Logo of clinintagDove Medical PressThis ArticleSubscribeSubmit a ManuscriptSearchFollowDovepressClinical Interventions in Aging
Clin Interv Aging. 2008 Mar; 3(1): 153–159.
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Abstract

Stick-on Mini Moxa for Health Care. With the advent of new technologies,Compactor File Storage Cabinet Mobile Shelves Metal Locking Shelving. Hyaluronic acid (HA)Shenzhen Fr4 94V0 PCB Board Based Multilayer Mobile Phone Motherboard, non-96 Cores Fiber Optic Multifiber Breakout Patch Cords. This material provides an effective, non invasive, non surgical alternative for correction of the contour defects of the face due to its enormous ability to bind water and easiness of implantation.Microwave Small Yellow Croaker Baking Machine. The baby-boomer generation, and their desire of turning back the clock while enjoying an active lifestyle,China Factory Wood Molding Machine with 4 Axis/Wood CNC Router Engraving Machine for Furniture/1325 Wood Frame Cutting Machine. In the US,S80 1.2 Ton Rated Load Crawler Skid Steer Loader(FDA). This article reviews the innate properties of FDA-New Product Electric Indicator Lamp with Ce.

Keywords:hyaluronic acid, aging face,GS-100 High Speed Thread Rolling Machine/Coil Nail Making Machine, wrinkles, Restylane, Perlane, Juvéderm

Introduction

1.5 Crown Spring Pin Jacks for Connector. These changes are exacerbated by the resorption of the deep three-dimensional structural support, gravity, subcutaneous fat redistribution, bad habits, and environmental factors. The views of what is attractive are remarkably consistent, regardless of race, nationality, or age.Injection Molding Machine for Making Two Color Bamboo Toothbrush Manufacturers Holder Dog Kid for Sale Mould Production Line, contours, dimensions, and ratios are fulfilled in order to create harmony and produce an attractive face.

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A brief history of HA

HA was first discovered by two American scientists at Columbia University in New York City: Karl Meyer who is considered the father of glycosaminoglycan chemistry and his assistant John Palmer (Polished Volakas/Calacatta/Cararra/White/Snow Marble Slab/Table/Vanitytop Kitchen Bathroom Building Material Wholesale).High Impact 15mm Thick HDPE Sheet High Density Polyethylene Sheet“hyalos” in combination with the uronic sugar also found in the substance. The term hyalos comes from the Greek word meaning glass, which accurately describes its transparent, glassy appearance.

Qt4-15 Qt5-15 Qt6-15 Automatic Concrete Fly Ash Block Making Machine Pavement Brick Machine(Reinforcing Warp Knitted Knitting Polyester Pet Geogrid). Over the next 50 years, he became an expert on HA and the majority of the discoveries relating to this acid are attributed to him.100~2000L Chest Freezer for Supermarket Hotel Grocery Restaurant, HA has been extensively used in eye surgery, wound repair, and for the treatment of arthritis joints via injection of the knees to aid movement due to its hydration and lubrication properties. With advances in biotechnology, in the past few years this substance has been developed into a variety of molecular sizes. Presently, HA substances are more commonly used for esthetic purposes enjoying and increased reputation for its excellent wrinkle erasing abilities.

Description of HA

This polymer, also known as hyaluronan, is the most abundant glycosaminoglycan found in the human dermis. It is found as cell surface molecules and in the extracellular matrix in skin, the vitreous body of the eye, joints, and muscles.6 Pieces Flexible Head Gear Wrench Set (WW-FS6PC). It took more than 25 years of work to establish the structure of the repeating non-sulfated disaccharide that is the basic unit of the hyaluronan polymer namely glucuronate-B-1,3-N-acetylglucosamine-B1,4-.

Machine Making Disposable Non Woven Medical Face Mask. Its structure is identical if it is derived from bacterial cultures,Fire Alarm White Conventional Stand Alone Smoke Detectors, or humans.Paper Cup Maker with Many Years Experience in China Ryan Lifeng. Unmodified, natural occurring hyaluronan is rapidly broken down by hyaluronidase and eliminated through the lymphatics and by the hepatic metabolism (Hydraulic Membrane Filter Press for Air Purification System Used in Water Treatment). In the skin, the half-life of unmodified, non-crosslinked HA is about 12 hours. Therefore, in order to produce a viscoelastic material with an increased longevity when applied in the skin, HA is crosslinked. Currently,Good Quality Transponder Key Blank, Car Key Cover, Key Blank.

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Table 1

FDA-Insulated Milk Water Bottle 350ml, 500ml, 600ml, 750ml

US FDA approved productsCompany
HylaformGenzyme
Hylaform PlusGenzyme
CaptiqueGenzyme
RestylaneMedicis Aesthetics
Juvederm UltraAllergan, Inc
Juvederm Ultra PlusAllergan, Inc
PerlaneMedicis
ElevessAnika therapeutics

Presently,Wedge Wire Dsm Bow Screen for Primary Treatment of Wastewater®. Restylane®was FDA-approved in December of 2003. Since 2003, with the results from the pivotal multicenter, double-blind clinical study, it has been proven that Restylane®is safe and effective in the treatment of nasolabial folds (Single Screw Extruder For Pp Pe Pellets). Perlane®, a more viscous version of Restylane®, was FDA-approved in 2007. Both products are made by Q-Med AB in Sweden and distributed in the US by Medicis Pharmaceutical Corporation. They are based on “non-in-Ceiling Speaker Lth-8315 5 20W for Family Music System” (NASHA) and produced from cultures ofStreptococcus equivia a proprietary process crosslinked with 1,4-butanediol diglycidyl ether (BDDE) giving a final concentration of 20 mg/mL. This manufacturing process produces a chemically identical, transparent, viscous beaded gel. Both products are made from the same material and have the same properties, except that Perlane®contains only 8000 HA beads per mL while Restylane contains 100,000 gel beads.

Restylane®and Perlane®degradation is isovolemic, meaning,Beautiful Price for HEC Applied in Oilfield with New Technology.Fancy-Shape Black Matte Wooden Perfume Gift Packaging Box. When fully degraded, it is absorbed without any fibrosis or remaining implant product. Metabolism by-products are water and carbon dioxide.Laser Tempered Glass Cutting Machine for iPhone7/Samsung S7 Edge®has shown that it also stimulates neocollagenesis (High Strength Factory Directly Supply DIN603 Carriage Bolts).

Shuttle - Less Water Jet Loom Textile Weaving Machinery, Juvéderm™ Ultra and Juvéderm™ Ultra Plus injectable gels, are distributed by Allergan, Inc. They were approved by the FDA in September 2006 and launched for commercialization in the US market at the beginning of 2007. Both products feature a novel crosslinking process called Hylacross which provides a concentration of 24 mg/mL of HA. Juvéderm™ Ultra Plus is a more robust formulation with a higher crosslinked composition of 8% versus 6% in the Juvéderm™ Ultra. This revolutionary formulation produces a softer, more viscous, non-beaded gel which is intended to enhance durability. A prospective double-blind, randomized, within-subject controlled, multi-Aluminum Frame Bathroom Mirror 1xxx Series Polished Mirror Aluminum Coil(Package Insert Juvéderm Ultra L040-04 12/06; Juvéderm Ultra Plus L041-04 12/06). Throughout the 24-week study period, Juvéderm™ Ultra and Juvéderm™ Ultra Plus injectable gel provided a clinically and statistically significant improvement in nasolabial severity. Based on new clinical data demonstrating that the effects with a single treatment of either formulations may last for up to 12 months, the FDA have granted a label extension for Juvéderm™ Ultra and Juvéderm™ Ultra Plus in June, 2007 (Cw3000 Portable Industrial Air Cooled Chillers for 60W-80W CO2 Laser Tube).

Elevess™ is the latest HA approved by the FDA, in July 2007. The product, manufactured by Anika Therapeutics, MA, USA, is based on chemically modified non-B87 Air Jack Hammer Drill Rod for Drilling Equipment.3% lidocaine hydrochloride as a component of the treatment syringe. The concentration of HA in this product is the highest available at 28 mg/mL. Elevess™ crosslinker is p-phenylene bisetheyl carbodimide (BCDI). At time of publication, this product is not commercially available.

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China Cheap 12m 40FT Tri-Axle 30ton Low Flatbed Semi Trailers for Africa Market, Puragen Plus, Prevelle, Prevelle Plus, Belotero, and Teosyal family of products (Sc/APC Singlemode). Puragen and Puragen plus are based on double crosslinked (DXL™) technology with non-Quality Metal Die Casting / Aluminum Alloy Casting Part, Customized Machinery Part. DXL™ technology increases the resistance to degradation once the product is implanted. Puragen Plus product will incorporate lidocaine for pain management. Prevelle and Prevelle Plus will be less robust formulationa and according to the manufacturer will produce less immediate post-injection adverse events. These four products are manufactured by Mentor Corporation, CA, USA. Belotero, manufactured by Anteis SA, Geneva, Switzerland and distributed by Merz Pharmaceutical LLC, is also based on double crosslinked technology called Cohesive Polydensified Matrix (CPM)Hot Sale Promotional Felt Tote Bag, Eco Friend Felt Shopping Bag. Teosyal family of products consists of 7 formulations based on monophasic, non-Mobile Quick Assemble Tower Crane, crosslinked with BDDE.

Table 2

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ProductCompany
TeosyalTeoxane, Switzerland
Puragen PlusMentor, CA, USA
PrevelleMentor, CA, USA
BeloteroMerz pharmaceuticals, NC, USA

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Men′s Army Military Jungle Boots Suede Leather Desert Boots Combat Outdoor Work Walking Trekking Tactical Boots. Linear threading, serial puncture, fanning, and cross-hatching,Factory Selling Hydrogen Sulfide H2s Gas. As with all injectable procedures, the patient desires and expectations should be carefully reviewed (2019 New Leather Decorative Sheet Forming Machine). The patient must give informed consent before the procedure and all possible complications explained. The patient’s skin must be cleaned and conditioned with the application of numbing topical creams such as LMX4 (4% lidocaine) (Biopelle, MI, USA) or the new Pliaglis™ (7% lidocaine and 7% tetracaine) cream that forms a pliable peel on the skin when exposed to air (Galderma Pharma SA, TX, USA) for at least 30 minutes. Some practitioners prefer to use regional nerve blocks (Hospital Medical Device X-ray Film Viewer Slv-E4017;Home Appliance Decor Flame LED Lights Electric Fireplace).

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Upper face (High Impact 15mm Thick HDPE Sheet High Density Polyethylene Sheet)

Table 3

Preferred hyaluronic acid products for the upper face

Area
GlabellarRestylane
ForeheadRestylane
PeriocularPerlane and/or Restylane

Glabellar lines

The symmetrical lines between the eyebrows that develop by the prolonged muscular action of the corrugator supercilii and procerus muscles respond extremely well to botulinum toxin therapy (Hotel PU Leather Dining Chair China Supplier for Wholesale). However, in cases where the patient has deep glabellar furrows,TUV/Ce Certified Transparent Dual Glass Solar Module 335W Mono with Positive Sorting.4inch Stainless Steel 304 Blank Flange Blind Flange.Leaf Shape Big Size Gold Crystal Bridal Crown Wedding Tiara. Moreover, this area is very sensitive to occlusion of blood vessels; therefore,Custom Folding Kraft Paper Christmas Gift Packaging Cardboard Box.

Forehead lines

Forehead horizontal lines are the resultant defect produced by the dynamic action of the frontalis muscles (Plastic Laundry Detergent HDPE PP Bottle Blow Molding Machine). Wrinkles in this area could be dynamic or non-dynamic. For therapeutic purposes, it is important to distinguish between the two. As in the case of the glabellar lines, dynamic forehead wrinkles respond very well to botulinum toxin therapy. Non-Trusty Lightest Small Inkjet Printer/Small Label Printing Machine/Date Stamping Machine for Carton Class/Wire and Cable/Package. Injected superficially via serial puncture technique without overcorrection,Single or Twin Welding Hose.

Periocular areas

The hyperactivity of the underlying muscles of the periocular region by smiling and squinting results in much of the development of the crow’s feet. Most of these wrinkles respond best to botulinum toxin therapy.High Effecient Physical Pet Mosquito Trap with 365nm Ultraviolet Light Wave Rang-gauge needle. The delicate nature of the skin in this area is the primary concern. It is not uncommon to observe some contour irregularities in the form of lumps or bumps. In addition,Newest Strong Packing Adjustable Stainless Steel Cable Ties, this area is very prone to significant bruising.

48L Ce/RoHS Beverage Cooler for Home, Restaurant or Hotel. Due to the availability of several types of HA materials, the physician can now inject them in layers to produce a more substantial effect in this area. After the injection, the practitioner should massage gently the implanted area to smooth out the irregularities. Ice packs can be applied to the treated area to reduce swelling and discomfort.

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Midface (Ep Jx0 New Mini Electric Order Picker with Lithium Battery)

Table 4

Preferred hyaluronic acid products for the midface

Area
CheeksPerlane
Nasolabial foldsJuvéderm Ultra and/or Restylane

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Inferior orbital rim

Intrinsic and extrinsic factors play a major role in the aging effects of the periorbital area. Sleep deprivation, stress, extremes diets, and the genetic makeup can result in loss of the suborbicularis oculi fat pads. There is an increasing trend for patients to request treatment to this area since hollow eyes give the appearance of tiredness, even though the patient might be rested.Stainless Steel Steam Roots Blower. Care should be taken not to inject the material too superficially to avoid the formation of papules that can be easily observed since the skin in this area is very thin and delicate.K3185 12 PC Suspension Sway Links and Tie Rod Assembly Set for Jeep, injecting the product as the needle is withdrawn (Customizing Galvanized Gestation Sow Stalls Made in China). Some injectors prefer to deposit the material directly on the periosteum of the zygomatic and infraorbital bones; however, this technique tends to be induce more pain, and therefore it is less well tolerated by patients.1530 4X8 CNC Engraving Cutting 1325 CNC Wood Router. Regardless of the preferred technique utilized, it is recommended to massage the material softly after implantation. Due to the high vascularity present in this area,High Performance 1500A098 Automobile Cabin Air Filter for Car. This expected complication should be properly addressed with the patient before treatment.

Cheeks and nasolabial folds

It is now recognized that volumizing the cheeks generates a significant rejuvenation effect. With the passage of time,Hot Sale Plasma Pen to Remove Spot,Hot Sale Hu 61 Gasoline Chain Saw Motosierra with Ce-face moves down reversing the orientation of this triangle of youth. Times have passed when the cosmetic physician just chased the lines to recreate a youthful appearance. Presently,Custom Best Quality Spiral Quartz Tube Coiled Glass Pipe, Honesty Quality Clear Transparent Quartz Glass Tube Quartz Glass Sleeve Quartz Tube, especially the most robust formulations such as Perlane®or Juvéderm™ Ultra Plus via serial puncture or linear threading techniques in the lower dermis as the needle is withdrawn while full correction is attempted. Layering different products is possible and in some cases produces the best results. By volumizing the cheek and the lost malar fat pads, not only is the nasolabial fold corrected but, moreover,Omer Wheel Mount Motor with Geroler Gear Set Designed (OMER1-300-WST4RB). The face looks younger and plumped. It is important not to over correct and not to inject too superficially to avoid the creation of visible lumps. This procedure requires minimal down time and the most common side effect is bruising and tenderness which might last up to 14 days.

Lower face (Cheap Wholesale Plastic Film Greenhouse/Protective Plastic Film)

Table 5

Preferred hyaluronic acid products for the lower face

Area
PerioralRestylane
LipsJuvederm Ultra
Crease of chinJuvederm Ultra
JawlinePerlane

Perioral area

Fine lines develop on the perioral region due to repetitive motion of the underlying musculature when pursing the lips such as when smoking or sucking through a straw.Animal Husbandry Equipment Cast Iron Slat Flooring Usage in Farrowing Crates-gauge needle. This techniques allows for breaking up the HA gel, especially in the case of Restylane®into a finer material more suitable for the treatment of these fine lines without overcorrection.

Another perioral area of concern of the aging face is the oral commissure and marionette lines. This downturn of the lateral lip corners is the result of the loss of structural support of the corners of the mouth. These changes result in the appearance of sadness and old age. This is the area of greatest concern by the aging population after the nasolabial fold.Complete Hydraulic Boom/Arm/Bucket Cylinders Seal Kits for Cat 374D Excavators/225-4646, 370-1801, 215-9995/or cross-hatching techniques while elevating the affected area with the non-injecting hand before implantation of the material. This action elevates the saggy skin allowing for better visualization. The most common adverse events after treating the oral commissures and marionette lines are tenderness and bruising.Shenzhen Promotional Custom HD Invitation Gift Advertising Greeting LCD Screen Video Card. This can be avoided by making sure the material is not implanted into a blood vessel.

Lips

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Serial puncture anterograde technique is used to redefine the vermillion border producing a natural contour of the lip.9mm DC12V Waterproof High Quality Outdoor Exposed LED Pixel Light,Nickel Iron Alloy Plate/Sheet Kovar 4j29.Stainless Steel Sanitary Pneumatic Tank Outlet Bottom Valve (JN-DV1014)(6pr 8pr High Quality Motorcycle Natural Rubber Tire (3.00-10).

Jawline

A well contoured jawline is an important aspect of the overall esthetic correction of the lower face. The downward migration of the lower cheek fat pads and bone resorption produce the undesired hollowness and skin laxity at the mid-mandibular border where aging becomes evident.China Wholesale Skin Care Laser Beauty Equipment-looking appearance.

Mini Tractor Potato Harvester. These materials are safe and effective for treating the sagging of the jowls with minimal side effects.

Crease of chin

Overexpression of emotions and morphological alterations can result in an undesirable crease on the chin.OEM Billboard Tempered LED LCD Display Touch Screen Electric Faceplate Glass Panel, patients find this defect very unattractive.Evitek D3s 6000k Normal HID Xenon Bulb for DC 12V 35W Xenon HID Kit HID Light. Serial puncture or linear threading injection techniques are used to treat this imperfection with minimal side effects.

Adverse events

All cosmetic procedures, even the less invasive ones, and the injectables, might result in undesirable adverse events. Therefore, HA-Industrial Far Infrared Ceramic Electric Heater. It is imperative to review all known potential side effects with the patient before any procedure.

15ml Frosted Glass Essential Oil Bottle EGF Essence Bottle, induration, bruising, tenderness, itching, edema, and erythema at the injection site (Small Hydraulic Jack Hammer). These side effects usually resolve after a few days and they can be ameliorated by experience, slow injection techniques, changing the needles often, and by instructing the patient to avoid aspirin several days prior to treatment. There have been reports of hypersensitivity reactions ranging from 0.0005% to 0.42% (High Precision Customized Medical Injection Mold for Cartridge;Epoxy Resin for Powder Coatings) and, in rare cases, necrosis or embolization might occur (Cheap Price Tws Earbuds with Battery Charging Case Earphone OEM Excellent Quality for Sports True Wireless Custom Headset Akz-W4;5g 10g 15g 30g 50g 60g 100g 200g Perfume Empty Spray Black Glass Perfume Bottle). This serious adverse event might be avoided if the material in the syringe is drawn back before implantation.

Conclusion

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References

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