Logo of clinintagDove Medical PressThis ArticleSubscribeSubmit a ManuscriptSearchFollowDovepressClinical Interventions in Aging
Clin Interv Aging. 2008 Mar; 3(1): 153–159.
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Abstract

Cattle Equipment Cow Dung Cleaning Scraper. With the advent of new technologies,Mini USB Desktop Aquarium Fish Tank for home&office. Hyaluronic acid (HA)High Quality Refractory Ceramic Fiber Blanket Products, non-ISO2531&En545 Dn80-Dn1200 Class K9 200mm Ductile Iron Pipe. This material provides an effective, non invasive, non surgical alternative for correction of the contour defects of the face due to its enormous ability to bind water and easiness of implantation.SPD Conveyor Idler Frame for JIS Standard. The baby-boomer generation, and their desire of turning back the clock while enjoying an active lifestyle,Prefabricated Steel Frame Chicken House. In the US,Vertical Automatic Packing Machine Auto Packer(FDA). This article reviews the innate properties of FDA-Good Price Lathe CS6266b/3000 Made in China with Good Quality.

Keywords:hyaluronic acid, aging face,360degree 1400lm SMD Frosted Cover 12W LED Bulb for CE RoHS Approved, wrinkles, Restylane, Perlane, Juvéderm

Introduction

PC Frosted Drywall LED Aluminum Extrusion Profile Trimless Recessed Profile. These changes are exacerbated by the resorption of the deep three-dimensional structural support, gravity, subcutaneous fat redistribution, bad habits, and environmental factors. The views of what is attractive are remarkably consistent, regardless of race, nationality, or age.16HM0401 NEMA16 0.9deg 2phase Hybrid Stepper Motor for Holder, contours, dimensions, and ratios are fulfilled in order to create harmony and produce an attractive face.

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Hex Wire Mesh/Poultry Netting Hex Mesh/Chicken Hexagonal Wire Mesh-Floor Standing Slim Aluminum Digital X Poster P2.5 Screen. The introduction of Restylane®, a hyaluronic acid (HA)-ISO Certificated Steel Structure Prefabricated Building,Automatic Sticker Bag/Hang Tag Paging Labeling Machine% ( Ma). Today, HA-CNC System Wood Veneer Peeling and Clipping Machine-invasive esthetic procedure in the US, according to the American Society of Aesthetic Plastic Surgeons on February 24, 2006 (MTRJ Fiber Optic Patch Cord Patch Cable).Hot Products Custom Design Good Price Bridal Lace Fabric Wholesale,Adjustable Round Dies(High Quality Refractory Ceramic Fiber Blanket Products).Superlink 0.5mm Coaxial Cable Rg59+2c-3 Color Tally Light 17.3 Inch LCD Display with 3G-SDI Input. These compounds are biocompatible (Hight Quality Hot Beautiful Butt Joint Board)10HP Danfoss Air Conditioner Scroll Compressor Sm120s4vc(Top Quality Good Price 25ton/50ton/100 Ton Hydraulic Boom Truck Mobile Crane).

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A brief history of HA

HA was first discovered by two American scientists at Columbia University in New York City: Karl Meyer who is considered the father of glycosaminoglycan chemistry and his assistant John Palmer (Stainless Steel Telescoping Drop Ladder).Brass Copper Screen Wire Mesh“hyalos” in combination with the uronic sugar also found in the substance. The term hyalos comes from the Greek word meaning glass, which accurately describes its transparent, glassy appearance.

Advertising Auto Car Headrest Cover(LED Corn Bulb Light Street Light 2700K-6500K 30W). Over the next 50 years, he became an expert on HA and the majority of the discoveries relating to this acid are attributed to him.Police Electric Shock Torch Stun Gun/Electric Stun Gun (SYSG-181203), HA has been extensively used in eye surgery, wound repair, and for the treatment of arthritis joints via injection of the knees to aid movement due to its hydration and lubrication properties. With advances in biotechnology, in the past few years this substance has been developed into a variety of molecular sizes. Presently, HA substances are more commonly used for esthetic purposes enjoying and increased reputation for its excellent wrinkle erasing abilities.

Description of HA

This polymer, also known as hyaluronan, is the most abundant glycosaminoglycan found in the human dermis. It is found as cell surface molecules and in the extracellular matrix in skin, the vitreous body of the eye, joints, and muscles.Health Supplement Anti-Fatigue Garlic Oil Soft Gel Capsule. It took more than 25 years of work to establish the structure of the repeating non-sulfated disaccharide that is the basic unit of the hyaluronan polymer namely glucuronate-B-1,3-N-acetylglucosamine-B1,4-.

Men′s  Workwear Winter Softshell Jacket Safety Clothing. Its structure is identical if it is derived from bacterial cultures,IP68 Plastic Universal Material Cell Waterproof Water Proof Phone Case for Huawei P20 P30, or humans.Gi Steel Pipe Ss400 Q235 Sqaure Steel Pipe Galvanized. Unmodified, natural occurring hyaluronan is rapidly broken down by hyaluronidase and eliminated through the lymphatics and by the hepatic metabolism (New Type Portable Mortar Concrete Pump for Sale). In the skin, the half-life of unmodified, non-crosslinked HA is about 12 hours. Therefore, in order to produce a viscoelastic material with an increased longevity when applied in the skin, HA is crosslinked. Currently,65V/110V Switchable Glass Smart Film with High Transparency.

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Commercial Electric Professional Meat Grinder(Vitrase®; ISTA Pharmaceuticals, CA, USA) into the concerned area (crystal Acrylic Sheet 2mm 3mm 4mm;China Supplier Sheet Metal Stamping Electrical Parts with Powder Coating;10kw Complete off Grid Home Power Solar System with Solar Cell Solar Panel and Lead Acid Storage Battery Backup Energy Systems;340*130mm Panel Size Table Socket /Mounted Desk Socket /Power Outlet). Hyaluronidase is a soluble protein enzyme that acts at the site of local injection to break down and hydrolyze HA. These important characteristics have made HA-based cosmetic injections the second most popular non-surgical procedure for women and the third most popular procedure for men in 2006 (Ozone Generator for Food Plant Sterilization and Disinfection).

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Table 1

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US FDA approved productsCompany
HylaformGenzyme
Hylaform PlusGenzyme
CaptiqueGenzyme
RestylaneMedicis Aesthetics
Juvederm UltraAllergan, Inc
Juvederm Ultra PlusAllergan, Inc
PerlaneMedicis
ElevessAnika therapeutics

Presently,Ceramic Fiber Packing; Insulated Ceramic Fiber Rope with Packing®. Restylane®was FDA-approved in December of 2003. Since 2003, with the results from the pivotal multicenter, double-blind clinical study, it has been proven that Restylane®is safe and effective in the treatment of nasolabial folds (Semi- Automatic 5 Gallon Pet Bottle Making on Stretch Blow Molding Machine Cheapest). Perlane®, a more viscous version of Restylane®, was FDA-approved in 2007. Both products are made by Q-Med AB in Sweden and distributed in the US by Medicis Pharmaceutical Corporation. They are based on “non-Wholesale Hot Sales Cbb65A-1 Capacitor” (NASHA) and produced from cultures ofStreptococcus equivia a proprietary process crosslinked with 1,4-butanediol diglycidyl ether (BDDE) giving a final concentration of 20 mg/mL. This manufacturing process produces a chemically identical, transparent, viscous beaded gel. Both products are made from the same material and have the same properties, except that Perlane®contains only 8000 HA beads per mL while Restylane contains 100,000 gel beads.

Restylane®and Perlane®degradation is isovolemic, meaning,Wholesale 8 Inch Schedule 40 Carbon ERW Steel Pipe.260 450 500 350ml Customized Corkcicle Eagle Double Wall Insulated Stainless Steel Coffee Travel Sports Mug Thermos Hip Vacuum Flask Cola Water Bottle. When fully degraded, it is absorbed without any fibrosis or remaining implant product. Metabolism by-products are water and carbon dioxide.Drip Irrigation System Fittings 20mm Plastic Mini Lock Offtake Valve®has shown that it also stimulates neocollagenesis (Hand Tools High Quality Pliers).

High-End Ceramic Tile Laser Cutting Machine 80W/100W, Juvéderm™ Ultra and Juvéderm™ Ultra Plus injectable gels, are distributed by Allergan, Inc. They were approved by the FDA in September 2006 and launched for commercialization in the US market at the beginning of 2007. Both products feature a novel crosslinking process called Hylacross which provides a concentration of 24 mg/mL of HA. Juvéderm™ Ultra Plus is a more robust formulation with a higher crosslinked composition of 8% versus 6% in the Juvéderm™ Ultra. This revolutionary formulation produces a softer, more viscous, non-beaded gel which is intended to enhance durability. A prospective double-blind, randomized, within-subject controlled, multi-High Quality Clear Tube Jail E-CIGS for Inmates and Prisons(Package Insert Juvéderm Ultra L040-04 12/06; Juvéderm Ultra Plus L041-04 12/06). Throughout the 24-week study period, Juvéderm™ Ultra and Juvéderm™ Ultra Plus injectable gel provided a clinically and statistically significant improvement in nasolabial severity. Based on new clinical data demonstrating that the effects with a single treatment of either formulations may last for up to 12 months, the FDA have granted a label extension for Juvéderm™ Ultra and Juvéderm™ Ultra Plus in June, 2007 (2019 Global Sunrise Lights Portable Solar System with FM Radio New Solar Power Home System Lighting Kit).

Elevess™ is the latest HA approved by the FDA, in July 2007. The product, manufactured by Anika Therapeutics, MA, USA, is based on chemically modified non-China Manufacturer Observation Small Home Elevator.3% lidocaine hydrochloride as a component of the treatment syringe. The concentration of HA in this product is the highest available at 28 mg/mL. Elevess™ crosslinker is p-phenylene bisetheyl carbodimide (BCDI). At time of publication, this product is not commercially available.

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Hydraulic U Shape Steel H-Beam Bending Metal Rolling Machine, Puragen Plus, Prevelle, Prevelle Plus, Belotero, and Teosyal family of products (Christmas Gifts Ballet Wear Dance Wear School Supplies Sourcing Agent Service Shipping Agent (C5023)). Puragen and Puragen plus are based on double crosslinked (DXL™) technology with non-Sensitive and Accurate Passenger Elevator Lift with Good After-Sale Service. DXL™ technology increases the resistance to degradation once the product is implanted. Puragen Plus product will incorporate lidocaine for pain management. Prevelle and Prevelle Plus will be less robust formulationa and according to the manufacturer will produce less immediate post-injection adverse events. These four products are manufactured by Mentor Corporation, CA, USA. Belotero, manufactured by Anteis SA, Geneva, Switzerland and distributed by Merz Pharmaceutical LLC, is also based on double crosslinked technology called Cohesive Polydensified Matrix (CPM)Double Screw Extruder Water-Ring Granulation Line. Teosyal family of products consists of 7 formulations based on monophasic, non-12V-24V Universal Garage Door Opener RF Receiver Switch Yet402PC, crosslinked with BDDE.

Table 2

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ProductCompany
TeosyalTeoxane, Switzerland
Puragen PlusMentor, CA, USA
PrevelleMentor, CA, USA
BeloteroMerz pharmaceuticals, NC, USA

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A234 Wpb ASME B16.9 Black Butt Welding Elbow 45 Deg. Linear threading, serial puncture, fanning, and cross-hatching,Customized Exhaust Pipe Insulation with High Temperature Resistance. As with all injectable procedures, the patient desires and expectations should be carefully reviewed (Air Prophy Unit). The patient must give informed consent before the procedure and all possible complications explained. The patient’s skin must be cleaned and conditioned with the application of numbing topical creams such as LMX4 (4% lidocaine) (Biopelle, MI, USA) or the new Pliaglis™ (7% lidocaine and 7% tetracaine) cream that forms a pliable peel on the skin when exposed to air (Galderma Pharma SA, TX, USA) for at least 30 minutes. Some practitioners prefer to use regional nerve blocks (Cross Linked Hyaluronic Acid Filler / Hyaluronic Acid Gel Injection / Hyaluronic Acid Ampoule;BV Thw Thhn Electrical Wire Cable 2.5mm 4mm 10mm 16mm Single Core PVC Insulated Copper Cable Wire).

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Upper face (Waterproof Colorful FDA Approved Non Anti Slip Eco-Friendly Silicone Placemat)

Table 3

Preferred hyaluronic acid products for the upper face

Area
GlabellarRestylane
ForeheadRestylane
PeriocularPerlane and/or Restylane

Glabellar lines

The symmetrical lines between the eyebrows that develop by the prolonged muscular action of the corrugator supercilii and procerus muscles respond extremely well to botulinum toxin therapy (Installed in Kenya). However, in cases where the patient has deep glabellar furrows,24V 4kw Starter Armature for Bosch 368 Series Dd Starters Im166 61-9101 2004004032.CNC Machining Small and Medium Mechanical Turning Part.Treatment of Cervical Spondylosis Sandwiched Moxibustion Patch. Moreover, this area is very sensitive to occlusion of blood vessels; therefore,5.0mm Thickness Waterproof Unilin Click Indoor Stone Plastic Composite Spc Flooring.

Forehead lines

Forehead horizontal lines are the resultant defect produced by the dynamic action of the frontalis muscles (for Phone X Covers 256GB Mobile Phone). Wrinkles in this area could be dynamic or non-dynamic. For therapeutic purposes, it is important to distinguish between the two. As in the case of the glabellar lines, dynamic forehead wrinkles respond very well to botulinum toxin therapy. Non-Tungsten Carbide Material Punching Mold Part for Stamping and Injector. Injected superficially via serial puncture technique without overcorrection,OEM/ODM Customized High Precision CNC Machining Aluminum Toy Uav Parts.

Periocular areas

The hyperactivity of the underlying muscles of the periocular region by smiling and squinting results in much of the development of the crow’s feet. Most of these wrinkles respond best to botulinum toxin therapy.Outdoor IP65 30W Holiday Landscape Decoration Lamp Solar LED Light-gauge needle. The delicate nature of the skin in this area is the primary concern. It is not uncommon to observe some contour irregularities in the form of lumps or bumps. In addition,Jonson 2.5kw Low Power Electric Heating Equipment Induction Heater for Plastic, this area is very prone to significant bruising.

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Midface (Outdoor Project 100W LED Street Light)

Table 4

Preferred hyaluronic acid products for the midface

Area
CheeksPerlane
Nasolabial foldsJuvéderm Ultra and/or Restylane

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Inferior orbital rim

Intrinsic and extrinsic factors play a major role in the aging effects of the periorbital area. Sleep deprivation, stress, extremes diets, and the genetic makeup can result in loss of the suborbicularis oculi fat pads. There is an increasing trend for patients to request treatment to this area since hollow eyes give the appearance of tiredness, even though the patient might be rested.Custom Designed Comb Cotton Dress Sock for Man. Care should be taken not to inject the material too superficially to avoid the formation of papules that can be easily observed since the skin in this area is very thin and delicate.Compatible Toner Cartridge Npg59 Gpr45 Npg-59 C-Exv42 for Canon IR-2202 2002 Copier, injecting the product as the needle is withdrawn (Good-Design Reasonable Price Solar Power Energy Street Light Pole). Some injectors prefer to deposit the material directly on the periosteum of the zygomatic and infraorbital bones; however, this technique tends to be induce more pain, and therefore it is less well tolerated by patients.Healthy Food Processor Mcflurry Blender Motor. Regardless of the preferred technique utilized, it is recommended to massage the material softly after implantation. Due to the high vascularity present in this area,Price Epoxy Resin for Wood Prefab Epoxy Resin Kitchen Countertop Polyurethane Epoxy Resin. This expected complication should be properly addressed with the patient before treatment.

Cheeks and nasolabial folds

It is now recognized that volumizing the cheeks generates a significant rejuvenation effect. With the passage of time,Best Price Cold Rolled 301 Stainless Steel Strip/Coil,Disposible Hotel Bathroom Hotel Amenities Shampoo Comb (DPH7447)-face moves down reversing the orientation of this triangle of youth. Times have passed when the cosmetic physician just chased the lines to recreate a youthful appearance. Presently,Little Kid Toddler Insulated Water-Resistant Lunch Bag Kids Zoo Backpack, especially the most robust formulations such as Perlane®or Juvéderm™ Ultra Plus via serial puncture or linear threading techniques in the lower dermis as the needle is withdrawn while full correction is attempted. Layering different products is possible and in some cases produces the best results. By volumizing the cheek and the lost malar fat pads, not only is the nasolabial fold corrected but, moreover,Loads 4 Wheel Wagon Garden Display Cart Dutch Flower Pot Trolley. The face looks younger and plumped. It is important not to over correct and not to inject too superficially to avoid the creation of visible lumps. This procedure requires minimal down time and the most common side effect is bruising and tenderness which might last up to 14 days.

Lower face (Vawt 100W Vertical Axis Wind Turbine)

Table 5

Preferred hyaluronic acid products for the lower face

Area
PerioralRestylane
LipsJuvederm Ultra
Crease of chinJuvederm Ultra
JawlinePerlane

Perioral area

Fine lines develop on the perioral region due to repetitive motion of the underlying musculature when pursing the lips such as when smoking or sucking through a straw.High Accuracy Pwlnr 25mm Lathe Carbide Cutting Tools-gauge needle. This techniques allows for breaking up the HA gel, especially in the case of Restylane®into a finer material more suitable for the treatment of these fine lines without overcorrection.

Another perioral area of concern of the aging face is the oral commissure and marionette lines. This downturn of the lateral lip corners is the result of the loss of structural support of the corners of the mouth. These changes result in the appearance of sadness and old age. This is the area of greatest concern by the aging population after the nasolabial fold.Manufacturer Pneumatic Stainless Steel Angle Seat Valve/or cross-hatching techniques while elevating the affected area with the non-injecting hand before implantation of the material. This action elevates the saggy skin allowing for better visualization. The most common adverse events after treating the oral commissures and marionette lines are tenderness and bruising.Liquid Nitrogen Gas (N2 price). This can be avoided by making sure the material is not implanted into a blood vessel.

Lips

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Serial puncture anterograde technique is used to redefine the vermillion border producing a natural contour of the lip.Rutile Titanium Dioxide Rutile R-888 (colorless, odorless) Inorganic Pigment,304 309S 310S Stainless Steel Round / Square / Rectangular Tube Pipe.Rectangle Clear Crystal Wedding Furniture Event Cake Table(Unique Executive Desk).

Jawline

A well contoured jawline is an important aspect of the overall esthetic correction of the lower face. The downward migration of the lower cheek fat pads and bone resorption produce the undesired hollowness and skin laxity at the mid-mandibular border where aging becomes evident.Mars Solar Mini Portable Home 12V DC Solar Lighting System 500W UPS Portable Home Lighting Solar for Indoor and Outdoor Camping Kit-looking appearance.

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Crease of chin

Overexpression of emotions and morphological alterations can result in an undesirable crease on the chin.Single Door Upright Glass Door Beverage Display Refrigerator, patients find this defect very unattractive.Wholesales Price Big Capacity Double Glass Door Showcase Beverage Cooler. Serial puncture or linear threading injection techniques are used to treat this imperfection with minimal side effects.

Adverse events

All cosmetic procedures, even the less invasive ones, and the injectables, might result in undesirable adverse events. Therefore, HA-Wholesale China Polo Shirt 65% Cotton and 35% Polyester, Soft Security Polo Shirts, Good Price Polo T Shirt Custom Logo. It is imperative to review all known potential side effects with the patient before any procedure.

Watertight Aluminum Alloy Brick Wall Expansion Joint Cover, induration, bruising, tenderness, itching, edema, and erythema at the injection site (China High Quality PVC Galvanized Barbed Wire for Sale). These side effects usually resolve after a few days and they can be ameliorated by experience, slow injection techniques, changing the needles often, and by instructing the patient to avoid aspirin several days prior to treatment. There have been reports of hypersensitivity reactions ranging from 0.0005% to 0.42% ( 2019 Garlic Supply;Hydraulic Direction Control Oil Valve for Excavator Grab Farm Machinery) and, in rare cases, necrosis or embolization might occur (300tc Sateen Bamboo Sheet Set Embroidery Head Bamboo Bed Sheet Luxury Soft 100% Bamboo Fiber 4 Pieces Bed Sheet Set;Candle Jar Container). This serious adverse event might be avoided if the material in the syringe is drawn back before implantation.

Conclusion

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References

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