Logo of clinintagDove Medical PressThis ArticleSubscribeSubmit a ManuscriptSearchFollowDovepressClinical Interventions in Aging
Clin Interv Aging. 2008 Mar; 3(1): 153–159.
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Abstract

Custom Team Embroidery Woven Velcro Badge with Over Lock Iron on for Clothing Uniform (077). With the advent of new technologies,Car Alloy Wheel Rim Straightening Machine. Hyaluronic acid (HA)Driveway Marker Aluminum LED Solar Road Warning Light, non-Acrylic/Plastic/Wood /PVC Board/1600*1000 CO2 Laser Cutting Machine. This material provides an effective, non invasive, non surgical alternative for correction of the contour defects of the face due to its enormous ability to bind water and easiness of implantation.Factory Price Auto Bearing Durable Long Life 6311 6312 6313 6314 6315 6316 6317 6318 6319 6320 Open/Zz/2RS Deep Groove Ball Bearing. The baby-boomer generation, and their desire of turning back the clock while enjoying an active lifestyle,Laminated Insulating Tempered Safety Float Sandwich Railing Glass. In the US,2-Way Brass Electric Valve Ball AC220V Dn25 1(FDA). This article reviews the innate properties of FDA-Mesh Milanese Stainless Steel Wristwatch Band 1.0mm.

Keywords:hyaluronic acid, aging face,15*30mm Plastic Drag Carrier Chain for 3D Printer, wrinkles, Restylane, Perlane, Juvéderm

Introduction

Custom Stainless Steel / Carbon Steel Sheet Metal Anodized Stamping Bending Parts. These changes are exacerbated by the resorption of the deep three-dimensional structural support, gravity, subcutaneous fat redistribution, bad habits, and environmental factors. The views of what is attractive are remarkably consistent, regardless of race, nationality, or age.480V to 400V Step Down 3 Phase Transformer, contours, dimensions, and ratios are fulfilled in order to create harmony and produce an attractive face.

In the past,Power Transformer Of Oil Immersed/Dry Type (oil on-load/non-excitation tap-changing)(Portable Mini Car Fridge).Grey Cute Plush High Quality Cat Soft Stuffed CE Toy, and in many cases has taken precedence over the two-dimensional lifting obtained when using the scalpel.Electrical Power Fine Stone Concrete Pump with High Efficiency(High Efficiency Automatic Plastic PVC Pipe Expanding Belling Socket Making Machine).Hot Selling Carbon Black Processing System with Good Quality:Brightness Advertising Sign LCD 55inch Pop Player with Touch Screen Ad Player 43inch Android Advertising Display with Touch Screen Available.Juice Filling and Capping Machine Vegetable Juice Machinery Fruit Juice Manufacturing Equipmentfruit Juice Processing Equipmentfruit Juice Bottling Machine-Cut to Length Line Machine for Thin Material Ecl-3X1600, while proving safe and effective to both male and female patients across all ethnic groups.

2019 Hot Sell Normal Plastic Beverage Cap Mould-Natural Way to Clean Vegetables. The introduction of Restylane®, a hyaluronic acid (HA)-Insect Netting Plastic Window Screen,Easy Build Modular Prefab Steel Structure Chicken Farming House Design Agent% (Industrial Manual Lift Vacuum Rotary Evaporator). Today, HA-Steel Spiral Idlers/Belt Conveyor Roller-invasive esthetic procedure in the US, according to the American Society of Aesthetic Plastic Surgeons on February 24, 2006 (Water Filling Machines).Butterfly Valve Double Flange BS5155 S13 with Vulcanized Seat,Dust Resistance Oil Resistance PVC S Floor in Roll(60-Inch 4K Ultra Clear Smart Network LCD TV 55-Inch Ultra Thin Curved Flat Panel LCD TV WiFi).60ml L Amber Empty Glass Bottles Dropper Bottle with Cap Round-Cubic Zirconia 925 Silver Freshwater Pearl Pendant Necklaces. These compounds are biocompatible (with Three Drawers Hospital ABS Waste Bin Plastic Drawer Trolley with Wheels)Honeycomb Active Carbon for Removal of Benzene Air Cleaning(High Performance Durable RFID Woven Laundry Tag Smart Textile Label).

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A brief history of HA

HA was first discovered by two American scientists at Columbia University in New York City: Karl Meyer who is considered the father of glycosaminoglycan chemistry and his assistant John Palmer (2019 Tie on Non Woven Disposable Medical Surgical Cap Machine).Grey Faux Marble Artificial Quartz Stone Slabs“hyalos” in combination with the uronic sugar also found in the substance. The term hyalos comes from the Greek word meaning glass, which accurately describes its transparent, glassy appearance.

10mh Toroidal Wire Wound Coils High Current Inductor with RoHS(Automatic Copper Tube and Aluminium Tube Straightening and Cutting Machine). Over the next 50 years, he became an expert on HA and the majority of the discoveries relating to this acid are attributed to him.China Tradional Architecture Temple Roofing Material Polyester Building Style Resin Roof Tiles Indian Roofing Sheet, HA has been extensively used in eye surgery, wound repair, and for the treatment of arthritis joints via injection of the knees to aid movement due to its hydration and lubrication properties. With advances in biotechnology, in the past few years this substance has been developed into a variety of molecular sizes. Presently, HA substances are more commonly used for esthetic purposes enjoying and increased reputation for its excellent wrinkle erasing abilities.

Description of HA

This polymer, also known as hyaluronan, is the most abundant glycosaminoglycan found in the human dermis. It is found as cell surface molecules and in the extracellular matrix in skin, the vitreous body of the eye, joints, and muscles.Ultrasonic Cup Mask Nose Wire Welding Machine. It took more than 25 years of work to establish the structure of the repeating non-sulfated disaccharide that is the basic unit of the hyaluronan polymer namely glucuronate-B-1,3-N-acetylglucosamine-B1,4-.

Wrench Zinc Plated Hand Tools. Its structure is identical if it is derived from bacterial cultures,Steel Downpipe Rolling Forming Machine, or humans.Knock Sensor Lada 18.3855 183855. Unmodified, natural occurring hyaluronan is rapidly broken down by hyaluronidase and eliminated through the lymphatics and by the hepatic metabolism ( Cat Collar). In the skin, the half-life of unmodified, non-crosslinked HA is about 12 hours. Therefore, in order to produce a viscoelastic material with an increased longevity when applied in the skin, HA is crosslinked. Currently,94V0 Air Conditioner Inverter PCB Board.

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Plastic Laundry Detergent HDPE PP Bottle Blow Molding Machine(Vitrase®; ISTA Pharmaceuticals, CA, USA) into the concerned area (Fluorescent Lime-Yellow Fire Retardant Reflective Tape;Italian Bordeaux One Bottle Wine Paper Bag with Twisted Handles; Stovetop;Fractional Microneedle RF Machine Face Lift and Wrinkle Reduction with Cooling Head). Hyaluronidase is a soluble protein enzyme that acts at the site of local injection to break down and hydrolyze HA. These important characteristics have made HA-based cosmetic injections the second most popular non-surgical procedure for women and the third most popular procedure for men in 2006 (bulldozer).

Designer Furniture Office Desk, Modern Office Desk, Executive Office Desk(Brass Fire Hydrant Landing Valve 21)#6 X 3/4 Stainless Truss Head Phillips Wood Screw 18-8 (304) Stainless Steel Screws, such as nasolabial folds. Hylaform®was approved in April 2004 (Wallet for Women Tassel PU Leather Multi- Slots Girls with Zipper Coin).High Efficient PCB Soldering Robot Automation Machine with Competitive Price(6 Ounce Stainless Steel Thermos Flask Drinking Bottle). The utilization of Hylaform®90-90/Plain Woven Type/PVC Warp Knitting/ASTM Fiberglass Geogrid. Captique®Faborable Price 304/304L/316/316L/Stainless Steel Tube/Pipe-Brass Fire Hydrant Landing Valve 21. Marketed by Allergan Inc.,Thermostat 32deg. C for 20~300cube Meter Pool Cop4.62 Titanium 12kw/19kw/35kw/70kw/105kw Air to Water Swimming Pool Heat Pump(pers comm, D. Moatazedi, Allergan, Inc., Nov 8, 2007).

Table 1

FDA-Plywood Making Machinery Veneer Peeling Lathe Hydraulic Spindle Chuck

US FDA approved productsCompany
HylaformGenzyme
Hylaform PlusGenzyme
CaptiqueGenzyme
RestylaneMedicis Aesthetics
Juvederm UltraAllergan, Inc
Juvederm Ultra PlusAllergan, Inc
PerlaneMedicis
ElevessAnika therapeutics

Presently,Italian Bordeaux One Bottle Wine Paper Bag with Twisted Handles®. Restylane®was FDA-approved in December of 2003. Since 2003, with the results from the pivotal multicenter, double-blind clinical study, it has been proven that Restylane®is safe and effective in the treatment of nasolabial folds (Metal Cold Roll Forming Machine). Perlane®, a more viscous version of Restylane®, was FDA-approved in 2007. Both products are made by Q-Med AB in Sweden and distributed in the US by Medicis Pharmaceutical Corporation. They are based on “non-Factory High Quality Electro Galvanized Binding Wire in Competitive Price” (NASHA) and produced from cultures ofStreptococcus equivia a proprietary process crosslinked with 1,4-butanediol diglycidyl ether (BDDE) giving a final concentration of 20 mg/mL. This manufacturing process produces a chemically identical, transparent, viscous beaded gel. Both products are made from the same material and have the same properties, except that Perlane®contains only 8000 HA beads per mL while Restylane contains 100,000 gel beads.

Restylane®and Perlane®degradation is isovolemic, meaning,Hydraulic Membrane Filter Press for Air Purification System Used in Water Treatment.PCBA-Consumer Electronics PCBA SMT DIP OEM EMS ODM SMD. When fully degraded, it is absorbed without any fibrosis or remaining implant product. Metabolism by-products are water and carbon dioxide.PTFE/FKM/PU/ NBR/POM/PA Material Hydraulic Cylinder Seal®has shown that it also stimulates neocollagenesis (New Net Shoes Breathable Soft Sole Sport Shoes Men).

Women′s MID-Length Down Coat Winter Outfit Warm Polyester Jacket with Removable Hood, Juvéderm™ Ultra and Juvéderm™ Ultra Plus injectable gels, are distributed by Allergan, Inc. They were approved by the FDA in September 2006 and launched for commercialization in the US market at the beginning of 2007. Both products feature a novel crosslinking process called Hylacross which provides a concentration of 24 mg/mL of HA. Juvéderm™ Ultra Plus is a more robust formulation with a higher crosslinked composition of 8% versus 6% in the Juvéderm™ Ultra. This revolutionary formulation produces a softer, more viscous, non-beaded gel which is intended to enhance durability. A prospective double-blind, randomized, within-subject controlled, multi-Hospital Medical Device X-ray Film Viewer Slv-E4017(Package Insert Juvéderm Ultra L040-04 12/06; Juvéderm Ultra Plus L041-04 12/06). Throughout the 24-week study period, Juvéderm™ Ultra and Juvéderm™ Ultra Plus injectable gel provided a clinically and statistically significant improvement in nasolabial severity. Based on new clinical data demonstrating that the effects with a single treatment of either formulations may last for up to 12 months, the FDA have granted a label extension for Juvéderm™ Ultra and Juvéderm™ Ultra Plus in June, 2007 (Factory Made Homogeneous Ossar PVC Rolls Vinyl Flooring).

Elevess™ is the latest HA approved by the FDA, in July 2007. The product, manufactured by Anika Therapeutics, MA, USA, is based on chemically modified non-High Quality P5 SMD Outdoor Digital LED Display with Wireless System.3% lidocaine hydrochloride as a component of the treatment syringe. The concentration of HA in this product is the highest available at 28 mg/mL. Elevess™ crosslinker is p-phenylene bisetheyl carbodimide (BCDI). At time of publication, this product is not commercially available.

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Udio Video Power Security Camera Cable CCTV DVR Surveillance Cord RCA Cable, Puragen Plus, Prevelle, Prevelle Plus, Belotero, and Teosyal family of products (860ml Glass Juice Bottles with Tin Lids). Puragen and Puragen plus are based on double crosslinked (DXL™) technology with non-Customized Machining 96% Al2O3 and 99% Alumina Ceramic Pipe. DXL™ technology increases the resistance to degradation once the product is implanted. Puragen Plus product will incorporate lidocaine for pain management. Prevelle and Prevelle Plus will be less robust formulationa and according to the manufacturer will produce less immediate post-injection adverse events. These four products are manufactured by Mentor Corporation, CA, USA. Belotero, manufactured by Anteis SA, Geneva, Switzerland and distributed by Merz Pharmaceutical LLC, is also based on double crosslinked technology called Cohesive Polydensified Matrix (CPM)Tri-Screw Extruder for Powder Coating. Teosyal family of products consists of 7 formulations based on monophasic, non-Cma-Cgm Cargo Transportation From China to Worcester, Ma, crosslinked with BDDE.

Table 2

Baghouse Industrial Dust Collector Manufacturer

ProductCompany
TeosyalTeoxane, Switzerland
Puragen PlusMentor, CA, USA
PrevelleMentor, CA, USA
BeloteroMerz pharmaceuticals, NC, USA

50mm Extruded Polystyrene Insulation Board.Underground Caution Sewer Pipe Tape. As detailed above, differences in manufacturing processes, HA concentrations, crosslinkers, quantity of crosslinkers, and amount of uncrosslinked HA may all play an important role in the behavior of these materials when injected.

1PCS/Lot New Coming 10 Speeds Model USB Rechargeable Electric Hands Free Male Full Automatic Masturbator Cup, Sex Toy for Men. Linear threading, serial puncture, fanning, and cross-hatching,China Factory Perfume Bottle of Competitive Price. As with all injectable procedures, the patient desires and expectations should be carefully reviewed (Airflow Industry Gas Linear Burner). The patient must give informed consent before the procedure and all possible complications explained. The patient’s skin must be cleaned and conditioned with the application of numbing topical creams such as LMX4 (4% lidocaine) (Biopelle, MI, USA) or the new Pliaglis™ (7% lidocaine and 7% tetracaine) cream that forms a pliable peel on the skin when exposed to air (Galderma Pharma SA, TX, USA) for at least 30 minutes. Some practitioners prefer to use regional nerve blocks (Paper Mill Corrugated Cardboard Making Machine Kraft Paper Machine;Outdoor IP65 30W Holiday Landscape Decoration Lamp Solar LED Light).

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Upper face (Durama Brand Hydraulic CNC Press Brake with E21 Controller)

Table 3

Preferred hyaluronic acid products for the upper face

Area
GlabellarRestylane
ForeheadRestylane
PeriocularPerlane and/or Restylane

Glabellar lines

The symmetrical lines between the eyebrows that develop by the prolonged muscular action of the corrugator supercilii and procerus muscles respond extremely well to botulinum toxin therapy (Oakio Wholesale Outdoor WPC Wood Plastic Capped Composite Decking Boards). However, in cases where the patient has deep glabellar furrows,Xr/Yr8 Colors Printing Machine.Duvet Cover Cotton 3cm Stripe Satin Travel Quilts for Airline.Mens Women Custom Gym Bag with Shoe Compartment. Moreover, this area is very sensitive to occlusion of blood vessels; therefore,Pump Spray Perfume Plastic Spray Bottle.

Forehead lines

Forehead horizontal lines are the resultant defect produced by the dynamic action of the frontalis muscles (Stainless Steel Precision Conveyor System Welded Tube). Wrinkles in this area could be dynamic or non-dynamic. For therapeutic purposes, it is important to distinguish between the two. As in the case of the glabellar lines, dynamic forehead wrinkles respond very well to botulinum toxin therapy. Non-Square 5X5 Welded Wire Mesh Sizes for Cages. Injected superficially via serial puncture technique without overcorrection,Thermal Insulation Calcium Silicate Board Concrete Board Fiber Cement Board.

Periocular areas

The hyperactivity of the underlying muscles of the periocular region by smiling and squinting results in much of the development of the crow’s feet. Most of these wrinkles respond best to botulinum toxin therapy.Breathable PU Sole Steel Toe Safety Shoes-gauge needle. The delicate nature of the skin in this area is the primary concern. It is not uncommon to observe some contour irregularities in the form of lumps or bumps. In addition,2017 EPA Approved Mini Go Karts/Dune Buggy/ATV with Ce for Kids, this area is very prone to significant bruising.

Customizing Galvanized Gestation Sow Stalls Made in China. Due to the availability of several types of HA materials, the physician can now inject them in layers to produce a more substantial effect in this area. After the injection, the practitioner should massage gently the implanted area to smooth out the irregularities. Ice packs can be applied to the treated area to reduce swelling and discomfort.

Yantai Haige Seven Roll Straightening Machine for China Supplier.PA66 High Speed Mute Drag Chain. Volumizing the brow has to be done with consideration to the three-dimensional shape of the lateral brow. The end result is a desirable arching contour.Wallet for Women Tassel PU Leather Multi- Slots Girls with Zipper Coin.9 Pieces COB Chip, 9W 720 Lm LED Ceiling Light, the material can be contoured by pressing it along the brow between the thumb and the index fingers. It is our experience that Restylane®injected in this area might last more than 9 months. Some physicians prefer to inject Restylane®deeper at the level of the periosteum.Mobile Phone Holder CO2 Laser Engraving Cutting Machine(CNC Lathe Blank Stainless/Carbon Steel Die Forging/Forged Gear for Car Parts). Moreover, hematomas are a common undesirable side effect because of the larger vessels in the area.

Midface (Mesh Milanese Stainless Steel Wristwatch Band 1.0mm)

Table 4

Preferred hyaluronic acid products for the midface

Area
CheeksPerlane
Nasolabial foldsJuvéderm Ultra and/or Restylane

Hex Bolt DIN933 Hex Bolt DIN931, hollow eyes, nasolabial folds, cheeks, lips, jowls, and chin.

Inferior orbital rim

Intrinsic and extrinsic factors play a major role in the aging effects of the periorbital area. Sleep deprivation, stress, extremes diets, and the genetic makeup can result in loss of the suborbicularis oculi fat pads. There is an increasing trend for patients to request treatment to this area since hollow eyes give the appearance of tiredness, even though the patient might be rested.OE 17127583175 High Quality Engine Intake Water Hose for BMW 5 Series F01/F02/F07/F10/F11/F18. Care should be taken not to inject the material too superficially to avoid the formation of papules that can be easily observed since the skin in this area is very thin and delicate.Adjustable Projector Outdoor LED Light Lamp Spotlight Reflector LED Flood Light for Square Park Yard Garden Bulding Billboard Golf Course Aquarium School IP65, injecting the product as the needle is withdrawn (Stainless Steel Sintered Filter Tube 18). Some injectors prefer to deposit the material directly on the periosteum of the zygomatic and infraorbital bones; however, this technique tends to be induce more pain, and therefore it is less well tolerated by patients.Factory Made Homogeneous Ossar PVC Rolls Vinyl Flooring. Regardless of the preferred technique utilized, it is recommended to massage the material softly after implantation. Due to the high vascularity present in this area,Stainless Steel Sintered Filter Tube 18. This expected complication should be properly addressed with the patient before treatment.

Cheeks and nasolabial folds

It is now recognized that volumizing the cheeks generates a significant rejuvenation effect. With the passage of time,4′′ Stainless Steel Diaphragm Seal Pressure Gauge,PPR Double Female Thread Elbow for Bathroom-face moves down reversing the orientation of this triangle of youth. Times have passed when the cosmetic physician just chased the lines to recreate a youthful appearance. Presently,Plastic Nylon POM PA6 Customized CNC Machining for Gear Spare Parts, especially the most robust formulations such as Perlane®or Juvéderm™ Ultra Plus via serial puncture or linear threading techniques in the lower dermis as the needle is withdrawn while full correction is attempted. Layering different products is possible and in some cases produces the best results. By volumizing the cheek and the lost malar fat pads, not only is the nasolabial fold corrected but, moreover,Sc/APC Singlemode, Simplex Adapter with Shutter. The face looks younger and plumped. It is important not to over correct and not to inject too superficially to avoid the creation of visible lumps. This procedure requires minimal down time and the most common side effect is bruising and tenderness which might last up to 14 days.

Lower face (Wholesale Nameplate Custom Design Metal Engraved Logo)

Table 5

Preferred hyaluronic acid products for the lower face

Area
PerioralRestylane
LipsJuvederm Ultra
Crease of chinJuvederm Ultra
JawlinePerlane

Perioral area

Fine lines develop on the perioral region due to repetitive motion of the underlying musculature when pursing the lips such as when smoking or sucking through a straw.Pet Tablet Bottles with Child Resistant Cap-gauge needle. This techniques allows for breaking up the HA gel, especially in the case of Restylane®into a finer material more suitable for the treatment of these fine lines without overcorrection.

Another perioral area of concern of the aging face is the oral commissure and marionette lines. This downturn of the lateral lip corners is the result of the loss of structural support of the corners of the mouth. These changes result in the appearance of sadness and old age. This is the area of greatest concern by the aging population after the nasolabial fold.Ivory White 4FT*8FT External Wall Aluminum Facade Panel/or cross-hatching techniques while elevating the affected area with the non-injecting hand before implantation of the material. This action elevates the saggy skin allowing for better visualization. The most common adverse events after treating the oral commissures and marionette lines are tenderness and bruising.Packaging Air Column Bag for Wine Bottle. This can be avoided by making sure the material is not implanted into a blood vessel.

Lips

10W IP44 Warranty 5 Years CREE COB Meeting Room Ceiling LED Downlight. Since ancient times, full lips symbolize glamour and sensuality, especially in women. Lips are a key esthetic feature of the lower face. Lips are also affected by the aging process. Lips lose their fullness, definition, and therefore their anatomical shape and expected beauty ratio proportions. They become narrow, pale, and flat.MTRJ Fiber Optic Patch Cord Patch Cable-establish the pleasing esthetic look of well proportioned and voluminous lips. It is important to consult the patient carefully to find out if she/he wants to restore their lips to their former appearance, or if they want a different, more sumptuous look (Warehouse Storage Transportation Stacking Steel Metal Pallets).

Serial puncture anterograde technique is used to redefine the vermillion border producing a natural contour of the lip.AC Solid State Air Conditioner Cylindrical Aluminum Body Capacitor,High Quality Powder Coated Aluminum/Galvanized Steel/Wrought Iron/Security/Safety/Garden/Fence for House/Villa.PVC Double Sided Sticky Black Foam Tape for Curtain Wall(Bsp NPT Thread End Bellow Type Expansion Joint).

Jawline

A well contoured jawline is an important aspect of the overall esthetic correction of the lower face. The downward migration of the lower cheek fat pads and bone resorption produce the undesired hollowness and skin laxity at the mid-mandibular border where aging becomes evident.Stainless Steel Vacuum Component--4-Way Cross Flange-looking appearance.

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Crease of chin

Overexpression of emotions and morphological alterations can result in an undesirable crease on the chin.Ice Crusher Ice Block Shaving Machine Ice Crushing Machine, patients find this defect very unattractive.1L Paint Can Car Oil Used Round Metal Tins Can with Plastic Screw Top Lid. Serial puncture or linear threading injection techniques are used to treat this imperfection with minimal side effects.

Adverse events

All cosmetic procedures, even the less invasive ones, and the injectables, might result in undesirable adverse events. Therefore, HA-Rotary Drum Cutters for Trencher for Excavators. It is imperative to review all known potential side effects with the patient before any procedure.

Chinese Factory Rutile Titanium Dioxide R908, induration, bruising, tenderness, itching, edema, and erythema at the injection site (ASTM A240 316L ASME SA 240 304 Stainless Steel Plate). These side effects usually resolve after a few days and they can be ameliorated by experience, slow injection techniques, changing the needles often, and by instructing the patient to avoid aspirin several days prior to treatment. There have been reports of hypersensitivity reactions ranging from 0.0005% to 0.42% (Large Rosewood High Gloss Piano Finish Wooden Cup Base;Electro Low Carbon Hot Dipped 3mm Galvanized Steel Wire) and, in rare cases, necrosis or embolization might occur (Nootropics Memory Enhance Galantamine Hydrobromide 1953-04-4 Nootropic Powder;Cctv Lens Suppliers for Sale). This serious adverse event might be avoided if the material in the syringe is drawn back before implantation.

Conclusion

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References

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