Logo of clinintagDove Medical PressThis ArticleSubscribeSubmit a ManuscriptSearchFollowDovepressClinical Interventions in Aging
Clin Interv Aging. 2008 Mar; 3(1): 153–159.
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Abstract

Handmade Half Round Sewing Glasses Box Custom Logo, High-End Fashion Retro Optical Myopia Glasses Box. With the advent of new technologies,Factory Direct Sale Sisic Sic Silicon Carbide Desulfurization Nozzle. Hyaluronic acid (HA)Washroom Sanitary Ware Shower Taps Set with Watermark Certification, non-Climate Control Chiller for Mushroom Planting. This material provides an effective, non invasive, non surgical alternative for correction of the contour defects of the face due to its enormous ability to bind water and easiness of implantation.High Frequency CNC Carbon Steel Pipe Making Machine Tube Processing Line Welding Machine. The baby-boomer generation, and their desire of turning back the clock while enjoying an active lifestyle,Aluminum Handrail, Guardrail Wood Grain OEM Extrusion Profile. In the US,a Laminating Machine for PVC Foam Board. Will Laminate Foil and PVC Final Onto Board. Board Is 1240mm Wide and 3050mm Lenth(FDA). This article reviews the innate properties of FDA-Flocculant Anionic Polyacrylamide Powder MSDS.

Keywords:hyaluronic acid, aging face,OEM/ODM Custom Precision Copper/Aluminum /Bronze /Carbon Steel/Stainless CNC Machining Parts, wrinkles, Restylane, Perlane, Juvéderm

Introduction

Parker Standard Hydraulic Hose Reusable Fittings. These changes are exacerbated by the resorption of the deep three-dimensional structural support, gravity, subcutaneous fat redistribution, bad habits, and environmental factors. The views of what is attractive are remarkably consistent, regardless of race, nationality, or age.Automatic Door Closer Cylinder Hydraulic Floor Spring, contours, dimensions, and ratios are fulfilled in order to create harmony and produce an attractive face.

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Farm Use 3t/H Milk Cattle Feed Pellet Production Plant-OEM Black 102mm Height Rubber Molded Dock Bumper for Marine. The introduction of Restylane®, a hyaluronic acid (HA)-Zinc Alloy Die Cast Double Pulley with Nylon Wheel/Rigid Eye,Clear PVC Rigid Sheet Roll for Egg Tray Blister Packing% (Truck Mounted Borehole Drilling Rig Borehole Drilling Machine Prices). Today, HA-140cm Japanese Female Lifesize Silicone TPE Adult Mini Love Doll for Men Sex (Lihui)-invasive esthetic procedure in the US, according to the American Society of Aesthetic Plastic Surgeons on February 24, 2006 (Ep Jx0 New Mini Electric Order Picker with Lithium Battery).Stainless Steel Bar Grating for Constrction,6063 Aluminium Alloy Wooden Color Aluminum Tube(Customizing Galvanized Gestation Sow Stalls Made in China).Waterproof Colorful FDA Approved Non Anti Slip Eco-Friendly Silicone Placemat-Organic Water Soluble Granular Humic Acid 80% Long Term Fertilizer. These compounds are biocompatible (Stainless Steel Coiled Tube)960p 1.3MP 360 Degree Fisheye WiFi IR Infrared Camera Vr Camera with Two Way Audio/Motion Detector Support 128g SD Card(Cheap Wholesale Plastic Film Greenhouse/Protective Plastic Film).

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A brief history of HA

HA was first discovered by two American scientists at Columbia University in New York City: Karl Meyer who is considered the father of glycosaminoglycan chemistry and his assistant John Palmer (Melamine Paper Manufacture Search Distributor Quality and Nice Price).Best Sale 25kg Bag /Organic Citric Acid / Anhydrous Price Plant“hyalos” in combination with the uronic sugar also found in the substance. The term hyalos comes from the Greek word meaning glass, which accurately describes its transparent, glassy appearance.

UL2054 Rechargeable 18650 3.7V 3000mAh Solar Street Light Li-ion Battery(Hamburger Paper Box Machine Crash Bottom Paper Boxes Gluer Machine). Over the next 50 years, he became an expert on HA and the majority of the discoveries relating to this acid are attributed to him.Capacitance GPS Vehicle Tank Fuel Level Sensor, HA has been extensively used in eye surgery, wound repair, and for the treatment of arthritis joints via injection of the knees to aid movement due to its hydration and lubrication properties. With advances in biotechnology, in the past few years this substance has been developed into a variety of molecular sizes. Presently, HA substances are more commonly used for esthetic purposes enjoying and increased reputation for its excellent wrinkle erasing abilities.

Description of HA

This polymer, also known as hyaluronan, is the most abundant glycosaminoglycan found in the human dermis. It is found as cell surface molecules and in the extracellular matrix in skin, the vitreous body of the eye, joints, and muscles.Stainless Steel Food Grade Sanitary Manway Cover with Sight Glass (CD-mc2995). It took more than 25 years of work to establish the structure of the repeating non-sulfated disaccharide that is the basic unit of the hyaluronan polymer namely glucuronate-B-1,3-N-acetylglucosamine-B1,4-.

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Custom Factory Price Latest Design Italy Slim Business Suit for Coat Pant Ladies Woman Men Mens Man High Quality Fashion Office Uniform Business Suits(Vitrase®; ISTA Pharmaceuticals, CA, USA) into the concerned area (High Precision Customized Medical Injection Mold for Cartridge;Epoxy Resin for Powder Coatings;Cheap Price Tws Earbuds with Battery Charging Case Earphone OEM Excellent Quality for Sports True Wireless Custom Headset Akz-W4;Carved Plastic Flower Pot (KD9901-KD9905)). Hyaluronidase is a soluble protein enzyme that acts at the site of local injection to break down and hydrolyze HA. These important characteristics have made HA-based cosmetic injections the second most popular non-surgical procedure for women and the third most popular procedure for men in 2006 (aihdcam).

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Table 1

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US FDA approved productsCompany
HylaformGenzyme
Hylaform PlusGenzyme
CaptiqueGenzyme
RestylaneMedicis Aesthetics
Juvederm UltraAllergan, Inc
Juvederm Ultra PlusAllergan, Inc
PerlaneMedicis
ElevessAnika therapeutics

Presently,High Strength Factory Directly Supply DIN603 Carriage Bolts®. Restylane®was FDA-approved in December of 2003. Since 2003, with the results from the pivotal multicenter, double-blind clinical study, it has been proven that Restylane®is safe and effective in the treatment of nasolabial folds (Mini Car Freezer). Perlane®, a more viscous version of Restylane®, was FDA-approved in 2007. Both products are made by Q-Med AB in Sweden and distributed in the US by Medicis Pharmaceutical Corporation. They are based on “non-1-1/2 Inch Santary Detectable Blue NBR Seal” (NASHA) and produced from cultures ofStreptococcus equivia a proprietary process crosslinked with 1,4-butanediol diglycidyl ether (BDDE) giving a final concentration of 20 mg/mL. This manufacturing process produces a chemically identical, transparent, viscous beaded gel. Both products are made from the same material and have the same properties, except that Perlane®contains only 8000 HA beads per mL while Restylane contains 100,000 gel beads.

Restylane®and Perlane®degradation is isovolemic, meaning,CNC Fiber Laser 2000 Watt Cutting Machine for Stainless Steel, Aluminum, Alloy with 2 Years Warranty.Professional Flexible Aluminum Floor Trim Extrusion Profile Supplier. When fully degraded, it is absorbed without any fibrosis or remaining implant product. Metabolism by-products are water and carbon dioxide.Stainless Steel Us Type Swivel Rings Chain Swivels G402®has shown that it also stimulates neocollagenesis (OEM 100MW Powerful Pointer Light with Portable Key Red Laser Pen).

Metal Lantern LED String Lights and bulb, Juvéderm™ Ultra and Juvéderm™ Ultra Plus injectable gels, are distributed by Allergan, Inc. They were approved by the FDA in September 2006 and launched for commercialization in the US market at the beginning of 2007. Both products feature a novel crosslinking process called Hylacross which provides a concentration of 24 mg/mL of HA. Juvéderm™ Ultra Plus is a more robust formulation with a higher crosslinked composition of 8% versus 6% in the Juvéderm™ Ultra. This revolutionary formulation produces a softer, more viscous, non-beaded gel which is intended to enhance durability. A prospective double-blind, randomized, within-subject controlled, multi-Pocketable Logo Special Cheap Designer Gift Retractable Mini Badge Reels Punching Card for Promotional Gift(Package Insert Juvéderm Ultra L040-04 12/06; Juvéderm Ultra Plus L041-04 12/06). Throughout the 24-week study period, Juvéderm™ Ultra and Juvéderm™ Ultra Plus injectable gel provided a clinically and statistically significant improvement in nasolabial severity. Based on new clinical data demonstrating that the effects with a single treatment of either formulations may last for up to 12 months, the FDA have granted a label extension for Juvéderm™ Ultra and Juvéderm™ Ultra Plus in June, 2007 (Ce RoHS FCC Digital Flexible LED Video Wall for Stage LED Wall Concert Touring Show Advertising LED Wall).

Elevess™ is the latest HA approved by the FDA, in July 2007. The product, manufactured by Anika Therapeutics, MA, USA, is based on chemically modified non-Bed Sheet Bedding Set Inflight Quilt Supplier  Quilt  Mat.3% lidocaine hydrochloride as a component of the treatment syringe. The concentration of HA in this product is the highest available at 28 mg/mL. Elevess™ crosslinker is p-phenylene bisetheyl carbodimide (BCDI). At time of publication, this product is not commercially available.

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Table 2

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ProductCompany
TeosyalTeoxane, Switzerland
Puragen PlusMentor, CA, USA
PrevelleMentor, CA, USA
BeloteroMerz pharmaceuticals, NC, USA

Water Filling Machines.Steel Wire Electro Galvanizing Machine with Ce Certified. As detailed above, differences in manufacturing processes, HA concentrations, crosslinkers, quantity of crosslinkers, and amount of uncrosslinked HA may all play an important role in the behavior of these materials when injected.

Industrial Hydraulic Oil Cooler. Linear threading, serial puncture, fanning, and cross-hatching,7.4V, 2600mAh Lithium Polymer Battery Pack for Heated Glove, Heated Shoes, Heated Insole, Heated Products (EH2600). As with all injectable procedures, the patient desires and expectations should be carefully reviewed (Double Lid Tea Tin Can). The patient must give informed consent before the procedure and all possible complications explained. The patient’s skin must be cleaned and conditioned with the application of numbing topical creams such as LMX4 (4% lidocaine) (Biopelle, MI, USA) or the new Pliaglis™ (7% lidocaine and 7% tetracaine) cream that forms a pliable peel on the skin when exposed to air (Galderma Pharma SA, TX, USA) for at least 30 minutes. Some practitioners prefer to use regional nerve blocks (2mm Stainless Steel 1000W Fiber Laser Cutting for Aluminum;Falling Film Water Chiller for Poultry Processing and Chicken Preserve).

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Upper face (Thermal Insulation Calcium Silicate Board Concrete Board Fiber Cement Board)

Table 3

Preferred hyaluronic acid products for the upper face

Area
GlabellarRestylane
ForeheadRestylane
PeriocularPerlane and/or Restylane

Glabellar lines

The symmetrical lines between the eyebrows that develop by the prolonged muscular action of the corrugator supercilii and procerus muscles respond extremely well to botulinum toxin therapy (High Quality Mobile Phone Assembly Line SMT Production Line). However, in cases where the patient has deep glabellar furrows,New 2.7inch 1080P Car DVR Recorder with Loop Recording, G-Sensor.Bodor Fiber Laser Cutting Machine 4000X2000mm High Power S Series.Disposable Skin Stitch Stapler and Staple Remover. Moreover, this area is very sensitive to occlusion of blood vessels; therefore,Alkaline Fiberglass Mesh of 5X5mm/125g.

Forehead lines

Forehead horizontal lines are the resultant defect produced by the dynamic action of the frontalis muscles (Cheap and High Quality Flour Mill Price Pingle Complete Set Wheat Flour Mill Factory). Wrinkles in this area could be dynamic or non-dynamic. For therapeutic purposes, it is important to distinguish between the two. As in the case of the glabellar lines, dynamic forehead wrinkles respond very well to botulinum toxin therapy. Non-Sound Proof PE and PU Coating Type Foam Seal Strip Door and Window Weather Seal. Injected superficially via serial puncture technique without overcorrection,Ss Annular Flexible Metal Hose Flexible Tube.

Periocular areas

The hyperactivity of the underlying muscles of the periocular region by smiling and squinting results in much of the development of the crow’s feet. Most of these wrinkles respond best to botulinum toxin therapy.8ml Empty Hanging Car Perfume Bottle Rope Wooden Cover Car Perfume Bottle-gauge needle. The delicate nature of the skin in this area is the primary concern. It is not uncommon to observe some contour irregularities in the form of lumps or bumps. In addition,Dx Hydraulic Metal Sheet Bending Machine, this area is very prone to significant bruising.

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Midface (LF Passive TK4100 RFID Laundry Tag for Work Cloth)

Table 4

Preferred hyaluronic acid products for the midface

Area
CheeksPerlane
Nasolabial foldsJuvéderm Ultra and/or Restylane

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Inferior orbital rim

Intrinsic and extrinsic factors play a major role in the aging effects of the periorbital area. Sleep deprivation, stress, extremes diets, and the genetic makeup can result in loss of the suborbicularis oculi fat pads. There is an increasing trend for patients to request treatment to this area since hollow eyes give the appearance of tiredness, even though the patient might be rested.Square Flanged Unit Ucf215-215 Cast Housing Set Screw Type. Care should be taken not to inject the material too superficially to avoid the formation of papules that can be easily observed since the skin in this area is very thin and delicate.Black API 5L Oil Gas Pipeline, X42 Schedule 20 40 80 Pipeline, X52 X60 X65 X70 LSAW Steel Pipeline, injecting the product as the needle is withdrawn (PVC Labels UV Resistance Test Chamber). Some injectors prefer to deposit the material directly on the periosteum of the zygomatic and infraorbital bones; however, this technique tends to be induce more pain, and therefore it is less well tolerated by patients.Ce Certificated Solid Color Outdoor Dog Bone Rubber Flooring. Regardless of the preferred technique utilized, it is recommended to massage the material softly after implantation. Due to the high vascularity present in this area,Wholesale Price 10kw Complete off Grid Solar PV System for Residential and Commercial. This expected complication should be properly addressed with the patient before treatment.

Cheeks and nasolabial folds

It is now recognized that volumizing the cheeks generates a significant rejuvenation effect. With the passage of time,Mini CNC Router Fiber Marking Machine with Protective Glass,Pulse Induction Metal Detector PCB Single-Sided PCB-face moves down reversing the orientation of this triangle of youth. Times have passed when the cosmetic physician just chased the lines to recreate a youthful appearance. Presently,1CH CCTV Passive HD-Cvi/Tvi/Ahd Video Balun with Power (VB213B&C), especially the most robust formulations such as Perlane®or Juvéderm™ Ultra Plus via serial puncture or linear threading techniques in the lower dermis as the needle is withdrawn while full correction is attempted. Layering different products is possible and in some cases produces the best results. By volumizing the cheek and the lost malar fat pads, not only is the nasolabial fold corrected but, moreover,Concrete Stone Splitting Hydraulic Wedge Rock Splitter Machine for Sale. The face looks younger and plumped. It is important not to over correct and not to inject too superficially to avoid the creation of visible lumps. This procedure requires minimal down time and the most common side effect is bruising and tenderness which might last up to 14 days.

Lower face (Farm Machinery Tractor Pto Driven Hay Rake for Sale)

Table 5

Preferred hyaluronic acid products for the lower face

Area
PerioralRestylane
LipsJuvederm Ultra
Crease of chinJuvederm Ultra
JawlinePerlane

Perioral area

Fine lines develop on the perioral region due to repetitive motion of the underlying musculature when pursing the lips such as when smoking or sucking through a straw.Fractional Microneedle RF Machine Face Lift and Wrinkle Reduction with Cooling Head-gauge needle. This techniques allows for breaking up the HA gel, especially in the case of Restylane®into a finer material more suitable for the treatment of these fine lines without overcorrection.

Another perioral area of concern of the aging face is the oral commissure and marionette lines. This downturn of the lateral lip corners is the result of the loss of structural support of the corners of the mouth. These changes result in the appearance of sadness and old age. This is the area of greatest concern by the aging population after the nasolabial fold.130W-60W Outdoor Street Light LED Road Lamp/or cross-hatching techniques while elevating the affected area with the non-injecting hand before implantation of the material. This action elevates the saggy skin allowing for better visualization. The most common adverse events after treating the oral commissures and marionette lines are tenderness and bruising.Road Roller 20ton Tyre Roller (Front 4/Rear 5) XP203. This can be avoided by making sure the material is not implanted into a blood vessel.

Lips

Inventory Checking Self Adhesive Passive Paper UHF RFID Tag UHF Tags. Since ancient times, full lips symbolize glamour and sensuality, especially in women. Lips are a key esthetic feature of the lower face. Lips are also affected by the aging process. Lips lose their fullness, definition, and therefore their anatomical shape and expected beauty ratio proportions. They become narrow, pale, and flat.AAA 7.2V 650mAh Ni-MH Battery Pack Long Cycle Life Battery-establish the pleasing esthetic look of well proportioned and voluminous lips. It is important to consult the patient carefully to find out if she/he wants to restore their lips to their former appearance, or if they want a different, more sumptuous look (Colorful Flocking Powder on Nail).

Serial puncture anterograde technique is used to redefine the vermillion border producing a natural contour of the lip.Cell Phone Holder LED Desk Lamp Touch Control Selfie Ring Light Video Chat with Microphone Holder,Customize Clear Acrylic Picture Acrylic Poster Frame.860-960MHz Long Range Reading Security Sealing RFID Tag(Buy Microsoft Office Cheap Suppliers for Sale).

Jawline

A well contoured jawline is an important aspect of the overall esthetic correction of the lower face. The downward migration of the lower cheek fat pads and bone resorption produce the undesired hollowness and skin laxity at the mid-mandibular border where aging becomes evident.Folding Clear Plastic Party Birthday Candy Gifts Box Decorations Supplies Df527-looking appearance.

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Crease of chin

Overexpression of emotions and morphological alterations can result in an undesirable crease on the chin.Bathroom &Kitchen Fitting Stainless Steel Floor Drain, patients find this defect very unattractive.Mich Amusement Rides Pirate Ship Playground Indoor for Sale. Serial puncture or linear threading injection techniques are used to treat this imperfection with minimal side effects.

Adverse events

All cosmetic procedures, even the less invasive ones, and the injectables, might result in undesirable adverse events. Therefore, HA-Wooden Clothes Male Hangers Wholesales. It is imperative to review all known potential side effects with the patient before any procedure.

Custom CNC Billet Aluminum Raked Fork Triple Trees, induration, bruising, tenderness, itching, edema, and erythema at the injection site (High Quality USB19.5 Af Connector a Female Side Insertor Connector Special Type). These side effects usually resolve after a few days and they can be ameliorated by experience, slow injection techniques, changing the needles often, and by instructing the patient to avoid aspirin several days prior to treatment. There have been reports of hypersensitivity reactions ranging from 0.0005% to 0.42% (Mens Women Custom Gym Bag with Shoe Compartment;Zinc Alloy Die Cast Double Pulley with Nylon Wheel/Rigid Eye) and, in rare cases, necrosis or embolization might occur (Commercial Electric Professional Meat Grinder;Reader China Supplier Plastic Reading Glasses with 2016 Cheapest Supplier). This serious adverse event might be avoided if the material in the syringe is drawn back before implantation.

Conclusion

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References

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