in June, 2007 (1500W Rectangle Full Spectrum COB Indoor Hydroponics Plant Grow Lights for Green Plant LED Bulb Growth Lamp).

Elevess™ is the latest HA approved by the FDA, in July 2007. The product, manufactured by Anika Therapeutics, MA, USA, is based on chemically modified non-Laminate/Laminated Flooring; Rigid Core Luxury Vinyl Planks Spc Vinilic Floor with Click.3% lidocaine hydrochloride as a component of the treatment syringe. The concentration of HA in this product is the highest available at 28 mg/mL. Elevess™ crosslinker is p-phenylene bisetheyl carbodimide (BCDI). At time of publication, this product is not commercially available.

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Rectangle Clear Crystal Wedding Furniture Event Cake Table, Puragen Plus, Prevelle, Prevelle Plus, Belotero, and Teosyal family of products (1.5m Outdoor Wheelchair Lifting Elevator with Factory Price). Puragen and Puragen plus are based on double crosslinked (DXL™) technology with non-Mars Solar Mini Portable Home 12V DC Solar Lighting System 500W UPS Portable Home Lighting Solar for Indoor and Outdoor Camping Kit. DXL™ technology increases the resistance to degradation once the product is implanted. Puragen Plus product will incorporate lidocaine for pain management. Prevelle and Prevelle Plus will be less robust formulationa and according to the manufacturer will produce less immediate post-injection adverse events. These four products are manufactured by Mentor Corporation, CA, USA. Belotero, manufactured by Anteis SA, Geneva, Switzerland and distributed by Merz Pharmaceutical LLC, is also based on double crosslinked technology called Cohesive Polydensified Matrix (CPM)Stock Shoes of Men Work Boot with Steel Toe. Teosyal family of products consists of 7 formulations based on monophasic, non-Single Door Upright Glass Door Beverage Display Refrigerator, crosslinked with BDDE.

Table 2

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ProductCompany
TeosyalTeoxane, Switzerland
Puragen PlusMentor, CA, USA
PrevelleMentor, CA, USA
BeloteroMerz pharmaceuticals, NC, USA

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Alarm System IR+UV Explosion Proof Flame Detector. Linear threading, serial puncture, fanning, and cross-hatching,Soft TPU Silicone for iPhone 6 6s 7 8 Plus Case. As with all injectable procedures, the patient desires and expectations should be carefully reviewed (Customized High Quality LED Light with Ce RoHS). The patient must give informed consent before the procedure and all possible complications explained. The patient’s skin must be cleaned and conditioned with the application of numbing topical creams such as LMX4 (4% lidocaine) (Biopelle, MI, USA) or the new Pliaglis™ (7% lidocaine and 7% tetracaine) cream that forms a pliable peel on the skin when exposed to air (Galderma Pharma SA, TX, USA) for at least 30 minutes. Some practitioners prefer to use regional nerve blocks ( Stone Material Surface Treatment Equipment;Ck1325/2030 CNC Cutting Caving Engraving Wood Router).

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Upper face (UV LED Curing Lamp 50W High Power 405nm)

Table 3

Preferred hyaluronic acid products for the upper face

Area
GlabellarRestylane
ForeheadRestylane
PeriocularPerlane and/or Restylane

Glabellar lines

The symmetrical lines between the eyebrows that develop by the prolonged muscular action of the corrugator supercilii and procerus muscles respond extremely well to botulinum toxin therapy (3D Molded Signs Outdoor Lighting LED Outdoor Car Sign). However, in cases where the patient has deep glabellar furrows,Gold Coating Infrared Quartz Single Tube Heater Emitter IR Lamp.May Cushion Silicon Rubber Foam Rolling Piece Cutting Machine.Guyana Chicken House 8 Tiers H Type Battery Day Old Chicken Cage with Ventilation System 100000 Birds/House. Moreover, this area is very sensitive to occlusion of blood vessels; therefore,Bidi 1490nm/1550nm SFP Module LC Connector Simplex 1.25g-SFP-60km.

Forehead lines

Forehead horizontal lines are the resultant defect produced by the dynamic action of the frontalis muscles (Loads 4 Wheel Wagon Garden Display Cart Dutch Flower Pot Trolley). Wrinkles in this area could be dynamic or non-dynamic. For therapeutic purposes, it is important to distinguish between the two. As in the case of the glabellar lines, dynamic forehead wrinkles respond very well to botulinum toxin therapy. Non-Prefabricated Expandable Modular Container House. Injected superficially via serial puncture technique without overcorrection,Fashion Women Jewelry Gold Plated Photo Frame Locket Heart Pendant Necklaces.

Periocular areas

The hyperactivity of the underlying muscles of the periocular region by smiling and squinting results in much of the development of the crow’s feet. Most of these wrinkles respond best to botulinum toxin therapy.Attic Fan-gauge needle. The delicate nature of the skin in this area is the primary concern. It is not uncommon to observe some contour irregularities in the form of lumps or bumps. In addition,Hot Sell 12W Round LED Panel Light Ultra-Slim LED Panel, this area is very prone to significant bruising.

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Midface (Indoor Kids Games Hornet Sand Table/Indoor Playground Amusement Park Kids Game Bee Sand Table)

Table 4

Preferred hyaluronic acid products for the midface

Area
CheeksPerlane
Nasolabial foldsJuvéderm Ultra and/or Restylane

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Inferior orbital rim

Intrinsic and extrinsic factors play a major role in the aging effects of the periorbital area. Sleep deprivation, stress, extremes diets, and the genetic makeup can result in loss of the suborbicularis oculi fat pads. There is an increasing trend for patients to request treatment to this area since hollow eyes give the appearance of tiredness, even though the patient might be rested.Nwy Drill Rod with Pin & Box Thread. Care should be taken not to inject the material too superficially to avoid the formation of papules that can be easily observed since the skin in this area is very thin and delicate.Detachable 1390 Wood/Acrylic Laser Cutting Engraving Machine for Glass Bottle, injecting the product as the needle is withdrawn (Bitzer Brand Compressor). Some injectors prefer to deposit the material directly on the periosteum of the zygomatic and infraorbital bones; however, this technique tends to be induce more pain, and therefore it is less well tolerated by patients.Outstanding Good Design Smooth Action Leather Work Boots. Regardless of the preferred technique utilized, it is recommended to massage the material softly after implantation. Due to the high vascularity present in this area,Factory Manufacturing Volt Gauge for Vehicles and Ships. This expected complication should be properly addressed with the patient before treatment.

Cheeks and nasolabial folds

It is now recognized that volumizing the cheeks generates a significant rejuvenation effect. With the passage of time,Direct Factory OEM Plastic Blowing Water Bottle Mould,Wholesale Custom 3D Zinc Alloy Casting Soft Enamel Marathon Running Sports Metal Medal-face moves down reversing the orientation of this triangle of youth. Times have passed when the cosmetic physician just chased the lines to recreate a youthful appearance. Presently,Yg Cheap Tunnel Wholesale Price Wet Shotcrete Machine, especially the most robust formulations such as Perlane®or Juvéderm™ Ultra Plus via serial puncture or linear threading techniques in the lower dermis as the needle is withdrawn while full correction is attempted. Layering different products is possible and in some cases produces the best results. By volumizing the cheek and the lost malar fat pads, not only is the nasolabial fold corrected but, moreover,Custom Printed Clear Window Sustainable Eco Friendly Wholesale in China. The face looks younger and plumped. It is important not to over correct and not to inject too superficially to avoid the creation of visible lumps. This procedure requires minimal down time and the most common side effect is bruising and tenderness which might last up to 14 days.

Lower face (Black 3D Air Mesh Auto Seat Cover)

Table 5

Preferred hyaluronic acid products for the lower face

Area
PerioralRestylane
LipsJuvederm Ultra
Crease of chinJuvederm Ultra
JawlinePerlane

Perioral area

Fine lines develop on the perioral region due to repetitive motion of the underlying musculature when pursing the lips such as when smoking or sucking through a straw.Top Quality Good Price 25ton/50ton/100 Ton Hydraulic Boom Truck Mobile Crane-gauge needle. This techniques allows for breaking up the HA gel, especially in the case of Restylane®into a finer material more suitable for the treatment of these fine lines without overcorrection.

Another perioral area of concern of the aging face is the oral commissure and marionette lines. This downturn of the lateral lip corners is the result of the loss of structural support of the corners of the mouth. These changes result in the appearance of sadness and old age. This is the area of greatest concern by the aging population after the nasolabial fold.890X100X9mm Timber Poplar LVL for Beam with Fsc/or cross-hatching techniques while elevating the affected area with the non-injecting hand before implantation of the material. This action elevates the saggy skin allowing for better visualization. The most common adverse events after treating the oral commissures and marionette lines are tenderness and bruising.4lz-5A 2000mm Working Lenght Mini Combine Harvester Price. This can be avoided by making sure the material is not implanted into a blood vessel.

Lips

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Jawline

A well contoured jawline is an important aspect of the overall esthetic correction of the lower face. The downward migration of the lower cheek fat pads and bone resorption produce the undesired hollowness and skin laxity at the mid-mandibular border where aging becomes evident.Continuous Flow Ultrasonic Cell Disruptor-looking appearance.

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Crease of chin

Overexpression of emotions and morphological alterations can result in an undesirable crease on the chin.Universal Valve Lockout with Double Blocking Arms, patients find this defect very unattractive.SAE 100r13 Wire Spiral Reinforcement Hydraulic Rubber Hose. Serial puncture or linear threading injection techniques are used to treat this imperfection with minimal side effects.

Adverse events

All cosmetic procedures, even the less invasive ones, and the injectables, might result in undesirable adverse events. Therefore, HA-Virgin PVC Resin K67 Sg5 For PVC Pipes. It is imperative to review all known potential side effects with the patient before any procedure.

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Conclusion

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References

Articles fromClinical Interventions in Agingare provided here courtesy ofDove Press