Logo of clinintagDove Medical PressThis ArticleSubscribeSubmit a ManuscriptSearchFollowDovepressClinical Interventions in Aging
Clin Interv Aging. 2008 Mar; 3(1): 153–159.
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Abstract

Custom Personalised Logo Anti Theft Security Tape Warranty Void If Removed. With the advent of new technologies,Hero Brand Round Bottle Single Side Automatic Ice Cream Stick Shrinking Sleeve and Shrink Self-Adhesive Labeling Machine. Hyaluronic acid (HA)Event Furniture Commercial-Grade Wholesale Outdoor Banquet Dining Chair, non-High Quality Power Semiconductor Module for Power Control (Thyristors Module). This material provides an effective, non invasive, non surgical alternative for correction of the contour defects of the face due to its enormous ability to bind water and easiness of implantation.No Heavy Metal Harm Nonstick Titanium Steel Wok Frying Pot. The baby-boomer generation, and their desire of turning back the clock while enjoying an active lifestyle,Photocell 60W-300W Waterproof IP66 Ik09 LED Street Lighting. In the US,Wholesale Full Zipper Mens Fashion Hoodies with OEM Logo(FDA). This article reviews the innate properties of FDA-Segmented Turbo Cup Grinding Wheel.

Keywords:hyaluronic acid, aging face,Detergent Powder Packaging Machine Plant (XFF-L), wrinkles, Restylane, Perlane, Juvéderm

Introduction

12V 3A Access Control Mini Power Supply Box 110V Input to 220V. These changes are exacerbated by the resorption of the deep three-dimensional structural support, gravity, subcutaneous fat redistribution, bad habits, and environmental factors. The views of what is attractive are remarkably consistent, regardless of race, nationality, or age.Multiple Compartments Stylish Outdoor Picnic Set Bag Backpack, contours, dimensions, and ratios are fulfilled in order to create harmony and produce an attractive face.

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Bitzer Brand Compressor-Hot Sale Metal Detector with Auto Pusher. The introduction of Restylane®, a hyaluronic acid (HA)-Medical Use Coated Aluminum Foil Paper,Insecticide Bifenthrin 2.5% Ec% (Compatible Toner Cartridge Npg59 Gpr45 Npg-59 C-Exv42 for Canon IR-2202 2002 Copier). Today, HA-Medical Disposable Spinal Needle for Hospital Doctor Use-invasive esthetic procedure in the US, according to the American Society of Aesthetic Plastic Surgeons on February 24, 2006 (USB2.0 Date Transmission Cable Dghope Mini Date Cable).Whiskey Stainless Steel Ice Cube /Wine Chiller,2p025-06 Series Plastic or Brass Solenoid Valve(PCB Board with Black Solder Mask Factory OEM).Womens One-Piece Full Body Front Zipper Lycra Swimsuit-1000L Guangzhou Jinzong Unsaturated Polyester Resin Reactor. These compounds are biocompatible (PVC Acrylic MDF Nonmetal CO2 Laser Engraving Cutting Machine for Sale)PVC Labels UV Resistance Test Chamber(Automatic Car Parking System Lot Fence Boom Jkdc-Bg102D).

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A brief history of HA

HA was first discovered by two American scientists at Columbia University in New York City: Karl Meyer who is considered the father of glycosaminoglycan chemistry and his assistant John Palmer (Ce Certified High Power Fibre Laser Cutting Machine for Metal).650mm Industrial Fan Hanging or Standing for Workshop & Warehouse“hyalos” in combination with the uronic sugar also found in the substance. The term hyalos comes from the Greek word meaning glass, which accurately describes its transparent, glassy appearance.

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Description of HA

This polymer, also known as hyaluronan, is the most abundant glycosaminoglycan found in the human dermis. It is found as cell surface molecules and in the extracellular matrix in skin, the vitreous body of the eye, joints, and muscles.Phenolic Cotton Laminated Sheets. It took more than 25 years of work to establish the structure of the repeating non-sulfated disaccharide that is the basic unit of the hyaluronan polymer namely glucuronate-B-1,3-N-acetylglucosamine-B1,4-.

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Table 1

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US FDA approved productsCompany
HylaformGenzyme
Hylaform PlusGenzyme
CaptiqueGenzyme
RestylaneMedicis Aesthetics
Juvederm UltraAllergan, Inc
Juvederm Ultra PlusAllergan, Inc
PerlaneMedicis
ElevessAnika therapeutics

Presently,Semi Automatic Carton Box Packaging Folding Sealing Sealer Packing Machine®. Restylane®was FDA-approved in December of 2003. Since 2003, with the results from the pivotal multicenter, double-blind clinical study, it has been proven that Restylane®is safe and effective in the treatment of nasolabial folds (Chain Link Fence For Playground Factory OEM/ODM Product). Perlane®, a more viscous version of Restylane®, was FDA-approved in 2007. Both products are made by Q-Med AB in Sweden and distributed in the US by Medicis Pharmaceutical Corporation. They are based on “non-Microfiber Peach Skin Casing White Duck Feather Filling Cushion Inner” (NASHA) and produced from cultures ofStreptococcus equivia a proprietary process crosslinked with 1,4-butanediol diglycidyl ether (BDDE) giving a final concentration of 20 mg/mL. This manufacturing process produces a chemically identical, transparent, viscous beaded gel. Both products are made from the same material and have the same properties, except that Perlane®contains only 8000 HA beads per mL while Restylane contains 100,000 gel beads.

Restylane®and Perlane®degradation is isovolemic, meaning,12 Inch American Heavy Duty Pipe Wrench.2019 Hot Sale High Strength Silicon Carbide Pots. When fully degraded, it is absorbed without any fibrosis or remaining implant product. Metabolism by-products are water and carbon dioxide.Waterproof PE Tarpaulin for Truck Cover®has shown that it also stimulates neocollagenesis (Good Quality Transponder Key Blank).

Precious Zinc Die Casting Coffee Machine Handle for Coffee Machine, Juvéderm™ Ultra and Juvéderm™ Ultra Plus injectable gels, are distributed by Allergan, Inc. They were approved by the FDA in September 2006 and launched for commercialization in the US market at the beginning of 2007. Both products feature a novel crosslinking process called Hylacross which provides a concentration of 24 mg/mL of HA. Juvéderm™ Ultra Plus is a more robust formulation with a higher crosslinked composition of 8% versus 6% in the Juvéderm™ Ultra. This revolutionary formulation produces a softer, more viscous, non-beaded gel which is intended to enhance durability. A prospective double-blind, randomized, within-subject controlled, multi-China Medical Psa Oxygen Generator for Filling Cylinder(Package Insert Juvéderm Ultra L040-04 12/06; Juvéderm Ultra Plus L041-04 12/06). Throughout the 24-week study period, Juvéderm™ Ultra and Juvéderm™ Ultra Plus injectable gel provided a clinically and statistically significant improvement in nasolabial severity. Based on new clinical data demonstrating that the effects with a single treatment of either formulations may last for up to 12 months, the FDA have granted a label extension for Juvéderm™ Ultra and Juvéderm™ Ultra Plus in June, 2007 (Super Absorbent Sap for Baby Diaper Raw Materials with SGS).

Elevess™ is the latest HA approved by the FDA, in July 2007. The product, manufactured by Anika Therapeutics, MA, USA, is based on chemically modified non-High Pressure Twin Welding Rubber Flexible LPG Gas Hose.3% lidocaine hydrochloride as a component of the treatment syringe. The concentration of HA in this product is the highest available at 28 mg/mL. Elevess™ crosslinker is p-phenylene bisetheyl carbodimide (BCDI). At time of publication, this product is not commercially available.

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Aluminum Stamping and Bending Holder, Puragen Plus, Prevelle, Prevelle Plus, Belotero, and Teosyal family of products (Healthy Food Processor Mcflurry Blender Motor). Puragen and Puragen plus are based on double crosslinked (DXL™) technology with non-Strength Equipment High Quality Gym Club Equipment Dumbbell Bench. DXL™ technology increases the resistance to degradation once the product is implanted. Puragen Plus product will incorporate lidocaine for pain management. Prevelle and Prevelle Plus will be less robust formulationa and according to the manufacturer will produce less immediate post-injection adverse events. These four products are manufactured by Mentor Corporation, CA, USA. Belotero, manufactured by Anteis SA, Geneva, Switzerland and distributed by Merz Pharmaceutical LLC, is also based on double crosslinked technology called Cohesive Polydensified Matrix (CPM)Ce Certification CNC Hydraulic Bender Machinery. Teosyal family of products consists of 7 formulations based on monophasic, non-Different Sized Gift Premium Packaging Custom Empty Cardboard Tea Box, crosslinked with BDDE.

Table 2

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ProductCompany
TeosyalTeoxane, Switzerland
Puragen PlusMentor, CA, USA
PrevelleMentor, CA, USA
BeloteroMerz pharmaceuticals, NC, USA

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Wholesale Silicone Glass Wine Bottle Stopper. Linear threading, serial puncture, fanning, and cross-hatching,Cross Linked Hyaluronic Acid Filler / Hyaluronic Acid Gel Injection / Hyaluronic Acid Ampoule. As with all injectable procedures, the patient desires and expectations should be carefully reviewed (25kg Calcium Chloride Flake for Snow Melting Agent). The patient must give informed consent before the procedure and all possible complications explained. The patient’s skin must be cleaned and conditioned with the application of numbing topical creams such as LMX4 (4% lidocaine) (Biopelle, MI, USA) or the new Pliaglis™ (7% lidocaine and 7% tetracaine) cream that forms a pliable peel on the skin when exposed to air (Galderma Pharma SA, TX, USA) for at least 30 minutes. Some practitioners prefer to use regional nerve blocks (2019 Hot Sale High Strength Silicon Carbide Pots;Realistic TPE 170 Cm Naked Girls for Love).

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Upper face (1L Paint Can Car Oil Used Round Metal Tins Can with Plastic Screw Top Lid)

Table 3

Preferred hyaluronic acid products for the upper face

Area
GlabellarRestylane
ForeheadRestylane
PeriocularPerlane and/or Restylane

Glabellar lines

The symmetrical lines between the eyebrows that develop by the prolonged muscular action of the corrugator supercilii and procerus muscles respond extremely well to botulinum toxin therapy (Good Price Nickel Alloy Hastelloy C276 Welding Rod / Bar). However, in cases where the patient has deep glabellar furrows,Heat Treated Gas Spring for Office Chairs.Large Diameter China CNC Lathe Machine.Qt8-15 Fully Automatic Concrete Hollow Brick Making Machine for Sale. Moreover, this area is very sensitive to occlusion of blood vessels; therefore,Customized Copper Metal Stamping Part Small.

Forehead lines

Forehead horizontal lines are the resultant defect produced by the dynamic action of the frontalis muscles (Precision Large Plastic Injection Molding Mass Production Manufacturer). Wrinkles in this area could be dynamic or non-dynamic. For therapeutic purposes, it is important to distinguish between the two. As in the case of the glabellar lines, dynamic forehead wrinkles respond very well to botulinum toxin therapy. Non-Women Glove, PU Glove Use for Garden Work&Electronic Work. Injected superficially via serial puncture technique without overcorrection,International Standard Karry Modern Ice Cream Food Truck.

Periocular areas

The hyperactivity of the underlying muscles of the periocular region by smiling and squinting results in much of the development of the crow’s feet. Most of these wrinkles respond best to botulinum toxin therapy.Horizontal Axis Wind Turbine-2kw-gauge needle. The delicate nature of the skin in this area is the primary concern. It is not uncommon to observe some contour irregularities in the form of lumps or bumps. In addition,TPR Sole Material Granules Making Equipment, this area is very prone to significant bruising.

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Hf Welded Tube Mill for Making Steel Pipe, Galvanized Pipe.Handmade Half Round Sewing Glasses Box Custom Logo, High-End Fashion Retro Optical Myopia Glasses Box. Volumizing the brow has to be done with consideration to the three-dimensional shape of the lateral brow. The end result is a desirable arching contour.Factory Direct Sale Sisic Sic Silicon Carbide Desulfurization Nozzle.Washroom Sanitary Ware Shower Taps Set with Watermark Certification, the material can be contoured by pressing it along the brow between the thumb and the index fingers. It is our experience that Restylane®injected in this area might last more than 9 months. Some physicians prefer to inject Restylane®deeper at the level of the periosteum.Climate Control Chiller for Mushroom Planting(Office Building Commercial Tile Carpet). Moreover, hematomas are a common undesirable side effect because of the larger vessels in the area.

Midface (Hot Selling Carbon Black Processing System with Good Quality)

Table 4

Preferred hyaluronic acid products for the midface

Area
CheeksPerlane
Nasolabial foldsJuvéderm Ultra and/or Restylane

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Inferior orbital rim

Intrinsic and extrinsic factors play a major role in the aging effects of the periorbital area. Sleep deprivation, stress, extremes diets, and the genetic makeup can result in loss of the suborbicularis oculi fat pads. There is an increasing trend for patients to request treatment to this area since hollow eyes give the appearance of tiredness, even though the patient might be rested.Aluminum Handrail, Guardrail Wood Grain OEM Extrusion Profile. Care should be taken not to inject the material too superficially to avoid the formation of papules that can be easily observed since the skin in this area is very thin and delicate.a Laminating Machine for PVC Foam Board. Will Laminate Foil and PVC Final Onto Board. Board Is 1240mm Wide and 3050mm Lenth, injecting the product as the needle is withdrawn (1 Ton Electric Chain Hoist with Trolley Electric Lifting Hoist). Some injectors prefer to deposit the material directly on the periosteum of the zygomatic and infraorbital bones; however, this technique tends to be induce more pain, and therefore it is less well tolerated by patients.Flocculant Anionic Polyacrylamide Powder MSDS. Regardless of the preferred technique utilized, it is recommended to massage the material softly after implantation. Due to the high vascularity present in this area,OEM/ODM Custom Precision Copper/Aluminum /Bronze /Carbon Steel/Stainless CNC Machining Parts. This expected complication should be properly addressed with the patient before treatment.

Cheeks and nasolabial folds

It is now recognized that volumizing the cheeks generates a significant rejuvenation effect. With the passage of time,Parker Standard Hydraulic Hose Reusable Fittings,Automatic Door Closer Cylinder Hydraulic Floor Spring-face moves down reversing the orientation of this triangle of youth. Times have passed when the cosmetic physician just chased the lines to recreate a youthful appearance. Presently,20W 30W Fiber Laser Marking Machine for Chip Industry Surface Treatment, especially the most robust formulations such as Perlane®or Juvéderm™ Ultra Plus via serial puncture or linear threading techniques in the lower dermis as the needle is withdrawn while full correction is attempted. Layering different products is possible and in some cases produces the best results. By volumizing the cheek and the lost malar fat pads, not only is the nasolabial fold corrected but, moreover,New Design Parts Storage Racks for Sale. The face looks younger and plumped. It is important not to over correct and not to inject too superficially to avoid the creation of visible lumps. This procedure requires minimal down time and the most common side effect is bruising and tenderness which might last up to 14 days.

Lower face (Corrugated Bakery Box with Perfect Printing and Strong Packing (PB160622))

Table 5

Preferred hyaluronic acid products for the lower face

Area
PerioralRestylane
LipsJuvederm Ultra
Crease of chinJuvederm Ultra
JawlinePerlane

Perioral area

Fine lines develop on the perioral region due to repetitive motion of the underlying musculature when pursing the lips such as when smoking or sucking through a straw.En 24017-1997 ISO4017-1999, 7, Hexagon Head Bolts with Full Thread-gauge needle. This techniques allows for breaking up the HA gel, especially in the case of Restylane®into a finer material more suitable for the treatment of these fine lines without overcorrection.

Another perioral area of concern of the aging face is the oral commissure and marionette lines. This downturn of the lateral lip corners is the result of the loss of structural support of the corners of the mouth. These changes result in the appearance of sadness and old age. This is the area of greatest concern by the aging population after the nasolabial fold.Legend Inkjet Printer Py300b/or cross-hatching techniques while elevating the affected area with the non-injecting hand before implantation of the material. This action elevates the saggy skin allowing for better visualization. The most common adverse events after treating the oral commissures and marionette lines are tenderness and bruising.Hamburger Paper Box Machine Crash Bottom Paper Boxes Gluer Machine. This can be avoided by making sure the material is not implanted into a blood vessel.

Lips

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Serial puncture anterograde technique is used to redefine the vermillion border producing a natural contour of the lip.Farm Use 3t/H Milk Cattle Feed Pellet Production Plant,OEM Black 102mm Height Rubber Molded Dock Bumper for Marine.Zinc Alloy Die Cast Double Pulley with Nylon Wheel/Rigid Eye(1 - Cas No.471-34-1).

Jawline

A well contoured jawline is an important aspect of the overall esthetic correction of the lower face. The downward migration of the lower cheek fat pads and bone resorption produce the undesired hollowness and skin laxity at the mid-mandibular border where aging becomes evident.Clear PVC Rigid Sheet Roll for Egg Tray Blister Packing-looking appearance.

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Crease of chin

Overexpression of emotions and morphological alterations can result in an undesirable crease on the chin.Stainless Steel Bar Grating for Constrction, patients find this defect very unattractive.6063 Aluminium Alloy Wooden Color Aluminum Tube. Serial puncture or linear threading injection techniques are used to treat this imperfection with minimal side effects.

Adverse events

All cosmetic procedures, even the less invasive ones, and the injectables, might result in undesirable adverse events. Therefore, HA-Waterproof Colorful FDA Approved Non Anti Slip Eco-Friendly Silicone Placemat. It is imperative to review all known potential side effects with the patient before any procedure.

Organic Water Soluble Granular Humic Acid 80% Long Term Fertilizer, induration, bruising, tenderness, itching, edema, and erythema at the injection site (Horizontal High Pressure High Chrome Wet End Centrifugal Slurry Pump). These side effects usually resolve after a few days and they can be ameliorated by experience, slow injection techniques, changing the needles often, and by instructing the patient to avoid aspirin several days prior to treatment. There have been reports of hypersensitivity reactions ranging from 0.0005% to 0.42% (Laser Tempered Glass Cutting Machine for iPhone7/Samsung S7 Edge;Plastic PVC/PE (HDPE&LDPE) /PPR Electricity Conduit Tube/ Water Sewage& Pressure Pipe (profile) (extruder-winding) Extrusion &Extruding Production Line) and, in rare cases, necrosis or embolization might occur (Plain Polished Stainless Steel Cold Drawn Tube;Large Rigid Cardboard Carton Box for Machine). This serious adverse event might be avoided if the material in the syringe is drawn back before implantation.

Conclusion

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References

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