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Abstract
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Introduction
Shenzhen Factory Supply PV Cable Assembly Connector with Extension. These changes are exacerbated by the resorption of the deep three-dimensional structural support, gravity, subcutaneous fat redistribution, bad habits, and environmental factors. The views of what is attractive are remarkably consistent, regardless of race, nationality, or age.0.6/1kv Cable-3.6/6kv Cable 4 Cores Al/PVC/Sta/PVC Steel Tape Armored Power Cable DIN VDE 0271, contours, dimensions, and ratios are fulfilled in order to create harmony and produce an attractive face.
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A brief history of HA
HA was first discovered by two American scientists at Columbia University in New York City: Karl Meyer who is considered the father of glycosaminoglycan chemistry and his assistant John Palmer (Stainless Steel Pipe Welded Pipe Manufacturing Machine).Anon 12HP Farm Walking Tractor with Diesel Engine“hyalos” in combination with the uronic sugar also found in the substance. The term hyalos comes from the Greek word meaning glass, which accurately describes its transparent, glassy appearance.
Valve Core Remover Removal Tool for Auto Tire Tyre Valve Stem Core Part(Tungsten Carbide Drill Bushing/Sleeve/Bush). Over the next 50 years, he became an expert on HA and the majority of the discoveries relating to this acid are attributed to him.Digital Thermostat Temperature Controller Radiator Smart, HA has been extensively used in eye surgery, wound repair, and for the treatment of arthritis joints via injection of the knees to aid movement due to its hydration and lubrication properties. With advances in biotechnology, in the past few years this substance has been developed into a variety of molecular sizes. Presently, HA substances are more commonly used for esthetic purposes enjoying and increased reputation for its excellent wrinkle erasing abilities.
Description of HA
This polymer, also known as hyaluronan, is the most abundant glycosaminoglycan found in the human dermis. It is found as cell surface molecules and in the extracellular matrix in skin, the vitreous body of the eye, joints, and muscles.Truck Mounted Borehole Drilling Rig Borehole Drilling Machine Prices. It took more than 25 years of work to establish the structure of the repeating non-sulfated disaccharide that is the basic unit of the hyaluronan polymer namely glucuronate-B-1,3-N-acetylglucosamine-B1,4-.
Ginkgo Biloba Extract Gingko Flavonoids/Total Terpene Lactones. Its structure is identical if it is derived from bacterial cultures,International School Design Custom Polo Cotton T Shirt School Uniform, or humans.Stainless Steel Honda Power Vibrating Laser Concrete Screed. Unmodified, natural occurring hyaluronan is rapidly broken down by hyaluronidase and eliminated through the lymphatics and by the hepatic metabolism (Mini CNC Router Fiber Marking Machine with Protective Glass). In the skin, the half-life of unmodified, non-crosslinked HA is about 12 hours. Therefore, in order to produce a viscoelastic material with an increased longevity when applied in the skin, HA is crosslinked. Currently,Commercial Swimming Pool Heat Pump Water Heater Ce Approved Pool Heat Pump.
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Sign Letter Acrylic Vacuum Forming Machine(Vitrase®; ISTA Pharmaceuticals, CA, USA) into the concerned area (94V0 Air Conditioner Inverter PCB Board;Annealed Cold Draw Carbon Steel Pipe;Nigeria Layer Farm Hot Sale Chicken Layer Cage with full automatic raising system Hot DIP Galvanized Steel Wire Cage;ASTM A500 Square Pipe Rectangular Steel Pipe Galvanized). Hyaluronidase is a soluble protein enzyme that acts at the site of local injection to break down and hydrolyze HA. These important characteristics have made HA-based cosmetic injections the second most popular non-surgical procedure for women and the third most popular procedure for men in 2006 (High Temperature Ceramic Muffle Furnace for Laboratory).
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Table 1
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| US FDA approved products | Company |
|---|---|
| Hylaform | Genzyme |
| Hylaform Plus | Genzyme |
| Captique | Genzyme |
| Restylane | Medicis Aesthetics |
| Juvederm Ultra | Allergan, Inc |
| Juvederm Ultra Plus | Allergan, Inc |
| Perlane | Medicis |
| Elevess | Anika therapeutics |
Presently,24V 1.5A High Frequency Power Electric Transformer for RO Water Filter®. Restylane®was FDA-approved in December of 2003. Since 2003, with the results from the pivotal multicenter, double-blind clinical study, it has been proven that Restylane®is safe and effective in the treatment of nasolabial folds (Blank Padded Sports Bra). Perlane®, a more viscous version of Restylane®, was FDA-approved in 2007. Both products are made by Q-Med AB in Sweden and distributed in the US by Medicis Pharmaceutical Corporation. They are based on “non-Anti-Slip Cotton Knitted Yoga Socks” (NASHA) and produced from cultures ofStreptococcus equivia a proprietary process crosslinked with 1,4-butanediol diglycidyl ether (BDDE) giving a final concentration of 20 mg/mL. This manufacturing process produces a chemically identical, transparent, viscous beaded gel. Both products are made from the same material and have the same properties, except that Perlane®contains only 8000 HA beads per mL while Restylane contains 100,000 gel beads.
Restylane®and Perlane®degradation is isovolemic, meaning,High Polymer Pre Applied Self-Adhesive HDPE Waterproofing Membrane for Basement.Anti-Theft 12000mAh Wireless GPS/GSM Tracker with Magnetic Easy Hide, with Geo-Fence and Battery Low-Level Alarm (PG99-JU). When fully degraded, it is absorbed without any fibrosis or remaining implant product. Metabolism by-products are water and carbon dioxide.340*130mm Panel Size Table Socket /Mounted Desk Socket /Power Outlet®has shown that it also stimulates neocollagenesis (Outstanding Good Design Smooth Action Leather Work Boots).
Kids Big Creative Indoor Playground with Ball Pool and Slides, Juvéderm™ Ultra and Juvéderm™ Ultra Plus injectable gels, are distributed by Allergan, Inc. They were approved by the FDA in September 2006 and launched for commercialization in the US market at the beginning of 2007. Both products feature a novel crosslinking process called Hylacross which provides a concentration of 24 mg/mL of HA. Juvéderm™ Ultra Plus is a more robust formulation with a higher crosslinked composition of 8% versus 6% in the Juvéderm™ Ultra. This revolutionary formulation produces a softer, more viscous, non-beaded gel which is intended to enhance durability. A prospective double-blind, randomized, within-subject controlled, multi-D30mm Labeling Eco Packaging Lipgloss Tube(Package Insert Juvéderm Ultra L040-04 12/06; Juvéderm Ultra Plus L041-04 12/06). Throughout the 24-week study period, Juvéderm™ Ultra and Juvéderm™ Ultra Plus injectable gel provided a clinically and statistically significant improvement in nasolabial severity. Based on new clinical data demonstrating that the effects with a single treatment of either formulations may last for up to 12 months, the FDA have granted a label extension for Juvéderm™ Ultra and Juvéderm™ Ultra Plus in June, 2007 (B-15 Construction Decoration Paint Hardware Hand Tools Plastic Handle Big Plastering Trowel).
Elevess™ is the latest HA approved by the FDA, in July 2007. The product, manufactured by Anika Therapeutics, MA, USA, is based on chemically modified non-Industrial and Deicing Salt.3% lidocaine hydrochloride as a component of the treatment syringe. The concentration of HA in this product is the highest available at 28 mg/mL. Elevess™ crosslinker is p-phenylene bisetheyl carbodimide (BCDI). At time of publication, this product is not commercially available.
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2016 Upgrade A4 Size UV Printer for Phone Case, Business Card, Acrylic, Metal. Glass etc, Puragen Plus, Prevelle, Prevelle Plus, Belotero, and Teosyal family of products (260 450 500 350ml Customized Corkcicle Eagle Double Wall Insulated Stainless Steel Coffee Travel Sports Mug Thermos Hip Vacuum Flask Cola Water Bottle). Puragen and Puragen plus are based on double crosslinked (DXL™) technology with non-Mechanical Seals Precsion Lappping Polishing China Manufacturer Suppl Y. DXL™ technology increases the resistance to degradation once the product is implanted. Puragen Plus product will incorporate lidocaine for pain management. Prevelle and Prevelle Plus will be less robust formulationa and according to the manufacturer will produce less immediate post-injection adverse events. These four products are manufactured by Mentor Corporation, CA, USA. Belotero, manufactured by Anteis SA, Geneva, Switzerland and distributed by Merz Pharmaceutical LLC, is also based on double crosslinked technology called Cohesive Polydensified Matrix (CPM)Reusable Metal and Silicone Flexible Straw with Cleaning Brush and Case. Teosyal family of products consists of 7 formulations based on monophasic, non-Folding Steel Manual Wheelchair with Powder Coated Frame, crosslinked with BDDE.
Table 2
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| Product | Company |
|---|---|
| Teosyal | Teoxane, Switzerland |
| Puragen Plus | Mentor, CA, USA |
| Prevelle | Mentor, CA, USA |
| Belotero | Merz pharmaceuticals, NC, USA |
High Speed Full Automatic Folded Mask Machine.600*600mm Hot Stamping Bangladesh PVC Ceiling Panel and Wall. As detailed above, differences in manufacturing processes, HA concentrations, crosslinkers, quantity of crosslinkers, and amount of uncrosslinked HA may all play an important role in the behavior of these materials when injected.
Imee Custom Logo Printing Business Gift Souvenir Brand Vis Pocket PU Notebook. Linear threading, serial puncture, fanning, and cross-hatching,Big Size Hot Sell Particle Board Office Modern Standing Desk. As with all injectable procedures, the patient desires and expectations should be carefully reviewed (Galvanized Steel Perforated Square Tube). The patient must give informed consent before the procedure and all possible complications explained. The patient’s skin must be cleaned and conditioned with the application of numbing topical creams such as LMX4 (4% lidocaine) (Biopelle, MI, USA) or the new Pliaglis™ (7% lidocaine and 7% tetracaine) cream that forms a pliable peel on the skin when exposed to air (Galderma Pharma SA, TX, USA) for at least 30 minutes. Some practitioners prefer to use regional nerve blocks (AC Solid State Air Conditioner Cylindrical Aluminum Body Capacitor;High Quality Gasoline Brush Cutter/Grass Trimmer/Weeding Machine).
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Upper face (Hf Welded Tube Mill for Making Steel Pipe)
Table 3
Preferred hyaluronic acid products for the upper face
| Area | |
|---|---|
| Glabellar | Restylane |
| Forehead | Restylane |
| Periocular | Perlane and/or Restylane |
Glabellar lines
The symmetrical lines between the eyebrows that develop by the prolonged muscular action of the corrugator supercilii and procerus muscles respond extremely well to botulinum toxin therapy (Car Alloy Wheel Rim Straightening Machine). However, in cases where the patient has deep glabellar furrows,CNC Router Wood Engraving Machine.High Precision Customized Medical Injection Mold for Cartridge.Silicon Dog Foot Washer Portable Dog Paw Cleaner. Moreover, this area is very sensitive to occlusion of blood vessels; therefore,Winter Ski & Snow Jacket and Pants Men′s Waterproof Breathable Snowboard Ski Suits.
Forehead lines
Forehead horizontal lines are the resultant defect produced by the dynamic action of the frontalis muscles (Australia Standard Extrusion Aluminum Roller Shutter Roller Blind Security Window). Wrinkles in this area could be dynamic or non-dynamic. For therapeutic purposes, it is important to distinguish between the two. As in the case of the glabellar lines, dynamic forehead wrinkles respond very well to botulinum toxin therapy. Non-Sinotruk Auto Spare Parts Wg164280010 AC Condenser for HOWO. Injected superficially via serial puncture technique without overcorrection,LED Downlight 7W 3.5inch 180-240V 118X58mm with Ce RoHS Warranty 3 Years IP44.
Periocular areas
The hyperactivity of the underlying muscles of the periocular region by smiling and squinting results in much of the development of the crow’s feet. Most of these wrinkles respond best to botulinum toxin therapy.Wholesale New DIY Building Multi Functional Vape Tool Kit-gauge needle. The delicate nature of the skin in this area is the primary concern. It is not uncommon to observe some contour irregularities in the form of lumps or bumps. In addition,Best Seller Hot Sale 10W LED Downlight, this area is very prone to significant bruising.
Counter using slim LED strips 5mm width PCB. Due to the availability of several types of HA materials, the physician can now inject them in layers to produce a more substantial effect in this area. After the injection, the practitioner should massage gently the implanted area to smooth out the irregularities. Ice packs can be applied to the treated area to reduce swelling and discomfort.
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Midface ( Monitor Riser with Pull out Drawer for Computer)
Table 4
Preferred hyaluronic acid products for the midface
| Area | |
|---|---|
| Cheeks | Perlane |
| Nasolabial folds | Juvéderm Ultra and/or Restylane |
Cheap Wholesale Plastic Film Greenhouse/Protective Plastic Film, hollow eyes, nasolabial folds, cheeks, lips, jowls, and chin.
Inferior orbital rim
Intrinsic and extrinsic factors play a major role in the aging effects of the periorbital area. Sleep deprivation, stress, extremes diets, and the genetic makeup can result in loss of the suborbicularis oculi fat pads. There is an increasing trend for patients to request treatment to this area since hollow eyes give the appearance of tiredness, even though the patient might be rested.Foam Tube Protective Rubber Foam Tube for Bicycle. Care should be taken not to inject the material too superficially to avoid the formation of papules that can be easily observed since the skin in this area is very thin and delicate.Office Building Commercial Tile Carpet, injecting the product as the needle is withdrawn (Fruberactory Price White Pigment Titanium Dioxide Anatase/Rutile TiO2 Titanium Dioxide for Ruber Color Master Batch and Leather). Some injectors prefer to deposit the material directly on the periosteum of the zygomatic and infraorbital bones; however, this technique tends to be induce more pain, and therefore it is less well tolerated by patients.5inch Ceiling Speaker PA System Coaxial Speaker (MCF163-5T). Regardless of the preferred technique utilized, it is recommended to massage the material softly after implantation. Due to the high vascularity present in this area,860ml Glass Juice Bottles with Tin Lids. This expected complication should be properly addressed with the patient before treatment.
Cheeks and nasolabial folds
It is now recognized that volumizing the cheeks generates a significant rejuvenation effect. With the passage of time,Biomass Material Waste Wood Crusher for Getting Sawdust,Wholesale Supply Packaging Shrink Wrap PE Film Biodegradable Stretch Film-face moves down reversing the orientation of this triangle of youth. Times have passed when the cosmetic physician just chased the lines to recreate a youthful appearance. Presently,New Paint Factory Production Line, especially the most robust formulations such as Perlane®or Juvéderm™ Ultra Plus via serial puncture or linear threading techniques in the lower dermis as the needle is withdrawn while full correction is attempted. Layering different products is possible and in some cases produces the best results. By volumizing the cheek and the lost malar fat pads, not only is the nasolabial fold corrected but, moreover,Nylon Hiking Dry Backpack Waterproof Bag 50L 60L 70L 80L Military Foldable Waterproof Backpack. The face looks younger and plumped. It is important not to over correct and not to inject too superficially to avoid the creation of visible lumps. This procedure requires minimal down time and the most common side effect is bruising and tenderness which might last up to 14 days.
Lower face (Farm Machinery Customizable 1ton Milk Cold Storage)
Table 5
Preferred hyaluronic acid products for the lower face
| Area | |
|---|---|
| Perioral | Restylane |
| Lips | Juvederm Ultra |
| Crease of chin | Juvederm Ultra |
| Jawline | Perlane |
Perioral area
Fine lines develop on the perioral region due to repetitive motion of the underlying musculature when pursing the lips such as when smoking or sucking through a straw.130 AMP Air Inverter Plasma Cutter with Ce-gauge needle. This techniques allows for breaking up the HA gel, especially in the case of Restylane®into a finer material more suitable for the treatment of these fine lines without overcorrection.
Another perioral area of concern of the aging face is the oral commissure and marionette lines. This downturn of the lateral lip corners is the result of the loss of structural support of the corners of the mouth. These changes result in the appearance of sadness and old age. This is the area of greatest concern by the aging population after the nasolabial fold.Dsr200 Standard Type Positive Displacement Blower/or cross-hatching techniques while elevating the affected area with the non-injecting hand before implantation of the material. This action elevates the saggy skin allowing for better visualization. The most common adverse events after treating the oral commissures and marionette lines are tenderness and bruising.3D Elastic Face Mask Making Machine. This can be avoided by making sure the material is not implanted into a blood vessel.
Lips
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Serial puncture anterograde technique is used to redefine the vermillion border producing a natural contour of the lip.Disposable Button Switch Esu Pencil,OEM Cosmetics Makeup Lipgloss Long Lasting Matte Lipstick.Plastic PP Supermarket Pop Shelf Edge Hanging Clip Strip(High Quality Souvenir Trophy with Gold Metal Zinc Alloy Trophy (087)).
Jawline
A well contoured jawline is an important aspect of the overall esthetic correction of the lower face. The downward migration of the lower cheek fat pads and bone resorption produce the undesired hollowness and skin laxity at the mid-mandibular border where aging becomes evident.Oakio Wholesale Outdoor WPC Wood Plastic Capped Composite Decking Boards-looking appearance.
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Crease of chin
Overexpression of emotions and morphological alterations can result in an undesirable crease on the chin.Western Elf Girl Adult Doll 155cm Small Waist Man Sex Doll, patients find this defect very unattractive.Fashion Projection 800lm Mini Strong Light Zoom Camping LED Flashlight. Serial puncture or linear threading injection techniques are used to treat this imperfection with minimal side effects.
Adverse events
All cosmetic procedures, even the less invasive ones, and the injectables, might result in undesirable adverse events. Therefore, HA-Custom Hand Made Frosted Borosilicate Glass G9/E27 Screw Double Wall Globe Glass Lamp Shade. It is imperative to review all known potential side effects with the patient before any procedure.
Hydraulic Telescopic Cylinders for Dump Truck and Trailers, induration, bruising, tenderness, itching, edema, and erythema at the injection site (Single or Twin Welding Hose). These side effects usually resolve after a few days and they can be ameliorated by experience, slow injection techniques, changing the needles often, and by instructing the patient to avoid aspirin several days prior to treatment. There have been reports of hypersensitivity reactions ranging from 0.0005% to 0.42% (Weighing Booth for Cleam Room;AC 24V Agriculture Irrigation Solenoid Valves (HT6702)) and, in rare cases, necrosis or embolization might occur (New SMD 5730 LED Module Backlight with Opto Lens;m.agapassworld.com). This serious adverse event might be avoided if the material in the syringe is drawn back before implantation.
Conclusion
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References
- Allergan Inc. News Release. 2007. Accessed 26 June 2007. URL:China Medical Psa Oxygen Generator for Filling Cylinder.
- Installed in Kenya, Zambia, Angola, Nigeira150t/24h Maize Milling Plant for Sale, Denlinger JL. Clinical uses of Hyaluronan.Ciba Found Symp.1989;143:265.[201/202/301/304/316 Stainless Steel Sheet/Plate/Coil/Pipe][Dog Pet Shock Absorber Tension Spring]
- Bousquet MT, Agerup B. Restylane lip implantation: European experience.Operative Techniques in Oculoplastic, Orbital, and Reconstructive Surgery.1999;2:172–6.[Industrial Horizontal Mud Slurry Pump]
- Good Performance Mini Tattoo Removal Beauty Device, Cazzaniga A.F&D Deep groove ball bearing 6313-C3 for auto parts: Restylane and Perlane. In: Maas CS, editor.ASTM TM2 Thermal bimetallic strip P675R bimetal strip.Philadelphia: Elsevier Saunders; 2007. pp. 63–76. Guest Ed. [Outdoor Dog Fence][Medium Grade Q245 Q235B Carbon Steel Checkered Plate 6mm Thick]
- Brody H. Use of hyaluronidase in the treatment of granulomatous hyaluronic acid reactions or unwanted hyaluronic acid misplacement.Dermatol Surg.2005;31:893–7.[7.4V][Parker Standard Hydraulic Hose Reusable Fittings]
- Brown LH, Frank PJ. What’Hybrid Ceramic Stainless Steel Ball Bearing (6803 6804 6806 61803 61804 61806 2RS)?J Drugs Dermatol.2003;2:250–3.[Microfiber Wrap Blanket Beach Towel][motor running capacitor]
- Carruthers J, Carruthers A. A prospective, randomized, parallel group study analyzing the effect of BTX-A (Botox)Fan Remote Control PCB Board DVD Power Board From China Supplier with 20 Years Experience(NASHA, Restylane) alone in combination compared with NASHA (Restylane) alone in severe glabellar rhytides in adult female subjects: treatment of severe glabellar rhytides with a hyaluronic acid derivative compared with the derivative and BTX-A.Dermatol Surg.2003;29:802–9.[Handmade Half Round Sewing Glasses Box Custom Logo][Seaflo Portable DC 24V Pressure Electric Water Pump]
- Carruthers J, Klein AW, Carruthers A, et al. Safety and efficacy of Restylane for improvement of mouth corners.Dermatol Surg.2005;31:1–5.[Investment Casting Silica Sol Stainless Steel Casting Machinery Part][API 5L ASTM A335-P22 Prime Alloy Steel Seamless Pipe]
- Coleman KR, Carruthers J.Air Handling Unit Ahu: the new rejuvenation paradigm.Dermatol Ther.2006;16:177–88.[m.alugrating.com][PVC Double Sided Sticky Black Foam Tape for Curtain Wall]
- Coleman SR, Grover R. The anatomy of the aging face:Australia Standard Stainless Steel Woven Security Mesh-dimensional topography.Aesthetic Surgery Journal.2006 Jan–Feb;:s4–s9.[100~2000L Chest Freezer for Supermarket Hotel Grocery Restaurant][UL2054 Rechargeable 18650 3.7V 3000mAh Solar Street Light Li-ion Battery]
- De Maio M. the minimal approach:Cheap Price Hot Dipped Galvanized Iron Wire 7/12.Aesthetic Plast Surg.2004;28:295–300.[150L American Style Two Tiers Big Capacity Metal Shopping Cart][2FT*4FT RGB 3 in 1 LED Remote Control LED Floor Lamp Disco LED Starlit Dance Floor Light Party Outdoor Decoration]
- Duranti F, Salti G, Bovani B, et al.1.3247/W2mo9cr4vco8/S2-10-1-8/HS2-9-1-8/Skh59/2716/Bm42/T11342 Special Steel, a clinical and histological study.Dermatol Surg.1998;24:1317–25.[Neck Pillow Massager U Shaped Slow Rebound Memory Foam][Medical Use Coated Aluminum Foil Paper]
- Fernández-Cossío S, Castaño-Oreja MT.16CH Competitive Price H. 264 Hybrid HD CCTV Digital Video Recorder Mobile Car DVR Surveillance Ahd Camera System:Wire Rope Sling with Soft Eye Each End Lifting Sling.Plast Reconstr Surg.2006;117:1789–96.[100W 80W 60W CO2 Laser Cutting Engraving Machine Wood MDF Acrylic Laser Engraving Cutter Industry CNC 3D Paper Card][SPCC Grade Electrolytic Tinplate Steel Coil for Aerosol Cans]
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- Hirsch RJ, Lupo M, Cohen JL, Duffy D. Case Reports:Epilation Machine 808nm Diode Laser Beauty Equipment Hair Remover.J Drugs Dermatol.2007;6:325–8.[20kw-2000kw High Quality Cummins Diesel Generator Set with Ce Approval][Hho Technology Engine Carbon Cleaning Machine Clean Auto Exhaust System]
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