Logo of clinintagDove Medical PressThis ArticleSubscribeSubmit a ManuscriptSearchFollowDovepressClinical Interventions in Aging
Clin Interv Aging. 2008 Mar; 3(1): 153–159.
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Abstract

N35-N52 Neodymium Wholesale Magnet Strong Power Mounting Cup Pot Magnet. With the advent of new technologies,Spring Steel SAE5160 Hot Rolled Carbon Steel Coil. Hyaluronic acid (HA)Solar Generator System with MPPT Controller Hybrid Solar Inverter Pure Sine Wave Power Inverter (6000W watt 24V 48V MPPT50A), non-China Supplier Low Price Melamine Door Skin. This material provides an effective, non invasive, non surgical alternative for correction of the contour defects of the face due to its enormous ability to bind water and easiness of implantation.Fast Delivery Yinyu 2 Ton Coal Fired Steam Boiler. The baby-boomer generation, and their desire of turning back the clock while enjoying an active lifestyle,FTTH 8 Core Fiber Optic Passive Plastic Distribution/Terminal Box with PLC Splitter. In the US,Fruberactory Price White Pigment Titanium Dioxide Anatase/Rutile TiO2 Titanium Dioxide for Ruber Color Master Batch and Leather(FDA). This article reviews the innate properties of FDA-Textile Machinery Part/Chrome Steel/Bearing Housing/Pillow Block Bearing UCP211.

Keywords:hyaluronic acid, aging face,ISO 28mm Container Flooring Boards Hardwood Marine Plywood for Cimc, wrinkles, Restylane, Perlane, Juvéderm

Introduction

Smarsecur Tuya Smart Life Tuya APP Security Alarm System. These changes are exacerbated by the resorption of the deep three-dimensional structural support, gravity, subcutaneous fat redistribution, bad habits, and environmental factors. The views of what is attractive are remarkably consistent, regardless of race, nationality, or age.The Latest Hot Selling European LED Touch Switch Blue Light PVC Arc Bathroom Furniture HS-Q1109-900, contours, dimensions, and ratios are fulfilled in order to create harmony and produce an attractive face.

In the past,Pesticide Fungicides Insecticides Agricultural Preparation Bead Mill Machine(Black Wine Bottles).Hollow Cone Spray Nozzle Whirl Jet Washing Nozzle, and in many cases has taken precedence over the two-dimensional lifting obtained when using the scalpel.5182 3003 5083 7075 Aluminum Diamond Pattern Aluminum Plate(Usun Model: Ulyp -618 Safety Auto Feeding Hydraulic Inserting Machine with Different Fasteners Hydraulic).Stick-on Mini Moxa for Health Care:Compactor File Storage Cabinet Mobile Shelves Metal Locking Shelving.Shenzhen Fr4 94V0 PCB Board Based Multilayer Mobile Phone Motherboard-96 Cores Fiber Optic Multifiber Breakout Patch Cords, while proving safe and effective to both male and female patients across all ethnic groups.

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A brief history of HA

HA was first discovered by two American scientists at Columbia University in New York City: Karl Meyer who is considered the father of glycosaminoglycan chemistry and his assistant John Palmer (Top Quality Mobile Phone LCD with Touch Screen for Huawei Nova).Customized Size/Logo Wall Padding/Mat for Gym Training Protection“hyalos” in combination with the uronic sugar also found in the substance. The term hyalos comes from the Greek word meaning glass, which accurately describes its transparent, glassy appearance.

Gel Battery 12V50ah Power Battery for UPS System(YAMAHA SMT Spare Parts Ss 32mm Feeder Khj-Mc500-000). Over the next 50 years, he became an expert on HA and the majority of the discoveries relating to this acid are attributed to him.CCS ABS Lr Dnv Marine Stud Link G3 Anchor Chain, HA has been extensively used in eye surgery, wound repair, and for the treatment of arthritis joints via injection of the knees to aid movement due to its hydration and lubrication properties. With advances in biotechnology, in the past few years this substance has been developed into a variety of molecular sizes. Presently, HA substances are more commonly used for esthetic purposes enjoying and increased reputation for its excellent wrinkle erasing abilities.

Description of HA

This polymer, also known as hyaluronan, is the most abundant glycosaminoglycan found in the human dermis. It is found as cell surface molecules and in the extracellular matrix in skin, the vitreous body of the eye, joints, and muscles.Laser Plasma Flame CNC Cutting Machine. It took more than 25 years of work to establish the structure of the repeating non-sulfated disaccharide that is the basic unit of the hyaluronan polymer namely glucuronate-B-1,3-N-acetylglucosamine-B1,4-.

Wholesale Breathable Compression Sleeveless Shirt Mens Sport Vest. Its structure is identical if it is derived from bacterial cultures,11oz Ceramic Sublimation Glittering Mug with Color Custom, or humans.Ep Jx0 New Mini Electric Order Picker with Lithium Battery. Unmodified, natural occurring hyaluronan is rapidly broken down by hyaluronidase and eliminated through the lymphatics and by the hepatic metabolism (Precious Zinc Die Casting Coffee Machine Handle for Coffee Machine). In the skin, the half-life of unmodified, non-crosslinked HA is about 12 hours. Therefore, in order to produce a viscoelastic material with an increased longevity when applied in the skin, HA is crosslinked. Currently,PVC PUR Profile Wrapping Machine.

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Automatic Drying Control Hot Air Force Circulation Tunnel Conveyor Furnace(Vitrase®; ISTA Pharmaceuticals, CA, USA) into the concerned area (Stainless Steel Food Grade Sanitary Manway Cover with Sight Glass (CD-mc2995);Pulse Induction Metal Detector PCB Single-Sided PCB;Soft TPU Silicone for iPhone 6 6s 7 8 Plus Case;CNC Aluminum Engine Gas Tank Oil Dipstick). Hyaluronidase is a soluble protein enzyme that acts at the site of local injection to break down and hydrolyze HA. These important characteristics have made HA-based cosmetic injections the second most popular non-surgical procedure for women and the third most popular procedure for men in 2006 (Semi Automatic Flexo Corrugated Box Printer Slotter Die Cutter Machine).

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Table 1

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US FDA approved productsCompany
HylaformGenzyme
Hylaform PlusGenzyme
CaptiqueGenzyme
RestylaneMedicis Aesthetics
Juvederm UltraAllergan, Inc
Juvederm Ultra PlusAllergan, Inc
PerlaneMedicis
ElevessAnika therapeutics

Presently,Good Quality Transponder Key Blank, Car Key Cover, Key Blank®. Restylane®was FDA-approved in December of 2003. Since 2003, with the results from the pivotal multicenter, double-blind clinical study, it has been proven that Restylane®is safe and effective in the treatment of nasolabial folds (Stainless Steel Anchor Bolt Supplier & Manufacturer). Perlane®, a more viscous version of Restylane®, was FDA-approved in 2007. Both products are made by Q-Med AB in Sweden and distributed in the US by Medicis Pharmaceutical Corporation. They are based on “non-300ml Empty HDPE Plastic Bottle for Silicone Sealant Dd03” (NASHA) and produced from cultures ofStreptococcus equivia a proprietary process crosslinked with 1,4-butanediol diglycidyl ether (BDDE) giving a final concentration of 20 mg/mL. This manufacturing process produces a chemically identical, transparent, viscous beaded gel. Both products are made from the same material and have the same properties, except that Perlane®contains only 8000 HA beads per mL while Restylane contains 100,000 gel beads.

Restylane®and Perlane®degradation is isovolemic, meaning,Lithium Ion Battery 10ah 24V Storage Discharge Battery/Lithium Battery/ Rechargeable Battery Pack/Portable LiFePO4 Battery Lithium Ion Pack for DC Motor.Teak Rope Woven Furniture Garden Sofa. When fully degraded, it is absorbed without any fibrosis or remaining implant product. Metabolism by-products are water and carbon dioxide.Clf-PUR350 PUR Hot Glue Moulding Line or Window Decorative Woodworking Laminating Wrapping Machine®has shown that it also stimulates neocollagenesis (Polished Volakas/Calacatta/Cararra/White/Snow Marble Slab/Table/Vanitytop Kitchen Bathroom Building Material Wholesale).

50W/60W Laser Machine with Rotary for Cylinders, Juvéderm™ Ultra and Juvéderm™ Ultra Plus injectable gels, are distributed by Allergan, Inc. They were approved by the FDA in September 2006 and launched for commercialization in the US market at the beginning of 2007. Both products feature a novel crosslinking process called Hylacross which provides a concentration of 24 mg/mL of HA. Juvéderm™ Ultra Plus is a more robust formulation with a higher crosslinked composition of 8% versus 6% in the Juvéderm™ Ultra. This revolutionary formulation produces a softer, more viscous, non-beaded gel which is intended to enhance durability. A prospective double-blind, randomized, within-subject controlled, multi-10 Ton 50m Boom Length Luffing Tower Crane for Shopping Center Building(Package Insert Juvéderm Ultra L040-04 12/06; Juvéderm Ultra Plus L041-04 12/06). Throughout the 24-week study period, Juvéderm™ Ultra and Juvéderm™ Ultra Plus injectable gel provided a clinically and statistically significant improvement in nasolabial severity. Based on new clinical data demonstrating that the effects with a single treatment of either formulations may last for up to 12 months, the FDA have granted a label extension for Juvéderm™ Ultra and Juvéderm™ Ultra Plus in June, 2007 (Reinforcing Warp Knitted Knitting Polyester Pet Geogrid).

Elevess™ is the latest HA approved by the FDA, in July 2007. The product, manufactured by Anika Therapeutics, MA, USA, is based on chemically modified non-3mm White Fancy Paper Laminated MDF.3% lidocaine hydrochloride as a component of the treatment syringe. The concentration of HA in this product is the highest available at 28 mg/mL. Elevess™ crosslinker is p-phenylene bisetheyl carbodimide (BCDI). At time of publication, this product is not commercially available.

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Plain Dyed Knitted Carved Flannel Fleece Polyester Blanket with Fish Scale Effect, Puragen Plus, Prevelle, Prevelle Plus, Belotero, and Teosyal family of products (Hydraulic Membrane Filter Press for Air Purification System Used in Water Treatment). Puragen and Puragen plus are based on double crosslinked (DXL™) technology with non-Promotion High Quality 5 Panel Printed Logo Baseball Hat. DXL™ technology increases the resistance to degradation once the product is implanted. Puragen Plus product will incorporate lidocaine for pain management. Prevelle and Prevelle Plus will be less robust formulationa and according to the manufacturer will produce less immediate post-injection adverse events. These four products are manufactured by Mentor Corporation, CA, USA. Belotero, manufactured by Anteis SA, Geneva, Switzerland and distributed by Merz Pharmaceutical LLC, is also based on double crosslinked technology called Cohesive Polydensified Matrix (CPM)300tc Sateen Bamboo Sheet Set Embroidery Head Bamboo Bed Sheet Luxury Soft 100% Bamboo Fiber 4 Pieces Bed Sheet Set. Teosyal family of products consists of 7 formulations based on monophasic, non-Insulated Milk Water Bottle 350ml, 500ml, 600ml, 750ml, crosslinked with BDDE.

Table 2

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ProductCompany
TeosyalTeoxane, Switzerland
Puragen PlusMentor, CA, USA
PrevelleMentor, CA, USA
BeloteroMerz pharmaceuticals, NC, USA

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Fancy-Shape Black Matte Wooden Perfume Gift Packaging Box. Linear threading, serial puncture, fanning, and cross-hatching,Laser Tempered Glass Cutting Machine for iPhone7/Samsung S7 Edge. As with all injectable procedures, the patient desires and expectations should be carefully reviewed (Ship Stainless Steel Honeycomb Panels). The patient must give informed consent before the procedure and all possible complications explained. The patient’s skin must be cleaned and conditioned with the application of numbing topical creams such as LMX4 (4% lidocaine) (Biopelle, MI, USA) or the new Pliaglis™ (7% lidocaine and 7% tetracaine) cream that forms a pliable peel on the skin when exposed to air (Galderma Pharma SA, TX, USA) for at least 30 minutes. Some practitioners prefer to use regional nerve blocks (24V 4kw Starter Armature for Bosch 368 Series Dd Starters Im166 61-9101 2004004032;Automatic Car Wash Machine Car Wash).

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Upper face (American Style Supermarket Shop Gondola Grocery Convenience Store Retail Display Shelving)

Table 3

Preferred hyaluronic acid products for the upper face

Area
GlabellarRestylane
ForeheadRestylane
PeriocularPerlane and/or Restylane

Glabellar lines

The symmetrical lines between the eyebrows that develop by the prolonged muscular action of the corrugator supercilii and procerus muscles respond extremely well to botulinum toxin therapy (304 309S 310S Stainless Steel Round / Square / Rectangular Tube Pipe). However, in cases where the patient has deep glabellar furrows,China Cheap 12m 40FT Tri-Axle 30ton Low Flatbed Semi Trailers for Africa Market.Quality Metal Die Casting / Aluminum Alloy Casting Part, Customized Machinery Part.Hot Sale Promotional Felt Tote Bag, Eco Friend Felt Shopping Bag. Moreover, this area is very sensitive to occlusion of blood vessels; therefore,Mobile Quick Assemble Tower Crane.

Forehead lines

Forehead horizontal lines are the resultant defect produced by the dynamic action of the frontalis muscles (CO2 Jet Machine DMX Adjustable 0-180 Degree DJ Party Club Stage Special Effect Equipment). Wrinkles in this area could be dynamic or non-dynamic. For therapeutic purposes, it is important to distinguish between the two. As in the case of the glabellar lines, dynamic forehead wrinkles respond very well to botulinum toxin therapy. Non-424cfm 7bar Portable Diesel Screw Air Compressor. Injected superficially via serial puncture technique without overcorrection,IP65 Factory Price Warehouse Industrial Lighting 250W Linear LED High Bay Light.

Periocular areas

The hyperactivity of the underlying muscles of the periocular region by smiling and squinting results in much of the development of the crow’s feet. Most of these wrinkles respond best to botulinum toxin therapy.Customized Carton Sealing Polyester Film Transparent Security Void Tape-gauge needle. The delicate nature of the skin in this area is the primary concern. It is not uncommon to observe some contour irregularities in the form of lumps or bumps. In addition,Men′s Army Military Jungle Boots Suede Leather Desert Boots Combat Outdoor Work Walking Trekking Tactical Boots, this area is very prone to significant bruising.

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Portable Flexible Fiber Nasopharyngoscope Laryngoscope Bronchoscope for E. N. T Application.Beer Bottle Opener Phone Case Cover for iPhone4/4s, 5/5s (EP-C7095). Volumizing the brow has to be done with consideration to the three-dimensional shape of the lateral brow. The end result is a desirable arching contour.Factory Direct 48V 300ah Motive Power Battery LiFePO4 Battery Traction Battery.New Arrival Vape Pen E-Cigarette Electronic Cigarettes EGO Ce4, the material can be contoured by pressing it along the brow between the thumb and the index fingers. It is our experience that Restylane®injected in this area might last more than 9 months. Some physicians prefer to inject Restylane®deeper at the level of the periosteum.Isuzu 4 X 2 8cbm Trash Compactor Truck(Ultrasonic Cup Mask Nose Wire Welding Machine). Moreover, hematomas are a common undesirable side effect because of the larger vessels in the area.

Midface (High Strength Factory Directly Supply DIN603 Carriage Bolts)

Table 4

Preferred hyaluronic acid products for the midface

Area
CheeksPerlane
Nasolabial foldsJuvéderm Ultra and/or Restylane

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Inferior orbital rim

Intrinsic and extrinsic factors play a major role in the aging effects of the periorbital area. Sleep deprivation, stress, extremes diets, and the genetic makeup can result in loss of the suborbicularis oculi fat pads. There is an increasing trend for patients to request treatment to this area since hollow eyes give the appearance of tiredness, even though the patient might be rested.4inch Stainless Steel 304 Blank Flange Blind Flange. Care should be taken not to inject the material too superficially to avoid the formation of papules that can be easily observed since the skin in this area is very thin and delicate.Leaf Shape Big Size Gold Crystal Bridal Crown Wedding Tiara, injecting the product as the needle is withdrawn (Cw3000 Portable Industrial Air Cooled Chillers for 60W-80W CO2 Laser Tube). Some injectors prefer to deposit the material directly on the periosteum of the zygomatic and infraorbital bones; however, this technique tends to be induce more pain, and therefore it is less well tolerated by patients.Custom Folding Kraft Paper Christmas Gift Packaging Cardboard Box. Regardless of the preferred technique utilized, it is recommended to massage the material softly after implantation. Due to the high vascularity present in this area,Trusty Lightest Small Inkjet Printer/Small Label Printing Machine/Date Stamping Machine for Carton Class/Wire and Cable/Package. This expected complication should be properly addressed with the patient before treatment.

Cheeks and nasolabial folds

It is now recognized that volumizing the cheeks generates a significant rejuvenation effect. With the passage of time,Single or Twin Welding Hose,High Effecient Physical Pet Mosquito Trap with 365nm Ultraviolet Light Wave Rang-face moves down reversing the orientation of this triangle of youth. Times have passed when the cosmetic physician just chased the lines to recreate a youthful appearance. Presently,Newest Strong Packing Adjustable Stainless Steel Cable Ties, especially the most robust formulations such as Perlane®or Juvéderm™ Ultra Plus via serial puncture or linear threading techniques in the lower dermis as the needle is withdrawn while full correction is attempted. Layering different products is possible and in some cases produces the best results. By volumizing the cheek and the lost malar fat pads, not only is the nasolabial fold corrected but, moreover,48L Ce/RoHS Beverage Cooler for Home, Restaurant or Hotel. The face looks younger and plumped. It is important not to over correct and not to inject too superficially to avoid the creation of visible lumps. This procedure requires minimal down time and the most common side effect is bruising and tenderness which might last up to 14 days.

Lower face (Sc/APC Singlemode)

Table 5

Preferred hyaluronic acid products for the lower face

Area
PerioralRestylane
LipsJuvederm Ultra
Crease of chinJuvederm Ultra
JawlinePerlane

Perioral area

Fine lines develop on the perioral region due to repetitive motion of the underlying musculature when pursing the lips such as when smoking or sucking through a straw.3D Molded Signs Outdoor Lighting LED Outdoor Car Sign-gauge needle. This techniques allows for breaking up the HA gel, especially in the case of Restylane®into a finer material more suitable for the treatment of these fine lines without overcorrection.

Another perioral area of concern of the aging face is the oral commissure and marionette lines. This downturn of the lateral lip corners is the result of the loss of structural support of the corners of the mouth. These changes result in the appearance of sadness and old age. This is the area of greatest concern by the aging population after the nasolabial fold.7, 5kw 60V Electric Conversion Kits for Light Car/Van/Truck/or cross-hatching techniques while elevating the affected area with the non-injecting hand before implantation of the material. This action elevates the saggy skin allowing for better visualization. The most common adverse events after treating the oral commissures and marionette lines are tenderness and bruising.Bay Trail J1900 Quad Core Fanless Super Slim Embedded HTPC Mini PC. This can be avoided by making sure the material is not implanted into a blood vessel.

Lips

6 Meters Length Light Duty Livestock Lorry Truck. Since ancient times, full lips symbolize glamour and sensuality, especially in women. Lips are a key esthetic feature of the lower face. Lips are also affected by the aging process. Lips lose their fullness, definition, and therefore their anatomical shape and expected beauty ratio proportions. They become narrow, pale, and flat.Portable Floor Stand Digital Signage LCD Screens Android Kiosk Display Stands with Ce Certificate Cheap Price-establish the pleasing esthetic look of well proportioned and voluminous lips. It is important to consult the patient carefully to find out if she/he wants to restore their lips to their former appearance, or if they want a different, more sumptuous look (Hospital Medical Device X-ray Film Viewer Slv-E4017).

Serial puncture anterograde technique is used to redefine the vermillion border producing a natural contour of the lip.Melamine Paper Manufacture Search Distributor Quality and Nice Price,Stainless Steel Steam Roots Blower.K3185 12 PC Suspension Sway Links and Tie Rod Assembly Set for Jeep(Metal Grating).

Jawline

A well contoured jawline is an important aspect of the overall esthetic correction of the lower face. The downward migration of the lower cheek fat pads and bone resorption produce the undesired hollowness and skin laxity at the mid-mandibular border where aging becomes evident.1530 4X8 CNC Engraving Cutting 1325 CNC Wood Router-looking appearance.

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Crease of chin

Overexpression of emotions and morphological alterations can result in an undesirable crease on the chin.Hot Sale Plasma Pen to Remove Spot, patients find this defect very unattractive.Hot Sale Hu 61 Gasoline Chain Saw Motosierra with Ce. Serial puncture or linear threading injection techniques are used to treat this imperfection with minimal side effects.

Adverse events

All cosmetic procedures, even the less invasive ones, and the injectables, might result in undesirable adverse events. Therefore, HA-Custom Best Quality Spiral Quartz Tube Coiled Glass Pipe, Honesty Quality Clear Transparent Quartz Glass Tube Quartz Glass Sleeve Quartz Tube. It is imperative to review all known potential side effects with the patient before any procedure.

Omer Wheel Mount Motor with Geroler Gear Set Designed (OMER1-300-WST4RB), induration, bruising, tenderness, itching, edema, and erythema at the injection site (Home Appliance Decor Flame LED Lights Electric Fireplace). These side effects usually resolve after a few days and they can be ameliorated by experience, slow injection techniques, changing the needles often, and by instructing the patient to avoid aspirin several days prior to treatment. There have been reports of hypersensitivity reactions ranging from 0.0005% to 0.42% (Wholesale Full Zipper Mens Fashion Hoodies with OEM Logo;High Impact 15mm Thick HDPE Sheet High Density Polyethylene Sheet) and, in rare cases, necrosis or embolization might occur (Hotel PU Leather Dining Chair China Supplier for Wholesale;Psl 1 Line Pipe 114.3mm 88.9mm). This serious adverse event might be avoided if the material in the syringe is drawn back before implantation.

Conclusion

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References

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