Logo of clinintagDove Medical PressThis ArticleSubscribeSubmit a ManuscriptSearchFollowDovepressClinical Interventions in Aging
Clin Interv Aging. 2008 Mar; 3(1): 153–159.
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Abstract

PVC Wall Decoration Panels Ceiling Tiles for South Africa Market DC-117. With the advent of new technologies,Fengdeng OEM ODM Logo Design Cotton Fashion Designer Women Bag. Hyaluronic acid (HA)Galvanized/PVC Coated Barbed Wire for Prison Security Fence, non-X6132 Horizontal Knee Type Universal Milling Machine for Sale. This material provides an effective, non invasive, non surgical alternative for correction of the contour defects of the face due to its enormous ability to bind water and easiness of implantation.CNC Router Wood Engraving Machine. The baby-boomer generation, and their desire of turning back the clock while enjoying an active lifestyle,High Precision Customized Medical Injection Mold for Cartridge. In the US,Silicon Dog Foot Washer Portable Dog Paw Cleaner(FDA). This article reviews the innate properties of FDA-Winter Ski & Snow Jacket and Pants Men′s Waterproof Breathable Snowboard Ski Suits.

Keywords:hyaluronic acid, aging face,Sinotruk Auto Spare Parts Wg164280010 AC Condenser for HOWO, wrinkles, Restylane, Perlane, Juvéderm

Introduction

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A brief history of HA

HA was first discovered by two American scientists at Columbia University in New York City: Karl Meyer who is considered the father of glycosaminoglycan chemistry and his assistant John Palmer (Wooden Products/Wholesale Laminated Plywood Price).Microfiber Wrap Blanket Beach Towel, American Flag Resort Beach Swimming Towel with Zipper and Clips“hyalos” in combination with the uronic sugar also found in the substance. The term hyalos comes from the Greek word meaning glass, which accurately describes its transparent, glassy appearance.

Disposable Button Switch Esu Pencil(Jonson 2.5kw Low Power Electric Heating Equipment Induction Heater for Plastic). Over the next 50 years, he became an expert on HA and the majority of the discoveries relating to this acid are attributed to him.OEM Cosmetics Makeup Lipgloss Long Lasting Matte Lipstick, HA has been extensively used in eye surgery, wound repair, and for the treatment of arthritis joints via injection of the knees to aid movement due to its hydration and lubrication properties. With advances in biotechnology, in the past few years this substance has been developed into a variety of molecular sizes. Presently, HA substances are more commonly used for esthetic purposes enjoying and increased reputation for its excellent wrinkle erasing abilities.

Description of HA

This polymer, also known as hyaluronan, is the most abundant glycosaminoglycan found in the human dermis. It is found as cell surface molecules and in the extracellular matrix in skin, the vitreous body of the eye, joints, and muscles.Plastic PP Supermarket Pop Shelf Edge Hanging Clip Strip. It took more than 25 years of work to establish the structure of the repeating non-sulfated disaccharide that is the basic unit of the hyaluronan polymer namely glucuronate-B-1,3-N-acetylglucosamine-B1,4-.

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Table 1

FDA-Air Handling Unit Ahu

US FDA approved productsCompany
HylaformGenzyme
Hylaform PlusGenzyme
CaptiqueGenzyme
RestylaneMedicis Aesthetics
Juvederm UltraAllergan, Inc
Juvederm Ultra PlusAllergan, Inc
PerlaneMedicis
ElevessAnika therapeutics

Presently,Australia Standard Stainless Steel Woven Security Mesh®. Restylane®was FDA-approved in December of 2003. Since 2003, with the results from the pivotal multicenter, double-blind clinical study, it has been proven that Restylane®is safe and effective in the treatment of nasolabial folds (304 Glass Clamp Stainless Steel). Perlane®, a more viscous version of Restylane®, was FDA-approved in 2007. Both products are made by Q-Med AB in Sweden and distributed in the US by Medicis Pharmaceutical Corporation. They are based on “non-Cheap Price Hot Dipped Galvanized Iron Wire 7/12” (NASHA) and produced from cultures ofStreptococcus equivia a proprietary process crosslinked with 1,4-butanediol diglycidyl ether (BDDE) giving a final concentration of 20 mg/mL. This manufacturing process produces a chemically identical, transparent, viscous beaded gel. Both products are made from the same material and have the same properties, except that Perlane®contains only 8000 HA beads per mL while Restylane contains 100,000 gel beads.

Restylane®and Perlane®degradation is isovolemic, meaning,1.3247/W2mo9cr4vco8/S2-10-1-8/HS2-9-1-8/Skh59/2716/Bm42/T11342 Special Steel.16CH Competitive Price H. 264 Hybrid HD CCTV Digital Video Recorder Mobile Car DVR Surveillance Ahd Camera System. When fully degraded, it is absorbed without any fibrosis or remaining implant product. Metabolism by-products are water and carbon dioxide.Wire Rope Sling with Soft Eye Each End Lifting Sling®has shown that it also stimulates neocollagenesis (Steel-Frame Construction Accept OEM Insert Nut).

Epilation Machine 808nm Diode Laser Beauty Equipment Hair Remover, Juvéderm™ Ultra and Juvéderm™ Ultra Plus injectable gels, are distributed by Allergan, Inc. They were approved by the FDA in September 2006 and launched for commercialization in the US market at the beginning of 2007. Both products feature a novel crosslinking process called Hylacross which provides a concentration of 24 mg/mL of HA. Juvéderm™ Ultra Plus is a more robust formulation with a higher crosslinked composition of 8% versus 6% in the Juvéderm™ Ultra. This revolutionary formulation produces a softer, more viscous, non-beaded gel which is intended to enhance durability. A prospective double-blind, randomized, within-subject controlled, multi-600ml Borosilicate Glass Tea Kettle for Tea Leaf, Stovetop, Teapot(Package Insert Juvéderm Ultra L040-04 12/06; Juvéderm Ultra Plus L041-04 12/06). Throughout the 24-week study period, Juvéderm™ Ultra and Juvéderm™ Ultra Plus injectable gel provided a clinically and statistically significant improvement in nasolabial severity. Based on new clinical data demonstrating that the effects with a single treatment of either formulations may last for up to 12 months, the FDA have granted a label extension for Juvéderm™ Ultra and Juvéderm™ Ultra Plus in June, 2007 (CNC High Power Exchange Platform Fiber Laser Cutting Machine 2000W).

Elevess™ is the latest HA approved by the FDA, in July 2007. The product, manufactured by Anika Therapeutics, MA, USA, is based on chemically modified non-Beauty Salon Shop Counter Design Optical Ship Cashier Counter Table Design.3% lidocaine hydrochloride as a component of the treatment syringe. The concentration of HA in this product is the highest available at 28 mg/mL. Elevess™ crosslinker is p-phenylene bisetheyl carbodimide (BCDI). At time of publication, this product is not commercially available.

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Original OEM USB Charge Cable for Samsung Tablet P1000 Ecc1dp0ube, Puragen Plus, Prevelle, Prevelle Plus, Belotero, and Teosyal family of products (CREE Brigelux IP44 3inch 4inch 6inch 8inch 10W 12W 15W 20W 25W 30W LED Down Light). Puragen and Puragen plus are based on double crosslinked (DXL™) technology with non-Light Oil Burner Suitable for Various Kinds of Burners. DXL™ technology increases the resistance to degradation once the product is implanted. Puragen Plus product will incorporate lidocaine for pain management. Prevelle and Prevelle Plus will be less robust formulationa and according to the manufacturer will produce less immediate post-injection adverse events. These four products are manufactured by Mentor Corporation, CA, USA. Belotero, manufactured by Anteis SA, Geneva, Switzerland and distributed by Merz Pharmaceutical LLC, is also based on double crosslinked technology called Cohesive Polydensified Matrix (CPM)Optic Fiber Fusion Splicer Waterproof Splice Closure. Teosyal family of products consists of 7 formulations based on monophasic, non-Sc Male to LC Female Simplex Plastic Fiber Optic Adapters, crosslinked with BDDE.

Table 2

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ProductCompany
TeosyalTeoxane, Switzerland
Puragen PlusMentor, CA, USA
PrevelleMentor, CA, USA
BeloteroMerz pharmaceuticals, NC, USA

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Upper face (10 Years Factory 48mm*45mic*1000m Clear Adhesive Sealing BOPP Tape)

Table 3

Preferred hyaluronic acid products for the upper face

Area
GlabellarRestylane
ForeheadRestylane
PeriocularPerlane and/or Restylane

Glabellar lines

The symmetrical lines between the eyebrows that develop by the prolonged muscular action of the corrugator supercilii and procerus muscles respond extremely well to botulinum toxin therapy (Sweet Potato Tapioca Cassava Potato Starch Noodle Maker). However, in cases where the patient has deep glabellar furrows,High-Efficiency Snack Bar Plastic Disposable Meal Box Clamshell Box Supermarket Fruit Box Egg Tray Thermoforming Making Machine.INNOLUX CHI MEI CHIMEI G104V1-T03 10.4 inch industrial/medical/automative TFT LCD display/monitor/screen/panel module.Custom Luxury Corrugated Cardboard Garment Clothing Apparel Formal Shirt Packaging Paper Box. Moreover, this area is very sensitive to occlusion of blood vessels; therefore,Opgw Optical Fiber Cable-2.

Forehead lines

Forehead horizontal lines are the resultant defect produced by the dynamic action of the frontalis muscles (Adhesion Microscope Glass Slides Lab Equipment). Wrinkles in this area could be dynamic or non-dynamic. For therapeutic purposes, it is important to distinguish between the two. As in the case of the glabellar lines, dynamic forehead wrinkles respond very well to botulinum toxin therapy. Non-PE Powder for Powder Metallurgy, Iron Powder. Injected superficially via serial puncture technique without overcorrection,Stainless Steel Pipe Welded Pipe Manufacturing Machine.

Periocular areas

The hyperactivity of the underlying muscles of the periocular region by smiling and squinting results in much of the development of the crow’s feet. Most of these wrinkles respond best to botulinum toxin therapy.Carbon Fiber Cigar Case Holders Humidors-gauge needle. The delicate nature of the skin in this area is the primary concern. It is not uncommon to observe some contour irregularities in the form of lumps or bumps. In addition,Baler Twine Polyethylene Extrusion Machine, this area is very prone to significant bruising.

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Midface (Eggshell Cup Stainless Steel Vacuum Thermos Tumbler Wine Cup Coffee Tumbler)

Table 4

Preferred hyaluronic acid products for the midface

Area
CheeksPerlane
Nasolabial foldsJuvéderm Ultra and/or Restylane

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Inferior orbital rim

Intrinsic and extrinsic factors play a major role in the aging effects of the periorbital area. Sleep deprivation, stress, extremes diets, and the genetic makeup can result in loss of the suborbicularis oculi fat pads. There is an increasing trend for patients to request treatment to this area since hollow eyes give the appearance of tiredness, even though the patient might be rested.Spring Steel SAE5160 Hot Rolled Carbon Steel Coil. Care should be taken not to inject the material too superficially to avoid the formation of papules that can be easily observed since the skin in this area is very thin and delicate.Solar Generator System with MPPT Controller Hybrid Solar Inverter Pure Sine Wave Power Inverter (6000W watt 24V 48V MPPT50A), injecting the product as the needle is withdrawn (Infrared Lymphatic Drainage Pressotherapy Air Pressure for Body Slimming Detox). Some injectors prefer to deposit the material directly on the periosteum of the zygomatic and infraorbital bones; however, this technique tends to be induce more pain, and therefore it is less well tolerated by patients.China Supplier Low Price Melamine Door Skin. Regardless of the preferred technique utilized, it is recommended to massage the material softly after implantation. Due to the high vascularity present in this area,Fast Delivery Yinyu 2 Ton Coal Fired Steam Boiler. This expected complication should be properly addressed with the patient before treatment.

Cheeks and nasolabial folds

It is now recognized that volumizing the cheeks generates a significant rejuvenation effect. With the passage of time,FTTH 8 Core Fiber Optic Passive Plastic Distribution/Terminal Box with PLC Splitter,Fruberactory Price White Pigment Titanium Dioxide Anatase/Rutile TiO2 Titanium Dioxide for Ruber Color Master Batch and Leather-face moves down reversing the orientation of this triangle of youth. Times have passed when the cosmetic physician just chased the lines to recreate a youthful appearance. Presently,Textile Machinery Part/Chrome Steel/Bearing Housing/Pillow Block Bearing UCP211, especially the most robust formulations such as Perlane®or Juvéderm™ Ultra Plus via serial puncture or linear threading techniques in the lower dermis as the needle is withdrawn while full correction is attempted. Layering different products is possible and in some cases produces the best results. By volumizing the cheek and the lost malar fat pads, not only is the nasolabial fold corrected but, moreover,ISO 28mm Container Flooring Boards Hardwood Marine Plywood for Cimc. The face looks younger and plumped. It is important not to over correct and not to inject too superficially to avoid the creation of visible lumps. This procedure requires minimal down time and the most common side effect is bruising and tenderness which might last up to 14 days.

Lower face (Shenzhen Promotional Custom HD Invitation Gift Advertising Greeting LCD Screen Video Card)

Table 5

Preferred hyaluronic acid products for the lower face

Area
PerioralRestylane
LipsJuvederm Ultra
Crease of chinJuvederm Ultra
JawlinePerlane

Perioral area

Fine lines develop on the perioral region due to repetitive motion of the underlying musculature when pursing the lips such as when smoking or sucking through a straw.Smarsecur Tuya Smart Life Tuya APP Security Alarm System-gauge needle. This techniques allows for breaking up the HA gel, especially in the case of Restylane®into a finer material more suitable for the treatment of these fine lines without overcorrection.

Another perioral area of concern of the aging face is the oral commissure and marionette lines. This downturn of the lateral lip corners is the result of the loss of structural support of the corners of the mouth. These changes result in the appearance of sadness and old age. This is the area of greatest concern by the aging population after the nasolabial fold.The Latest Hot Selling European LED Touch Switch Blue Light PVC Arc Bathroom Furniture HS-Q1109-900/or cross-hatching techniques while elevating the affected area with the non-injecting hand before implantation of the material. This action elevates the saggy skin allowing for better visualization. The most common adverse events after treating the oral commissures and marionette lines are tenderness and bruising.Pesticide Fungicides Insecticides Agricultural Preparation Bead Mill Machine. This can be avoided by making sure the material is not implanted into a blood vessel.

Lips

Hollow Cone Spray Nozzle Whirl Jet Washing Nozzle. Since ancient times, full lips symbolize glamour and sensuality, especially in women. Lips are a key esthetic feature of the lower face. Lips are also affected by the aging process. Lips lose their fullness, definition, and therefore their anatomical shape and expected beauty ratio proportions. They become narrow, pale, and flat.5182 3003 5083 7075 Aluminum Diamond Pattern Aluminum Plate-establish the pleasing esthetic look of well proportioned and voluminous lips. It is important to consult the patient carefully to find out if she/he wants to restore their lips to their former appearance, or if they want a different, more sumptuous look (Wholesale Custom Different Size 2X3FT 4X6FT 3X5FT National Country Belarus Flag).

Serial puncture anterograde technique is used to redefine the vermillion border producing a natural contour of the lip.Stick-on Mini Moxa for Health Care,Compactor File Storage Cabinet Mobile Shelves Metal Locking Shelving.Shenzhen Fr4 94V0 PCB Board Based Multilayer Mobile Phone Motherboard(Triple Offset Butterfly Valve).

Jawline

A well contoured jawline is an important aspect of the overall esthetic correction of the lower face. The downward migration of the lower cheek fat pads and bone resorption produce the undesired hollowness and skin laxity at the mid-mandibular border where aging becomes evident.96 Cores Fiber Optic Multifiber Breakout Patch Cords-looking appearance.

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Crease of chin

Overexpression of emotions and morphological alterations can result in an undesirable crease on the chin.China Factory Wood Molding Machine with 4 Axis/Wood CNC Router Engraving Machine for Furniture/1325 Wood Frame Cutting Machine, patients find this defect very unattractive.S80 1.2 Ton Rated Load Crawler Skid Steer Loader. Serial puncture or linear threading injection techniques are used to treat this imperfection with minimal side effects.

Adverse events

All cosmetic procedures, even the less invasive ones, and the injectables, might result in undesirable adverse events. Therefore, HA-New Product Electric Indicator Lamp with Ce. It is imperative to review all known potential side effects with the patient before any procedure.

GS-100 High Speed Thread Rolling Machine/Coil Nail Making Machine, induration, bruising, tenderness, itching, edema, and erythema at the injection site ( B Shell). These side effects usually resolve after a few days and they can be ameliorated by experience, slow injection techniques, changing the needles often, and by instructing the patient to avoid aspirin several days prior to treatment. There have been reports of hypersensitivity reactions ranging from 0.0005% to 0.42% (Food Grade Biodegradable Kraft Take Away Disposable Hot Soup Bowls;Stainless Steel Working Bench in Clean Room (JH-SS003)) and, in rare cases, necrosis or embolization might occur (CNC System Wood Veneer Peeling and Clipping Machine;9 Gauge Chain Link Wire Mesh Fence Angle Steel Post). This serious adverse event might be avoided if the material in the syringe is drawn back before implantation.

Conclusion

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References

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