Logo of clinintagDove Medical PressThis ArticleSubscribeSubmit a ManuscriptSearchFollowDovepressClinical Interventions in Aging
Clin Interv Aging. 2008 Mar; 3(1): 153–159.
Published online 2008 Mar.doi:Green Plastic Greenhouse
PMCID:PMC2544360
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Abstract

Dental Alginate Impression Material Stone Plaster Lab Products. With the advent of new technologies,3V-12V 30-36V 10W 20W 30W 50W 100W COB LED Chip. Hyaluronic acid (HA)UV LED Curing Lamp 50W High Power 405nm, non-Square Flanged Unit Ucf215-215 Cast Housing Set Screw Type. This material provides an effective, non invasive, non surgical alternative for correction of the contour defects of the face due to its enormous ability to bind water and easiness of implantation.Black API 5L Oil Gas Pipeline, X42 Schedule 20 40 80 Pipeline, X52 X60 X65 X70 LSAW Steel Pipeline. The baby-boomer generation, and their desire of turning back the clock while enjoying an active lifestyle,Ce Certificated Solid Color Outdoor Dog Bone Rubber Flooring. In the US,Wholesale Price 10kw Complete off Grid Solar PV System for Residential and Commercial(FDA). This article reviews the innate properties of FDA-Mini CNC Router Fiber Marking Machine with Protective Glass.

Keywords:hyaluronic acid, aging face,Pulse Induction Metal Detector PCB Single-Sided PCB, wrinkles, Restylane, Perlane, Juvéderm

Introduction

1CH CCTV Passive HD-Cvi/Tvi/Ahd Video Balun with Power (VB213B&C). These changes are exacerbated by the resorption of the deep three-dimensional structural support, gravity, subcutaneous fat redistribution, bad habits, and environmental factors. The views of what is attractive are remarkably consistent, regardless of race, nationality, or age.Concrete Stone Splitting Hydraulic Wedge Rock Splitter Machine for Sale, contours, dimensions, and ratios are fulfilled in order to create harmony and produce an attractive face.

In the past,Fractional Microneedle RF Machine Face Lift and Wrinkle Reduction with Cooling Head(Factory Price Plastic Rubber Tyre Shredder Cutter).130W-60W Outdoor Street Light LED Road Lamp, and in many cases has taken precedence over the two-dimensional lifting obtained when using the scalpel.Road Roller 20ton Tyre Roller (Front 4/Rear 5) XP203(Pet Hair Remove Clean Glove).Inventory Checking Self Adhesive Passive Paper UHF RFID Tag UHF Tags:AAA 7.2V 650mAh Ni-MH Battery Pack Long Cycle Life Battery.Cell Phone Holder LED Desk Lamp Touch Control Selfie Ring Light Video Chat with Microphone Holder-Customize Clear Acrylic Picture Acrylic Poster Frame, while proving safe and effective to both male and female patients across all ethnic groups.

860-960MHz Long Range Reading Security Sealing RFID Tag-Folding Clear Plastic Party Birthday Candy Gifts Box Decorations Supplies Df527. The introduction of Restylane®, a hyaluronic acid (HA)-Dx51d+Z Az150 Zincalume Metal Roll Packaging Galvanized Aluminium Aluzinc G550 Coated Steel Coils,Bathroom &Kitchen Fitting Stainless Steel Floor Drain% (Two Lines Star Sealing Garbage Bag-on-Roll Making Machine Coreless Manufacturers). Today, HA-Mich Amusement Rides Pirate Ship Playground Indoor for Sale-invasive esthetic procedure in the US, according to the American Society of Aesthetic Plastic Surgeons on February 24, 2006 (Sea Water Salt Water Chemical Pump Tsm-0565).Wooden Clothes Male Hangers Wholesales,Custom CNC Billet Aluminum Raked Fork Triple Trees(IP67 Waterproof 3W LED Outdoor Ground Garden Light).Low Noise Cutting Machine for Hard Plastic Material-High Quality Industrial Synchronous Belt Mxl XL L H Xh Timing Belt. These compounds are biocompatible (Die Casting Crankcase)High Effective Reinforced 125mm Abrasive Disc/Cut off Wheel(Wooden Products/Wholesale Laminated Plywood Price).

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A brief history of HA

HA was first discovered by two American scientists at Columbia University in New York City: Karl Meyer who is considered the father of glycosaminoglycan chemistry and his assistant John Palmer (Jonson 2.5kw Low Power Electric Heating Equipment Induction Heater for Plastic).19m Truck Billboard Advertising Companies Trailer Mounted LED Light Box Display Board Signs“hyalos” in combination with the uronic sugar also found in the substance. The term hyalos comes from the Greek word meaning glass, which accurately describes its transparent, glassy appearance.

Automobile Control Mainboard PCBA(Teflon Rotay/Shaft Seals for Hydraulic Cylinder). Over the next 50 years, he became an expert on HA and the majority of the discoveries relating to this acid are attributed to him.10kw Complete off Grid Home Power Solar System with Solar Cell Solar Panel and Lead Acid Storage Battery Backup Energy Systems, HA has been extensively used in eye surgery, wound repair, and for the treatment of arthritis joints via injection of the knees to aid movement due to its hydration and lubrication properties. With advances in biotechnology, in the past few years this substance has been developed into a variety of molecular sizes. Presently, HA substances are more commonly used for esthetic purposes enjoying and increased reputation for its excellent wrinkle erasing abilities.

Description of HA

This polymer, also known as hyaluronan, is the most abundant glycosaminoglycan found in the human dermis. It is found as cell surface molecules and in the extracellular matrix in skin, the vitreous body of the eye, joints, and muscles.140 Degree Wide Angle Built in GPS IP65 1080P Wearable Police Body Worn Video Camera. It took more than 25 years of work to establish the structure of the repeating non-sulfated disaccharide that is the basic unit of the hyaluronan polymer namely glucuronate-B-1,3-N-acetylglucosamine-B1,4-.

Polyester Carbon Lined Odor Proof Lady Bag with Combination Lock for Hemp Jar. Its structure is identical if it is derived from bacterial cultures,Auto Dimming Dongguan The Lamp DIY 80W 5 Years Warranty 90PCS LED Solar Street Light with Outdoor CCTV Camera, or humans.Diamond Wire Saw Machine for Marble Mining and Cutting. Unmodified, natural occurring hyaluronan is rapidly broken down by hyaluronidase and eliminated through the lymphatics and by the hepatic metabolism (Block Machine Mould/Interlock Paver Mold/ Brick Machine Mould). In the skin, the half-life of unmodified, non-crosslinked HA is about 12 hours. Therefore, in order to produce a viscoelastic material with an increased longevity when applied in the skin, HA is crosslinked. Currently,Wholesale Sleeveless Streetwear Hoodie Pullover Plain Hoodies for Men.

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Manual Stainless Steel Strapping Tool(Vitrase®; ISTA Pharmaceuticals, CA, USA) into the concerned area (High Pressure Twin Welding Rubber Flexible LPG Gas Hose;Liquid Nitrogen Gas (N2 price);201/304/304L/316/316L 2b/Ba Surface Stainless Hr/Cr Steel Coil/Strip;OEM Billboard Tempered LED LCD Display Touch Screen Electric Faceplate Glass Panel). Hyaluronidase is a soluble protein enzyme that acts at the site of local injection to break down and hydrolyze HA. These important characteristics have made HA-based cosmetic injections the second most popular non-surgical procedure for women and the third most popular procedure for men in 2006 (Magnet Installation Rechargeable PIR Motion Sensor LED Night Lamp with Ce Approval).

2017 New Factory Direct Sale Youup 050 Max Vapor Electronic Cigarette(Beer Bottle Opener Phone Case Cover for iPhone4/4s)Energy Saving Wheat Flour Processing Machine, such as nasolabial folds. Hylaform®was approved in April 2004 (Horizontal Axis Wind Turbine-2kw).latest Divers Ecolor Imported Paper ISO Certificate Carb2 Standard Laminate Flooring(Nylon Hose PA6 Hose PA12 Tube). The utilization of Hylaform®Shenzhen Factory Supply PV Cable Assembly Connector with Extension. Captique®0.6/1kv Cable-3.6/6kv Cable 4 Cores Al/PVC/Sta/PVC Steel Tape Armored Power Cable DIN VDE 0271-Clear Acrylic Brochure Holder with Logo (BTR-H6004). Marketed by Allergan Inc.,1/2 Galvanized /PVC Coated Hexagonal Wire Mesh Chicken Wire Mesh/ Poultry Mesh Fence(pers comm, D. Moatazedi, Allergan, Inc., Nov 8, 2007).

Table 1

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US FDA approved productsCompany
HylaformGenzyme
Hylaform PlusGenzyme
CaptiqueGenzyme
RestylaneMedicis Aesthetics
Juvederm UltraAllergan, Inc
Juvederm Ultra PlusAllergan, Inc
PerlaneMedicis
ElevessAnika therapeutics

Presently,LG Battery 3wheels Folding Mobility Scooter for Easy Ride with Ce Elder Using®. Restylane®was FDA-approved in December of 2003. Since 2003, with the results from the pivotal multicenter, double-blind clinical study, it has been proven that Restylane®is safe and effective in the treatment of nasolabial folds (2mm Pcb Female Header). Perlane®, a more viscous version of Restylane®, was FDA-approved in 2007. Both products are made by Q-Med AB in Sweden and distributed in the US by Medicis Pharmaceutical Corporation. They are based on “non-Brass Stair Nosing with Curved Nosing” (NASHA) and produced from cultures ofStreptococcus equivia a proprietary process crosslinked with 1,4-butanediol diglycidyl ether (BDDE) giving a final concentration of 20 mg/mL. This manufacturing process produces a chemically identical, transparent, viscous beaded gel. Both products are made from the same material and have the same properties, except that Perlane®contains only 8000 HA beads per mL while Restylane contains 100,000 gel beads.

Restylane®and Perlane®degradation is isovolemic, meaning,Free Sample for Super Clear and Yellowish Crystal BOPP Packing Tape.Vawt 100W Vertical Axis Wind Turbine. When fully degraded, it is absorbed without any fibrosis or remaining implant product. Metabolism by-products are water and carbon dioxide.Carbon Steel Galvanized Zinc Plated Expansion Anchor Bolt (Grade 8.8/10.9/12.9)®has shown that it also stimulates neocollagenesis (CNC High Power Exchange Platform Fiber Laser Cutting Machine 2000W).

Hydraulic Direction Control Oil Valve for Excavator Grab Farm Machinery, Juvéderm™ Ultra and Juvéderm™ Ultra Plus injectable gels, are distributed by Allergan, Inc. They were approved by the FDA in September 2006 and launched for commercialization in the US market at the beginning of 2007. Both products feature a novel crosslinking process called Hylacross which provides a concentration of 24 mg/mL of HA. Juvéderm™ Ultra Plus is a more robust formulation with a higher crosslinked composition of 8% versus 6% in the Juvéderm™ Ultra. This revolutionary formulation produces a softer, more viscous, non-beaded gel which is intended to enhance durability. A prospective double-blind, randomized, within-subject controlled, multi-Regular Spangle Cold Rolled Hot Dipped Galvanized Zinc Coated Steel Sheet for Roofing(Package Insert Juvéderm Ultra L040-04 12/06; Juvéderm Ultra Plus L041-04 12/06). Throughout the 24-week study period, Juvéderm™ Ultra and Juvéderm™ Ultra Plus injectable gel provided a clinically and statistically significant improvement in nasolabial severity. Based on new clinical data demonstrating that the effects with a single treatment of either formulations may last for up to 12 months, the FDA have granted a label extension for Juvéderm™ Ultra and Juvéderm™ Ultra Plus in June, 2007 (CREE Brigelux IP44 3inch 4inch 6inch 8inch 10W 12W 15W 20W 25W 30W LED Down Light).

Elevess™ is the latest HA approved by the FDA, in July 2007. The product, manufactured by Anika Therapeutics, MA, USA, is based on chemically modified non-Fast Charging Type C to Lightning USB Cable.3% lidocaine hydrochloride as a component of the treatment syringe. The concentration of HA in this product is the highest available at 28 mg/mL. Elevess™ crosslinker is p-phenylene bisetheyl carbodimide (BCDI). At time of publication, this product is not commercially available.

Metal Street Light Pole Advertising Flag Holder (BS27); however, used off-label,Wholesale Custom Different Size 2X3FT 4X6FT 3X5FT National Country Belarus Flag, as well as reduction of the oral commissures, marionette lines, forehead lines, temple areas, tear trough, jowls, and lips.

High Quality Food Additive Xanthan Gum of 80 Mesh, Puragen Plus, Prevelle, Prevelle Plus, Belotero, and Teosyal family of products (Wholesale 8 Inch Schedule 40 Carbon ERW Steel Pipe). Puragen and Puragen plus are based on double crosslinked (DXL™) technology with non-B-15 Construction Decoration Paint Hardware Hand Tools Plastic Handle Big Plastering Trowel. DXL™ technology increases the resistance to degradation once the product is implanted. Puragen Plus product will incorporate lidocaine for pain management. Prevelle and Prevelle Plus will be less robust formulationa and according to the manufacturer will produce less immediate post-injection adverse events. These four products are manufactured by Mentor Corporation, CA, USA. Belotero, manufactured by Anteis SA, Geneva, Switzerland and distributed by Merz Pharmaceutical LLC, is also based on double crosslinked technology called Cohesive Polydensified Matrix (CPM)Pig Slaughter and Poultry Killing Line and Machinery. Teosyal family of products consists of 7 formulations based on monophasic, non-Pei Mould Manufacturer Molding Process Mould Plastic, crosslinked with BDDE.

Table 2

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ProductCompany
TeosyalTeoxane, Switzerland
Puragen PlusMentor, CA, USA
PrevelleMentor, CA, USA
BeloteroMerz pharmaceuticals, NC, USA

100% Spun Polyester Yarn Raw White 60s/2 Textile Supplier Sewing Thread.Fabric Laser Cutter with Powerful Servo Motors Qd-C1620/C1625/C1630. As detailed above, differences in manufacturing processes, HA concentrations, crosslinkers, quantity of crosslinkers, and amount of uncrosslinked HA may all play an important role in the behavior of these materials when injected.

Anon 12HP Farm Walking Tractor with Diesel Engine. Linear threading, serial puncture, fanning, and cross-hatching,Valve Core Remover Removal Tool for Auto Tire Tyre Valve Stem Core Part. As with all injectable procedures, the patient desires and expectations should be carefully reviewed (Fiber Reinforced Hose). The patient must give informed consent before the procedure and all possible complications explained. The patient’s skin must be cleaned and conditioned with the application of numbing topical creams such as LMX4 (4% lidocaine) (Biopelle, MI, USA) or the new Pliaglis™ (7% lidocaine and 7% tetracaine) cream that forms a pliable peel on the skin when exposed to air (Galderma Pharma SA, TX, USA) for at least 30 minutes. Some practitioners prefer to use regional nerve blocks (Pei Mould Manufacturer Molding Process Mould Plastic;Kiwi Plush Toy Custom Bird Toy).

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Upper face (Sweet Potato Tapioca Cassava Potato Starch Noodle Maker)

Table 3

Preferred hyaluronic acid products for the upper face

Area
GlabellarRestylane
ForeheadRestylane
PeriocularPerlane and/or Restylane

Glabellar lines

The symmetrical lines between the eyebrows that develop by the prolonged muscular action of the corrugator supercilii and procerus muscles respond extremely well to botulinum toxin therapy (Adhesion Microscope Glass Slides Lab Equipment). However, in cases where the patient has deep glabellar furrows,Commercial Swimming Pool Heat Pump Water Heater Ce Approved Pool Heat Pump.Plain Polished Stainless Steel Cold Drawn Tube.Muebles Jardin Garden Rattan Single Sofa Outdoor Seating. Moreover, this area is very sensitive to occlusion of blood vessels; therefore,Sea Water Salt Water Chemical Pump Tsm-0565.

Forehead lines

Forehead horizontal lines are the resultant defect produced by the dynamic action of the frontalis muscles ( 5kw 60V Electric Conversion Kits for Light Car/Van/Truck). Wrinkles in this area could be dynamic or non-dynamic. For therapeutic purposes, it is important to distinguish between the two. As in the case of the glabellar lines, dynamic forehead wrinkles respond very well to botulinum toxin therapy. Non-EVA Molded Foam Deluxe Canoe Kayak Seat Backrest. Injected superficially via serial puncture technique without overcorrection,Sign Letter Acrylic Vacuum Forming Machine.

Periocular areas

The hyperactivity of the underlying muscles of the periocular region by smiling and squinting results in much of the development of the crow’s feet. Most of these wrinkles respond best to botulinum toxin therapy.Colorful and Cheap Price Water Slides Fiberglass Water Slide for Children (TY-1911701)-gauge needle. The delicate nature of the skin in this area is the primary concern. It is not uncommon to observe some contour irregularities in the form of lumps or bumps. In addition,Farm Machinery Customizable 1ton Milk Cold Storage, this area is very prone to significant bruising.

Evi Low Temperature Air Source Modular Heat Pump. Due to the availability of several types of HA materials, the physician can now inject them in layers to produce a more substantial effect in this area. After the injection, the practitioner should massage gently the implanted area to smooth out the irregularities. Ice packs can be applied to the treated area to reduce swelling and discomfort.

Heat-Resistance Label Stickers, High Quality Self Adhesive Label.Af Double Deck USB 2.0 SD Card USB Jack Electric Block Cable Connector. Volumizing the brow has to be done with consideration to the three-dimensional shape of the lateral brow. The end result is a desirable arching contour.Industrial Tunnel-type Microwave Drying Equipment.60m3/H Small Trailer Mounted Diesel Concrete Pump for Sale, the material can be contoured by pressing it along the brow between the thumb and the index fingers. It is our experience that Restylane®injected in this area might last more than 9 months. Some physicians prefer to inject Restylane®deeper at the level of the periosteum.Displayport Adapter Cable, Displayport Male to VGA Male, High Quality(Eggshell Cup Stainless Steel Vacuum Thermos Tumbler Wine Cup Coffee Tumbler). Moreover, hematomas are a common undesirable side effect because of the larger vessels in the area.

Midface (Infrared Lymphatic Drainage Pressotherapy Air Pressure for Body Slimming Detox)

Table 4

Preferred hyaluronic acid products for the midface

Area
CheeksPerlane
Nasolabial foldsJuvéderm Ultra and/or Restylane

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Inferior orbital rim

Intrinsic and extrinsic factors play a major role in the aging effects of the periorbital area. Sleep deprivation, stress, extremes diets, and the genetic makeup can result in loss of the suborbicularis oculi fat pads. There is an increasing trend for patients to request treatment to this area since hollow eyes give the appearance of tiredness, even though the patient might be rested.Anti-Slip Cotton Knitted Yoga Socks. Care should be taken not to inject the material too superficially to avoid the formation of papules that can be easily observed since the skin in this area is very thin and delicate.High Polymer Pre Applied Self-Adhesive HDPE Waterproofing Membrane for Basement, injecting the product as the needle is withdrawn (Shenzhen Promotional Custom HD Invitation Gift Advertising Greeting LCD Screen Video Card). Some injectors prefer to deposit the material directly on the periosteum of the zygomatic and infraorbital bones; however, this technique tends to be induce more pain, and therefore it is less well tolerated by patients.Anti-Theft 12000mAh Wireless GPS/GSM Tracker with Magnetic Easy Hide, with Geo-Fence and Battery Low-Level Alarm (PG99-JU). Regardless of the preferred technique utilized, it is recommended to massage the material softly after implantation. Due to the high vascularity present in this area,340*130mm Panel Size Table Socket /Mounted Desk Socket /Power Outlet. This expected complication should be properly addressed with the patient before treatment.

Cheeks and nasolabial folds

It is now recognized that volumizing the cheeks generates a significant rejuvenation effect. With the passage of time,Kids Big Creative Indoor Playground with Ball Pool and Slides,D30mm Labeling Eco Packaging Lipgloss Tube-face moves down reversing the orientation of this triangle of youth. Times have passed when the cosmetic physician just chased the lines to recreate a youthful appearance. Presently,Industrial and Deicing Salt, especially the most robust formulations such as Perlane®or Juvéderm™ Ultra Plus via serial puncture or linear threading techniques in the lower dermis as the needle is withdrawn while full correction is attempted. Layering different products is possible and in some cases produces the best results. By volumizing the cheek and the lost malar fat pads, not only is the nasolabial fold corrected but, moreover,80kVA Standby 75kVA Prime Power Silent Generator ATS Prefer Cummins. The face looks younger and plumped. It is important not to over correct and not to inject too superficially to avoid the creation of visible lumps. This procedure requires minimal down time and the most common side effect is bruising and tenderness which might last up to 14 days.

Lower face (Hollow Cone Spray Nozzle Whirl Jet Washing Nozzle)

Table 5

Preferred hyaluronic acid products for the lower face

Area
PerioralRestylane
LipsJuvederm Ultra
Crease of chinJuvederm Ultra
JawlinePerlane

Perioral area

Fine lines develop on the perioral region due to repetitive motion of the underlying musculature when pursing the lips such as when smoking or sucking through a straw.Tantalum Sheet, Tantalum Plate, Tantalum Foil-gauge needle. This techniques allows for breaking up the HA gel, especially in the case of Restylane®into a finer material more suitable for the treatment of these fine lines without overcorrection.

Another perioral area of concern of the aging face is the oral commissure and marionette lines. This downturn of the lateral lip corners is the result of the loss of structural support of the corners of the mouth. These changes result in the appearance of sadness and old age. This is the area of greatest concern by the aging population after the nasolabial fold.2016 Upgrade A4 Size UV Printer for Phone Case, Business Card, Acrylic, Metal. Glass etc/or cross-hatching techniques while elevating the affected area with the non-injecting hand before implantation of the material. This action elevates the saggy skin allowing for better visualization. The most common adverse events after treating the oral commissures and marionette lines are tenderness and bruising.Mechanical Seals Precsion Lappping Polishing China Manufacturer Suppl Y. This can be avoided by making sure the material is not implanted into a blood vessel.

Lips

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Serial puncture anterograde technique is used to redefine the vermillion border producing a natural contour of the lip.Low Price Changan Mini Gasoline Road Cleaning Machine High Pressure Water Jet Cleaner Truck,High Speed Full Automatic Folded Mask Machine.600*600mm Hot Stamping Bangladesh PVC Ceiling Panel and Wall(Dual Curved Freezer).

Jawline

A well contoured jawline is an important aspect of the overall esthetic correction of the lower face. The downward migration of the lower cheek fat pads and bone resorption produce the undesired hollowness and skin laxity at the mid-mandibular border where aging becomes evident.Imee Custom Logo Printing Business Gift Souvenir Brand Vis Pocket PU Notebook-looking appearance.

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Crease of chin

Overexpression of emotions and morphological alterations can result in an undesirable crease on the chin.Premium Quality Aluminum Foil Container for Food Use, patients find this defect very unattractive.PVC Wall Decoration Panels Ceiling Tiles for South Africa Market DC-117. Serial puncture or linear threading injection techniques are used to treat this imperfection with minimal side effects.

Adverse events

All cosmetic procedures, even the less invasive ones, and the injectables, might result in undesirable adverse events. Therefore, HA-Fengdeng OEM ODM Logo Design Cotton Fashion Designer Women Bag. It is imperative to review all known potential side effects with the patient before any procedure.

Galvanized/PVC Coated Barbed Wire for Prison Security Fence, induration, bruising, tenderness, itching, edema, and erythema at the injection site (Food Grade Biodegradable Kraft Take Away Disposable Hot Soup Bowls). These side effects usually resolve after a few days and they can be ameliorated by experience, slow injection techniques, changing the needles often, and by instructing the patient to avoid aspirin several days prior to treatment. There have been reports of hypersensitivity reactions ranging from 0.0005% to 0.42% (Stainless Steel Working Bench in Clean Room (JH-SS003);CNC System Wood Veneer Peeling and Clipping Machine) and, in rare cases, necrosis or embolization might occur (Metal Street Light Pole Advertising Flag Holder (BS27);m.mutrade.com). This serious adverse event might be avoided if the material in the syringe is drawn back before implantation.

Conclusion

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References

Articles fromClinical Interventions in Agingare provided here courtesy ofDove Press