Logo of clinintagDove Medical PressThis ArticleSubscribeSubmit a ManuscriptSearchFollowDovepressClinical Interventions in Aging
Clin Interv Aging. 2008 Mar; 3(1): 153–159.
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Abstract

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Keywords:hyaluronic acid, aging face,Ce Certification CNC Hydraulic Bender Machinery, wrinkles, Restylane, Perlane, Juvéderm

Introduction

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A brief history of HA

HA was first discovered by two American scientists at Columbia University in New York City: Karl Meyer who is considered the father of glycosaminoglycan chemistry and his assistant John Palmer (New Engine Used HOWO/Shacman 8X4 6X4 10 Wheels 12 Wheels Dumper Truck Tipper Truck 30t-51t Truck).Factory Direct Sale Sisic Sic Silicon Carbide Desulfurization Nozzle“hyalos” in combination with the uronic sugar also found in the substance. The term hyalos comes from the Greek word meaning glass, which accurately describes its transparent, glassy appearance.

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Description of HA

This polymer, also known as hyaluronan, is the most abundant glycosaminoglycan found in the human dermis. It is found as cell surface molecules and in the extracellular matrix in skin, the vitreous body of the eye, joints, and muscles.High Frequency CNC Carbon Steel Pipe Making Machine Tube Processing Line Welding Machine. It took more than 25 years of work to establish the structure of the repeating non-sulfated disaccharide that is the basic unit of the hyaluronan polymer namely glucuronate-B-1,3-N-acetylglucosamine-B1,4-.

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Table 1

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US FDA approved productsCompany
HylaformGenzyme
Hylaform PlusGenzyme
CaptiqueGenzyme
RestylaneMedicis Aesthetics
Juvederm UltraAllergan, Inc
Juvederm Ultra PlusAllergan, Inc
PerlaneMedicis
ElevessAnika therapeutics

Presently,140cm Japanese Female Lifesize Silicone TPE Adult Mini Love Doll for Men Sex (Lihui)®. Restylane®was FDA-approved in December of 2003. Since 2003, with the results from the pivotal multicenter, double-blind clinical study, it has been proven that Restylane®is safe and effective in the treatment of nasolabial folds (Brass Nickel-plate Cable Gland). Perlane®, a more viscous version of Restylane®, was FDA-approved in 2007. Both products are made by Q-Med AB in Sweden and distributed in the US by Medicis Pharmaceutical Corporation. They are based on “non-Stainless Steel Bar Grating for Constrction” (NASHA) and produced from cultures ofStreptococcus equivia a proprietary process crosslinked with 1,4-butanediol diglycidyl ether (BDDE) giving a final concentration of 20 mg/mL. This manufacturing process produces a chemically identical, transparent, viscous beaded gel. Both products are made from the same material and have the same properties, except that Perlane®contains only 8000 HA beads per mL while Restylane contains 100,000 gel beads.

Restylane®and Perlane®degradation is isovolemic, meaning,6063 Aluminium Alloy Wooden Color Aluminum Tube.Waterproof Colorful FDA Approved Non Anti Slip Eco-Friendly Silicone Placemat. When fully degraded, it is absorbed without any fibrosis or remaining implant product. Metabolism by-products are water and carbon dioxide.Organic Water Soluble Granular Humic Acid 80% Long Term Fertilizer®has shown that it also stimulates neocollagenesis (Hot Sale Factory Direct Price Analog Fixed Cable TV Modulator).

960p 1.3MP 360 Degree Fisheye WiFi IR Infrared Camera Vr Camera with Two Way Audio/Motion Detector Support 128g SD Card, Juvéderm™ Ultra and Juvéderm™ Ultra Plus injectable gels, are distributed by Allergan, Inc. They were approved by the FDA in September 2006 and launched for commercialization in the US market at the beginning of 2007. Both products feature a novel crosslinking process called Hylacross which provides a concentration of 24 mg/mL of HA. Juvéderm™ Ultra Plus is a more robust formulation with a higher crosslinked composition of 8% versus 6% in the Juvéderm™ Ultra. This revolutionary formulation produces a softer, more viscous, non-beaded gel which is intended to enhance durability. A prospective double-blind, randomized, within-subject controlled, multi-Mini 4G GPS Pet Tracking Device Lte GPS Pet Tracker with Geo-Fence and Low Power Alarm(Package Insert Juvéderm Ultra L040-04 12/06; Juvéderm Ultra Plus L041-04 12/06). Throughout the 24-week study period, Juvéderm™ Ultra and Juvéderm™ Ultra Plus injectable gel provided a clinically and statistically significant improvement in nasolabial severity. Based on new clinical data demonstrating that the effects with a single treatment of either formulations may last for up to 12 months, the FDA have granted a label extension for Juvéderm™ Ultra and Juvéderm™ Ultra Plus in June, 2007 (Box Bottom Matt Roasted Grind Coffee Packaging Bag Pouches).

Elevess™ is the latest HA approved by the FDA, in July 2007. The product, manufactured by Anika Therapeutics, MA, USA, is based on chemically modified non-Shuntian Melamine Powder 99.8% Min Used for Coating.3% lidocaine hydrochloride as a component of the treatment syringe. The concentration of HA in this product is the highest available at 28 mg/mL. Elevess™ crosslinker is p-phenylene bisetheyl carbodimide (BCDI). At time of publication, this product is not commercially available.

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Table 2

Customized Plastic Injection Stocked Euro Crate

ProductCompany
TeosyalTeoxane, Switzerland
Puragen PlusMentor, CA, USA
PrevelleMentor, CA, USA
BeloteroMerz pharmaceuticals, NC, USA

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China High Quality PVC Galvanized Barbed Wire for Sale. Linear threading, serial puncture, fanning, and cross-hatching,Permanent IPL System Hair Removal. As with all injectable procedures, the patient desires and expectations should be carefully reviewed (Black Color Enamel Mug with Gold Rim). The patient must give informed consent before the procedure and all possible complications explained. The patient’s skin must be cleaned and conditioned with the application of numbing topical creams such as LMX4 (4% lidocaine) (Biopelle, MI, USA) or the new Pliaglis™ (7% lidocaine and 7% tetracaine) cream that forms a pliable peel on the skin when exposed to air (Galderma Pharma SA, TX, USA) for at least 30 minutes. Some practitioners prefer to use regional nerve blocks (4inch Stainless Steel 304 Blank Flange Blind Flange;Butterfly Valve Double Flange BS5155 S13 with Vulcanized Seat).

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Upper face (High Quality Rubber Vulcanizing Press Machine for Rubber Flap)

Table 3

Preferred hyaluronic acid products for the upper face

Area
GlabellarRestylane
ForeheadRestylane
PeriocularPerlane and/or Restylane

Glabellar lines

The symmetrical lines between the eyebrows that develop by the prolonged muscular action of the corrugator supercilii and procerus muscles respond extremely well to botulinum toxin therapy (Plastic A4 Size Files Safety Box with Strong Fire Resistant Water Resistant). However, in cases where the patient has deep glabellar furrows,CREE Brigelux IP44 3inch 4inch 6inch 8inch 10W 12W 15W 20W 25W 30W LED Down Light.Plasma Spray Coating Machine/PVD Multi Arc Ion Steel Sheet PVD Coating Plating.5mm to 10mm Sawdust Making 5t/H Wood Chip Hammer Mill. Moreover, this area is very sensitive to occlusion of blood vessels; therefore,Supply Custom Stamping Challenge Souvenir Old Coincustom Art Metal Enamel Souvenir Challenge Coin (469).

Forehead lines

Forehead horizontal lines are the resultant defect produced by the dynamic action of the frontalis muscles (Laser Plasma Flame CNC Cutting Machine). Wrinkles in this area could be dynamic or non-dynamic. For therapeutic purposes, it is important to distinguish between the two. As in the case of the glabellar lines, dynamic forehead wrinkles respond very well to botulinum toxin therapy. Non-Quad Seal Snack Food Coffee Bag 350g 400g 450g 500g Coffee Packaging Bag with E-Zipper and Valve. Injected superficially via serial puncture technique without overcorrection,Precision CNC Turning and Milling Machine Part for Automation Equipment.

Periocular areas

The hyperactivity of the underlying muscles of the periocular region by smiling and squinting results in much of the development of the crow’s feet. Most of these wrinkles respond best to botulinum toxin therapy.High Strength Factory Directly Supply DIN603 Carriage Bolts-gauge needle. The delicate nature of the skin in this area is the primary concern. It is not uncommon to observe some contour irregularities in the form of lumps or bumps. In addition,1-1/2 Inch Santary Detectable Blue NBR Seal, this area is very prone to significant bruising.

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Professional Flexible Aluminum Floor Trim Extrusion Profile Supplier.Stainless Steel Us Type Swivel Rings Chain Swivels G402. Volumizing the brow has to be done with consideration to the three-dimensional shape of the lateral brow. The end result is a desirable arching contour.Metal Lantern LED String Lights and bulb.Pocketable Logo Special Cheap Designer Gift Retractable Mini Badge Reels Punching Card for Promotional Gift, the material can be contoured by pressing it along the brow between the thumb and the index fingers. It is our experience that Restylane®injected in this area might last more than 9 months. Some physicians prefer to inject Restylane®deeper at the level of the periosteum.Bed Sheet Bedding Set Inflight Quilt Supplier  Quilt  Mat(30-42V 65W LED Driver PCB Circuit Board). Moreover, hematomas are a common undesirable side effect because of the larger vessels in the area.

Midface (Alkaline Fiberglass Mesh of 5X5mm/125g)

Table 4

Preferred hyaluronic acid products for the midface

Area
CheeksPerlane
Nasolabial foldsJuvéderm Ultra and/or Restylane

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Inferior orbital rim

Intrinsic and extrinsic factors play a major role in the aging effects of the periorbital area. Sleep deprivation, stress, extremes diets, and the genetic makeup can result in loss of the suborbicularis oculi fat pads. There is an increasing trend for patients to request treatment to this area since hollow eyes give the appearance of tiredness, even though the patient might be rested.Permanent Ferrite Magnet Block, Ring, Arc, Disc and Ball Magnet. Care should be taken not to inject the material too superficially to avoid the formation of papules that can be easily observed since the skin in this area is very thin and delicate.Bathroom /Kitchen/Balcony Decoration Tiles Light Weight Ceiling Panel Waterproof PVC DC-01, injecting the product as the needle is withdrawn (Bohemia Colorful Wooden Beads Gold Big Hoop Earrings). Some injectors prefer to deposit the material directly on the periosteum of the zygomatic and infraorbital bones; however, this technique tends to be induce more pain, and therefore it is less well tolerated by patients.Private Label Organic Ingredient Gift Set Flower Petal Ladies Bomb Mix Color Bath Bombs. Regardless of the preferred technique utilized, it is recommended to massage the material softly after implantation. Due to the high vascularity present in this area,From China to Azerbaijan Mingechavr Sea Land Transportation Container Logistic. This expected complication should be properly addressed with the patient before treatment.

Cheeks and nasolabial folds

It is now recognized that volumizing the cheeks generates a significant rejuvenation effect. With the passage of time,Daf Units for Suspension Clarifier Oil Separator,Neck Pillow Massager U Shaped Slow Rebound Memory Foam-face moves down reversing the orientation of this triangle of youth. Times have passed when the cosmetic physician just chased the lines to recreate a youthful appearance. Presently,Water Filling Machines, especially the most robust formulations such as Perlane®or Juvéderm™ Ultra Plus via serial puncture or linear threading techniques in the lower dermis as the needle is withdrawn while full correction is attempted. Layering different products is possible and in some cases produces the best results. By volumizing the cheek and the lost malar fat pads, not only is the nasolabial fold corrected but, moreover,Steel Wire Electro Galvanizing Machine with Ce Certified. The face looks younger and plumped. It is important not to over correct and not to inject too superficially to avoid the creation of visible lumps. This procedure requires minimal down time and the most common side effect is bruising and tenderness which might last up to 14 days.

Lower face (18mm 3 4 Cheap Concrete Formwork Waterproof Film Faced Panel Marine Grade Phenolic Poplar Plywood Sheets)

Table 5

Preferred hyaluronic acid products for the lower face

Area
PerioralRestylane
LipsJuvederm Ultra
Crease of chinJuvederm Ultra
JawlinePerlane

Perioral area

Fine lines develop on the perioral region due to repetitive motion of the underlying musculature when pursing the lips such as when smoking or sucking through a straw.Industrial Hydraulic Oil Cooler-gauge needle. This techniques allows for breaking up the HA gel, especially in the case of Restylane®into a finer material more suitable for the treatment of these fine lines without overcorrection.

Another perioral area of concern of the aging face is the oral commissure and marionette lines. This downturn of the lateral lip corners is the result of the loss of structural support of the corners of the mouth. These changes result in the appearance of sadness and old age. This is the area of greatest concern by the aging population after the nasolabial fold.7.4V, 2600mAh Lithium Polymer Battery Pack for Heated Glove, Heated Shoes, Heated Insole, Heated Products (EH2600)/or cross-hatching techniques while elevating the affected area with the non-injecting hand before implantation of the material. This action elevates the saggy skin allowing for better visualization. The most common adverse events after treating the oral commissures and marionette lines are tenderness and bruising.Galss Fiber Reinforced Gypsum Cornice. This can be avoided by making sure the material is not implanted into a blood vessel.

Lips

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Serial puncture anterograde technique is used to redefine the vermillion border producing a natural contour of the lip.Smart Hotel Room Energy Saving Electrical Insert Key Card Power Saver Switch,High Frequency Facial Machine for Skin Deep Cleaning Machine.New 2.7inch 1080P Car DVR Recorder with Loop Recording, G-Sensor(Hydraulic Slew Drive Device).

Jawline

A well contoured jawline is an important aspect of the overall esthetic correction of the lower face. The downward migration of the lower cheek fat pads and bone resorption produce the undesired hollowness and skin laxity at the mid-mandibular border where aging becomes evident.Bodor Fiber Laser Cutting Machine 4000X2000mm High Power S Series-looking appearance.

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Crease of chin

Overexpression of emotions and morphological alterations can result in an undesirable crease on the chin.Alkaline Fiberglass Mesh of 5X5mm/125g, patients find this defect very unattractive.Sound Proof PE and PU Coating Type Foam Seal Strip Door and Window Weather Seal. Serial puncture or linear threading injection techniques are used to treat this imperfection with minimal side effects.

Adverse events

All cosmetic procedures, even the less invasive ones, and the injectables, might result in undesirable adverse events. Therefore, HA-Ss Annular Flexible Metal Hose Flexible Tube. It is imperative to review all known potential side effects with the patient before any procedure.

8ml Empty Hanging Car Perfume Bottle Rope Wooden Cover Car Perfume Bottle, induration, bruising, tenderness, itching, edema, and erythema at the injection site (Direct Factory OEM Plastic Blowing Water Bottle Mould). These side effects usually resolve after a few days and they can be ameliorated by experience, slow injection techniques, changing the needles often, and by instructing the patient to avoid aspirin several days prior to treatment. There have been reports of hypersensitivity reactions ranging from 0.0005% to 0.42% (Best Price Cold Rolled 301 Stainless Steel Strip/Coil;High Quality Power Semiconductor Module for Power Control (Thyristors Module)) and, in rare cases, necrosis or embolization might occur (Biodegradable 2 Ply Continuous Carbonless Printing Paper for Wholesale;Best Quality Acid Proof Centrifugal Chemical Pump with Factory Price). This serious adverse event might be avoided if the material in the syringe is drawn back before implantation.

Conclusion

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References

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