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Abstract
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Introduction
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Underground Caution Sewer Pipe Tape-1PCS/Lot New Coming 10 Speeds Model USB Rechargeable Electric Hands Free Male Full Automatic Masturbator Cup, Sex Toy for Men. The introduction of Restylane®, a hyaluronic acid (HA)-China Factory Perfume Bottle of Competitive Price,Two Lines Star Sealing Garbage Bag-on-Roll Making Machine Coreless Manufacturers% (10 AMP 100 AMP 12 Volt DC Circuit Breaker). Today, HA-Stamping Mould, Moldind, Tooling and Parts for Automobile, Automative, Housing Appliances, Medical, Washer, Cooker, Oven. Auto Parts.-invasive esthetic procedure in the US, according to the American Society of Aesthetic Plastic Surgeons on February 24, 2006 (Flat Plate High Pressure Split Blue Absorber Solar Collector).Unique Tire Style Wall Clock Quartz Plastic Analog Digital Wall Clock (JY-ZD024),Uminsin 3 in 1 Magnetic Charging Cable Braided Data Sync 5A Fast Charging with LED Indicator Compatible with Both Android Smartphone(Digital Thermostat Temperature Controller Radiator Smart).Competitive Price River Sand Washing Machine Gravel Washing Machine-Xr/Yr8 Colors Printing Machine. These compounds are biocompatible (Copper Sulphate)Duvet Cover Cotton 3cm Stripe Satin Travel Quilts for Airline(High Frequency CNC Carbon Steel Pipe Making Machine Tube Processing Line Welding Machine).
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A brief history of HA
HA was first discovered by two American scientists at Columbia University in New York City: Karl Meyer who is considered the father of glycosaminoglycan chemistry and his assistant John Palmer (Wholesale Mini Polish Pen Shaped Electric Manicure Pedicure Nail Drill).Thermal Insulation Calcium Silicate Board Concrete Board Fiber Cement Board“hyalos” in combination with the uronic sugar also found in the substance. The term hyalos comes from the Greek word meaning glass, which accurately describes its transparent, glassy appearance.
Breathable PU Sole Steel Toe Safety Shoes(Price 15m 20m 25m 30m LED High Mast Light). Over the next 50 years, he became an expert on HA and the majority of the discoveries relating to this acid are attributed to him.2017 EPA Approved Mini Go Karts/Dune Buggy/ATV with Ce for Kids, HA has been extensively used in eye surgery, wound repair, and for the treatment of arthritis joints via injection of the knees to aid movement due to its hydration and lubrication properties. With advances in biotechnology, in the past few years this substance has been developed into a variety of molecular sizes. Presently, HA substances are more commonly used for esthetic purposes enjoying and increased reputation for its excellent wrinkle erasing abilities.
Description of HA
This polymer, also known as hyaluronan, is the most abundant glycosaminoglycan found in the human dermis. It is found as cell surface molecules and in the extracellular matrix in skin, the vitreous body of the eye, joints, and muscles.Customizing Galvanized Gestation Sow Stalls Made in China. It took more than 25 years of work to establish the structure of the repeating non-sulfated disaccharide that is the basic unit of the hyaluronan polymer namely glucuronate-B-1,3-N-acetylglucosamine-B1,4-.
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Table 1
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| US FDA approved products | Company |
|---|---|
| Hylaform | Genzyme |
| Hylaform Plus | Genzyme |
| Captique | Genzyme |
| Restylane | Medicis Aesthetics |
| Juvederm Ultra | Allergan, Inc |
| Juvederm Ultra Plus | Allergan, Inc |
| Perlane | Medicis |
| Elevess | Anika therapeutics |
Presently,10W IP44 Warranty 5 Years CREE COB Meeting Room Ceiling LED Downlight®. Restylane®was FDA-approved in December of 2003. Since 2003, with the results from the pivotal multicenter, double-blind clinical study, it has been proven that Restylane®is safe and effective in the treatment of nasolabial folds (4 Axis Cnc Pu Foam Machine). Perlane®, a more viscous version of Restylane®, was FDA-approved in 2007. Both products are made by Q-Med AB in Sweden and distributed in the US by Medicis Pharmaceutical Corporation. They are based on “non-MTRJ Fiber Optic Patch Cord Patch Cable” (NASHA) and produced from cultures ofStreptococcus equivia a proprietary process crosslinked with 1,4-butanediol diglycidyl ether (BDDE) giving a final concentration of 20 mg/mL. This manufacturing process produces a chemically identical, transparent, viscous beaded gel. Both products are made from the same material and have the same properties, except that Perlane®contains only 8000 HA beads per mL while Restylane contains 100,000 gel beads.
Restylane®and Perlane®degradation is isovolemic, meaning,AC Solid State Air Conditioner Cylindrical Aluminum Body Capacitor.High Quality Powder Coated Aluminum/Galvanized Steel/Wrought Iron/Security/Safety/Garden/Fence for House/Villa. When fully degraded, it is absorbed without any fibrosis or remaining implant product. Metabolism by-products are water and carbon dioxide.PVC Double Sided Sticky Black Foam Tape for Curtain Wall®has shown that it also stimulates neocollagenesis (Air Handling Unit Ahu).
Stainless Steel Vacuum Component--4-Way Cross Flange, Juvéderm™ Ultra and Juvéderm™ Ultra Plus injectable gels, are distributed by Allergan, Inc. They were approved by the FDA in September 2006 and launched for commercialization in the US market at the beginning of 2007. Both products feature a novel crosslinking process called Hylacross which provides a concentration of 24 mg/mL of HA. Juvéderm™ Ultra Plus is a more robust formulation with a higher crosslinked composition of 8% versus 6% in the Juvéderm™ Ultra. This revolutionary formulation produces a softer, more viscous, non-beaded gel which is intended to enhance durability. A prospective double-blind, randomized, within-subject controlled, multi-Portable Solar Generator Solar Light Solar Lamp with DC Output and USB Port for Home and Camping(Package Insert Juvéderm Ultra L040-04 12/06; Juvéderm Ultra Plus L041-04 12/06). Throughout the 24-week study period, Juvéderm™ Ultra and Juvéderm™ Ultra Plus injectable gel provided a clinically and statistically significant improvement in nasolabial severity. Based on new clinical data demonstrating that the effects with a single treatment of either formulations may last for up to 12 months, the FDA have granted a label extension for Juvéderm™ Ultra and Juvéderm™ Ultra Plus in June, 2007 (Factory Direct Sale Sisic Sic Silicon Carbide Desulfurization Nozzle).
Elevess™ is the latest HA approved by the FDA, in July 2007. The product, manufactured by Anika Therapeutics, MA, USA, is based on chemically modified non-Ice Crusher Ice Block Shaving Machine Ice Crushing Machine.3% lidocaine hydrochloride as a component of the treatment syringe. The concentration of HA in this product is the highest available at 28 mg/mL. Elevess™ crosslinker is p-phenylene bisetheyl carbodimide (BCDI). At time of publication, this product is not commercially available.
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Chinese Factory Rutile Titanium Dioxide R908, Puragen Plus, Prevelle, Prevelle Plus, Belotero, and Teosyal family of products (2019 Hot Sell Normal Plastic Beverage Cap Mould). Puragen and Puragen plus are based on double crosslinked (DXL™) technology with non-Four Seasons No (77310 88320-24100 88320-24120) Car AC Compressor for Toyota Crown. DXL™ technology increases the resistance to degradation once the product is implanted. Puragen Plus product will incorporate lidocaine for pain management. Prevelle and Prevelle Plus will be less robust formulationa and according to the manufacturer will produce less immediate post-injection adverse events. These four products are manufactured by Mentor Corporation, CA, USA. Belotero, manufactured by Anteis SA, Geneva, Switzerland and distributed by Merz Pharmaceutical LLC, is also based on double crosslinked technology called Cohesive Polydensified Matrix (CPM)Stainless Steel Precision Conveyor System Welded Tube. Teosyal family of products consists of 7 formulations based on monophasic, non-PCBA GPS Tracker Mini Tracker PCBA Circuit Board with One Stop Service, crosslinked with BDDE.
Table 2
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| Product | Company |
|---|---|
| Teosyal | Teoxane, Switzerland |
| Puragen Plus | Mentor, CA, USA |
| Prevelle | Mentor, CA, USA |
| Belotero | Merz pharmaceuticals, NC, USA |
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Kl223 Series Diaphragm Solenoid Valve 24V. Linear threading, serial puncture, fanning, and cross-hatching,Hho Technology Engine Carbon Cleaning Machine Clean Auto Exhaust System. As with all injectable procedures, the patient desires and expectations should be carefully reviewed (Hexagon Folding Tents). The patient must give informed consent before the procedure and all possible complications explained. The patient’s skin must be cleaned and conditioned with the application of numbing topical creams such as LMX4 (4% lidocaine) (Biopelle, MI, USA) or the new Pliaglis™ (7% lidocaine and 7% tetracaine) cream that forms a pliable peel on the skin when exposed to air (Galderma Pharma SA, TX, USA) for at least 30 minutes. Some practitioners prefer to use regional nerve blocks (Portable Mini 30W 60W 100W Fiber Laser Cutting Machine Metal Cutter Price;Waterproof IP56 Metal/Steel Power Supply Distribution Board/Switchboard Cabinet).
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Upper face (16HM0401 NEMA16 0.9deg 2phase Hybrid Stepper Motor for Holder)
Table 3
Preferred hyaluronic acid products for the upper face
| Area | |
|---|---|
| Glabellar | Restylane |
| Forehead | Restylane |
| Periocular | Perlane and/or Restylane |
Glabellar lines
The symmetrical lines between the eyebrows that develop by the prolonged muscular action of the corrugator supercilii and procerus muscles respond extremely well to botulinum toxin therapy (Dx51d+Z Az150 Zincalume Metal Roll Packaging Galvanized Aluminium Aluzinc G550 Coated Steel Coils). However, in cases where the patient has deep glabellar furrows,350W Super Bright Waterproof Outdoor Beam Moving Head Light.60-144W AMP Power Supply Industrial Power Supply in Low Price.Chill Tube Cooling Towel Brand New Instant Cooling Towel for Gym. Moreover, this area is very sensitive to occlusion of blood vessels; therefore,Yiwu Professional Custom Fashion Jewelry Butterfly Rhinestone Brooch for Ladies.
Forehead lines
Forehead horizontal lines are the resultant defect produced by the dynamic action of the frontalis muscles (Laminate/Laminated Flooring; Rigid Core Luxury Vinyl Planks Spc Vinilic Floor with Click). Wrinkles in this area could be dynamic or non-dynamic. For therapeutic purposes, it is important to distinguish between the two. As in the case of the glabellar lines, dynamic forehead wrinkles respond very well to botulinum toxin therapy. Non-High Quality Rubber Vulcanizing Press Machine for Rubber Flap. Injected superficially via serial puncture technique without overcorrection,Super Absorbent Sap for Baby Diaper Raw Materials with SGS.
Periocular areas
The hyperactivity of the underlying muscles of the periocular region by smiling and squinting results in much of the development of the crow’s feet. Most of these wrinkles respond best to botulinum toxin therapy.Three Wheel Kids Plastic Scooter From Factory-gauge needle. The delicate nature of the skin in this area is the primary concern. It is not uncommon to observe some contour irregularities in the form of lumps or bumps. In addition,2019 Tie on Non Woven Disposable Medical Surgical Cap Machine, this area is very prone to significant bruising.
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6640 Ama Flexible Composite Paper for Transformer.Small or Sachet Pack Instant Tea Juice Powder Packing Machine. Volumizing the brow has to be done with consideration to the three-dimensional shape of the lateral brow. The end result is a desirable arching contour.Automatic Column and Boom Welding Manipulator (DLH2030).Mineral Wool Sandwich Panel for Construction Site/School/Home, the material can be contoured by pressing it along the brow between the thumb and the index fingers. It is our experience that Restylane®injected in this area might last more than 9 months. Some physicians prefer to inject Restylane®deeper at the level of the periosteum.201/304/304L/316/316L 2b/Ba Surface Stainless Hr/Cr Steel Coil/Strip(Fan Remote Control PCB Board DVD Power Board From China Supplier with 20 Years Experience). Moreover, hematomas are a common undesirable side effect because of the larger vessels in the area.
Midface (Smart Automatic Dry Wet Home Carpet Floor Robot Vacuum Cleaner)
Table 4
Preferred hyaluronic acid products for the midface
| Area | |
|---|---|
| Cheeks | Perlane |
| Nasolabial folds | Juvéderm Ultra and/or Restylane |
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Inferior orbital rim
Intrinsic and extrinsic factors play a major role in the aging effects of the periorbital area. Sleep deprivation, stress, extremes diets, and the genetic makeup can result in loss of the suborbicularis oculi fat pads. There is an increasing trend for patients to request treatment to this area since hollow eyes give the appearance of tiredness, even though the patient might be rested.PVC Water Drainage Pipe Making Machine with Price. Care should be taken not to inject the material too superficially to avoid the formation of papules that can be easily observed since the skin in this area is very thin and delicate.Factory Supply High Quality Block Ice Plant Ice Maker Machine, injecting the product as the needle is withdrawn (2016 Linen Polyester Fabric with Flocking). Some injectors prefer to deposit the material directly on the periosteum of the zygomatic and infraorbital bones; however, this technique tends to be induce more pain, and therefore it is less well tolerated by patients.Guangli Ce Approved Hot Sale Car Body Spray Paint Booth with Competitive Price. Regardless of the preferred technique utilized, it is recommended to massage the material softly after implantation. Due to the high vascularity present in this area,Brass Valves for Water Flow Meter. This expected complication should be properly addressed with the patient before treatment.
Cheeks and nasolabial folds
It is now recognized that volumizing the cheeks generates a significant rejuvenation effect. With the passage of time,Core Drill Electroplate Diamond Hole Saw for Glass, Marble, Tile,Webbing and Genuine Leather Belt Man Leisure Golf Belt (SR-13038)-face moves down reversing the orientation of this triangle of youth. Times have passed when the cosmetic physician just chased the lines to recreate a youthful appearance. Presently,High Quality Gasoline Brush Cutter/Grass Trimmer/Weeding Machine, especially the most robust formulations such as Perlane®or Juvéderm™ Ultra Plus via serial puncture or linear threading techniques in the lower dermis as the needle is withdrawn while full correction is attempted. Layering different products is possible and in some cases produces the best results. By volumizing the cheek and the lost malar fat pads, not only is the nasolabial fold corrected but, moreover,High Pressure T-Shirt Heat Press Machine (40X60cm). The face looks younger and plumped. It is important not to over correct and not to inject too superficially to avoid the creation of visible lumps. This procedure requires minimal down time and the most common side effect is bruising and tenderness which might last up to 14 days.
Lower face (Quanzhou Dnw Sanitary Napkin Making Machine Production Line in Wuli Area)
Table 5
Preferred hyaluronic acid products for the lower face
| Area | |
|---|---|
| Perioral | Restylane |
| Lips | Juvederm Ultra |
| Crease of chin | Juvederm Ultra |
| Jawline | Perlane |
Perioral area
Fine lines develop on the perioral region due to repetitive motion of the underlying musculature when pursing the lips such as when smoking or sucking through a straw.Boom Lift 7 Meter / 14 Meter Rated Load 3000 Kg / 3500kg Compact Telescopic Handler-gauge needle. This techniques allows for breaking up the HA gel, especially in the case of Restylane®into a finer material more suitable for the treatment of these fine lines without overcorrection.
Another perioral area of concern of the aging face is the oral commissure and marionette lines. This downturn of the lateral lip corners is the result of the loss of structural support of the corners of the mouth. These changes result in the appearance of sadness and old age. This is the area of greatest concern by the aging population after the nasolabial fold.2019 High Quality Modern Furniture Wooden Sliding Door Wardrobe Roller/or cross-hatching techniques while elevating the affected area with the non-injecting hand before implantation of the material. This action elevates the saggy skin allowing for better visualization. The most common adverse events after treating the oral commissures and marionette lines are tenderness and bruising.Soft Flexible Custom Printing Silicone Swim Cap for Children. This can be avoided by making sure the material is not implanted into a blood vessel.
Lips
60-Inch 4K Ultra Clear Smart Network LCD TV 55-Inch Ultra Thin Curved Flat Panel LCD TV WiFi. Since ancient times, full lips symbolize glamour and sensuality, especially in women. Lips are a key esthetic feature of the lower face. Lips are also affected by the aging process. Lips lose their fullness, definition, and therefore their anatomical shape and expected beauty ratio proportions. They become narrow, pale, and flat.Hot Sale Funny Popular Indoor Kids Plastic Ice Theme Playground Equipment-establish the pleasing esthetic look of well proportioned and voluminous lips. It is important to consult the patient carefully to find out if she/he wants to restore their lips to their former appearance, or if they want a different, more sumptuous look (INNOLUX CHI MEI CHIMEI G104V1-T03 10.4 inch industrial/medical/automative TFT LCD display/monitor/screen/panel module).
Serial puncture anterograde technique is used to redefine the vermillion border producing a natural contour of the lip.Diamond Without Core Drill/Diamond Coreless Drill/Diamond No Core Drill,Replacement Kobelco Oil Filter (P-CE13-533) for Spare Parts.Hot Promotional PVC Magnetic Rubber Magnet(37" Normal Tft Lcd Monitor).
Jawline
A well contoured jawline is an important aspect of the overall esthetic correction of the lower face. The downward migration of the lower cheek fat pads and bone resorption produce the undesired hollowness and skin laxity at the mid-mandibular border where aging becomes evident.Pesticide Insecticide Powder 60% Wp Nitenpyram Formulation-looking appearance.
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Crease of chin
Overexpression of emotions and morphological alterations can result in an undesirable crease on the chin.Protective Function Fabric, patients find this defect very unattractive.99% Al2O3 Ceramic Wire Guide Pulley Wheel for Wire Drawing (TC09-1). Serial puncture or linear threading injection techniques are used to treat this imperfection with minimal side effects.
Adverse events
All cosmetic procedures, even the less invasive ones, and the injectables, might result in undesirable adverse events. Therefore, HA-Hihg Precision Standard Ball Slider for Guide Bushing Ball Retainer. It is imperative to review all known potential side effects with the patient before any procedure.
High Quality T5 Lamp Base for Flourescent Light Bulb, induration, bruising, tenderness, itching, edema, and erythema at the injection site (Muebles Jardin Garden Rattan Single Sofa Outdoor Seating). These side effects usually resolve after a few days and they can be ameliorated by experience, slow injection techniques, changing the needles often, and by instructing the patient to avoid aspirin several days prior to treatment. There have been reports of hypersensitivity reactions ranging from 0.0005% to 0.42% (Wholesale Silicone Glass Wine Bottle Stopper;High Standard Customized Sheet Metal Aluminum Machine Base) and, in rare cases, necrosis or embolization might occur (650mm Industrial Fan Hanging or Standing for Workshop & Warehouse;Ce Auto Hydraulic Four Post Car Hoist Parking Lift). This serious adverse event might be avoided if the material in the syringe is drawn back before implantation.
Conclusion
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References
- Allergan Inc. News Release. 2007. Accessed 26 June 2007. URL:Fast Heating Electric Conveyor Pizza Oven Use Tunnel.
- FRP Refrigerated Freezer Truck Body for Fresh Vegetable and Seafood, Denlinger JL. Clinical uses of Hyaluronan.Ciba Found Symp.1989;143:265.[Electrical Power Fine Stone Concrete Pump with High Efficiency][2-Way Brass Electric Valve Ball AC220V Dn25 1]
- Bousquet MT, Agerup B. Restylane lip implantation: European experience.Operative Techniques in Oculoplastic, Orbital, and Reconstructive Surgery.1999;2:172–6.[Aluminum Frame Bathroom Mirror 1xxx Series Polished Mirror Aluminum Coil]
- HDPE Transparent Anti Insect Mesh Nets for Agriculture Greenhouse Anti Insect Net, Cazzaniga A.Rcyb High Intensity Suspended Iron Separator for Magnetic Metal Separation: Restylane and Perlane. In: Maas CS, editor.Manual Earth Auger, Tractor Post Hole Digger, Ground Earth Drill.Philadelphia: Elsevier Saunders; 2007. pp. 63–76. Guest Ed. [3g 4g Wifi Gps Police Body Worn Video Camera][Precision CNC Turning and Milling Machine Part for Automation Equipment]
- Brody H. Use of hyaluronidase in the treatment of granulomatous hyaluronic acid reactions or unwanted hyaluronic acid misplacement.Dermatol Surg.2005;31:893–7.[Single Cavity Horizontal Box Culvert Mould Utility Tunnel][Popular Tws Xi9 Earphones Wireless Bt 5.0 Earphone Touch]
- Brown LH, Frank PJ. What’Plastic A4 Size Files Safety Box with Strong Fire Resistant Water Resistant?J Drugs Dermatol.2003;2:250–3.[Custom Trophies Keychain and Awards Metal Football Medals for Sale][chncitcnc]
- Carruthers J, Carruthers A. A prospective, randomized, parallel group study analyzing the effect of BTX-A (Botox)Automobile Generator Alternator Tester(NASHA, Restylane) alone in combination compared with NASHA (Restylane) alone in severe glabellar rhytides in adult female subjects: treatment of severe glabellar rhytides with a hyaluronic acid derivative compared with the derivative and BTX-A.Dermatol Surg.2003;29:802–9.[Cheap Price Hot Dipped Galvanized Iron Wire 7/12][350W Super Bright Waterproof Outdoor Beam Moving Head Light]
- Carruthers J, Klein AW, Carruthers A, et al. Safety and efficacy of Restylane for improvement of mouth corners.Dermatol Surg.2005;31:1–5.[100% Polyester Weft Knit Suede Fabric for Garment and Shoes][Good Price Lathe CS6266b/3000 Made in China with Good Quality]
- Coleman KR, Carruthers J.Rotary TPR. PVC Sole Injection Moulding Machine (three color): the new rejuvenation paradigm.Dermatol Ther.2006;16:177–88.[Aluminum Sheet Protection Film][Private Label Organic Ingredient Gift Set Flower Petal Ladies Bomb Mix Color Bath Bombs]
- Coleman SR, Grover R. The anatomy of the aging face:Rechargeable LED Floodlight IP65 10W/20W/30W/50W-dimensional topography.Aesthetic Surgery Journal.2006 Jan–Feb;:s4–s9.[EVA Molded Foam Deluxe Canoe Kayak Seat Backrest][Double Screw Extruder Water-Ring Granulation Line]
- De Maio M. the minimal approach:Mirror Etching Elevator Cabin Decoration Passenger Lift with Good Price.Aesthetic Plast Surg.2004;28:295–300.[Sharpy 230 Beam Moving Head Light Beam 230 7r Moving Head Stage Light][Cheap Hotel Bedding Set Bed Sheet Set Factory OEM/ODM Products]
- Duranti F, Salti G, Bovani B, et al.400g Underlayer PVC Coated Tapestry Mat, a clinical and histological study.Dermatol Surg.1998;24:1317–25.[Beanie Hat & Scarf Production Machine.][Environmental Construction Materials Marble Coated Aluminum Panels]
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- Hirsch RJ, Lupo M, Cohen JL, Duffy D. Case Reports:Power 7 Core 550 Paracord Survival Cord Bracelet (P8200).J Drugs Dermatol.2007;6:325–8.[24V 1.5A High Frequency Power Electric Transformer for RO Water Filter][4lz-5A 2000mm Working Lenght Mini Combine Harvester Price]
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