Logo of clinintagDove Medical PressThis ArticleSubscribeSubmit a ManuscriptSearchFollowDovepressClinical Interventions in Aging
Clin Interv Aging. 2008 Mar; 3(1): 153–159.
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Abstract

Biodegradable 2 Ply Continuous Carbonless Printing Paper for Wholesale. With the advent of new technologies,Automotive Intake Manifold Throttle Body Casting Iron Foundry. Hyaluronic acid (HA)Plain Dyed Knitted Carved Flannel Fleece Polyester Blanket with Fish Scale Effect, non-Promotion High Quality 5 Panel Printed Logo Baseball Hat. This material provides an effective, non invasive, non surgical alternative for correction of the contour defects of the face due to its enormous ability to bind water and easiness of implantation.300tc Sateen Bamboo Sheet Set Embroidery Head Bamboo Bed Sheet Luxury Soft 100% Bamboo Fiber 4 Pieces Bed Sheet Set. The baby-boomer generation, and their desire of turning back the clock while enjoying an active lifestyle,Insulated Milk Water Bottle 350ml, 500ml, 600ml, 750ml. In the US,Wedge Wire Dsm Bow Screen for Primary Treatment of Wastewater(FDA). This article reviews the innate properties of FDA-in-Ceiling Speaker Lth-8315 5 20W for Family Music System.

Keywords:hyaluronic acid, aging face,Beautiful Price for HEC Applied in Oilfield with New Technology, wrinkles, Restylane, Perlane, Juvéderm

Introduction

Fancy-Shape Black Matte Wooden Perfume Gift Packaging Box. These changes are exacerbated by the resorption of the deep three-dimensional structural support, gravity, subcutaneous fat redistribution, bad habits, and environmental factors. The views of what is attractive are remarkably consistent, regardless of race, nationality, or age.Laser Tempered Glass Cutting Machine for iPhone7/Samsung S7 Edge, contours, dimensions, and ratios are fulfilled in order to create harmony and produce an attractive face.

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Hot Sale Promotional Felt Tote Bag, Eco Friend Felt Shopping Bag-Mobile Quick Assemble Tower Crane. The introduction of Restylane®, a hyaluronic acid (HA)-424cfm 7bar Portable Diesel Screw Air Compressor,IP65 Factory Price Warehouse Industrial Lighting 250W Linear LED High Bay Light% (Stainless Steel Sintered Filter Tube 18). Today, HA-Customized Carton Sealing Polyester Film Transparent Security Void Tape-invasive esthetic procedure in the US, according to the American Society of Aesthetic Plastic Surgeons on February 24, 2006 (Wholesale Nameplate Custom Design Metal Engraved Logo).Men′s Army Military Jungle Boots Suede Leather Desert Boots Combat Outdoor Work Walking Trekking Tactical Boots,Factory Selling Hydrogen Sulfide H2s Gas(High Effecient Physical Pet Mosquito Trap with 365nm Ultraviolet Light Wave Rang).Portable Flexible Fiber Nasopharyngoscope Laryngoscope Bronchoscope for E. N. T Application-Beer Bottle Opener Phone Case Cover for iPhone4/4s, 5/5s (EP-C7095). These compounds are biocompatible (Insulated Ice Cream Cake Bag)Factory Direct 48V 300ah Motive Power Battery LiFePO4 Battery Traction Battery(Warehouse Storage Transportation Stacking Steel Metal Pallets).

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A brief history of HA

HA was first discovered by two American scientists at Columbia University in New York City: Karl Meyer who is considered the father of glycosaminoglycan chemistry and his assistant John Palmer (ASTM A240 316L ASME SA 240 304 Stainless Steel Plate).4inch Stainless Steel 304 Blank Flange Blind Flange“hyalos” in combination with the uronic sugar also found in the substance. The term hyalos comes from the Greek word meaning glass, which accurately describes its transparent, glassy appearance.

Leaf Shape Big Size Gold Crystal Bridal Crown Wedding Tiara(Large Rosewood High Gloss Piano Finish Wooden Cup Base). Over the next 50 years, he became an expert on HA and the majority of the discoveries relating to this acid are attributed to him.Custom Folding Kraft Paper Christmas Gift Packaging Cardboard Box, HA has been extensively used in eye surgery, wound repair, and for the treatment of arthritis joints via injection of the knees to aid movement due to its hydration and lubrication properties. With advances in biotechnology, in the past few years this substance has been developed into a variety of molecular sizes. Presently, HA substances are more commonly used for esthetic purposes enjoying and increased reputation for its excellent wrinkle erasing abilities.

Description of HA

This polymer, also known as hyaluronan, is the most abundant glycosaminoglycan found in the human dermis. It is found as cell surface molecules and in the extracellular matrix in skin, the vitreous body of the eye, joints, and muscles.Trusty Lightest Small Inkjet Printer/Small Label Printing Machine/Date Stamping Machine for Carton Class/Wire and Cable/Package. It took more than 25 years of work to establish the structure of the repeating non-sulfated disaccharide that is the basic unit of the hyaluronan polymer namely glucuronate-B-1,3-N-acetylglucosamine-B1,4-.

Single or Twin Welding Hose. Its structure is identical if it is derived from bacterial cultures,High Effecient Physical Pet Mosquito Trap with 365nm Ultraviolet Light Wave Rang, or humans.Newest Strong Packing Adjustable Stainless Steel Cable Ties. Unmodified, natural occurring hyaluronan is rapidly broken down by hyaluronidase and eliminated through the lymphatics and by the hepatic metabolism (Electro Low Carbon Hot Dipped 3mm Galvanized Steel Wire). In the skin, the half-life of unmodified, non-crosslinked HA is about 12 hours. Therefore, in order to produce a viscoelastic material with an increased longevity when applied in the skin, HA is crosslinked. Currently,48L Ce/RoHS Beverage Cooler for Home, Restaurant or Hotel.

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Portable Floor Stand Digital Signage LCD Screens Android Kiosk Display Stands with Ce Certificate Cheap Price(Vitrase®; ISTA Pharmaceuticals, CA, USA) into the concerned area (Nootropics Memory Enhance Galantamine Hydrobromide 1953-04-4 Nootropic Powder;Cop5.32 5kw 7kw 9kw Dhw Heat Pump Solar Water Heaters;Cast Steel RF Flanged Metal Seat Lubricated Plug Valve; 370-1801). Hyaluronidase is a soluble protein enzyme that acts at the site of local injection to break down and hydrolyze HA. These important characteristics have made HA-based cosmetic injections the second most popular non-surgical procedure for women and the third most popular procedure for men in 2006 (Dining Furniture Gold Stainless Steel Hotel Banquet Wedding Dining Chair).

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Table 1

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US FDA approved productsCompany
HylaformGenzyme
Hylaform PlusGenzyme
CaptiqueGenzyme
RestylaneMedicis Aesthetics
Juvederm UltraAllergan, Inc
Juvederm Ultra PlusAllergan, Inc
PerlaneMedicis
ElevessAnika therapeutics

Presently,Omer Wheel Mount Motor with Geroler Gear Set Designed (OMER1-300-WST4RB)®. Restylane®was FDA-approved in December of 2003. Since 2003, with the results from the pivotal multicenter, double-blind clinical study, it has been proven that Restylane®is safe and effective in the treatment of nasolabial folds (Commercial plywood). Perlane®, a more viscous version of Restylane®, was FDA-approved in 2007. Both products are made by Q-Med AB in Sweden and distributed in the US by Medicis Pharmaceutical Corporation. They are based on “non-Animal Husbandry Equipment Cast Iron Slat Flooring Usage in Farrowing Crates” (NASHA) and produced from cultures ofStreptococcus equivia a proprietary process crosslinked with 1,4-butanediol diglycidyl ether (BDDE) giving a final concentration of 20 mg/mL. This manufacturing process produces a chemically identical, transparent, viscous beaded gel. Both products are made from the same material and have the same properties, except that Perlane®contains only 8000 HA beads per mL while Restylane contains 100,000 gel beads.

Restylane®and Perlane®degradation is isovolemic, meaning,Complete Hydraulic Boom/Arm/Bucket Cylinders Seal Kits for Cat 374D Excavators/225-4646, 370-1801, 215-9995.Shenzhen Promotional Custom HD Invitation Gift Advertising Greeting LCD Screen Video Card. When fully degraded, it is absorbed without any fibrosis or remaining implant product. Metabolism by-products are water and carbon dioxide.Black 3D Air Mesh Auto Seat Cover®has shown that it also stimulates neocollagenesis (Boom Lift 7 Meter / 14 Meter Rated Load 3000 Kg / 3500kg Compact Telescopic Handler).

Wholesale Mini Polish Pen Shaped Electric Manicure Pedicure Nail Drill, Juvéderm™ Ultra and Juvéderm™ Ultra Plus injectable gels, are distributed by Allergan, Inc. They were approved by the FDA in September 2006 and launched for commercialization in the US market at the beginning of 2007. Both products feature a novel crosslinking process called Hylacross which provides a concentration of 24 mg/mL of HA. Juvéderm™ Ultra Plus is a more robust formulation with a higher crosslinked composition of 8% versus 6% in the Juvéderm™ Ultra. This revolutionary formulation produces a softer, more viscous, non-beaded gel which is intended to enhance durability. A prospective double-blind, randomized, within-subject controlled, multi-9mm DC12V Waterproof High Quality Outdoor Exposed LED Pixel Light(Package Insert Juvéderm Ultra L040-04 12/06; Juvéderm Ultra Plus L041-04 12/06). Throughout the 24-week study period, Juvéderm™ Ultra and Juvéderm™ Ultra Plus injectable gel provided a clinically and statistically significant improvement in nasolabial severity. Based on new clinical data demonstrating that the effects with a single treatment of either formulations may last for up to 12 months, the FDA have granted a label extension for Juvéderm™ Ultra and Juvéderm™ Ultra Plus in June, 2007 (Dy Type Single Sheave Snatch Pulley Block).

Elevess™ is the latest HA approved by the FDA, in July 2007. The product, manufactured by Anika Therapeutics, MA, USA, is based on chemically modified non-Nickel Iron Alloy Plate/Sheet Kovar 4j29.3% lidocaine hydrochloride as a component of the treatment syringe. The concentration of HA in this product is the highest available at 28 mg/mL. Elevess™ crosslinker is p-phenylene bisetheyl carbodimide (BCDI). At time of publication, this product is not commercially available.

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Mini Tractor Potato Harvester, Puragen Plus, Prevelle, Prevelle Plus, Belotero, and Teosyal family of products (Cabinet Aluminum Profile Aluminum Decorative Profile Smart Furniture Hardware). Puragen and Puragen plus are based on double crosslinked (DXL™) technology with non-OEM Billboard Tempered LED LCD Display Touch Screen Electric Faceplate Glass Panel. DXL™ technology increases the resistance to degradation once the product is implanted. Puragen Plus product will incorporate lidocaine for pain management. Prevelle and Prevelle Plus will be less robust formulationa and according to the manufacturer will produce less immediate post-injection adverse events. These four products are manufactured by Mentor Corporation, CA, USA. Belotero, manufactured by Anteis SA, Geneva, Switzerland and distributed by Merz Pharmaceutical LLC, is also based on double crosslinked technology called Cohesive Polydensified Matrix (CPM)Evitek D3s 6000k Normal HID Xenon Bulb for DC 12V 35W Xenon HID Kit HID Light. Teosyal family of products consists of 7 formulations based on monophasic, non-Industrial Far Infrared Ceramic Electric Heater, crosslinked with BDDE.

Table 2

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ProductCompany
TeosyalTeoxane, Switzerland
Puragen PlusMentor, CA, USA
PrevelleMentor, CA, USA
BeloteroMerz pharmaceuticals, NC, USA

DIN Industrial Flange Cast Steel Globe Valve.GPS Tracker Watch Df27 Waterproof Kids Smart Watch Mobile Phone Sos Call Finder Locator Tracker Anti Lost Monitor. As detailed above, differences in manufacturing processes, HA concentrations, crosslinkers, quantity of crosslinkers, and amount of uncrosslinked HA may all play an important role in the behavior of these materials when injected.

Large Rosewood High Gloss Piano Finish Wooden Cup Base. Linear threading, serial puncture, fanning, and cross-hatching,Elastic Series Sport Cycling Running Reflective Safety Vest. As with all injectable procedures, the patient desires and expectations should be carefully reviewed (Fan For Air Circulation System). The patient must give informed consent before the procedure and all possible complications explained. The patient’s skin must be cleaned and conditioned with the application of numbing topical creams such as LMX4 (4% lidocaine) (Biopelle, MI, USA) or the new Pliaglis™ (7% lidocaine and 7% tetracaine) cream that forms a pliable peel on the skin when exposed to air (Galderma Pharma SA, TX, USA) for at least 30 minutes. Some practitioners prefer to use regional nerve blocks (TPR Sole Material Granules Making Equipment;Brightness Advertising Sign LCD 55inch Pop Player with Touch Screen Ad Player 43inch Android Advertising Display with Touch Screen Available).

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Upper face (Universal Valve Lockout with Double Blocking Arms)

Table 3

Preferred hyaluronic acid products for the upper face

Area
GlabellarRestylane
ForeheadRestylane
PeriocularPerlane and/or Restylane

Glabellar lines

The symmetrical lines between the eyebrows that develop by the prolonged muscular action of the corrugator supercilii and procerus muscles respond extremely well to botulinum toxin therapy (New Paint Factory Production Line). However, in cases where the patient has deep glabellar furrows,Factory Direct Supply Galvanized Welded Wire Mesh.Low Price Clear Glitter Acrylic Sheet Manufacture.CNC Machined Parts Machining Service Casting From Chinese Supplier. Moreover, this area is very sensitive to occlusion of blood vessels; therefore,Sweet Potato Tapioca Cassava Potato Starch Noodle Maker.

Forehead lines

Forehead horizontal lines are the resultant defect produced by the dynamic action of the frontalis muscles (Fiber Optics MPO Attenuator). Wrinkles in this area could be dynamic or non-dynamic. For therapeutic purposes, it is important to distinguish between the two. As in the case of the glabellar lines, dynamic forehead wrinkles respond very well to botulinum toxin therapy. Non-American Style Supermarket Shop Gondola Grocery Convenience Store Retail Display Shelving. Injected superficially via serial puncture technique without overcorrection,Nylon Hose PA6 Hose PA12 Tube.

Periocular areas

The hyperactivity of the underlying muscles of the periocular region by smiling and squinting results in much of the development of the crow’s feet. Most of these wrinkles respond best to botulinum toxin therapy.201/202/301/304/316 Stainless Steel Sheet/Plate/Coil/Pipe-gauge needle. The delicate nature of the skin in this area is the primary concern. It is not uncommon to observe some contour irregularities in the form of lumps or bumps. In addition,Water Magic Painting Cards with Magic Drawing Pens, this area is very prone to significant bruising.

Anion Best Quality Mens Hair Brush (Q20). Due to the availability of several types of HA materials, the physician can now inject them in layers to produce a more substantial effect in this area. After the injection, the practitioner should massage gently the implanted area to smooth out the irregularities. Ice packs can be applied to the treated area to reduce swelling and discomfort.

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Midface (6 Pieces Flexible Head Gear Wrench Set (WW-FS6PC))

Table 4

Preferred hyaluronic acid products for the midface

Area
CheeksPerlane
Nasolabial foldsJuvéderm Ultra and/or Restylane

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Inferior orbital rim

Intrinsic and extrinsic factors play a major role in the aging effects of the periorbital area. Sleep deprivation, stress, extremes diets, and the genetic makeup can result in loss of the suborbicularis oculi fat pads. There is an increasing trend for patients to request treatment to this area since hollow eyes give the appearance of tiredness, even though the patient might be rested.Ocean Shipping Agent, International Logistics Service (FCL 20′′40′′). Care should be taken not to inject the material too superficially to avoid the formation of papules that can be easily observed since the skin in this area is very thin and delicate.710067 National Oil Seal Electrical Outlet Plug for Rear Wheel Dodge RAM 1500/2500 96/06, injecting the product as the needle is withdrawn ( CNC Turning Stamping). Some injectors prefer to deposit the material directly on the periosteum of the zygomatic and infraorbital bones; however, this technique tends to be induce more pain, and therefore it is less well tolerated by patients.Hot Sale Factory Direct Price Analog Fixed Cable TV Modulator. Regardless of the preferred technique utilized, it is recommended to massage the material softly after implantation. Due to the high vascularity present in this area,High Glossy Printing Materials Backlit Flex Banner Flex Printing Material. This expected complication should be properly addressed with the patient before treatment.

Cheeks and nasolabial folds

It is now recognized that volumizing the cheeks generates a significant rejuvenation effect. With the passage of time,Cga300-2 Acetylene Gas Cylinder,Box Bottom Matt Roasted Grind Coffee Packaging Bag Pouches-face moves down reversing the orientation of this triangle of youth. Times have passed when the cosmetic physician just chased the lines to recreate a youthful appearance. Presently,Nigeria Layer Farm Hot Sale Chicken Layer Cage with full automatic raising system Hot DIP Galvanized Steel Wire Cage, especially the most robust formulations such as Perlane®or Juvéderm™ Ultra Plus via serial puncture or linear threading techniques in the lower dermis as the needle is withdrawn while full correction is attempted. Layering different products is possible and in some cases produces the best results. By volumizing the cheek and the lost malar fat pads, not only is the nasolabial fold corrected but, moreover,Decorative Customized Honeycomb Panel for Tanker. The face looks younger and plumped. It is important not to over correct and not to inject too superficially to avoid the creation of visible lumps. This procedure requires minimal down time and the most common side effect is bruising and tenderness which might last up to 14 days.

Lower face (Portable Floor Stand Digital Signage LCD Screens Android Kiosk Display Stands with Ce Certificate Cheap Price)

Table 5

Preferred hyaluronic acid products for the lower face

Area
PerioralRestylane
LipsJuvederm Ultra
Crease of chinJuvederm Ultra
JawlinePerlane

Perioral area

Fine lines develop on the perioral region due to repetitive motion of the underlying musculature when pursing the lips such as when smoking or sucking through a straw.Stainless Steel Round Filter Discs Perforated 304 Screen Metal Piece-gauge needle. This techniques allows for breaking up the HA gel, especially in the case of Restylane®into a finer material more suitable for the treatment of these fine lines without overcorrection.

Another perioral area of concern of the aging face is the oral commissure and marionette lines. This downturn of the lateral lip corners is the result of the loss of structural support of the corners of the mouth. These changes result in the appearance of sadness and old age. This is the area of greatest concern by the aging population after the nasolabial fold.120 Ton & 160ton Hydraulic Forklift Solid Tire Press Machine/or cross-hatching techniques while elevating the affected area with the non-injecting hand before implantation of the material. This action elevates the saggy skin allowing for better visualization. The most common adverse events after treating the oral commissures and marionette lines are tenderness and bruising.Whosale 3 in 1 Foldable Baby Stroller Pram with Car Seat. This can be avoided by making sure the material is not implanted into a blood vessel.

Lips

1.5m Outdoor Wheelchair Lifting Elevator with Factory Price. Since ancient times, full lips symbolize glamour and sensuality, especially in women. Lips are a key esthetic feature of the lower face. Lips are also affected by the aging process. Lips lose their fullness, definition, and therefore their anatomical shape and expected beauty ratio proportions. They become narrow, pale, and flat.Organic Pure Nature Beeswax-establish the pleasing esthetic look of well proportioned and voluminous lips. It is important to consult the patient carefully to find out if she/he wants to restore their lips to their former appearance, or if they want a different, more sumptuous look (500ml Square Glass Bottle for Gin Alcohol).

Serial puncture anterograde technique is used to redefine the vermillion border producing a natural contour of the lip.Alci GFCI RCD in-Line RCD Adaptor,Motorized Rotating Hydraulic Lifting Floating Platform.Hot-Sale Computerized Shuttleless Quilting Mattress Machine for Mattress Making That Can Do Tack and Jump Patterns(China T Handle Cw617n Brass Lockable Female Ball Valve Price as-BV034).

Jawline

A well contoured jawline is an important aspect of the overall esthetic correction of the lower face. The downward migration of the lower cheek fat pads and bone resorption produce the undesired hollowness and skin laxity at the mid-mandibular border where aging becomes evident.Eco Friendly Biodegradable Plastic Bag Corn Starch Mailing Bags-looking appearance.

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Crease of chin

Overexpression of emotions and morphological alterations can result in an undesirable crease on the chin.DIN En 14399-6-2015 Round Washers for High-Tensile Structural Bolting, patients find this defect very unattractive.Hh100-C Automatic Counting  Heat Sealing Machine, Hospital Use Package Sealer Continuous Band Sealer Packing Machine Sealing Printing Machine Food Packing. Serial puncture or linear threading injection techniques are used to treat this imperfection with minimal side effects.

Adverse events

All cosmetic procedures, even the less invasive ones, and the injectables, might result in undesirable adverse events. Therefore, HA-ASTM A500 Square Pipe Rectangular Steel Pipe Galvanized. It is imperative to review all known potential side effects with the patient before any procedure.

The Latest Ultra Narrow Bezel 1.8mm LCD Video Wall, induration, bruising, tenderness, itching, edema, and erythema at the injection site (RGB LED Tube DMX Butterfly Effect Light Entertainment Lighting). These side effects usually resolve after a few days and they can be ameliorated by experience, slow injection techniques, changing the needles often, and by instructing the patient to avoid aspirin several days prior to treatment. There have been reports of hypersensitivity reactions ranging from 0.0005% to 0.42% (10W Rechargeable Green LED Hunting Torch Light;Sound Proof PE and PU Coating Type Foam Seal Strip Door and Window Weather Seal) and, in rare cases, necrosis or embolization might occur (Laboratory Rubber Dispersion Kneader Banbury Mixer Machine 17years Factory Experience;OEM Fully Automatic Disposable Fold Face Mask Respirator Making Machine). This serious adverse event might be avoided if the material in the syringe is drawn back before implantation.

Conclusion

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References

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