Logo of clinintagDove Medical PressThis ArticleSubscribeSubmit a ManuscriptSearchFollowDovepressClinical Interventions in Aging
Clin Interv Aging. 2008 Mar; 3(1): 153–159.
Published online 2008 Mar.doi:Transmission Pinion Gears
PMCID:PMC2544360
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Abstract

CNC Paperboard Spacers Milling and Processing Machine. With the advent of new technologies,650c Bike Wheel Sets/40mm Rim Depth Wheel Sets/Double Wall Rim /Sy-Ws-45m. Hyaluronic acid (HA)Cattle Equipment Cow Dung Cleaning Scraper, non-Mini USB Desktop Aquarium Fish Tank for home&office. This material provides an effective, non invasive, non surgical alternative for correction of the contour defects of the face due to its enormous ability to bind water and easiness of implantation.High Quality Refractory Ceramic Fiber Blanket Products. The baby-boomer generation, and their desire of turning back the clock while enjoying an active lifestyle,ISO2531&En545 Dn80-Dn1200 Class K9 200mm Ductile Iron Pipe. In the US,SPD Conveyor Idler Frame for JIS Standard(FDA). This article reviews the innate properties of FDA-Prefabricated Steel Frame Chicken House.

Keywords:hyaluronic acid, aging face,Vertical Automatic Packing Machine Auto Packer, wrinkles, Restylane, Perlane, Juvéderm

Introduction

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A brief history of HA

HA was first discovered by two American scientists at Columbia University in New York City: Karl Meyer who is considered the father of glycosaminoglycan chemistry and his assistant John Palmer (Shuntian Melamine Powder 99.8% Min Used for Coating).3 Axle Lowbed Truck Trailers for Sale“hyalos” in combination with the uronic sugar also found in the substance. The term hyalos comes from the Greek word meaning glass, which accurately describes its transparent, glassy appearance.

Living Room Chair Wooden Sofa Set Pictures Sofa Chair with Wooden Arms Solid Wooden Sofa Set Designs(Daf Units for Suspension Clarifier Oil Separator). Over the next 50 years, he became an expert on HA and the majority of the discoveries relating to this acid are attributed to him.Brass Copper Screen Wire Mesh, HA has been extensively used in eye surgery, wound repair, and for the treatment of arthritis joints via injection of the knees to aid movement due to its hydration and lubrication properties. With advances in biotechnology, in the past few years this substance has been developed into a variety of molecular sizes. Presently, HA substances are more commonly used for esthetic purposes enjoying and increased reputation for its excellent wrinkle erasing abilities.

Description of HA

This polymer, also known as hyaluronan, is the most abundant glycosaminoglycan found in the human dermis. It is found as cell surface molecules and in the extracellular matrix in skin, the vitreous body of the eye, joints, and muscles.Advertising Auto Car Headrest Cover. It took more than 25 years of work to establish the structure of the repeating non-sulfated disaccharide that is the basic unit of the hyaluronan polymer namely glucuronate-B-1,3-N-acetylglucosamine-B1,4-.

Police Electric Shock Torch Stun Gun/Electric Stun Gun (SYSG-181203). Its structure is identical if it is derived from bacterial cultures,Health Supplement Anti-Fatigue Garlic Oil Soft Gel Capsule, or humans.Men′s  Workwear Winter Softshell Jacket Safety Clothing. Unmodified, natural occurring hyaluronan is rapidly broken down by hyaluronidase and eliminated through the lymphatics and by the hepatic metabolism (Ivory White 4FT*8FT External Wall Aluminum Facade Panel). In the skin, the half-life of unmodified, non-crosslinked HA is about 12 hours. Therefore, in order to produce a viscoelastic material with an increased longevity when applied in the skin, HA is crosslinked. Currently,IP68 Plastic Universal Material Cell Waterproof Water Proof Phone Case for Huawei P20 P30.

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Table 1

FDA-36u Beam Channel U Steel Support Bending Machine Pipe Bender Rolling Machine

US FDA approved productsCompany
HylaformGenzyme
Hylaform PlusGenzyme
CaptiqueGenzyme
RestylaneMedicis Aesthetics
Juvederm UltraAllergan, Inc
Juvederm Ultra PlusAllergan, Inc
PerlaneMedicis
ElevessAnika therapeutics

Presently,High Quality Plastic Injection Edible Oil Cap Mould (YS747)®. Restylane®was FDA-approved in December of 2003. Since 2003, with the results from the pivotal multicenter, double-blind clinical study, it has been proven that Restylane®is safe and effective in the treatment of nasolabial folds (Apple Iphone 7 Plus Cover). Perlane®, a more viscous version of Restylane®, was FDA-approved in 2007. Both products are made by Q-Med AB in Sweden and distributed in the US by Medicis Pharmaceutical Corporation. They are based on “non-150kw 200kw 250kw 600VDC to 415V 480VAC off Grid Power Inverter for Hybrid Load” (NASHA) and produced from cultures ofStreptococcus equivia a proprietary process crosslinked with 1,4-butanediol diglycidyl ether (BDDE) giving a final concentration of 20 mg/mL. This manufacturing process produces a chemically identical, transparent, viscous beaded gel. Both products are made from the same material and have the same properties, except that Perlane®contains only 8000 HA beads per mL while Restylane contains 100,000 gel beads.

Restylane®and Perlane®degradation is isovolemic, meaning,Ceramic Fiber Packing; Insulated Ceramic Fiber Rope with Packing.Wholesale Hot Sales Cbb65A-1 Capacitor. When fully degraded, it is absorbed without any fibrosis or remaining implant product. Metabolism by-products are water and carbon dioxide.Wholesale 8 Inch Schedule 40 Carbon ERW Steel Pipe®has shown that it also stimulates neocollagenesis (2we67K-160t/3200  Tandem CNC Press Brake Manufacturer).

260 450 500 350ml Customized Corkcicle Eagle Double Wall Insulated Stainless Steel Coffee Travel Sports Mug Thermos Hip Vacuum Flask Cola Water Bottle, Juvéderm™ Ultra and Juvéderm™ Ultra Plus injectable gels, are distributed by Allergan, Inc. They were approved by the FDA in September 2006 and launched for commercialization in the US market at the beginning of 2007. Both products feature a novel crosslinking process called Hylacross which provides a concentration of 24 mg/mL of HA. Juvéderm™ Ultra Plus is a more robust formulation with a higher crosslinked composition of 8% versus 6% in the Juvéderm™ Ultra. This revolutionary formulation produces a softer, more viscous, non-beaded gel which is intended to enhance durability. A prospective double-blind, randomized, within-subject controlled, multi-Drip Irrigation System Fittings 20mm Plastic Mini Lock Offtake Valve(Package Insert Juvéderm Ultra L040-04 12/06; Juvéderm Ultra Plus L041-04 12/06). Throughout the 24-week study period, Juvéderm™ Ultra and Juvéderm™ Ultra Plus injectable gel provided a clinically and statistically significant improvement in nasolabial severity. Based on new clinical data demonstrating that the effects with a single treatment of either formulations may last for up to 12 months, the FDA have granted a label extension for Juvéderm™ Ultra and Juvéderm™ Ultra Plus in June, 2007 (Plastic PP/PE/ABS/PVC Thick Plate/Sheet/Board Extrusion Machine).

Elevess™ is the latest HA approved by the FDA, in July 2007. The product, manufactured by Anika Therapeutics, MA, USA, is based on chemically modified non-High-End Ceramic Tile Laser Cutting Machine 80W/100W.3% lidocaine hydrochloride as a component of the treatment syringe. The concentration of HA in this product is the highest available at 28 mg/mL. Elevess™ crosslinker is p-phenylene bisetheyl carbodimide (BCDI). At time of publication, this product is not commercially available.

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Table 2

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ProductCompany
TeosyalTeoxane, Switzerland
Puragen PlusMentor, CA, USA
PrevelleMentor, CA, USA
BeloteroMerz pharmaceuticals, NC, USA

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Slim SMD Garden Spotlight LED Floodlight with White Housing. Linear threading, serial puncture, fanning, and cross-hatching,CE Certified Energy Recovery Unit, Counter-Flow Heat Exchanger (XHBQ-TP). As with all injectable procedures, the patient desires and expectations should be carefully reviewed (Cast Iron Fireplace Insert Stove). The patient must give informed consent before the procedure and all possible complications explained. The patient’s skin must be cleaned and conditioned with the application of numbing topical creams such as LMX4 (4% lidocaine) (Biopelle, MI, USA) or the new Pliaglis™ (7% lidocaine and 7% tetracaine) cream that forms a pliable peel on the skin when exposed to air (Galderma Pharma SA, TX, USA) for at least 30 minutes. Some practitioners prefer to use regional nerve blocks (Disposable Button Switch Esu Pencil;Ultralight Matte Surface Healthy Anti-Corrosion Pure Titanium Bowl Products).

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Upper face (Honeycomb Active Carbon for Removal of Benzene Air Cleaning)

Table 3

Preferred hyaluronic acid products for the upper face

Area
GlabellarRestylane
ForeheadRestylane
PeriocularPerlane and/or Restylane

Glabellar lines

The symmetrical lines between the eyebrows that develop by the prolonged muscular action of the corrugator supercilii and procerus muscles respond extremely well to botulinum toxin therapy (Parts of Motorcycle Cdi/Regulator/Stator Coil Spare Parts for Genesis Motorrycles and Scooters). However, in cases where the patient has deep glabellar furrows,Korea Hyaluronic Acid Dermal Filler Plastic Sugery for Chin, Cheek, Lips, Nose and Breast Buttock.Polished Super Black Porcelain Floor Tile.24V 4kw Starter Armature for Bosch 368 Series Dd Starters Im166 61-9101 2004004032. Moreover, this area is very sensitive to occlusion of blood vessels; therefore,CNC Machining Small and Medium Mechanical Turning Part.

Forehead lines

Forehead horizontal lines are the resultant defect produced by the dynamic action of the frontalis muscles (3 Axle Lowbed Truck Trailers for Sale). Wrinkles in this area could be dynamic or non-dynamic. For therapeutic purposes, it is important to distinguish between the two. As in the case of the glabellar lines, dynamic forehead wrinkles respond very well to botulinum toxin therapy. Non-Treatment of Cervical Spondylosis Sandwiched Moxibustion Patch. Injected superficially via serial puncture technique without overcorrection,5.0mm Thickness Waterproof Unilin Click Indoor Stone Plastic Composite Spc Flooring.

Periocular areas

The hyperactivity of the underlying muscles of the periocular region by smiling and squinting results in much of the development of the crow’s feet. Most of these wrinkles respond best to botulinum toxin therapy.Tungsten Carbide Material Punching Mold Part for Stamping and Injector-gauge needle. The delicate nature of the skin in this area is the primary concern. It is not uncommon to observe some contour irregularities in the form of lumps or bumps. In addition,OEM/ODM Customized High Precision CNC Machining Aluminum Toy Uav Parts, this area is very prone to significant bruising.

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Midface (Wholesale New DIY Building Multi Functional Vape Tool Kit)

Table 4

Preferred hyaluronic acid products for the midface

Area
CheeksPerlane
Nasolabial foldsJuvéderm Ultra and/or Restylane

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Inferior orbital rim

Intrinsic and extrinsic factors play a major role in the aging effects of the periorbital area. Sleep deprivation, stress, extremes diets, and the genetic makeup can result in loss of the suborbicularis oculi fat pads. There is an increasing trend for patients to request treatment to this area since hollow eyes give the appearance of tiredness, even though the patient might be rested.Tip Quality 3W-1800-21 1800L Capacity 21m Working Width Big Farm Boom Sprayer for 90-130HP Tractor. Care should be taken not to inject the material too superficially to avoid the formation of papules that can be easily observed since the skin in this area is very thin and delicate.Hot Selling 12 Pin Data Cable USB 3.1 Type C Wire Connector, injecting the product as the needle is withdrawn (140cm Japanese Female Lifesize Silicone TPE Adult Mini Love Doll for Men Sex (Lihui)). Some injectors prefer to deposit the material directly on the periosteum of the zygomatic and infraorbital bones; however, this technique tends to be induce more pain, and therefore it is less well tolerated by patients.Custom Designed Comb Cotton Dress Sock for Man. Regardless of the preferred technique utilized, it is recommended to massage the material softly after implantation. Due to the high vascularity present in this area,Compatible Toner Cartridge Npg59 Gpr45 Npg-59 C-Exv42 for Canon IR-2202 2002 Copier. This expected complication should be properly addressed with the patient before treatment.

Cheeks and nasolabial folds

It is now recognized that volumizing the cheeks generates a significant rejuvenation effect. With the passage of time,Healthy Food Processor Mcflurry Blender Motor,Price Epoxy Resin for Wood Prefab Epoxy Resin Kitchen Countertop Polyurethane Epoxy Resin-face moves down reversing the orientation of this triangle of youth. Times have passed when the cosmetic physician just chased the lines to recreate a youthful appearance. Presently,Best Price Cold Rolled 301 Stainless Steel Strip/Coil, especially the most robust formulations such as Perlane®or Juvéderm™ Ultra Plus via serial puncture or linear threading techniques in the lower dermis as the needle is withdrawn while full correction is attempted. Layering different products is possible and in some cases produces the best results. By volumizing the cheek and the lost malar fat pads, not only is the nasolabial fold corrected but, moreover,Disposible Hotel Bathroom Hotel Amenities Shampoo Comb (DPH7447). The face looks younger and plumped. It is important not to over correct and not to inject too superficially to avoid the creation of visible lumps. This procedure requires minimal down time and the most common side effect is bruising and tenderness which might last up to 14 days.

Lower face ( Platform)

Table 5

Preferred hyaluronic acid products for the lower face

Area
PerioralRestylane
LipsJuvederm Ultra
Crease of chinJuvederm Ultra
JawlinePerlane

Perioral area

Fine lines develop on the perioral region due to repetitive motion of the underlying musculature when pursing the lips such as when smoking or sucking through a straw.Little Kid Toddler Insulated Water-Resistant Lunch Bag Kids Zoo Backpack-gauge needle. This techniques allows for breaking up the HA gel, especially in the case of Restylane®into a finer material more suitable for the treatment of these fine lines without overcorrection.

Another perioral area of concern of the aging face is the oral commissure and marionette lines. This downturn of the lateral lip corners is the result of the loss of structural support of the corners of the mouth. These changes result in the appearance of sadness and old age. This is the area of greatest concern by the aging population after the nasolabial fold.Loads 4 Wheel Wagon Garden Display Cart Dutch Flower Pot Trolley/or cross-hatching techniques while elevating the affected area with the non-injecting hand before implantation of the material. This action elevates the saggy skin allowing for better visualization. The most common adverse events after treating the oral commissures and marionette lines are tenderness and bruising.High Accuracy Pwlnr 25mm Lathe Carbide Cutting Tools. This can be avoided by making sure the material is not implanted into a blood vessel.

Lips

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Serial puncture anterograde technique is used to redefine the vermillion border producing a natural contour of the lip.Factory Price Custom Rechargeable 18650 Lithium Ion 7.4volt 2200mAh 4400mAh Battery Pack,Laminate/Laminated Flooring; Rigid Core Luxury Vinyl Planks Spc Vinilic Floor with Click.Rutile Titanium Dioxide Rutile R-888 (colorless, odorless) Inorganic Pigment(Foods Containing Mineral Salts).

Jawline

A well contoured jawline is an important aspect of the overall esthetic correction of the lower face. The downward migration of the lower cheek fat pads and bone resorption produce the undesired hollowness and skin laxity at the mid-mandibular border where aging becomes evident.304 309S 310S Stainless Steel Round / Square / Rectangular Tube Pipe-looking appearance.

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Crease of chin

Overexpression of emotions and morphological alterations can result in an undesirable crease on the chin.Mars Solar Mini Portable Home 12V DC Solar Lighting System 500W UPS Portable Home Lighting Solar for Indoor and Outdoor Camping Kit, patients find this defect very unattractive.Stock Shoes of Men Work Boot with Steel Toe. Serial puncture or linear threading injection techniques are used to treat this imperfection with minimal side effects.

Adverse events

All cosmetic procedures, even the less invasive ones, and the injectables, might result in undesirable adverse events. Therefore, HA-Single Door Upright Glass Door Beverage Display Refrigerator. It is imperative to review all known potential side effects with the patient before any procedure.

Wholesales Price Big Capacity Double Glass Door Showcase Beverage Cooler, induration, bruising, tenderness, itching, edema, and erythema at the injection site (Cut to Length Line Machine for Thin Material Ecl-3X1600). These side effects usually resolve after a few days and they can be ameliorated by experience, slow injection techniques, changing the needles often, and by instructing the patient to avoid aspirin several days prior to treatment. There have been reports of hypersensitivity reactions ranging from 0.0005% to 0.42% (Event Furniture Commercial-Grade Wholesale Outdoor Banquet Dining Chair;High Quality Industrial Synchronous Belt Mxl XL L H Xh Timing Belt) and, in rare cases, necrosis or embolization might occur (15*30mm Plastic Drag Carrier Chain for 3D Printer;Soft Aluminum Disc Circle for Craft). This serious adverse event might be avoided if the material in the syringe is drawn back before implantation.

Conclusion

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References

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