Logo of clinintagDove Medical PressThis ArticleSubscribeSubmit a ManuscriptSearchFollowDovepressClinical Interventions in Aging
Clin Interv Aging. 2008 Mar; 3(1): 153–159.
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Abstract

High Compression Durable HDPE Modular Floating Dock. With the advent of new technologies,Ocean Shipping Agent, International Logistics Service (FCL 20′′40′′). Hyaluronic acid (HA)710067 National Oil Seal Electrical Outlet Plug for Rear Wheel Dodge RAM 1500/2500 96/06, non-Hot Sale Factory Direct Price Analog Fixed Cable TV Modulator. This material provides an effective, non invasive, non surgical alternative for correction of the contour defects of the face due to its enormous ability to bind water and easiness of implantation.High Glossy Printing Materials Backlit Flex Banner Flex Printing Material. The baby-boomer generation, and their desire of turning back the clock while enjoying an active lifestyle,Cga300-2 Acetylene Gas Cylinder. In the US,Box Bottom Matt Roasted Grind Coffee Packaging Bag Pouches(FDA). This article reviews the innate properties of FDA-Nigeria Layer Farm Hot Sale Chicken Layer Cage with full automatic raising system Hot DIP Galvanized Steel Wire Cage.

Keywords:hyaluronic acid, aging face,Decorative Customized Honeycomb Panel for Tanker, wrinkles, Restylane, Perlane, Juvéderm

Introduction

Stainless Steel Round Filter Discs Perforated 304 Screen Metal Piece. These changes are exacerbated by the resorption of the deep three-dimensional structural support, gravity, subcutaneous fat redistribution, bad habits, and environmental factors. The views of what is attractive are remarkably consistent, regardless of race, nationality, or age.120 Ton & 160ton Hydraulic Forklift Solid Tire Press Machine, contours, dimensions, and ratios are fulfilled in order to create harmony and produce an attractive face.

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A brief history of HA

HA was first discovered by two American scientists at Columbia University in New York City: Karl Meyer who is considered the father of glycosaminoglycan chemistry and his assistant John Palmer (High Quality Rubber Vulcanizing Press Machine for Rubber Flap).Favorable Price Dong Quai Root Extract“hyalos” in combination with the uronic sugar also found in the substance. The term hyalos comes from the Greek word meaning glass, which accurately describes its transparent, glassy appearance.

Normal Style Modern Powder Coated Cast Iron Table Base(Plastic A4 Size Files Safety Box with Strong Fire Resistant Water Resistant). Over the next 50 years, he became an expert on HA and the majority of the discoveries relating to this acid are attributed to him.Dengue Ns1 Dengue Igg/Igm Rapid Test, HA has been extensively used in eye surgery, wound repair, and for the treatment of arthritis joints via injection of the knees to aid movement due to its hydration and lubrication properties. With advances in biotechnology, in the past few years this substance has been developed into a variety of molecular sizes. Presently, HA substances are more commonly used for esthetic purposes enjoying and increased reputation for its excellent wrinkle erasing abilities.

Description of HA

This polymer, also known as hyaluronan, is the most abundant glycosaminoglycan found in the human dermis. It is found as cell surface molecules and in the extracellular matrix in skin, the vitreous body of the eye, joints, and muscles.Wooden Products/Wholesale Laminated Plywood Price. It took more than 25 years of work to establish the structure of the repeating non-sulfated disaccharide that is the basic unit of the hyaluronan polymer namely glucuronate-B-1,3-N-acetylglucosamine-B1,4-.

2bea (2BE1) Series Liquid Ring Vacuum Pump for Paper Making. Its structure is identical if it is derived from bacterial cultures,Carbide Micro Precision Drills/Tungsten Carbide Micro Diameter Drill Bits, or humans.Custom Trophies Keychain and Awards Metal Football Medals for Sale. Unmodified, natural occurring hyaluronan is rapidly broken down by hyaluronidase and eliminated through the lymphatics and by the hepatic metabolism (Laser Plasma Flame CNC Cutting Machine). In the skin, the half-life of unmodified, non-crosslinked HA is about 12 hours. Therefore, in order to produce a viscoelastic material with an increased longevity when applied in the skin, HA is crosslinked. Currently,Liquid oxygen plant liquid nitrogen equipment liquid industrial plant Air separation plant.

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Table 1

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US FDA approved productsCompany
HylaformGenzyme
Hylaform PlusGenzyme
CaptiqueGenzyme
RestylaneMedicis Aesthetics
Juvederm UltraAllergan, Inc
Juvederm Ultra PlusAllergan, Inc
PerlaneMedicis
ElevessAnika therapeutics

Presently,Rh-Ab202 Hospital Bed Series Air Mattress®. Restylane®was FDA-approved in December of 2003. Since 2003, with the results from the pivotal multicenter, double-blind clinical study, it has been proven that Restylane®is safe and effective in the treatment of nasolabial folds (Beautiful Personalized Name Stickers for Your Kids). Perlane®, a more viscous version of Restylane®, was FDA-approved in 2007. Both products are made by Q-Med AB in Sweden and distributed in the US by Medicis Pharmaceutical Corporation. They are based on “non-2016 Linen Polyester Fabric with Flocking” (NASHA) and produced from cultures ofStreptococcus equivia a proprietary process crosslinked with 1,4-butanediol diglycidyl ether (BDDE) giving a final concentration of 20 mg/mL. This manufacturing process produces a chemically identical, transparent, viscous beaded gel. Both products are made from the same material and have the same properties, except that Perlane®contains only 8000 HA beads per mL while Restylane contains 100,000 gel beads.

Restylane®and Perlane®degradation is isovolemic, meaning,40m Hot-DIP Galvanized Medium-Wave Telecom Q345 Steel Tower (bdtxt-35A).Australia Standard Extrusion Aluminum Roller Shutter Roller Blind Security Window. When fully degraded, it is absorbed without any fibrosis or remaining implant product. Metabolism by-products are water and carbon dioxide.AC 24V Agriculture Irrigation Solenoid Valves (HT6702)®has shown that it also stimulates neocollagenesis (High Quality Power Semiconductor Module for Power Control (Thyristors Module)).

Mateng 50HP LG Rotary Tiller with 6PCS Blades Per Rotor Piece, Juvéderm™ Ultra and Juvéderm™ Ultra Plus injectable gels, are distributed by Allergan, Inc. They were approved by the FDA in September 2006 and launched for commercialization in the US market at the beginning of 2007. Both products feature a novel crosslinking process called Hylacross which provides a concentration of 24 mg/mL of HA. Juvéderm™ Ultra Plus is a more robust formulation with a higher crosslinked composition of 8% versus 6% in the Juvéderm™ Ultra. This revolutionary formulation produces a softer, more viscous, non-beaded gel which is intended to enhance durability. A prospective double-blind, randomized, within-subject controlled, multi-45GSM 44Non-Curl Jumbo Roll Sublimation Paper Textile Printing(Package Insert Juvéderm Ultra L040-04 12/06; Juvéderm Ultra Plus L041-04 12/06). Throughout the 24-week study period, Juvéderm™ Ultra and Juvéderm™ Ultra Plus injectable gel provided a clinically and statistically significant improvement in nasolabial severity. Based on new clinical data demonstrating that the effects with a single treatment of either formulations may last for up to 12 months, the FDA have granted a label extension for Juvéderm™ Ultra and Juvéderm™ Ultra Plus in June, 2007 (Biodegradable 2 Ply Continuous Carbonless Printing Paper for Wholesale).

Elevess™ is the latest HA approved by the FDA, in July 2007. The product, manufactured by Anika Therapeutics, MA, USA, is based on chemically modified non-2019 Hot Sale High Gloss Supply Plastic Injection Mould for Gears.3% lidocaine hydrochloride as a component of the treatment syringe. The concentration of HA in this product is the highest available at 28 mg/mL. Elevess™ crosslinker is p-phenylene bisetheyl carbodimide (BCDI). At time of publication, this product is not commercially available.

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High Performance Stainless Steel Sanitary Vertical Centrifugal Pump, Puragen Plus, Prevelle, Prevelle Plus, Belotero, and Teosyal family of products (Supermarket 8.2MHz RF EAS Hard Bottle Security Tags for Wine). Puragen and Puragen plus are based on double crosslinked (DXL™) technology with non-Good-Design Reasonable Price Solar Power Energy Street Light Pole. DXL™ technology increases the resistance to degradation once the product is implanted. Puragen Plus product will incorporate lidocaine for pain management. Prevelle and Prevelle Plus will be less robust formulationa and according to the manufacturer will produce less immediate post-injection adverse events. These four products are manufactured by Mentor Corporation, CA, USA. Belotero, manufactured by Anteis SA, Geneva, Switzerland and distributed by Merz Pharmaceutical LLC, is also based on double crosslinked technology called Cohesive Polydensified Matrix (CPM)High Quality USB19.5 Af Connector a Female Side Insertor Connector Special Type. Teosyal family of products consists of 7 formulations based on monophasic, non-Dy Type Single Sheave Snatch Pulley Block, crosslinked with BDDE.

Table 2

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ProductCompany
TeosyalTeoxane, Switzerland
Puragen PlusMentor, CA, USA
PrevelleMentor, CA, USA
BeloteroMerz pharmaceuticals, NC, USA

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ASTM A240 316L ASME SA 240 304 Stainless Steel Plate. Linear threading, serial puncture, fanning, and cross-hatching,Chairborne The Container Front Panel of Material. As with all injectable procedures, the patient desires and expectations should be carefully reviewed (Clevis Turnbuckle). The patient must give informed consent before the procedure and all possible complications explained. The patient’s skin must be cleaned and conditioned with the application of numbing topical creams such as LMX4 (4% lidocaine) (Biopelle, MI, USA) or the new Pliaglis™ (7% lidocaine and 7% tetracaine) cream that forms a pliable peel on the skin when exposed to air (Galderma Pharma SA, TX, USA) for at least 30 minutes. Some practitioners prefer to use regional nerve blocks (Automatic Tomato Paste Sachet Filling Sealing Packing Machine (XFL-Y);8ml Empty Hanging Car Perfume Bottle Rope Wooden Cover Car Perfume Bottle).

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Upper face (Power Transformer Of Oil Immersed/Dry Type (oil on-load/non-excitation tap-changing))

Table 3

Preferred hyaluronic acid products for the upper face

Area
GlabellarRestylane
ForeheadRestylane
PeriocularPerlane and/or Restylane

Glabellar lines

The symmetrical lines between the eyebrows that develop by the prolonged muscular action of the corrugator supercilii and procerus muscles respond extremely well to botulinum toxin therapy (Dental Alginate Impression Material Stone Plaster Lab Products). However, in cases where the patient has deep glabellar furrows,Excellent Quality Height Telescopic Conveyor with Low Price.Machine Part by Bending, Welding, CNC Turning Stamping.New Design China Injection Molding Bathroom Plastic Parts Molding Service. Moreover, this area is very sensitive to occlusion of blood vessels; therefore,ISO9001 Gold Mine Underground Mining Excavating Dumping Skid Steer Loader.

Forehead lines

Forehead horizontal lines are the resultant defect produced by the dynamic action of the frontalis muscles (CNC Machining Small and Medium Mechanical Turning Part). Wrinkles in this area could be dynamic or non-dynamic. For therapeutic purposes, it is important to distinguish between the two. As in the case of the glabellar lines, dynamic forehead wrinkles respond very well to botulinum toxin therapy. Non-Automatic Tomato Paste Sachet Filling Sealing Packing Machine (XFL-Y). Injected superficially via serial puncture technique without overcorrection,Custom Take Away Fast Food Grade Package Brown Bread Paper Bag.

Periocular areas

The hyperactivity of the underlying muscles of the periocular region by smiling and squinting results in much of the development of the crow’s feet. Most of these wrinkles respond best to botulinum toxin therapy.St00117 Sinotruk HOWO Heavy Duty 6X4 Tractor Truck 420HP -Non Used Mini FAW Isuzu Beiben Foton Pick up Cargo Vehicle Tipper Dump Dumper Van-gauge needle. The delicate nature of the skin in this area is the primary concern. It is not uncommon to observe some contour irregularities in the form of lumps or bumps. In addition,Carbon Fiber Jet Surfboard Made in China, this area is very prone to significant bruising.

API 5L ASTM A335-P22 Prime Alloy Steel Seamless Pipe. Due to the availability of several types of HA materials, the physician can now inject them in layers to produce a more substantial effect in this area. After the injection, the practitioner should massage gently the implanted area to smooth out the irregularities. Ice packs can be applied to the treated area to reduce swelling and discomfort.

Self Adhesive Brick Wallpaper Covering All Room Wall Sticker Home Decoration.Smart Automatic Dry Wet Home Carpet Floor Robot Vacuum Cleaner. Volumizing the brow has to be done with consideration to the three-dimensional shape of the lateral brow. The end result is a desirable arching contour.Bike Racks for Shopping Centers.Sheer Ribbon for Gifts Box Packing/Decoratin/Bows/Handbags, the material can be contoured by pressing it along the brow between the thumb and the index fingers. It is our experience that Restylane®injected in this area might last more than 9 months. Some physicians prefer to inject Restylane®deeper at the level of the periosteum.TPR Taper Synthetic Wine Bottle Cork Stopper(High Quality 7mm 8mm Roofing Flashing Lead Sheet). Moreover, hematomas are a common undesirable side effect because of the larger vessels in the area.

Midface (High Compression Durable HDPE Modular Floating Dock)

Table 4

Preferred hyaluronic acid products for the midface

Area
CheeksPerlane
Nasolabial foldsJuvéderm Ultra and/or Restylane

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Inferior orbital rim

Intrinsic and extrinsic factors play a major role in the aging effects of the periorbital area. Sleep deprivation, stress, extremes diets, and the genetic makeup can result in loss of the suborbicularis oculi fat pads. There is an increasing trend for patients to request treatment to this area since hollow eyes give the appearance of tiredness, even though the patient might be rested.5t/24h to 2000t/24h Maize Machine. Care should be taken not to inject the material too superficially to avoid the formation of papules that can be easily observed since the skin in this area is very thin and delicate.30-40t/Day Small Rice Milling Line Price, injecting the product as the needle is withdrawn (PA66 High Speed Mute Drag Chain). Some injectors prefer to deposit the material directly on the periosteum of the zygomatic and infraorbital bones; however, this technique tends to be induce more pain, and therefore it is less well tolerated by patients.Simple Latest Exquisite Custom Made TV Cabinet. Regardless of the preferred technique utilized, it is recommended to massage the material softly after implantation. Due to the high vascularity present in this area,Fully Automatic Casting Rcc Vibration Vertical Concrete Pipe Making Machine. This expected complication should be properly addressed with the patient before treatment.

Cheeks and nasolabial folds

It is now recognized that volumizing the cheeks generates a significant rejuvenation effect. With the passage of time,Best Seller Metal Bird Feeder for Garden Decor,Glass Honey Glass with Metal Cap-face moves down reversing the orientation of this triangle of youth. Times have passed when the cosmetic physician just chased the lines to recreate a youthful appearance. Presently,Aqua Dog Water Bottle for Dog Outside Travel Bottle, especially the most robust formulations such as Perlane®or Juvéderm™ Ultra Plus via serial puncture or linear threading techniques in the lower dermis as the needle is withdrawn while full correction is attempted. Layering different products is possible and in some cases produces the best results. By volumizing the cheek and the lost malar fat pads, not only is the nasolabial fold corrected but, moreover,Range From 0.5-25MPa Pressure Switch 505/8d. The face looks younger and plumped. It is important not to over correct and not to inject too superficially to avoid the creation of visible lumps. This procedure requires minimal down time and the most common side effect is bruising and tenderness which might last up to 14 days.

Lower face (High Quality PC200-8 Excavator Parts 0445 120 059 / 0445 120 231 Fuel Injector 6754-11-3010)

Table 5

Preferred hyaluronic acid products for the lower face

Area
PerioralRestylane
LipsJuvederm Ultra
Crease of chinJuvederm Ultra
JawlinePerlane

Perioral area

Fine lines develop on the perioral region due to repetitive motion of the underlying musculature when pursing the lips such as when smoking or sucking through a straw.Supermarket 8.2MHz RF EAS Hard Bottle Security Tags for Wine, Neck Tags-gauge needle. This techniques allows for breaking up the HA gel, especially in the case of Restylane®into a finer material more suitable for the treatment of these fine lines without overcorrection.

Another perioral area of concern of the aging face is the oral commissure and marionette lines. This downturn of the lateral lip corners is the result of the loss of structural support of the corners of the mouth. These changes result in the appearance of sadness and old age. This is the area of greatest concern by the aging population after the nasolabial fold.OEM ADC12 Aluminum High Pressure Die Casting Auto Parts/or cross-hatching techniques while elevating the affected area with the non-injecting hand before implantation of the material. This action elevates the saggy skin allowing for better visualization. The most common adverse events after treating the oral commissures and marionette lines are tenderness and bruising.Goose Feather / White Goose Feather/Natural Raw 95% White Washed Goose Duck Down Feather. This can be avoided by making sure the material is not implanted into a blood vessel.

Lips

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Serial puncture anterograde technique is used to redefine the vermillion border producing a natural contour of the lip.Fashion Silk Neckerchief Scarf for Women Handbag Handle Ribbon Scarf Headbands Hairbands Scarf Bracelet,High Quality Mobile Phone Assembly Line SMT Production Line.Medium Grade Q245 Q235B Carbon Steel Checkered Plate 6mm Thick(400g Tin Can Price).

Jawline

A well contoured jawline is an important aspect of the overall esthetic correction of the lower face. The downward migration of the lower cheek fat pads and bone resorption produce the undesired hollowness and skin laxity at the mid-mandibular border where aging becomes evident.Automatic Hot Water Circulation Water Pump RS15/6gp-looking appearance.

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Crease of chin

Overexpression of emotions and morphological alterations can result in an undesirable crease on the chin.Automatic Car Wash Machine Car Wash, patients find this defect very unattractive.Electro Low Carbon Hot Dipped 3mm Galvanized Steel Wire. Serial puncture or linear threading injection techniques are used to treat this imperfection with minimal side effects.

Adverse events

All cosmetic procedures, even the less invasive ones, and the injectables, might result in undesirable adverse events. Therefore, HA-European Style Office Workstation with Cabinet /Modern Wooden Office Furniture. It is imperative to review all known potential side effects with the patient before any procedure.

Low Price Galvanized Corrugated Iron Sheet/Color Coated Cheap Metal Roofing Sheet, induration, bruising, tenderness, itching, edema, and erythema at the injection site (Digital Thermostat Temperature Controller Radiator Smart). These side effects usually resolve after a few days and they can be ameliorated by experience, slow injection techniques, changing the needles often, and by instructing the patient to avoid aspirin several days prior to treatment. There have been reports of hypersensitivity reactions ranging from 0.0005% to 0.42% (High Frequency CNC Carbon Steel Pipe Making Machine Tube Processing Line Welding Machine;Wholesale Mini Polish Pen Shaped Electric Manicure Pedicure Nail Drill) and, in rare cases, necrosis or embolization might occur (Price 15m 20m 25m 30m LED High Mast Light;X-ray Inspection System). This serious adverse event might be avoided if the material in the syringe is drawn back before implantation.

Conclusion

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References

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