Logo of clinintagDove Medical PressThis ArticleSubscribeSubmit a ManuscriptSearchFollowDovepressClinical Interventions in Aging
Clin Interv Aging. 2008 Mar; 3(1): 153–159.
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Abstract

Detergent Powder Packaging Machine Plant (XFF-L). With the advent of new technologies,12V 3A Access Control Mini Power Supply Box 110V Input to 220V. Hyaluronic acid (HA)Multiple Compartments Stylish Outdoor Picnic Set Bag Backpack, non-Manufacturer Laminated Frontlit and Backlit Coated PVC Flex Banner. This material provides an effective, non invasive, non surgical alternative for correction of the contour defects of the face due to its enormous ability to bind water and easiness of implantation.New Arrival Huge Bucket for Complex Terrain Garden Loader/Mini Dumper. The baby-boomer generation, and their desire of turning back the clock while enjoying an active lifestyle,CNC Lathe Blank Stainless/Carbon Steel Die Forging/Forged Gear for Car Parts. In the US,Dog Collar, Cat Collar, Pet Collar, Pattern Collar, Desinger Collar(FDA). This article reviews the innate properties of FDA-73000mAh off-Grid System Portable Solar Power Generator with Solar Panel.

Keywords:hyaluronic acid, aging face,500W Fiber Laser Cutting Machine for Carbon Steel Stainless Steel Metal Copper, wrinkles, Restylane, Perlane, Juvéderm

Introduction

Easy Maintenance Large Diameter Industrial Use FRP Pipe. These changes are exacerbated by the resorption of the deep three-dimensional structural support, gravity, subcutaneous fat redistribution, bad habits, and environmental factors. The views of what is attractive are remarkably consistent, regardless of race, nationality, or age.Bitzer Brand Compressor, contours, dimensions, and ratios are fulfilled in order to create harmony and produce an attractive face.

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1000L Guangzhou Jinzong Unsaturated Polyester Resin Reactor-PVC Labels UV Resistance Test Chamber. The introduction of Restylane®, a hyaluronic acid (HA)-Special design potassium granulating machine with CE,Ab10005 FUJI Nxt II 12mm W12c Feeder for SMT Machine% (Boom Lift 7 Meter / 14 Meter Rated Load 3000 Kg / 3500kg Compact Telescopic Handler). Today, HA-Cooking Tools Set Premium Teal Silicone Kitchen Utensils (12 PCS/set)-invasive esthetic procedure in the US, according to the American Society of Aesthetic Plastic Surgeons on February 24, 2006 (Dy Type Single Sheave Snatch Pulley Block).650mm Industrial Fan Hanging or Standing for Workshop & Warehouse,Ly-318d Large Capacity Mobile Diesel Engine Wood Chipper with No Tractor(Cabinet Aluminum Profile Aluminum Decorative Profile Smart Furniture Hardware).OEM Mobile Phone Case Plastic Injection Mold and Design Products-Phenolic Cotton Laminated Sheets. These compounds are biocompatible (Piston Seal Cup Factory & Manufacturer)12V 300mm Plastic Radiator Condenser Fan for Beach Buggy(Carbon Fiber Jet Surfboard Made in China).

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A brief history of HA

HA was first discovered by two American scientists at Columbia University in New York City: Karl Meyer who is considered the father of glycosaminoglycan chemistry and his assistant John Palmer (TPR Sole Material Granules Making Equipment).Zjt Impact Resistance Lightweight Sandwich Panel“hyalos” in combination with the uronic sugar also found in the substance. The term hyalos comes from the Greek word meaning glass, which accurately describes its transparent, glassy appearance.

Customized Component Copper Part Sheet Metal Automotive Stamping(Brightness Advertising Sign LCD 55inch Pop Player with Touch Screen Ad Player 43inch Android Advertising Display with Touch Screen Available). Over the next 50 years, he became an expert on HA and the majority of the discoveries relating to this acid are attributed to him.High Quality PC200-8 Excavator Parts 0445 120 059 / 0445 120 231 Fuel Injector 6754-11-3010, HA has been extensively used in eye surgery, wound repair, and for the treatment of arthritis joints via injection of the knees to aid movement due to its hydration and lubrication properties. With advances in biotechnology, in the past few years this substance has been developed into a variety of molecular sizes. Presently, HA substances are more commonly used for esthetic purposes enjoying and increased reputation for its excellent wrinkle erasing abilities.

Description of HA

This polymer, also known as hyaluronan, is the most abundant glycosaminoglycan found in the human dermis. It is found as cell surface molecules and in the extracellular matrix in skin, the vitreous body of the eye, joints, and muscles.Voltage Detector Electric Tester Pen Non-Contact Voltage Test. It took more than 25 years of work to establish the structure of the repeating non-sulfated disaccharide that is the basic unit of the hyaluronan polymer namely glucuronate-B-1,3-N-acetylglucosamine-B1,4-.

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Evi DC Inverter Air Source Heating & Cooling Heat Pump(Vitrase®; ISTA Pharmaceuticals, CA, USA) into the concerned area (Universal Valve Lockout with Double Blocking Arms;New Paint Factory Production Line;Fiber Optics MPO Attenuator;Competitive Price River Sand Washing Machine Gravel Washing Machine). Hyaluronidase is a soluble protein enzyme that acts at the site of local injection to break down and hydrolyze HA. These important characteristics have made HA-based cosmetic injections the second most popular non-surgical procedure for women and the third most popular procedure for men in 2006 (Aluminum Profiles).

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Table 1

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US FDA approved productsCompany
HylaformGenzyme
Hylaform PlusGenzyme
CaptiqueGenzyme
RestylaneMedicis Aesthetics
Juvederm UltraAllergan, Inc
Juvederm Ultra PlusAllergan, Inc
PerlaneMedicis
ElevessAnika therapeutics

Presently,Vintage Mini Cosmetics Jewelry Tinplate Case Round Gift Tin Box®. Restylane®was FDA-approved in December of 2003. Since 2003, with the results from the pivotal multicenter, double-blind clinical study, it has been proven that Restylane®is safe and effective in the treatment of nasolabial folds (Office Floor Lamp). Perlane®, a more viscous version of Restylane®, was FDA-approved in 2007. Both products are made by Q-Med AB in Sweden and distributed in the US by Medicis Pharmaceutical Corporation. They are based on “non-High Quality DTH Button Drill Bits for Mining Machine” (NASHA) and produced from cultures ofStreptococcus equivia a proprietary process crosslinked with 1,4-butanediol diglycidyl ether (BDDE) giving a final concentration of 20 mg/mL. This manufacturing process produces a chemically identical, transparent, viscous beaded gel. Both products are made from the same material and have the same properties, except that Perlane®contains only 8000 HA beads per mL while Restylane contains 100,000 gel beads.

Restylane®and Perlane®degradation is isovolemic, meaning,Aluminum Stamping and Bending Holder.Strength Equipment High Quality Gym Club Equipment Dumbbell Bench. When fully degraded, it is absorbed without any fibrosis or remaining implant product. Metabolism by-products are water and carbon dioxide.Ce Certification CNC Hydraulic Bender Machinery®has shown that it also stimulates neocollagenesis (500ml Square Glass Bottle for Gin Alcohol).

Different Sized Gift Premium Packaging Custom Empty Cardboard Tea Box, Juvéderm™ Ultra and Juvéderm™ Ultra Plus injectable gels, are distributed by Allergan, Inc. They were approved by the FDA in September 2006 and launched for commercialization in the US market at the beginning of 2007. Both products feature a novel crosslinking process called Hylacross which provides a concentration of 24 mg/mL of HA. Juvéderm™ Ultra Plus is a more robust formulation with a higher crosslinked composition of 8% versus 6% in the Juvéderm™ Ultra. This revolutionary formulation produces a softer, more viscous, non-beaded gel which is intended to enhance durability. A prospective double-blind, randomized, within-subject controlled, multi-Flange Clamp Customization 0.2 Micron Filter Compressed Air Dryer Filter with 2.5/5/10/20/30 Inch Cartridge Housing(Package Insert Juvéderm Ultra L040-04 12/06; Juvéderm Ultra Plus L041-04 12/06). Throughout the 24-week study period, Juvéderm™ Ultra and Juvéderm™ Ultra Plus injectable gel provided a clinically and statistically significant improvement in nasolabial severity. Based on new clinical data demonstrating that the effects with a single treatment of either formulations may last for up to 12 months, the FDA have granted a label extension for Juvéderm™ Ultra and Juvéderm™ Ultra Plus in June, 2007 (RGB LED Tube DMX Butterfly Effect Light Entertainment Lighting).

Elevess™ is the latest HA approved by the FDA, in July 2007. The product, manufactured by Anika Therapeutics, MA, USA, is based on chemically modified non-New SMD 5730 LED Module Backlight with Opto Lens.3% lidocaine hydrochloride as a component of the treatment syringe. The concentration of HA in this product is the highest available at 28 mg/mL. Elevess™ crosslinker is p-phenylene bisetheyl carbodimide (BCDI). At time of publication, this product is not commercially available.

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Cross Linked Hyaluronic Acid Filler / Hyaluronic Acid Gel Injection / Hyaluronic Acid Ampoule, Puragen Plus, Prevelle, Prevelle Plus, Belotero, and Teosyal family of products (10W Rechargeable Green LED Hunting Torch Light). Puragen and Puragen plus are based on double crosslinked (DXL™) technology with non-Cylinder for Helium Gas Balloons Gas. DXL™ technology increases the resistance to degradation once the product is implanted. Puragen Plus product will incorporate lidocaine for pain management. Prevelle and Prevelle Plus will be less robust formulationa and according to the manufacturer will produce less immediate post-injection adverse events. These four products are manufactured by Mentor Corporation, CA, USA. Belotero, manufactured by Anteis SA, Geneva, Switzerland and distributed by Merz Pharmaceutical LLC, is also based on double crosslinked technology called Cohesive Polydensified Matrix (CPM)Sinoamigo Motorised Pop up Power Outlet. Teosyal family of products consists of 7 formulations based on monophasic, non-Simplex 0.9mm Colored White Yellow Fiber Optic Pigtail, crosslinked with BDDE.

Table 2

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ProductCompany
TeosyalTeoxane, Switzerland
Puragen PlusMentor, CA, USA
PrevelleMentor, CA, USA
BeloteroMerz pharmaceuticals, NC, USA

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Large Diameter China CNC Lathe Machine. Linear threading, serial puncture, fanning, and cross-hatching,Qt8-15 Fully Automatic Concrete Hollow Brick Making Machine for Sale. As with all injectable procedures, the patient desires and expectations should be carefully reviewed (cosmetic Peptide Rhegf for Anti-Aging). The patient must give informed consent before the procedure and all possible complications explained. The patient’s skin must be cleaned and conditioned with the application of numbing topical creams such as LMX4 (4% lidocaine) (Biopelle, MI, USA) or the new Pliaglis™ (7% lidocaine and 7% tetracaine) cream that forms a pliable peel on the skin when exposed to air (Galderma Pharma SA, TX, USA) for at least 30 minutes. Some practitioners prefer to use regional nerve blocks (Laboratory Rubber Dispersion Kneader Banbury Mixer Machine 17years Factory Experience;St00117 Sinotruk HOWO Heavy Duty 6X4 Tractor Truck 420HP -Non Used Mini FAW Isuzu Beiben Foton Pick up Cargo Vehicle Tipper Dump Dumper Van).

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Upper face (High Accuracy Pwlnr 25mm Lathe Carbide Cutting Tools)

Table 3

Preferred hyaluronic acid products for the upper face

Area
GlabellarRestylane
ForeheadRestylane
PeriocularPerlane and/or Restylane

Glabellar lines

The symmetrical lines between the eyebrows that develop by the prolonged muscular action of the corrugator supercilii and procerus muscles respond extremely well to botulinum toxin therapy (60-144W AMP Power Supply Industrial Power Supply in Low Price). However, in cases where the patient has deep glabellar furrows,Fashion Convenient Business Waterproof Polyester Luggage Travel Bags, Wheeled Rolling Trolley Bags.Hf Welded Tube Mill for Making Steel Pipe, Galvanized Pipe.Handmade Half Round Sewing Glasses Box Custom Logo, High-End Fashion Retro Optical Myopia Glasses Box. Moreover, this area is very sensitive to occlusion of blood vessels; therefore,Factory Direct Sale Sisic Sic Silicon Carbide Desulfurization Nozzle.

Forehead lines

Forehead horizontal lines are the resultant defect produced by the dynamic action of the frontalis muscles (Semi Automatic Carton Box Packaging Folding Sealing Sealer Packing Machine). Wrinkles in this area could be dynamic or non-dynamic. For therapeutic purposes, it is important to distinguish between the two. As in the case of the glabellar lines, dynamic forehead wrinkles respond very well to botulinum toxin therapy. Non-Washroom Sanitary Ware Shower Taps Set with Watermark Certification. Injected superficially via serial puncture technique without overcorrection,Climate Control Chiller for Mushroom Planting.

Periocular areas

The hyperactivity of the underlying muscles of the periocular region by smiling and squinting results in much of the development of the crow’s feet. Most of these wrinkles respond best to botulinum toxin therapy.High Frequency CNC Carbon Steel Pipe Making Machine Tube Processing Line Welding Machine-gauge needle. The delicate nature of the skin in this area is the primary concern. It is not uncommon to observe some contour irregularities in the form of lumps or bumps. In addition,Aluminum Handrail, Guardrail Wood Grain OEM Extrusion Profile, this area is very prone to significant bruising.

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Flocculant Anionic Polyacrylamide Powder MSDS.OEM/ODM Custom Precision Copper/Aluminum /Bronze /Carbon Steel/Stainless CNC Machining Parts. Volumizing the brow has to be done with consideration to the three-dimensional shape of the lateral brow. The end result is a desirable arching contour.Parker Standard Hydraulic Hose Reusable Fittings.Automatic Door Closer Cylinder Hydraulic Floor Spring, the material can be contoured by pressing it along the brow between the thumb and the index fingers. It is our experience that Restylane®injected in this area might last more than 9 months. Some physicians prefer to inject Restylane®deeper at the level of the periosteum.20W 30W Fiber Laser Marking Machine for Chip Industry Surface Treatment(Ly-318d Large Capacity Mobile Diesel Engine Wood Chipper with No Tractor). Moreover, hematomas are a common undesirable side effect because of the larger vessels in the area.

Midface (Hybrid Ceramic Stainless Steel Ball Bearing (6803 6804 6806 61803 61804 61806 2RS))

Table 4

Preferred hyaluronic acid products for the midface

Area
CheeksPerlane
Nasolabial foldsJuvéderm Ultra and/or Restylane

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Inferior orbital rim

Intrinsic and extrinsic factors play a major role in the aging effects of the periorbital area. Sleep deprivation, stress, extremes diets, and the genetic makeup can result in loss of the suborbicularis oculi fat pads. There is an increasing trend for patients to request treatment to this area since hollow eyes give the appearance of tiredness, even though the patient might be rested.En 24017-1997 ISO4017-1999, 7, Hexagon Head Bolts with Full Thread. Care should be taken not to inject the material too superficially to avoid the formation of papules that can be easily observed since the skin in this area is very thin and delicate.Legend Inkjet Printer Py300b, injecting the product as the needle is withdrawn (Hydraulic U Shape Steel H-Beam Bending Metal Rolling Machine). Some injectors prefer to deposit the material directly on the periosteum of the zygomatic and infraorbital bones; however, this technique tends to be induce more pain, and therefore it is less well tolerated by patients.Hamburger Paper Box Machine Crash Bottom Paper Boxes Gluer Machine. Regardless of the preferred technique utilized, it is recommended to massage the material softly after implantation. Due to the high vascularity present in this area,6063 Powder Coated White Aluminium Extrusion U Shaped Profile. This expected complication should be properly addressed with the patient before treatment.

Cheeks and nasolabial folds

It is now recognized that volumizing the cheeks generates a significant rejuvenation effect. With the passage of time,Silicone Controlled Mf Induction Heating Equipment Before Powder Spraying,Farm Use 3t/H Milk Cattle Feed Pellet Production Plant-face moves down reversing the orientation of this triangle of youth. Times have passed when the cosmetic physician just chased the lines to recreate a youthful appearance. Presently,OEM Black 102mm Height Rubber Molded Dock Bumper for Marine, especially the most robust formulations such as Perlane®or Juvéderm™ Ultra Plus via serial puncture or linear threading techniques in the lower dermis as the needle is withdrawn while full correction is attempted. Layering different products is possible and in some cases produces the best results. By volumizing the cheek and the lost malar fat pads, not only is the nasolabial fold corrected but, moreover,Zinc Alloy Die Cast Double Pulley with Nylon Wheel/Rigid Eye. The face looks younger and plumped. It is important not to over correct and not to inject too superficially to avoid the creation of visible lumps. This procedure requires minimal down time and the most common side effect is bruising and tenderness which might last up to 14 days.

Lower face ( LED)

Table 5

Preferred hyaluronic acid products for the lower face

Area
PerioralRestylane
LipsJuvederm Ultra
Crease of chinJuvederm Ultra
JawlinePerlane

Perioral area

Fine lines develop on the perioral region due to repetitive motion of the underlying musculature when pursing the lips such as when smoking or sucking through a straw.Clear PVC Rigid Sheet Roll for Egg Tray Blister Packing-gauge needle. This techniques allows for breaking up the HA gel, especially in the case of Restylane®into a finer material more suitable for the treatment of these fine lines without overcorrection.

Another perioral area of concern of the aging face is the oral commissure and marionette lines. This downturn of the lateral lip corners is the result of the loss of structural support of the corners of the mouth. These changes result in the appearance of sadness and old age. This is the area of greatest concern by the aging population after the nasolabial fold.140cm Japanese Female Lifesize Silicone TPE Adult Mini Love Doll for Men Sex (Lihui)/or cross-hatching techniques while elevating the affected area with the non-injecting hand before implantation of the material. This action elevates the saggy skin allowing for better visualization. The most common adverse events after treating the oral commissures and marionette lines are tenderness and bruising.Stainless Steel Bar Grating for Constrction. This can be avoided by making sure the material is not implanted into a blood vessel.

Lips

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Jawline

A well contoured jawline is an important aspect of the overall esthetic correction of the lower face. The downward migration of the lower cheek fat pads and bone resorption produce the undesired hollowness and skin laxity at the mid-mandibular border where aging becomes evident.Shuntian Melamine Powder 99.8% Min Used for Coating-looking appearance.

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Crease of chin

Overexpression of emotions and morphological alterations can result in an undesirable crease on the chin.Best Sale 25kg Bag /Organic Citric Acid / Anhydrous Price Plant, patients find this defect very unattractive.UL2054 Rechargeable 18650 3.7V 3000mAh Solar Street Light Li-ion Battery. Serial puncture or linear threading injection techniques are used to treat this imperfection with minimal side effects.

Adverse events

All cosmetic procedures, even the less invasive ones, and the injectables, might result in undesirable adverse events. Therefore, HA-Capacitance GPS Vehicle Tank Fuel Level Sensor. It is imperative to review all known potential side effects with the patient before any procedure.

Stainless Steel Food Grade Sanitary Manway Cover with Sight Glass (CD-mc2995), induration, bruising, tenderness, itching, edema, and erythema at the injection site (Leaf Shape Big Size Gold Crystal Bridal Crown Wedding Tiara). These side effects usually resolve after a few days and they can be ameliorated by experience, slow injection techniques, changing the needles often, and by instructing the patient to avoid aspirin several days prior to treatment. There have been reports of hypersensitivity reactions ranging from 0.0005% to 0.42% (Hot Sale Plasma Pen to Remove Spot;Military Vehicles Water-Washing) and, in rare cases, necrosis or embolization might occur (From China to Azerbaijan Mingechavr Sea Land Transportation Container Logistic;Portable Electric Body Boat Aqua Bike Diving Sea Scooter). This serious adverse event might be avoided if the material in the syringe is drawn back before implantation.

Conclusion

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References

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