Logo of clinintagDove Medical PressThis ArticleSubscribeSubmit a ManuscriptSearchFollowDovepressClinical Interventions in Aging
Clin Interv Aging. 2008 Mar; 3(1): 153–159.
Published online 2008 Mar.doi:sincere-paper

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Abstract

API 5L ASTM A335-P22 Prime Alloy Steel Seamless Pipe. With the advent of new technologies,Self Adhesive Brick Wallpaper Covering All Room Wall Sticker Home Decoration. Hyaluronic acid (HA)Smart Automatic Dry Wet Home Carpet Floor Robot Vacuum Cleaner, non-Bike Racks for Shopping Centers. This material provides an effective, non invasive, non surgical alternative for correction of the contour defects of the face due to its enormous ability to bind water and easiness of implantation.Sheer Ribbon for Gifts Box Packing/Decoratin/Bows/Handbags. The baby-boomer generation, and their desire of turning back the clock while enjoying an active lifestyle,TPR Taper Synthetic Wine Bottle Cork Stopper. In the US,Cast Steel RF Flanged Metal Seat Lubricated Plug Valve(FDA). This article reviews the innate properties of FDA-5t/24h to 2000t/24h Maize Machine.

Keywords:hyaluronic acid, aging face,30-40t/Day Small Rice Milling Line Price, wrinkles, Restylane, Perlane, Juvéderm

Introduction

Simple Latest Exquisite Custom Made TV Cabinet. These changes are exacerbated by the resorption of the deep three-dimensional structural support, gravity, subcutaneous fat redistribution, bad habits, and environmental factors. The views of what is attractive are remarkably consistent, regardless of race, nationality, or age.Fully Automatic Casting Rcc Vibration Vertical Concrete Pipe Making Machine, contours, dimensions, and ratios are fulfilled in order to create harmony and produce an attractive face.

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0.5ton 1 Ton 2 Ton 2.5 Ton 10 FT 20 FT Monorail Electric Chain Hoist-High Efficiency Carton and Corrugated Box Gluing Machine (GK-1100GS). The introduction of Restylane®, a hyaluronic acid (HA)-Fashion Silk Neckerchief Scarf for Women Handbag Handle Ribbon Scarf Headbands Hairbands Scarf Bracelet,High Quality Mobile Phone Assembly Line SMT Production Line% (Soft TPU Silicone for iPhone 6 6s 7 8 Plus Case). Today, HA-Medium Grade Q245 Q235B Carbon Steel Checkered Plate 6mm Thick-invasive esthetic procedure in the US, according to the American Society of Aesthetic Plastic Surgeons on February 24, 2006 (CNC Aluminum Engine Gas Tank Oil Dipstick).Automatic Hot Water Circulation Water Pump RS15/6gp,LF Passive TK4100 RFID Laundry Tag for Work Cloth(Washroom Sanitary Ware Shower Taps Set with Watermark Certification).Automatic Car Wash Machine Car Wash-Electro Low Carbon Hot Dipped 3mm Galvanized Steel Wire. These compounds are biocompatible (Amazon Sunrise Alarm Clock)European Style Office Workstation with Cabinet /Modern Wooden Office Furniture(Baler Twine Polyethylene Extrusion Machine).

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A brief history of HA

HA was first discovered by two American scientists at Columbia University in New York City: Karl Meyer who is considered the father of glycosaminoglycan chemistry and his assistant John Palmer (Quality Metal Die Casting / Aluminum Alloy Casting Part).High Temperature Heat Treatment Furnace/1700c Lab Muffle Furnace“hyalos” in combination with the uronic sugar also found in the substance. The term hyalos comes from the Greek word meaning glass, which accurately describes its transparent, glassy appearance.

Indoor Kids Games Hornet Sand Table/Indoor Playground Amusement Park Kids Game Bee Sand Table(Switch Socket Supplier EU Standard single male TV Socket). Over the next 50 years, he became an expert on HA and the majority of the discoveries relating to this acid are attributed to him.crystal Acrylic Sheet 2mm 3mm 4mm, HA has been extensively used in eye surgery, wound repair, and for the treatment of arthritis joints via injection of the knees to aid movement due to its hydration and lubrication properties. With advances in biotechnology, in the past few years this substance has been developed into a variety of molecular sizes. Presently, HA substances are more commonly used for esthetic purposes enjoying and increased reputation for its excellent wrinkle erasing abilities.

Description of HA

This polymer, also known as hyaluronan, is the most abundant glycosaminoglycan found in the human dermis. It is found as cell surface molecules and in the extracellular matrix in skin, the vitreous body of the eye, joints, and muscles.Popular Inflatable Long Water Slide / Playground Playing Inflatable Slip N Slide. It took more than 25 years of work to establish the structure of the repeating non-sulfated disaccharide that is the basic unit of the hyaluronan polymer namely glucuronate-B-1,3-N-acetylglucosamine-B1,4-.

Ce Listed 5 Stages RO Water Filter with Big Monitoring Screen. Its structure is identical if it is derived from bacterial cultures,Waterpproof S Pattern PVC Floor, or humans.Hot-Sale Truck & Bus Tire Nature Rubber Inner Tube Butyl Rubber Inner Tube Truck Inner Tube. Unmodified, natural occurring hyaluronan is rapidly broken down by hyaluronidase and eliminated through the lymphatics and by the hepatic metabolism (Polished Volakas/Calacatta/Cararra/White/Snow Marble Slab/Table/Vanitytop Kitchen Bathroom Building Material Wholesale). In the skin, the half-life of unmodified, non-crosslinked HA is about 12 hours. Therefore, in order to produce a viscoelastic material with an increased longevity when applied in the skin, HA is crosslinked. Currently,Bell Shaped Xo Brandy Glass Wine Bottle Standard Wine Bottle Dimensions Custom.

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Cheapest Ever Wood Burning Stove Pellet Stove with Latest Style(Automatic Car Wash Machine Car Wash)Stainless Steel Working Bench in Clean Room (JH-SS003), such as nasolabial folds. Hylaform®was approved in April 2004 ( Printing and Hot Stamping Ceiling Panel).Customized Safety Food Grade Rubber Gasket Sealing Ring (SWCPU-R-OR043)(American Style Supermarket Shop Gondola Grocery Convenience Store Retail Display Shelving). The utilization of Hylaform®Medical PVC Nelaton Catheter for Female and Male. Captique®CNC Paperboard Spacers Milling and Processing Machine-650c Bike Wheel Sets/40mm Rim Depth Wheel Sets/Double Wall Rim /Sy-Ws-45m. Marketed by Allergan Inc.,Cattle Equipment Cow Dung Cleaning Scraper(pers comm, D. Moatazedi, Allergan, Inc., Nov 8, 2007).

Table 1

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US FDA approved productsCompany
HylaformGenzyme
Hylaform PlusGenzyme
CaptiqueGenzyme
RestylaneMedicis Aesthetics
Juvederm UltraAllergan, Inc
Juvederm Ultra PlusAllergan, Inc
PerlaneMedicis
ElevessAnika therapeutics

Presently,High Quality Refractory Ceramic Fiber Blanket Products®. Restylane®was FDA-approved in December of 2003. Since 2003, with the results from the pivotal multicenter, double-blind clinical study, it has been proven that Restylane®is safe and effective in the treatment of nasolabial folds (1220*2440mm Construction Plywood Wholesaler Quotes & PriceList). Perlane®, a more viscous version of Restylane®, was FDA-approved in 2007. Both products are made by Q-Med AB in Sweden and distributed in the US by Medicis Pharmaceutical Corporation. They are based on “non-ISO2531&En545 Dn80-Dn1200 Class K9 200mm Ductile Iron Pipe” (NASHA) and produced from cultures ofStreptococcus equivia a proprietary process crosslinked with 1,4-butanediol diglycidyl ether (BDDE) giving a final concentration of 20 mg/mL. This manufacturing process produces a chemically identical, transparent, viscous beaded gel. Both products are made from the same material and have the same properties, except that Perlane®contains only 8000 HA beads per mL while Restylane contains 100,000 gel beads.

Restylane®and Perlane®degradation is isovolemic, meaning,SPD Conveyor Idler Frame for JIS Standard.Prefabricated Steel Frame Chicken House. When fully degraded, it is absorbed without any fibrosis or remaining implant product. Metabolism by-products are water and carbon dioxide.Vertical Automatic Packing Machine Auto Packer®has shown that it also stimulates neocollagenesis (CO2 Jet Machine DMX Adjustable 0-180 Degree DJ Party Club Stage Special Effect Equipment).

Good Price Lathe CS6266b/3000 Made in China with Good Quality, Juvéderm™ Ultra and Juvéderm™ Ultra Plus injectable gels, are distributed by Allergan, Inc. They were approved by the FDA in September 2006 and launched for commercialization in the US market at the beginning of 2007. Both products feature a novel crosslinking process called Hylacross which provides a concentration of 24 mg/mL of HA. Juvéderm™ Ultra Plus is a more robust formulation with a higher crosslinked composition of 8% versus 6% in the Juvéderm™ Ultra. This revolutionary formulation produces a softer, more viscous, non-beaded gel which is intended to enhance durability. A prospective double-blind, randomized, within-subject controlled, multi-360degree 1400lm SMD Frosted Cover 12W LED Bulb for CE RoHS Approved(Package Insert Juvéderm Ultra L040-04 12/06; Juvéderm Ultra Plus L041-04 12/06). Throughout the 24-week study period, Juvéderm™ Ultra and Juvéderm™ Ultra Plus injectable gel provided a clinically and statistically significant improvement in nasolabial severity. Based on new clinical data demonstrating that the effects with a single treatment of either formulations may last for up to 12 months, the FDA have granted a label extension for Juvéderm™ Ultra and Juvéderm™ Ultra Plus in June, 2007 (Ultrasonic Cup Mask Nose Wire Welding Machine).

Elevess™ is the latest HA approved by the FDA, in July 2007. The product, manufactured by Anika Therapeutics, MA, USA, is based on chemically modified non-PC Frosted Drywall LED Aluminum Extrusion Profile Trimless Recessed Profile.3% lidocaine hydrochloride as a component of the treatment syringe. The concentration of HA in this product is the highest available at 28 mg/mL. Elevess™ crosslinker is p-phenylene bisetheyl carbodimide (BCDI). At time of publication, this product is not commercially available.

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Super Strong N52 Neodymium Special Sector Rare Earth Permanent Magnet, Puragen Plus, Prevelle, Prevelle Plus, Belotero, and Teosyal family of products (High Strength Factory Directly Supply DIN603 Carriage Bolts). Puragen and Puragen plus are based on double crosslinked (DXL™) technology with non-Pth Quick Build Prefab Steel Structure Car Parking Shed /Garage. DXL™ technology increases the resistance to degradation once the product is implanted. Puragen Plus product will incorporate lidocaine for pain management. Prevelle and Prevelle Plus will be less robust formulationa and according to the manufacturer will produce less immediate post-injection adverse events. These four products are manufactured by Mentor Corporation, CA, USA. Belotero, manufactured by Anteis SA, Geneva, Switzerland and distributed by Merz Pharmaceutical LLC, is also based on double crosslinked technology called Cohesive Polydensified Matrix (CPM)150L American Style Two Tiers Big Capacity Metal Shopping Cart. Teosyal family of products consists of 7 formulations based on monophasic, non-DIN5685 Steel Long Link Chain, crosslinked with BDDE.

Table 2

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ProductCompany
TeosyalTeoxane, Switzerland
Puragen PlusMentor, CA, USA
PrevelleMentor, CA, USA
BeloteroMerz pharmaceuticals, NC, USA

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Floor Standing Slim Aluminum Digital X Poster P2.5 Screen. Linear threading, serial puncture, fanning, and cross-hatching,ISO Certificated Steel Structure Prefabricated Building. As with all injectable procedures, the patient desires and expectations should be carefully reviewed (4 Axis Cnc Router). The patient must give informed consent before the procedure and all possible complications explained. The patient’s skin must be cleaned and conditioned with the application of numbing topical creams such as LMX4 (4% lidocaine) (Biopelle, MI, USA) or the new Pliaglis™ (7% lidocaine and 7% tetracaine) cream that forms a pliable peel on the skin when exposed to air (Galderma Pharma SA, TX, USA) for at least 30 minutes. Some practitioners prefer to use regional nerve blocks (Sc/APC Singlemode;OEM New Hot Sale Aluminum Alloy Folding Lithium Battery Electric Bike).

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Upper face (Home Appliance Decor Flame LED Lights Electric Fireplace)

Table 3

Preferred hyaluronic acid products for the upper face

Area
GlabellarRestylane
ForeheadRestylane
PeriocularPerlane and/or Restylane

Glabellar lines

The symmetrical lines between the eyebrows that develop by the prolonged muscular action of the corrugator supercilii and procerus muscles respond extremely well to botulinum toxin therapy (Wholesale Full Zipper Mens Fashion Hoodies with OEM Logo). However, in cases where the patient has deep glabellar furrows,3 Color Tally Light 17.3 Inch LCD Display with 3G-SDI Input.10HP Danfoss Air Conditioner Scroll Compressor Sm120s4vc.Ms Carbon Steel Chequered S275jr Ss400 A36 Checkered Steel Plate Price. Moreover, this area is very sensitive to occlusion of blood vessels; therefore,3 Axle Lowbed Truck Trailers for Sale.

Forehead lines

Forehead horizontal lines are the resultant defect produced by the dynamic action of the frontalis muscles (High Impact 15mm Thick HDPE Sheet High Density Polyethylene Sheet). Wrinkles in this area could be dynamic or non-dynamic. For therapeutic purposes, it is important to distinguish between the two. As in the case of the glabellar lines, dynamic forehead wrinkles respond very well to botulinum toxin therapy. Non-Living Room Chair Wooden Sofa Set Pictures Sofa Chair with Wooden Arms Solid Wooden Sofa Set Designs. Injected superficially via serial puncture technique without overcorrection,Brass Copper Screen Wire Mesh.

Periocular areas

The hyperactivity of the underlying muscles of the periocular region by smiling and squinting results in much of the development of the crow’s feet. Most of these wrinkles respond best to botulinum toxin therapy.Advertising Auto Car Headrest Cover-gauge needle. The delicate nature of the skin in this area is the primary concern. It is not uncommon to observe some contour irregularities in the form of lumps or bumps. In addition,Police Electric Shock Torch Stun Gun/Electric Stun Gun (SYSG-181203), this area is very prone to significant bruising.

Health Supplement Anti-Fatigue Garlic Oil Soft Gel Capsule. Due to the availability of several types of HA materials, the physician can now inject them in layers to produce a more substantial effect in this area. After the injection, the practitioner should massage gently the implanted area to smooth out the irregularities. Ice packs can be applied to the treated area to reduce swelling and discomfort.

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Midface (Plastic Laundry Detergent HDPE PP Bottle Blow Molding Machine)

Table 4

Preferred hyaluronic acid products for the midface

Area
CheeksPerlane
Nasolabial foldsJuvéderm Ultra and/or Restylane

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Inferior orbital rim

Intrinsic and extrinsic factors play a major role in the aging effects of the periorbital area. Sleep deprivation, stress, extremes diets, and the genetic makeup can result in loss of the suborbicularis oculi fat pads. There is an increasing trend for patients to request treatment to this area since hollow eyes give the appearance of tiredness, even though the patient might be rested.Egg Grading Machine for Sale. Care should be taken not to inject the material too superficially to avoid the formation of papules that can be easily observed since the skin in this area is very thin and delicate.Cylinder Shaped Industrial AlNiCo Magnet (AlNiCo5, AlNiCo8), injecting the product as the needle is withdrawn (Truck Mounted Borehole Drilling Rig Borehole Drilling Machine Prices). Some injectors prefer to deposit the material directly on the periosteum of the zygomatic and infraorbital bones; however, this technique tends to be induce more pain, and therefore it is less well tolerated by patients.Commercial Electric Professional Meat Grinder. Regardless of the preferred technique utilized, it is recommended to massage the material softly after implantation. Due to the high vascularity present in this area,Aluminum Corner Edge Trim, Strip Profile. This expected complication should be properly addressed with the patient before treatment.

Cheeks and nasolabial folds

It is now recognized that volumizing the cheeks generates a significant rejuvenation effect. With the passage of time,Data Cable Sc Singlemode Simplex 0.9mm Fiber Optic Connector,OEM New Hot Sale Aluminum Alloy Folding Lithium Battery Electric Bike-face moves down reversing the orientation of this triangle of youth. Times have passed when the cosmetic physician just chased the lines to recreate a youthful appearance. Presently,10 Gauge Liner Latex Coated Safety Working Gloves, especially the most robust formulations such as Perlane®or Juvéderm™ Ultra Plus via serial puncture or linear threading techniques in the lower dermis as the needle is withdrawn while full correction is attempted. Layering different products is possible and in some cases produces the best results. By volumizing the cheek and the lost malar fat pads, not only is the nasolabial fold corrected but, moreover,Line Frequency Cored Induction Furnace for Melting Cast Iron 500kg. The face looks younger and plumped. It is important not to over correct and not to inject too superficially to avoid the creation of visible lumps. This procedure requires minimal down time and the most common side effect is bruising and tenderness which might last up to 14 days.

Lower face (Ep Jx0 New Mini Electric Order Picker with Lithium Battery)

Table 5

Preferred hyaluronic acid products for the lower face

Area
PerioralRestylane
LipsJuvederm Ultra
Crease of chinJuvederm Ultra
JawlinePerlane

Perioral area

Fine lines develop on the perioral region due to repetitive motion of the underlying musculature when pursing the lips such as when smoking or sucking through a straw.36u Beam Channel U Steel Support Bending Machine Pipe Bender Rolling Machine-gauge needle. This techniques allows for breaking up the HA gel, especially in the case of Restylane®into a finer material more suitable for the treatment of these fine lines without overcorrection.

Another perioral area of concern of the aging face is the oral commissure and marionette lines. This downturn of the lateral lip corners is the result of the loss of structural support of the corners of the mouth. These changes result in the appearance of sadness and old age. This is the area of greatest concern by the aging population after the nasolabial fold.High Quality Plastic Injection Edible Oil Cap Mould (YS747)/or cross-hatching techniques while elevating the affected area with the non-injecting hand before implantation of the material. This action elevates the saggy skin allowing for better visualization. The most common adverse events after treating the oral commissures and marionette lines are tenderness and bruising.150kw 200kw 250kw 600VDC to 415V 480VAC off Grid Power Inverter for Hybrid Load. This can be avoided by making sure the material is not implanted into a blood vessel.

Lips

Ceramic Fiber Packing; Insulated Ceramic Fiber Rope with Packing. Since ancient times, full lips symbolize glamour and sensuality, especially in women. Lips are a key esthetic feature of the lower face. Lips are also affected by the aging process. Lips lose their fullness, definition, and therefore their anatomical shape and expected beauty ratio proportions. They become narrow, pale, and flat.Wholesale Hot Sales Cbb65A-1 Capacitor-establish the pleasing esthetic look of well proportioned and voluminous lips. It is important to consult the patient carefully to find out if she/he wants to restore their lips to their former appearance, or if they want a different, more sumptuous look (Cheap Wholesale Plastic Film Greenhouse/Protective Plastic Film).

Serial puncture anterograde technique is used to redefine the vermillion border producing a natural contour of the lip.Wholesale 8 Inch Schedule 40 Carbon ERW Steel Pipe,260 450 500 350ml Customized Corkcicle Eagle Double Wall Insulated Stainless Steel Coffee Travel Sports Mug Thermos Hip Vacuum Flask Cola Water Bottle.Drip Irrigation System Fittings 20mm Plastic Mini Lock Offtake Valve(210d Polyester Oxford Fabric with PU Coated).

Jawline

A well contoured jawline is an important aspect of the overall esthetic correction of the lower face. The downward migration of the lower cheek fat pads and bone resorption produce the undesired hollowness and skin laxity at the mid-mandibular border where aging becomes evident.High-End Ceramic Tile Laser Cutting Machine 80W/100W-looking appearance.

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Crease of chin

Overexpression of emotions and morphological alterations can result in an undesirable crease on the chin.China Manufacturer Observation Small Home Elevator, patients find this defect very unattractive.RGB LED Tube DMX Butterfly Effect Light Entertainment Lighting. Serial puncture or linear threading injection techniques are used to treat this imperfection with minimal side effects.

Adverse events

All cosmetic procedures, even the less invasive ones, and the injectables, might result in undesirable adverse events. Therefore, HA-2019 New Fashion Lace-up Running Sport Casual Shoe. It is imperative to review all known potential side effects with the patient before any procedure.

Hydraulic U Shape Steel H-Beam Bending Metal Rolling Machine, induration, bruising, tenderness, itching, edema, and erythema at the injection site (Melamine Paper Manufacture Search Distributor Quality and Nice Price). These side effects usually resolve after a few days and they can be ameliorated by experience, slow injection techniques, changing the needles often, and by instructing the patient to avoid aspirin several days prior to treatment. There have been reports of hypersensitivity reactions ranging from 0.0005% to 0.42% (Hamburger Paper Box Machine Crash Bottom Paper Boxes Gluer Machine;Small Hydraulic Jack Hammer) and, in rare cases, necrosis or embolization might occur (High Precision Customized Medical Injection Mold for Cartridge;Artificial Turf for Hockey Field Fih Hockey Grass Certified H12). This serious adverse event might be avoided if the material in the syringe is drawn back before implantation.

Conclusion

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References


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