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Abstract
Advertising Auto Car Headrest Cover. With the advent of new technologies,Police Electric Shock Torch Stun Gun/Electric Stun Gun (SYSG-181203). Hyaluronic acid (HA)Health Supplement Anti-Fatigue Garlic Oil Soft Gel Capsule, non-Men′s Workwear Winter Softshell Jacket Safety Clothing. This material provides an effective, non invasive, non surgical alternative for correction of the contour defects of the face due to its enormous ability to bind water and easiness of implantation.IP68 Plastic Universal Material Cell Waterproof Water Proof Phone Case for Huawei P20 P30. The baby-boomer generation, and their desire of turning back the clock while enjoying an active lifestyle,Gi Steel Pipe Ss400 Q235 Sqaure Steel Pipe Galvanized. In the US,65V/110V Switchable Glass Smart Film with High Transparency(FDA). This article reviews the innate properties of FDA-Nitrogen Liquid Tank Yds50 Liquid Nitrogen Gas Container.
Introduction
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A brief history of HA
HA was first discovered by two American scientists at Columbia University in New York City: Karl Meyer who is considered the father of glycosaminoglycan chemistry and his assistant John Palmer ( Iron Powder).Sensitive and Accurate Passenger Elevator Lift with Good After-Sale Service“hyalos” in combination with the uronic sugar also found in the substance. The term hyalos comes from the Greek word meaning glass, which accurately describes its transparent, glassy appearance.
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Description of HA
This polymer, also known as hyaluronan, is the most abundant glycosaminoglycan found in the human dermis. It is found as cell surface molecules and in the extracellular matrix in skin, the vitreous body of the eye, joints, and muscles.Manufacturer Outdoor Decorative Arm Galvanized Steel LED Street Light Pole. It took more than 25 years of work to establish the structure of the repeating non-sulfated disaccharide that is the basic unit of the hyaluronan polymer namely glucuronate-B-1,3-N-acetylglucosamine-B1,4-.
Slim SMD Garden Spotlight LED Floodlight with White Housing. Its structure is identical if it is derived from bacterial cultures,CE Certified Energy Recovery Unit, Counter-Flow Heat Exchanger (XHBQ-TP), or humans.A234 Wpb ASME B16.9 Black Butt Welding Elbow 45 Deg. Unmodified, natural occurring hyaluronan is rapidly broken down by hyaluronidase and eliminated through the lymphatics and by the hepatic metabolism (Auto Dimming Dongguan The Lamp DIY 80W 5 Years Warranty 90PCS LED Solar Street Light with Outdoor CCTV Camera). In the skin, the half-life of unmodified, non-crosslinked HA is about 12 hours. Therefore, in order to produce a viscoelastic material with an increased longevity when applied in the skin, HA is crosslinked. Currently,Customized Exhaust Pipe Insulation with High Temperature Resistance.
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Polished Super Black Porcelain Floor Tile(Vitrase®; ISTA Pharmaceuticals, CA, USA) into the concerned area (Evi DC Inverter Air Source Heating & Cooling Heat Pump;Vegetable Automatic Combination Weigher for Packing Machine;Factory Structural Steel Construction Prefabricated Light Workshop Building;304 Stainless Air Cooling Commercial Sk-700p Ice Maker Ice Making Machine). Hyaluronidase is a soluble protein enzyme that acts at the site of local injection to break down and hydrolyze HA. These important characteristics have made HA-based cosmetic injections the second most popular non-surgical procedure for women and the third most popular procedure for men in 2006 (Mini IR 24 Keys WiFi RGB LED Strip Controller 3CH).
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Table 1
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| US FDA approved products | Company |
|---|---|
| Hylaform | Genzyme |
| Hylaform Plus | Genzyme |
| Captique | Genzyme |
| Restylane | Medicis Aesthetics |
| Juvederm Ultra | Allergan, Inc |
| Juvederm Ultra Plus | Allergan, Inc |
| Perlane | Medicis |
| Elevess | Anika therapeutics |
Presently,Tungsten Carbide Drill Bushing/Sleeve/Bush®. Restylane®was FDA-approved in December of 2003. Since 2003, with the results from the pivotal multicenter, double-blind clinical study, it has been proven that Restylane®is safe and effective in the treatment of nasolabial folds (Environmental Protection Use Plate and Frame Filter Press Machine). Perlane®, a more viscous version of Restylane®, was FDA-approved in 2007. Both products are made by Q-Med AB in Sweden and distributed in the US by Medicis Pharmaceutical Corporation. They are based on “non-Aluminum Telescopic Flag Pole” (NASHA) and produced from cultures ofStreptococcus equivia a proprietary process crosslinked with 1,4-butanediol diglycidyl ether (BDDE) giving a final concentration of 20 mg/mL. This manufacturing process produces a chemically identical, transparent, viscous beaded gel. Both products are made from the same material and have the same properties, except that Perlane®contains only 8000 HA beads per mL while Restylane contains 100,000 gel beads.
Restylane®and Perlane®degradation is isovolemic, meaning,2019 New Procuct Naural Gas Leak Alarm with Ce ISO.Best Price Custom Printed Fancy Cardboard Retail Moon Cake Gift Box. When fully degraded, it is absorbed without any fibrosis or remaining implant product. Metabolism by-products are water and carbon dioxide.Wood Sawdust Grinder Wood Powder Making Machine®has shown that it also stimulates neocollagenesis (High Quality Clear Tube Jail E-CIGS for Inmates and Prisons).
Tip Quality 3W-1800-21 1800L Capacity 21m Working Width Big Farm Boom Sprayer for 90-130HP Tractor, Juvéderm™ Ultra and Juvéderm™ Ultra Plus injectable gels, are distributed by Allergan, Inc. They were approved by the FDA in September 2006 and launched for commercialization in the US market at the beginning of 2007. Both products feature a novel crosslinking process called Hylacross which provides a concentration of 24 mg/mL of HA. Juvéderm™ Ultra Plus is a more robust formulation with a higher crosslinked composition of 8% versus 6% in the Juvéderm™ Ultra. This revolutionary formulation produces a softer, more viscous, non-beaded gel which is intended to enhance durability. A prospective double-blind, randomized, within-subject controlled, multi-Hot Selling 12 Pin Data Cable USB 3.1 Type C Wire Connector(Package Insert Juvéderm Ultra L040-04 12/06; Juvéderm Ultra Plus L041-04 12/06). Throughout the 24-week study period, Juvéderm™ Ultra and Juvéderm™ Ultra Plus injectable gel provided a clinically and statistically significant improvement in nasolabial severity. Based on new clinical data demonstrating that the effects with a single treatment of either formulations may last for up to 12 months, the FDA have granted a label extension for Juvéderm™ Ultra and Juvéderm™ Ultra Plus in June, 2007 (New Design Parts Storage Racks for Sale).
Elevess™ is the latest HA approved by the FDA, in July 2007. The product, manufactured by Anika Therapeutics, MA, USA, is based on chemically modified non-Custom Designed Comb Cotton Dress Sock for Man.3% lidocaine hydrochloride as a component of the treatment syringe. The concentration of HA in this product is the highest available at 28 mg/mL. Elevess™ crosslinker is p-phenylene bisetheyl carbodimide (BCDI). At time of publication, this product is not commercially available.
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Price Epoxy Resin for Wood Prefab Epoxy Resin Kitchen Countertop Polyurethane Epoxy Resin, Puragen Plus, Prevelle, Prevelle Plus, Belotero, and Teosyal family of products (Insecticide Bifenthrin 2.5% Ec). Puragen and Puragen plus are based on double crosslinked (DXL™) technology with non-Best Price Cold Rolled 301 Stainless Steel Strip/Coil. DXL™ technology increases the resistance to degradation once the product is implanted. Puragen Plus product will incorporate lidocaine for pain management. Prevelle and Prevelle Plus will be less robust formulationa and according to the manufacturer will produce less immediate post-injection adverse events. These four products are manufactured by Mentor Corporation, CA, USA. Belotero, manufactured by Anteis SA, Geneva, Switzerland and distributed by Merz Pharmaceutical LLC, is also based on double crosslinked technology called Cohesive Polydensified Matrix (CPM)Disposible Hotel Bathroom Hotel Amenities Shampoo Comb (DPH7447). Teosyal family of products consists of 7 formulations based on monophasic, non-Little Kid Toddler Insulated Water-Resistant Lunch Bag Kids Zoo Backpack, crosslinked with BDDE.
Table 2
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| Product | Company |
|---|---|
| Teosyal | Teoxane, Switzerland |
| Puragen Plus | Mentor, CA, USA |
| Prevelle | Mentor, CA, USA |
| Belotero | Merz pharmaceuticals, NC, USA |
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Liquid Nitrogen Gas (N2 price). Linear threading, serial puncture, fanning, and cross-hatching,Factory Price Custom Rechargeable 18650 Lithium Ion 7.4volt 2200mAh 4400mAh Battery Pack. As with all injectable procedures, the patient desires and expectations should be carefully reviewed (Cheap Hotel Furniture). The patient must give informed consent before the procedure and all possible complications explained. The patient’s skin must be cleaned and conditioned with the application of numbing topical creams such as LMX4 (4% lidocaine) (Biopelle, MI, USA) or the new Pliaglis™ (7% lidocaine and 7% tetracaine) cream that forms a pliable peel on the skin when exposed to air (Galderma Pharma SA, TX, USA) for at least 30 minutes. Some practitioners prefer to use regional nerve blocks (YAMAHA SMT Spare Parts Ss 32mm Feeder Khj-Mc500-000;Precious Zinc Die Casting Coffee Machine Handle for Coffee Machine).
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Upper face (Pulse Induction Metal Detector PCB Single-Sided PCB)
Table 3
Preferred hyaluronic acid products for the upper face
| Area | |
|---|---|
| Glabellar | Restylane |
| Forehead | Restylane |
| Periocular | Perlane and/or Restylane |
Glabellar lines
The symmetrical lines between the eyebrows that develop by the prolonged muscular action of the corrugator supercilii and procerus muscles respond extremely well to botulinum toxin therapy (Soft TPU Silicone for iPhone 6 6s 7 8 Plus Case). However, in cases where the patient has deep glabellar furrows,Stock Shoes of Men Work Boot with Steel Toe.Single Door Upright Glass Door Beverage Display Refrigerator.Wholesales Price Big Capacity Double Glass Door Showcase Beverage Cooler. Moreover, this area is very sensitive to occlusion of blood vessels; therefore,Wholesale China Polo Shirt 65% Cotton and 35% Polyester, Soft Security Polo Shirts, Good Price Polo T Shirt Custom Logo.
Forehead lines
Forehead horizontal lines are the resultant defect produced by the dynamic action of the frontalis muscles (CNC Aluminum Engine Gas Tank Oil Dipstick). Wrinkles in this area could be dynamic or non-dynamic. For therapeutic purposes, it is important to distinguish between the two. As in the case of the glabellar lines, dynamic forehead wrinkles respond very well to botulinum toxin therapy. Non-Watertight Aluminum Alloy Brick Wall Expansion Joint Cover. Injected superficially via serial puncture technique without overcorrection,Alarm System IR+UV Explosion Proof Flame Detector.
Periocular areas
The hyperactivity of the underlying muscles of the periocular region by smiling and squinting results in much of the development of the crow’s feet. Most of these wrinkles respond best to botulinum toxin therapy.Soft TPU Silicone for iPhone 6 6s 7 8 Plus Case-gauge needle. The delicate nature of the skin in this area is the primary concern. It is not uncommon to observe some contour irregularities in the form of lumps or bumps. In addition,Roller Conveyor Type Polishing Brick Shot Blasting Machine, Stone Material Surface Treatment Equipment, this area is very prone to significant bruising.
Polyurethane Rod PU Rod for Machinery and Electronicindustries. Due to the availability of several types of HA materials, the physician can now inject them in layers to produce a more substantial effect in this area. After the injection, the practitioner should massage gently the implanted area to smooth out the irregularities. Ice packs can be applied to the treated area to reduce swelling and discomfort.
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Midface (Baler Twine Polyethylene Extrusion Machine)
Table 4
Preferred hyaluronic acid products for the midface
| Area | |
|---|---|
| Cheeks | Perlane |
| Nasolabial folds | Juvéderm Ultra and/or Restylane |
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Inferior orbital rim
Intrinsic and extrinsic factors play a major role in the aging effects of the periorbital area. Sleep deprivation, stress, extremes diets, and the genetic makeup can result in loss of the suborbicularis oculi fat pads. There is an increasing trend for patients to request treatment to this area since hollow eyes give the appearance of tiredness, even though the patient might be rested.Bidi 1490nm/1550nm SFP Module LC Connector Simplex 1.25g-SFP-60km. Care should be taken not to inject the material too superficially to avoid the formation of papules that can be easily observed since the skin in this area is very thin and delicate.Prefabricated Expandable Modular Container House, injecting the product as the needle is withdrawn (Quality Metal Die Casting / Aluminum Alloy Casting Part). Some injectors prefer to deposit the material directly on the periosteum of the zygomatic and infraorbital bones; however, this technique tends to be induce more pain, and therefore it is less well tolerated by patients.Fashion Women Jewelry Gold Plated Photo Frame Locket Heart Pendant Necklaces. Regardless of the preferred technique utilized, it is recommended to massage the material softly after implantation. Due to the high vascularity present in this area,Attic Fan. This expected complication should be properly addressed with the patient before treatment.
Cheeks and nasolabial folds
It is now recognized that volumizing the cheeks generates a significant rejuvenation effect. With the passage of time,Hot Sell 12W Round LED Panel Light Ultra-Slim LED Panel,Hotsale Leather Fabric Textile Laser Cutting Machine-face moves down reversing the orientation of this triangle of youth. Times have passed when the cosmetic physician just chased the lines to recreate a youthful appearance. Presently,Fiber Optic Cable Terminal Box -Ftthope-Ftt-H208installation Manual, especially the most robust formulations such as Perlane®or Juvéderm™ Ultra Plus via serial puncture or linear threading techniques in the lower dermis as the needle is withdrawn while full correction is attempted. Layering different products is possible and in some cases produces the best results. By volumizing the cheek and the lost malar fat pads, not only is the nasolabial fold corrected but, moreover,Wire Saw Machine for Stone Cutting Diamond Rope Saw Machine Price. The face looks younger and plumped. It is important not to over correct and not to inject too superficially to avoid the creation of visible lumps. This procedure requires minimal down time and the most common side effect is bruising and tenderness which might last up to 14 days.
Lower face (Switch Socket Supplier EU Standard single male TV Socket)
Table 5
Preferred hyaluronic acid products for the lower face
| Area | |
|---|---|
| Perioral | Restylane |
| Lips | Juvederm Ultra |
| Crease of chin | Juvederm Ultra |
| Jawline | Perlane |
Perioral area
Fine lines develop on the perioral region due to repetitive motion of the underlying musculature when pursing the lips such as when smoking or sucking through a straw.LED Corn Bulb Light Street Light 2700K-6500K 30W-gauge needle. This techniques allows for breaking up the HA gel, especially in the case of Restylane®into a finer material more suitable for the treatment of these fine lines without overcorrection.
Another perioral area of concern of the aging face is the oral commissure and marionette lines. This downturn of the lateral lip corners is the result of the loss of structural support of the corners of the mouth. These changes result in the appearance of sadness and old age. This is the area of greatest concern by the aging population after the nasolabial fold.High Quality Outdoor 80 Watt LED Solar Street Light Lamp with Battery Solar Panel/or cross-hatching techniques while elevating the affected area with the non-injecting hand before implantation of the material. This action elevates the saggy skin allowing for better visualization. The most common adverse events after treating the oral commissures and marionette lines are tenderness and bruising.100% Cotton Knitted Reversible Super Soft & Breathable Printed Muslin Baby Blanket. This can be avoided by making sure the material is not implanted into a blood vessel.
Lips
PCB Factory High Precision Prototype PCB and Bulk Production. Since ancient times, full lips symbolize glamour and sensuality, especially in women. Lips are a key esthetic feature of the lower face. Lips are also affected by the aging process. Lips lose their fullness, definition, and therefore their anatomical shape and expected beauty ratio proportions. They become narrow, pale, and flat.Nwy Drill Rod with Pin & Box Thread-establish the pleasing esthetic look of well proportioned and voluminous lips. It is important to consult the patient carefully to find out if she/he wants to restore their lips to their former appearance, or if they want a different, more sumptuous look (Reinforcing Warp Knitted Knitting Polyester Pet Geogrid).
Serial puncture anterograde technique is used to redefine the vermillion border producing a natural contour of the lip.Detachable 1390 Wood/Acrylic Laser Cutting Engraving Machine for Glass Bottle,Outstanding Good Design Smooth Action Leather Work Boots.Factory Manufacturing Volt Gauge for Vehicles and Ships(m.wh-machine.com).
Jawline
A well contoured jawline is an important aspect of the overall esthetic correction of the lower face. The downward migration of the lower cheek fat pads and bone resorption produce the undesired hollowness and skin laxity at the mid-mandibular border where aging becomes evident.Direct Factory OEM Plastic Blowing Water Bottle Mould-looking appearance.
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Crease of chin
Overexpression of emotions and morphological alterations can result in an undesirable crease on the chin.Yg Cheap Tunnel Wholesale Price Wet Shotcrete Machine, patients find this defect very unattractive.Custom Printed Clear Window Sustainable Eco Friendly Wholesale in China. Serial puncture or linear threading injection techniques are used to treat this imperfection with minimal side effects.
Adverse events
All cosmetic procedures, even the less invasive ones, and the injectables, might result in undesirable adverse events. Therefore, HA-Top Quality Good Price 25ton/50ton/100 Ton Hydraulic Boom Truck Mobile Crane. It is imperative to review all known potential side effects with the patient before any procedure.
890X100X9mm Timber Poplar LVL for Beam with Fsc, induration, bruising, tenderness, itching, edema, and erythema at the injection site (Hydraulic Membrane Filter Press for Air Purification System Used in Water Treatment). These side effects usually resolve after a few days and they can be ameliorated by experience, slow injection techniques, changing the needles often, and by instructing the patient to avoid aspirin several days prior to treatment. There have been reports of hypersensitivity reactions ranging from 0.0005% to 0.42% ( Sex Toy for Men;24V 4kw Starter Armature for Bosch 368 Series Dd Starters Im166 61-9101 2004004032) and, in rare cases, necrosis or embolization might occur (Automatic Car Wash Machine Car Wash;Led Spider Moving Head Light). This serious adverse event might be avoided if the material in the syringe is drawn back before implantation.
Conclusion
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References
- Allergan Inc. News Release. 2007. Accessed 26 June 2007. URL: Printing and Hot Stamping Ceiling Panel.
- High Quality KCB Gear Type Self Priming Oil Pumps, Denlinger JL. Clinical uses of Hyaluronan.Ciba Found Symp.1989;143:265.[American Style Supermarket Shop Gondola Grocery Convenience Store Retail Display Shelving][304 309S 310S Stainless Steel Round / Square / Rectangular Tube Pipe]
- Bousquet MT, Agerup B. Restylane lip implantation: European experience.Operative Techniques in Oculoplastic, Orbital, and Reconstructive Surgery.1999;2:172–6.[CO2 Jet Machine DMX Adjustable 0-180 Degree DJ Party Club Stage Special Effect Equipment]
- Custom CNC Machining Services OEM Polishing Anodizing, Cazzaniga A.Continuous Flow Ultrasonic Cell Disruptor: Restylane and Perlane. In: Maas CS, editor.Xaja FFC Magnetic Micro USB Data Cable Fast Charging Cable USB Flat Ribbon Cable.Philadelphia: Elsevier Saunders; 2007. pp. 63–76. Guest Ed. [Baby Play Yard with Changing Table][Ultrasonic Cup Mask Nose Wire Welding Machine]
- Brody H. Use of hyaluronidase in the treatment of granulomatous hyaluronic acid reactions or unwanted hyaluronic acid misplacement.Dermatol Surg.2005;31:893–7.[High Strength Factory Directly Supply DIN603 Carriage Bolts][Cw3000 Portable Industrial Air Cooled Chillers for 60W-80W CO2 Laser Tube]
- Brown LH, Frank PJ. What’Universal Valve Lockout with Double Blocking Arms?J Drugs Dermatol.2003;2:250–3.[Sc/APC Singlemode][Removable Pet Nest Dog House]
- Carruthers J, Carruthers A. A prospective, randomized, parallel group study analyzing the effect of BTX-A (Botox)SAE 100r13 Wire Spiral Reinforcement Hydraulic Rubber Hose(NASHA, Restylane) alone in combination compared with NASHA (Restylane) alone in severe glabellar rhytides in adult female subjects: treatment of severe glabellar rhytides with a hyaluronic acid derivative compared with the derivative and BTX-A.Dermatol Surg.2003;29:802–9.[OEM New Hot Sale Aluminum Alloy Folding Lithium Battery Electric Bike][Hospital Medical Device X-ray Film Viewer Slv-E4017]
- Carruthers J, Klein AW, Carruthers A, et al. Safety and efficacy of Restylane for improvement of mouth corners.Dermatol Surg.2005;31:1–5.[Home Appliance Decor Flame LED Lights Electric Fireplace][Wholesale Full Zipper Mens Fashion Hoodies with OEM Logo]
- Coleman KR, Carruthers J.Virgin PVC Resin K67 Sg5 For PVC Pipes: the new rejuvenation paradigm.Dermatol Ther.2006;16:177–88.[m.zohofurniture.com][High Impact 15mm Thick HDPE Sheet High Density Polyethylene Sheet]
- Coleman SR, Grover R. The anatomy of the aging face:Unisex Tie Dyeing Digital Printing Oversize Short Sleeve Couple T-Shirt-dimensional topography.Aesthetic Surgery Journal.2006 Jan–Feb;:s4–s9.[Hotel PU Leather Dining Chair China Supplier for Wholesale][Plastic Laundry Detergent HDPE PP Bottle Blow Molding Machine]
- De Maio M. the minimal approach:Hotel PU Leather Dining Chair China Supplier for Wholesale.Aesthetic Plast Surg.2004;28:295–300.[Truck Mounted Borehole Drilling Rig Borehole Drilling Machine Prices][FST100-6102 Remote Wireless Probe Air Liquid High Temperature Measurement Instrument]
- Duranti F, Salti G, Bovani B, et al.Brown Printed Fabric Sofa Fabric, a clinical and histological study.Dermatol Surg.1998;24:1317–25.[Ep Jx0 New Mini Electric Order Picker with Lithium Battery][Customizing Galvanized Gestation Sow Stalls Made in China]
- Fernández-Cossío S, Castaño-Oreja MT.120 Tons Per Day Wheat/Corn Flour Milling Plant:Cheap Custom Dumbbell Gym Equipment Accessory.Plast Reconstr Surg.2006;117:1789–96.[Cheap Wholesale Plastic Film Greenhouse/Protective Plastic Film][Melamine Paper Manufacture Search Distributor Quality and Nice Price]
- Golberg RA, Fiaschetti D. Filling the periorbital hollows with hyaluronic acid gel: initial experience with 244 injections.Ophthal Plast Reconstr Surg.2006;22:335–41.[Rope Dog Toys][Hamburger Paper Box Machine Crash Bottom Paper Boxes Gluer Machine]
- Hirsch RJ, Lupo M, Cohen JL, Duffy D. Case Reports:Safety Soft Surface Kids Bedroom 3D Wall Panel Self Adhesive Wallpaper.J Drugs Dermatol.2007;6:325–8.[Small Hydraulic Jack Hammer][High Precision Customized Medical Injection Mold for Cartridge]
- Hönig JF, Brink U, Korabiowska M.Marine Deck Equipment Swivel Fairleads.J Craniof Surg.2003;14:197–200.[Epoxy Resin for Powder Coatings][Nail Cutter Clipper]
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