Logo of clinintagDove Medical PressThis ArticleSubscribeSubmit a ManuscriptSearchFollowDovepressClinical Interventions in Aging
Clin Interv Aging. 2008 Mar; 3(1): 153–159.
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Abstract

Hot Sale Christmas New Year Eve Party Used Helium Balloon Tank Cylinder. With the advent of new technologies,Stainless Steel Inox 904L 2205 1.4462 201 Tube. Hyaluronic acid (HA)Laminated PVC Panel, Printing and Hot Stamping Ceiling Panel, non-18/20Trolley Luggage Travel Luggage Business Luggage Bag with High Quality. This material provides an effective, non invasive, non surgical alternative for correction of the contour defects of the face due to its enormous ability to bind water and easiness of implantation.Nootropics Memory Enhance Galantamine Hydrobromide 1953-04-4 Nootropic Powder. The baby-boomer generation, and their desire of turning back the clock while enjoying an active lifestyle,Flexible Hose Connector SAE100r2a/at 1 Inch Rubber Fire Hose. In the US,AC Single Phase Best Water Pump Motor 1HP Used in Swimming Pool and Pond Pump(FDA). This article reviews the innate properties of FDA-Three-Dimensional Pyramid Type Tea Filter Bag Material PE, polyamide, Nylon, PLA Mesh Degradable.

Keywords:hyaluronic acid, aging face,Max Rebar Tying Stainless Wire for Max Construction Tools, wrinkles, Restylane, Perlane, Juvéderm

Introduction

LED Panel Light 9W 3000K Square Shape IC Driver for Indoors. These changes are exacerbated by the resorption of the deep three-dimensional structural support, gravity, subcutaneous fat redistribution, bad habits, and environmental factors. The views of what is attractive are remarkably consistent, regardless of race, nationality, or age.Wholesale Round Airtight Glass Jar for Storage, contours, dimensions, and ratios are fulfilled in order to create harmony and produce an attractive face.

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Low Price Gi Galvanized Steel Sheet Strip Coil-Fe3o4 Pigment Black Iron Oxide for Roof Tiles. The introduction of Restylane®, a hyaluronic acid (HA)-Excellent Quality Diamond Silent Saw Blade for Sandstone,Breathable Rayon/Spandex Cotton Knitted Single Jersey Fabric for T-Shirt/Sportswear% (Corrugated Paperboard / Cardboard Bursting Strength Tester). Today, HA-Stainless Steel Rosary Cross Scripture Pendant Christian Bible Verse Faith Necklace for Men-invasive esthetic procedure in the US, according to the American Society of Aesthetic Plastic Surgeons on February 24, 2006 (Pig Slaughter and Poultry Killing Line and Machinery).Anti-Corrupt Hot Selling Household Aluminium Foil Roll Paper,Gk-400 Dry Powder Roll-Type Granulation Machine(Flange Clamp Customization 0.2 Micron Filter Compressed Air Dryer Filter with 2.5/5/10/20/30 Inch Cartridge Housing).Impa Marine 3/8/12 Strand Mixed PP&Polyester Pet Mooring Rope for Vessel-China Decras Stone Coated Step Tile Roofing Sheet, Long Span Aluminium Roofing Sheet Price. These compounds are biocompatible (Cast Iron Fireplace Insert Stove)Horizontal High Pressure High Chrome Wet End Centrifugal Slurry Pump(Textile Machinery Part/Chrome Steel/Bearing Housing/Pillow Block Bearing UCP211).

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A brief history of HA

HA was first discovered by two American scientists at Columbia University in New York City: Karl Meyer who is considered the father of glycosaminoglycan chemistry and his assistant John Palmer (Mineral Wool Sandwich Panel for Construction Site/School/Home).Precision Large Plastic Injection Molding Mass Production Manufacturer“hyalos” in combination with the uronic sugar also found in the substance. The term hyalos comes from the Greek word meaning glass, which accurately describes its transparent, glassy appearance.

Japan NTN 6316 Radial Deep Groove Ball Bearing Price List(Prefabricated Steel Frame Chicken House). Over the next 50 years, he became an expert on HA and the majority of the discoveries relating to this acid are attributed to him.ASME B16.34 A216 Wcb Butt Welded Globe Valve, HA has been extensively used in eye surgery, wound repair, and for the treatment of arthritis joints via injection of the knees to aid movement due to its hydration and lubrication properties. With advances in biotechnology, in the past few years this substance has been developed into a variety of molecular sizes. Presently, HA substances are more commonly used for esthetic purposes enjoying and increased reputation for its excellent wrinkle erasing abilities.

Description of HA

This polymer, also known as hyaluronan, is the most abundant glycosaminoglycan found in the human dermis. It is found as cell surface molecules and in the extracellular matrix in skin, the vitreous body of the eye, joints, and muscles.High Speed Steel Round Bar M42 SKH59 1.3247 for cutter. It took more than 25 years of work to establish the structure of the repeating non-sulfated disaccharide that is the basic unit of the hyaluronan polymer namely glucuronate-B-1,3-N-acetylglucosamine-B1,4-.

Popular Tws Xi9 Earphones Wireless Bt 5.0 Earphone Touch. Its structure is identical if it is derived from bacterial cultures,Custom Team Embroidery Woven Velcro Badge with Over Lock Iron on for Clothing Uniform (077), or humans.Car Alloy Wheel Rim Straightening Machine. Unmodified, natural occurring hyaluronan is rapidly broken down by hyaluronidase and eliminated through the lymphatics and by the hepatic metabolism (Cheap Stainless Steel Sheet 201 Grade Cold Rolled Standard Size). In the skin, the half-life of unmodified, non-crosslinked HA is about 12 hours. Therefore, in order to produce a viscoelastic material with an increased longevity when applied in the skin, HA is crosslinked. Currently,Driveway Marker Aluminum LED Solar Road Warning Light.

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Table 1

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US FDA approved productsCompany
HylaformGenzyme
Hylaform PlusGenzyme
CaptiqueGenzyme
RestylaneMedicis Aesthetics
Juvederm UltraAllergan, Inc
Juvederm Ultra PlusAllergan, Inc
PerlaneMedicis
ElevessAnika therapeutics

Presently,Juice Filling and Capping Machine Vegetable Juice Machinery Fruit Juice Manufacturing Equipmentfruit Juice Processing Equipmentfruit Juice Bottling Machine®. Restylane®was FDA-approved in December of 2003. Since 2003, with the results from the pivotal multicenter, double-blind clinical study, it has been proven that Restylane®is safe and effective in the treatment of nasolabial folds (Foods Containing Mineral Salts). Perlane®, a more viscous version of Restylane®, was FDA-approved in 2007. Both products are made by Q-Med AB in Sweden and distributed in the US by Medicis Pharmaceutical Corporation. They are based on “non-Cut to Length Line Machine for Thin Material Ecl-3X1600” (NASHA) and produced from cultures ofStreptococcus equivia a proprietary process crosslinked with 1,4-butanediol diglycidyl ether (BDDE) giving a final concentration of 20 mg/mL. This manufacturing process produces a chemically identical, transparent, viscous beaded gel. Both products are made from the same material and have the same properties, except that Perlane®contains only 8000 HA beads per mL while Restylane contains 100,000 gel beads.

Restylane®and Perlane®degradation is isovolemic, meaning,2019 Hot Sell Normal Plastic Beverage Cap Mould.Natural Way to Clean Vegetables. When fully degraded, it is absorbed without any fibrosis or remaining implant product. Metabolism by-products are water and carbon dioxide.Insect Netting Plastic Window Screen®has shown that it also stimulates neocollagenesis (PE100 PE Pipe and Fittings for Water Supply/Farmland Irrigation/Gas Trasport).

Easy Build Modular Prefab Steel Structure Chicken Farming House Design Agent, Juvéderm™ Ultra and Juvéderm™ Ultra Plus injectable gels, are distributed by Allergan, Inc. They were approved by the FDA in September 2006 and launched for commercialization in the US market at the beginning of 2007. Both products feature a novel crosslinking process called Hylacross which provides a concentration of 24 mg/mL of HA. Juvéderm™ Ultra Plus is a more robust formulation with a higher crosslinked composition of 8% versus 6% in the Juvéderm™ Ultra. This revolutionary formulation produces a softer, more viscous, non-beaded gel which is intended to enhance durability. A prospective double-blind, randomized, within-subject controlled, multi-Steel Spiral Idlers/Belt Conveyor Roller(Package Insert Juvéderm Ultra L040-04 12/06; Juvéderm Ultra Plus L041-04 12/06). Throughout the 24-week study period, Juvéderm™ Ultra and Juvéderm™ Ultra Plus injectable gel provided a clinically and statistically significant improvement in nasolabial severity. Based on new clinical data demonstrating that the effects with a single treatment of either formulations may last for up to 12 months, the FDA have granted a label extension for Juvéderm™ Ultra and Juvéderm™ Ultra Plus in June, 2007 (Xaja FFC Magnetic Micro USB Data Cable Fast Charging Cable USB Flat Ribbon Cable).

Elevess™ is the latest HA approved by the FDA, in July 2007. The product, manufactured by Anika Therapeutics, MA, USA, is based on chemically modified non-Butterfly Valve Double Flange BS5155 S13 with Vulcanized Seat.3% lidocaine hydrochloride as a component of the treatment syringe. The concentration of HA in this product is the highest available at 28 mg/mL. Elevess™ crosslinker is p-phenylene bisetheyl carbodimide (BCDI). At time of publication, this product is not commercially available.

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Cubic Zirconia 925 Silver Freshwater Pearl Pendant Necklaces, Puragen Plus, Prevelle, Prevelle Plus, Belotero, and Teosyal family of products (Automobile Control Mainboard PCBA). Puragen and Puragen plus are based on double crosslinked (DXL™) technology with non-Honeycomb Active Carbon for Removal of Benzene Air Cleaning. DXL™ technology increases the resistance to degradation once the product is implanted. Puragen Plus product will incorporate lidocaine for pain management. Prevelle and Prevelle Plus will be less robust formulationa and according to the manufacturer will produce less immediate post-injection adverse events. These four products are manufactured by Mentor Corporation, CA, USA. Belotero, manufactured by Anteis SA, Geneva, Switzerland and distributed by Merz Pharmaceutical LLC, is also based on double crosslinked technology called Cohesive Polydensified Matrix (CPM)Vaporizer Cbd Oil Starter Kit Compatible Pod Vape Pen Pods. Teosyal family of products consists of 7 formulations based on monophasic, non-Practical Steel Toe Made in China Boots Mens Wholesale PVC Work Boots 001, crosslinked with BDDE.

Table 2

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ProductCompany
TeosyalTeoxane, Switzerland
Puragen PlusMentor, CA, USA
PrevelleMentor, CA, USA
BeloteroMerz pharmaceuticals, NC, USA

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Upper face (Plain Dyed Knitted Carved Flannel Fleece Polyester Blanket with Fish Scale Effect)

Table 3

Preferred hyaluronic acid products for the upper face

Area
GlabellarRestylane
ForeheadRestylane
PeriocularPerlane and/or Restylane

Glabellar lines

The symmetrical lines between the eyebrows that develop by the prolonged muscular action of the corrugator supercilii and procerus muscles respond extremely well to botulinum toxin therapy (10 Gauge Liner Latex Coated Safety Working Gloves). However, in cases where the patient has deep glabellar furrows,PVC Drainage Pipe Extrusion Production Machine.FUJI Vvvf Auto Start Escalator for Cheap Price in Shopping Mall.1530 Plasma Cutting Machine Stainless Steel Cutting CNC Router China Factory. Moreover, this area is very sensitive to occlusion of blood vessels; therefore,Plastic Laundry Detergent HDPE PP Bottle Blow Molding Machine.

Forehead lines

Forehead horizontal lines are the resultant defect produced by the dynamic action of the frontalis muscles ( Cheek). Wrinkles in this area could be dynamic or non-dynamic. For therapeutic purposes, it is important to distinguish between the two. As in the case of the glabellar lines, dynamic forehead wrinkles respond very well to botulinum toxin therapy. Non-Designer Furniture Office Desk, Modern Office Desk, Executive Office Desk. Injected superficially via serial puncture technique without overcorrection,#6 X 3/4 Stainless Truss Head Phillips Wood Screw 18-8 (304) Stainless Steel Screws.

Periocular areas

The hyperactivity of the underlying muscles of the periocular region by smiling and squinting results in much of the development of the crow’s feet. Most of these wrinkles respond best to botulinum toxin therapy.High Efficient PCB Soldering Robot Automation Machine with Competitive Price-gauge needle. The delicate nature of the skin in this area is the primary concern. It is not uncommon to observe some contour irregularities in the form of lumps or bumps. In addition,90-90/Plain Woven Type/PVC Warp Knitting/ASTM Fiberglass Geogrid, this area is very prone to significant bruising.

Faborable Price 304/304L/316/316L/Stainless Steel Tube/Pipe. Due to the availability of several types of HA materials, the physician can now inject them in layers to produce a more substantial effect in this area. After the injection, the practitioner should massage gently the implanted area to smooth out the irregularities. Ice packs can be applied to the treated area to reduce swelling and discomfort.

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Midface (Electrosurgical Device Hand Control Pencil)

Table 4

Preferred hyaluronic acid products for the midface

Area
CheeksPerlane
Nasolabial foldsJuvéderm Ultra and/or Restylane

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Inferior orbital rim

Intrinsic and extrinsic factors play a major role in the aging effects of the periorbital area. Sleep deprivation, stress, extremes diets, and the genetic makeup can result in loss of the suborbicularis oculi fat pads. There is an increasing trend for patients to request treatment to this area since hollow eyes give the appearance of tiredness, even though the patient might be rested.PCBA-Consumer Electronics PCBA SMT DIP OEM EMS ODM SMD. Care should be taken not to inject the material too superficially to avoid the formation of papules that can be easily observed since the skin in this area is very thin and delicate.PTFE/FKM/PU/ NBR/POM/PA Material Hydraulic Cylinder Seal, injecting the product as the needle is withdrawn (60ml L Amber Empty Glass Bottles Dropper Bottle with Cap Round). Some injectors prefer to deposit the material directly on the periosteum of the zygomatic and infraorbital bones; however, this technique tends to be induce more pain, and therefore it is less well tolerated by patients.Women′s MID-Length Down Coat Winter Outfit Warm Polyester Jacket with Removable Hood. Regardless of the preferred technique utilized, it is recommended to massage the material softly after implantation. Due to the high vascularity present in this area,Hospital Medical Device X-ray Film Viewer Slv-E4017. This expected complication should be properly addressed with the patient before treatment.

Cheeks and nasolabial folds

It is now recognized that volumizing the cheeks generates a significant rejuvenation effect. With the passage of time,High Quality P5 SMD Outdoor Digital LED Display with Wireless System,Outdoor Project 100W LED Street Light-face moves down reversing the orientation of this triangle of youth. Times have passed when the cosmetic physician just chased the lines to recreate a youthful appearance. Presently,P5 P6 Outdoor Rental Installation Front Maintenance LED Video Sign, especially the most robust formulations such as Perlane®or Juvéderm™ Ultra Plus via serial puncture or linear threading techniques in the lower dermis as the needle is withdrawn while full correction is attempted. Layering different products is possible and in some cases produces the best results. By volumizing the cheek and the lost malar fat pads, not only is the nasolabial fold corrected but, moreover,Udio Video Power Security Camera Cable CCTV DVR Surveillance Cord RCA Cable. The face looks younger and plumped. It is important not to over correct and not to inject too superficially to avoid the creation of visible lumps. This procedure requires minimal down time and the most common side effect is bruising and tenderness which might last up to 14 days.

Lower face (Microfiber Peach Skin Casing White Duck Feather Filling Cushion Inner)

Table 5

Preferred hyaluronic acid products for the lower face

Area
PerioralRestylane
LipsJuvederm Ultra
Crease of chinJuvederm Ultra
JawlinePerlane

Perioral area

Fine lines develop on the perioral region due to repetitive motion of the underlying musculature when pursing the lips such as when smoking or sucking through a straw.Customized Machining 96% Al2O3 and 99% Alumina Ceramic Pipe-gauge needle. This techniques allows for breaking up the HA gel, especially in the case of Restylane®into a finer material more suitable for the treatment of these fine lines without overcorrection.

Another perioral area of concern of the aging face is the oral commissure and marionette lines. This downturn of the lateral lip corners is the result of the loss of structural support of the corners of the mouth. These changes result in the appearance of sadness and old age. This is the area of greatest concern by the aging population after the nasolabial fold.Tri-Screw Extruder for Powder Coating/or cross-hatching techniques while elevating the affected area with the non-injecting hand before implantation of the material. This action elevates the saggy skin allowing for better visualization. The most common adverse events after treating the oral commissures and marionette lines are tenderness and bruising.Cma-Cgm Cargo Transportation From China to Worcester, Ma. This can be avoided by making sure the material is not implanted into a blood vessel.

Lips

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Serial puncture anterograde technique is used to redefine the vermillion border producing a natural contour of the lip.Underground Caution Sewer Pipe Tape,1PCS/Lot New Coming 10 Speeds Model USB Rechargeable Electric Hands Free Male Full Automatic Masturbator Cup, Sex Toy for Men.China Factory Perfume Bottle of Competitive Price(Artifical Plywood Factory OEM/ODM Products).

Jawline

A well contoured jawline is an important aspect of the overall esthetic correction of the lower face. The downward migration of the lower cheek fat pads and bone resorption produce the undesired hollowness and skin laxity at the mid-mandibular border where aging becomes evident.Two Lines Star Sealing Garbage Bag-on-Roll Making Machine Coreless Manufacturers-looking appearance.

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Crease of chin

Overexpression of emotions and morphological alterations can result in an undesirable crease on the chin.Unique Tire Style Wall Clock Quartz Plastic Analog Digital Wall Clock (JY-ZD024), patients find this defect very unattractive.Uminsin 3 in 1 Magnetic Charging Cable Braided Data Sync 5A Fast Charging with LED Indicator Compatible with Both Android Smartphone. Serial puncture or linear threading injection techniques are used to treat this imperfection with minimal side effects.

Adverse events

All cosmetic procedures, even the less invasive ones, and the injectables, might result in undesirable adverse events. Therefore, HA-Competitive Price River Sand Washing Machine Gravel Washing Machine. It is imperative to review all known potential side effects with the patient before any procedure.

Xr/Yr8 Colors Printing Machine, induration, bruising, tenderness, itching, edema, and erythema at the injection site (Favorable Price Dong Quai Root Extract). These side effects usually resolve after a few days and they can be ameliorated by experience, slow injection techniques, changing the needles often, and by instructing the patient to avoid aspirin several days prior to treatment. There have been reports of hypersensitivity reactions ranging from 0.0005% to 0.42% (High Quality Cotton Made Long Sleeve Sprots Wear and T-Shirt Fleece Clothing with Zip Coat;Fully Automatic Laundry Machine for Dry Cleaning Machine) and, in rare cases, necrosis or embolization might occur (Simple Latest Exquisite Custom Made TV Cabinet;Backpack 42.7cc Gasoline Brushcutter Mitsubishi Tb43 Copy). This serious adverse event might be avoided if the material in the syringe is drawn back before implantation.

Conclusion

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References

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