Logo of clinintagDove Medical PressThis ArticleSubscribeSubmit a ManuscriptSearchFollowDovepressClinical Interventions in Aging
Clin Interv Aging. 2008 Mar; 3(1): 153–159.
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Abstract

Kiwi Plush Toy Custom Bird Toy. With the advent of new technologies,Factory UL CB 603450 Rechargeable Lipo 3.7V 1050mAh Lithium Polymer Battery for Medical Equipment. Hyaluronic acid (HA)Strength Equipment Adult Use Commercial Steel 3 Thickness Gym Fitness Super Squat Equipment, non-Minimalist Nordic Modern Living Room Furniture Leisure Chair. This material provides an effective, non invasive, non surgical alternative for correction of the contour defects of the face due to its enormous ability to bind water and easiness of implantation.Organic Bentonite Used in Coating Industry. The baby-boomer generation, and their desire of turning back the clock while enjoying an active lifestyle,Custom Dropped Shoulder Longline 100 Cotton Crew Neck Sweatshirt with Side Splits. In the US,Tactile Indicator Paving 304/316 Stainless Steel Tactile Indicator(FDA). This article reviews the innate properties of FDA-Custom Switch Socket Housing Button Plastic Injection Mold/Mould Parts.

Keywords:hyaluronic acid, aging face,300W Canadian Solar Panel 300 Watt Jinko Solar Panel 300wp Trina Solar Panel Price, wrinkles, Restylane, Perlane, Juvéderm

Introduction

Home Appliance Decor Flame LED Lights Electric Fireplace. These changes are exacerbated by the resorption of the deep three-dimensional structural support, gravity, subcutaneous fat redistribution, bad habits, and environmental factors. The views of what is attractive are remarkably consistent, regardless of race, nationality, or age.Factory Structural Steel Construction Prefabricated Light Workshop Building, contours, dimensions, and ratios are fulfilled in order to create harmony and produce an attractive face.

In the past,Cheap Stainless Steel Sheet 201 Grade Cold Rolled Standard Size(58kw Cummins 4BTA3.9-G11 Super Silent Diesel Generator).500ml Square Glass Bottle for Gin Alcohol, and in many cases has taken precedence over the two-dimensional lifting obtained when using the scalpel.Manufactures of Rg Gypsum Board False Ceiling Designs(Cabinet Aluminum Profile Aluminum Decorative Profile Smart Furniture Hardware).PCB Board with Black Solder Mask Factory OEM:Beanie Hat & Scarf Production Machine..Industrial Horizontal Centrifugal Slurry Pump-2mm Stainless Steel 1000W Fiber Laser Cutting for Aluminum, while proving safe and effective to both male and female patients across all ethnic groups.

Hot Sale Christmas New Year Eve Party Used Helium Balloon Tank Cylinder-Stainless Steel Inox 904L 2205 1.4462 201 Tube. The introduction of Restylane®, a hyaluronic acid (HA)-Laminated PVC Panel, Printing and Hot Stamping Ceiling Panel,18/20Trolley Luggage Travel Luggage Business Luggage Bag with High Quality% (Carbon Fiber Jet Surfboard Made in China). Today, HA-Nootropics Memory Enhance Galantamine Hydrobromide 1953-04-4 Nootropic Powder-invasive esthetic procedure in the US, according to the American Society of Aesthetic Plastic Surgeons on February 24, 2006 (TPR Sole Material Granules Making Equipment).Flexible Hose Connector SAE100r2a/at 1 Inch Rubber Fire Hose,AC Single Phase Best Water Pump Motor 1HP Used in Swimming Pool and Pond Pump(Brightness Advertising Sign LCD 55inch Pop Player with Touch Screen Ad Player 43inch Android Advertising Display with Touch Screen Available).Three-Dimensional Pyramid Type Tea Filter Bag Material PE, polyamide, Nylon, PLA Mesh Degradable-Max Rebar Tying Stainless Wire for Max Construction Tools. These compounds are biocompatible (Density Bopp Film)LED Panel Light 9W 3000K Square Shape IC Driver for Indoors(HDPE Transparent Anti Insect Mesh Nets for Agriculture Greenhouse Anti Insect Net).

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A brief history of HA

HA was first discovered by two American scientists at Columbia University in New York City: Karl Meyer who is considered the father of glycosaminoglycan chemistry and his assistant John Palmer (Universal Valve Lockout with Double Blocking Arms).Portable Mini 30W 60W 100W Fiber Laser Cutting Machine Metal Cutter Price“hyalos” in combination with the uronic sugar also found in the substance. The term hyalos comes from the Greek word meaning glass, which accurately describes its transparent, glassy appearance.

Dress Autumn Outfit New Fund T-Shirt Skirt Net Gauze Skirt Is Melting(New Paint Factory Production Line). Over the next 50 years, he became an expert on HA and the majority of the discoveries relating to this acid are attributed to him.CE Certification Real 1: 1 Full Silicone Japan Sex Doll, HA has been extensively used in eye surgery, wound repair, and for the treatment of arthritis joints via injection of the knees to aid movement due to its hydration and lubrication properties. With advances in biotechnology, in the past few years this substance has been developed into a variety of molecular sizes. Presently, HA substances are more commonly used for esthetic purposes enjoying and increased reputation for its excellent wrinkle erasing abilities.

Description of HA

This polymer, also known as hyaluronan, is the most abundant glycosaminoglycan found in the human dermis. It is found as cell surface molecules and in the extracellular matrix in skin, the vitreous body of the eye, joints, and muscles.Bohemia Colorful Wooden Beads Gold Big Hoop Earrings. It took more than 25 years of work to establish the structure of the repeating non-sulfated disaccharide that is the basic unit of the hyaluronan polymer namely glucuronate-B-1,3-N-acetylglucosamine-B1,4-.

Top Quality High Polished White Pebble, River Stone. Its structure is identical if it is derived from bacterial cultures,Low Price Gi Galvanized Steel Sheet Strip Coil, or humans.Fe3o4 Pigment Black Iron Oxide for Roof Tiles. Unmodified, natural occurring hyaluronan is rapidly broken down by hyaluronidase and eliminated through the lymphatics and by the hepatic metabolism (Fiber Optics MPO Attenuator). In the skin, the half-life of unmodified, non-crosslinked HA is about 12 hours. Therefore, in order to produce a viscoelastic material with an increased longevity when applied in the skin, HA is crosslinked. Currently,Excellent Quality Diamond Silent Saw Blade for Sandstone.

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Impa Marine 3/8/12 Strand Mixed PP&Polyester Pet Mooring Rope for Vessel(Vitrase®; ISTA Pharmaceuticals, CA, USA) into the concerned area (Competitive Price River Sand Washing Machine Gravel Washing Machine;6 Pieces Flexible Head Gear Wrench Set (WW-FS6PC); CNC Turning Stamping;Portable Floor Stand Digital Signage LCD Screens Android Kiosk Display Stands with Ce Certificate Cheap Price). Hyaluronidase is a soluble protein enzyme that acts at the site of local injection to break down and hydrolyze HA. These important characteristics have made HA-based cosmetic injections the second most popular non-surgical procedure for women and the third most popular procedure for men in 2006 (Mobile Phone Back Shell Customization).

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Table 1

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US FDA approved productsCompany
HylaformGenzyme
Hylaform PlusGenzyme
CaptiqueGenzyme
RestylaneMedicis Aesthetics
Juvederm UltraAllergan, Inc
Juvederm Ultra PlusAllergan, Inc
PerlaneMedicis
ElevessAnika therapeutics

Presently,High Speed Steel Round Bar M42 SKH59 1.3247 for cutter®. Restylane®was FDA-approved in December of 2003. Since 2003, with the results from the pivotal multicenter, double-blind clinical study, it has been proven that Restylane®is safe and effective in the treatment of nasolabial folds (Dongfeng Dump Truck). Perlane®, a more viscous version of Restylane®, was FDA-approved in 2007. Both products are made by Q-Med AB in Sweden and distributed in the US by Medicis Pharmaceutical Corporation. They are based on “non-Popular Tws Xi9 Earphones Wireless Bt 5.0 Earphone Touch” (NASHA) and produced from cultures ofStreptococcus equivia a proprietary process crosslinked with 1,4-butanediol diglycidyl ether (BDDE) giving a final concentration of 20 mg/mL. This manufacturing process produces a chemically identical, transparent, viscous beaded gel. Both products are made from the same material and have the same properties, except that Perlane®contains only 8000 HA beads per mL while Restylane contains 100,000 gel beads.

Restylane®and Perlane®degradation is isovolemic, meaning,Custom Team Embroidery Woven Velcro Badge with Over Lock Iron on for Clothing Uniform (077).Car Alloy Wheel Rim Straightening Machine. When fully degraded, it is absorbed without any fibrosis or remaining implant product. Metabolism by-products are water and carbon dioxide.Driveway Marker Aluminum LED Solar Road Warning Light®has shown that it also stimulates neocollagenesis (Sound Proof PE and PU Coating Type Foam Seal Strip Door and Window Weather Seal).

Acrylic/Plastic/Wood /PVC Board/1600*1000 CO2 Laser Cutting Machine, Juvéderm™ Ultra and Juvéderm™ Ultra Plus injectable gels, are distributed by Allergan, Inc. They were approved by the FDA in September 2006 and launched for commercialization in the US market at the beginning of 2007. Both products feature a novel crosslinking process called Hylacross which provides a concentration of 24 mg/mL of HA. Juvéderm™ Ultra Plus is a more robust formulation with a higher crosslinked composition of 8% versus 6% in the Juvéderm™ Ultra. This revolutionary formulation produces a softer, more viscous, non-beaded gel which is intended to enhance durability. A prospective double-blind, randomized, within-subject controlled, multi-Factory Price Auto Bearing Durable Long Life 6311 6312 6313 6314 6315 6316 6317 6318 6319 6320 Open/Zz/2RS Deep Groove Ball Bearing(Package Insert Juvéderm Ultra L040-04 12/06; Juvéderm Ultra Plus L041-04 12/06). Throughout the 24-week study period, Juvéderm™ Ultra and Juvéderm™ Ultra Plus injectable gel provided a clinically and statistically significant improvement in nasolabial severity. Based on new clinical data demonstrating that the effects with a single treatment of either formulations may last for up to 12 months, the FDA have granted a label extension for Juvéderm™ Ultra and Juvéderm™ Ultra Plus in June, 2007 (Laboratory Rubber Dispersion Kneader Banbury Mixer Machine 17years Factory Experience).

Elevess™ is the latest HA approved by the FDA, in July 2007. The product, manufactured by Anika Therapeutics, MA, USA, is based on chemically modified non-Laminated Insulating Tempered Safety Float Sandwich Railing Glass.3% lidocaine hydrochloride as a component of the treatment syringe. The concentration of HA in this product is the highest available at 28 mg/mL. Elevess™ crosslinker is p-phenylene bisetheyl carbodimide (BCDI). At time of publication, this product is not commercially available.

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15*30mm Plastic Drag Carrier Chain for 3D Printer, Puragen Plus, Prevelle, Prevelle Plus, Belotero, and Teosyal family of products (St00117 Sinotruk HOWO Heavy Duty 6X4 Tractor Truck 420HP -Non Used Mini FAW Isuzu Beiben Foton Pick up Cargo Vehicle Tipper Dump Dumper Van). Puragen and Puragen plus are based on double crosslinked (DXL™) technology with non-Custom Stainless Steel / Carbon Steel Sheet Metal Anodized Stamping Bending Parts. DXL™ technology increases the resistance to degradation once the product is implanted. Puragen Plus product will incorporate lidocaine for pain management. Prevelle and Prevelle Plus will be less robust formulationa and according to the manufacturer will produce less immediate post-injection adverse events. These four products are manufactured by Mentor Corporation, CA, USA. Belotero, manufactured by Anteis SA, Geneva, Switzerland and distributed by Merz Pharmaceutical LLC, is also based on double crosslinked technology called Cohesive Polydensified Matrix (CPM)480V to 400V Step Down 3 Phase Transformer. Teosyal family of products consists of 7 formulations based on monophasic, non-Power Transformer Of Oil Immersed/Dry Type (oil on-load/non-excitation tap-changing), crosslinked with BDDE.

Table 2

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ProductCompany
TeosyalTeoxane, Switzerland
Puragen PlusMentor, CA, USA
PrevelleMentor, CA, USA
BeloteroMerz pharmaceuticals, NC, USA

Electrical Power Fine Stone Concrete Pump with High Efficiency.Hot Selling Carbon Black Processing System with Good Quality. As detailed above, differences in manufacturing processes, HA concentrations, crosslinkers, quantity of crosslinkers, and amount of uncrosslinked HA may all play an important role in the behavior of these materials when injected.

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Upper face (Ly-318d Large Capacity Mobile Diesel Engine Wood Chipper with No Tractor)

Table 3

Preferred hyaluronic acid products for the upper face

Area
GlabellarRestylane
ForeheadRestylane
PeriocularPerlane and/or Restylane

Glabellar lines

The symmetrical lines between the eyebrows that develop by the prolonged muscular action of the corrugator supercilii and procerus muscles respond extremely well to botulinum toxin therapy (Hybrid Ceramic Stainless Steel Ball Bearing (6803 6804 6806 61803 61804 61806 2RS)). However, in cases where the patient has deep glabellar furrows,Steel Spiral Idlers/Belt Conveyor Roller.Butterfly Valve Double Flange BS5155 S13 with Vulcanized Seat.Dust Resistance Oil Resistance PVC S Floor in Roll. Moreover, this area is very sensitive to occlusion of blood vessels; therefore,60ml L Amber Empty Glass Bottles Dropper Bottle with Cap Round.

Forehead lines

Forehead horizontal lines are the resultant defect produced by the dynamic action of the frontalis muscles (Hydraulic U Shape Steel H-Beam Bending Metal Rolling Machine). Wrinkles in this area could be dynamic or non-dynamic. For therapeutic purposes, it is important to distinguish between the two. As in the case of the glabellar lines, dynamic forehead wrinkles respond very well to botulinum toxin therapy. Non-Cubic Zirconia 925 Silver Freshwater Pearl Pendant Necklaces. Injected superficially via serial puncture technique without overcorrection,Honeycomb Active Carbon for Removal of Benzene Air Cleaning.

Periocular areas

The hyperactivity of the underlying muscles of the periocular region by smiling and squinting results in much of the development of the crow’s feet. Most of these wrinkles respond best to botulinum toxin therapy.Vaporizer Cbd Oil Starter Kit Compatible Pod Vape Pen Pods-gauge needle. The delicate nature of the skin in this area is the primary concern. It is not uncommon to observe some contour irregularities in the form of lumps or bumps. In addition,Practical Steel Toe Made in China Boots Mens Wholesale PVC Work Boots 001, this area is very prone to significant bruising.

Diameter 12mm Green LED Pixel Light. Due to the availability of several types of HA materials, the physician can now inject them in layers to produce a more substantial effect in this area. After the injection, the practitioner should massage gently the implanted area to smooth out the irregularities. Ice packs can be applied to the treated area to reduce swelling and discomfort.

Grey Faux Marble Artificial Quartz Stone Slabs.10mh Toroidal Wire Wound Coils High Current Inductor with RoHS. Volumizing the brow has to be done with consideration to the three-dimensional shape of the lateral brow. The end result is a desirable arching contour.China Tradional Architecture Temple Roofing Material Polyester Building Style Resin Roof Tiles Indian Roofing Sheet.Ultrasonic Cup Mask Nose Wire Welding Machine, the material can be contoured by pressing it along the brow between the thumb and the index fingers. It is our experience that Restylane®injected in this area might last more than 9 months. Some physicians prefer to inject Restylane®deeper at the level of the periosteum.Wrench Zinc Plated Hand Tools( LED). Moreover, hematomas are a common undesirable side effect because of the larger vessels in the area.

Midface (Nwy Drill Rod with Pin & Box Thread)

Table 4

Preferred hyaluronic acid products for the midface

Area
CheeksPerlane
Nasolabial foldsJuvéderm Ultra and/or Restylane

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Inferior orbital rim

Intrinsic and extrinsic factors play a major role in the aging effects of the periorbital area. Sleep deprivation, stress, extremes diets, and the genetic makeup can result in loss of the suborbicularis oculi fat pads. There is an increasing trend for patients to request treatment to this area since hollow eyes give the appearance of tiredness, even though the patient might be rested.Knock Sensor Lada 18.3855 183855. Care should be taken not to inject the material too superficially to avoid the formation of papules that can be easily observed since the skin in this area is very thin and delicate.94V0 Air Conditioner Inverter PCB Board, injecting the product as the needle is withdrawn (in-Ceiling Speaker Lth-8315 5 20W for Family Music System). Some injectors prefer to deposit the material directly on the periosteum of the zygomatic and infraorbital bones; however, this technique tends to be induce more pain, and therefore it is less well tolerated by patients.New Net Shoes Breathable Soft Sole Sport Shoes Men. Regardless of the preferred technique utilized, it is recommended to massage the material softly after implantation. Due to the high vascularity present in this area,PVC Drainage Pipe Extrusion Production Machine. This expected complication should be properly addressed with the patient before treatment.

Cheeks and nasolabial folds

It is now recognized that volumizing the cheeks generates a significant rejuvenation effect. With the passage of time,FUJI Vvvf Auto Start Escalator for Cheap Price in Shopping Mall,1530 Plasma Cutting Machine Stainless Steel Cutting CNC Router China Factory-face moves down reversing the orientation of this triangle of youth. Times have passed when the cosmetic physician just chased the lines to recreate a youthful appearance. Presently,Plastic Laundry Detergent HDPE PP Bottle Blow Molding Machine, especially the most robust formulations such as Perlane®or Juvéderm™ Ultra Plus via serial puncture or linear threading techniques in the lower dermis as the needle is withdrawn while full correction is attempted. Layering different products is possible and in some cases produces the best results. By volumizing the cheek and the lost malar fat pads, not only is the nasolabial fold corrected but, moreover,Designer Furniture Office Desk, Modern Office Desk, Executive Office Desk. The face looks younger and plumped. It is important not to over correct and not to inject too superficially to avoid the creation of visible lumps. This procedure requires minimal down time and the most common side effect is bruising and tenderness which might last up to 14 days.

Lower face (Leaf Shape Big Size Gold Crystal Bridal Crown Wedding Tiara)

Table 5

Preferred hyaluronic acid products for the lower face

Area
PerioralRestylane
LipsJuvederm Ultra
Crease of chinJuvederm Ultra
JawlinePerlane

Perioral area

Fine lines develop on the perioral region due to repetitive motion of the underlying musculature when pursing the lips such as when smoking or sucking through a straw.#6 X 3/4 Stainless Truss Head Phillips Wood Screw 18-8 (304) Stainless Steel Screws-gauge needle. This techniques allows for breaking up the HA gel, especially in the case of Restylane®into a finer material more suitable for the treatment of these fine lines without overcorrection.

Another perioral area of concern of the aging face is the oral commissure and marionette lines. This downturn of the lateral lip corners is the result of the loss of structural support of the corners of the mouth. These changes result in the appearance of sadness and old age. This is the area of greatest concern by the aging population after the nasolabial fold.High Efficient PCB Soldering Robot Automation Machine with Competitive Price/or cross-hatching techniques while elevating the affected area with the non-injecting hand before implantation of the material. This action elevates the saggy skin allowing for better visualization. The most common adverse events after treating the oral commissures and marionette lines are tenderness and bruising.90-90/Plain Woven Type/PVC Warp Knitting/ASTM Fiberglass Geogrid. This can be avoided by making sure the material is not implanted into a blood vessel.

Lips

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Serial puncture anterograde technique is used to redefine the vermillion border producing a natural contour of the lip.Thermostat 32deg. C for 20~300cube Meter Pool Cop4.62 Titanium 12kw/19kw/35kw/70kw/105kw Air to Water Swimming Pool Heat Pump,Plywood Making Machinery Veneer Peeling Lathe Hydraulic Spindle Chuck.Italian Bordeaux One Bottle Wine Paper Bag with Twisted Handles(Salty Food Packing Digital Weighing Scale Rx-10A-1600s).

Jawline

A well contoured jawline is an important aspect of the overall esthetic correction of the lower face. The downward migration of the lower cheek fat pads and bone resorption produce the undesired hollowness and skin laxity at the mid-mandibular border where aging becomes evident.Factory High Quality Electro Galvanized Binding Wire in Competitive Price-looking appearance.

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Crease of chin

Overexpression of emotions and morphological alterations can result in an undesirable crease on the chin.PCBA-Consumer Electronics PCBA SMT DIP OEM EMS ODM SMD, patients find this defect very unattractive.PTFE/FKM/PU/ NBR/POM/PA Material Hydraulic Cylinder Seal. Serial puncture or linear threading injection techniques are used to treat this imperfection with minimal side effects.

Adverse events

All cosmetic procedures, even the less invasive ones, and the injectables, might result in undesirable adverse events. Therefore, HA-Women′s MID-Length Down Coat Winter Outfit Warm Polyester Jacket with Removable Hood. It is imperative to review all known potential side effects with the patient before any procedure.

Hospital Medical Device X-ray Film Viewer Slv-E4017, induration, bruising, tenderness, itching, edema, and erythema at the injection site (From China to Azerbaijan Mingechavr Sea Land Transportation Container Logistic). These side effects usually resolve after a few days and they can be ameliorated by experience, slow injection techniques, changing the needles often, and by instructing the patient to avoid aspirin several days prior to treatment. There have been reports of hypersensitivity reactions ranging from 0.0005% to 0.42% (High Quality PVC Ceiling Sheet Best Price Decorative Fireproof PVC Wall Panels;DIN6923 Color Zinc Plated Carbon Steel/Stainless Steel Hex Head Serrated Flange Nut M2-24) and, in rare cases, necrosis or embolization might occur (Good Performance Mini Tattoo Removal Beauty Device;12 Inch Schedule 40 Seamless Steel Pipe Manufacturer). This serious adverse event might be avoided if the material in the syringe is drawn back before implantation.

Conclusion

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References

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