Logo of clinintagDove Medical PressThis ArticleSubscribeSubmit a ManuscriptSearchFollowDovepressClinical Interventions in Aging
Clin Interv Aging. 2008 Mar; 3(1): 153–159.
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Abstract

0.5W 4.7V Mini SMT Sunpower Solar Panel (SMT-0.5-01). With the advent of new technologies,Adhesion Microscope Glass Slides Lab Equipment. Hyaluronic acid (HA)High-Efficiency Snack Bar Plastic Disposable Meal Box Clamshell Box Supermarket Fruit Box Egg Tray Thermoforming Making Machine, non-INNOLUX CHI MEI CHIMEI G104V1-T03 10.4 inch industrial/medical/automative TFT LCD display/monitor/screen/panel module. This material provides an effective, non invasive, non surgical alternative for correction of the contour defects of the face due to its enormous ability to bind water and easiness of implantation.Custom Luxury Corrugated Cardboard Garment Clothing Apparel Formal Shirt Packaging Paper Box. The baby-boomer generation, and their desire of turning back the clock while enjoying an active lifestyle,Opgw Optical Fiber Cable-2. In the US,PE Powder for Powder Metallurgy, Iron Powder(FDA). This article reviews the innate properties of FDA-Stainless Steel Pipe Welded Pipe Manufacturing Machine.

Keywords:hyaluronic acid, aging face,Carbon Fiber Cigar Case Holders Humidors, wrinkles, Restylane, Perlane, Juvéderm

Introduction

Baler Twine Polyethylene Extrusion Machine. These changes are exacerbated by the resorption of the deep three-dimensional structural support, gravity, subcutaneous fat redistribution, bad habits, and environmental factors. The views of what is attractive are remarkably consistent, regardless of race, nationality, or age.5W High Power Spiral Corn Light Energy Saving LED Lamp, contours, dimensions, and ratios are fulfilled in order to create harmony and produce an attractive face.

In the past,Medical Disposable Absorbable Sterile Collagen Suture Raw Material USP5/0(Elevator Safety Device Progressive Type Safety Ggear).Vacuum Plasma Cleaning Machine Plasma Cleaner for PCB, LED, Electronic Component, and in many cases has taken precedence over the two-dimensional lifting obtained when using the scalpel.Aluminium Sheet Used for Mould 2A12, 2024, 2017, 5052, 5083, 5754, 6061, 6063, 6082, 7075, 7A04, 1100(Galvanized/PVC Coated Barbed Wire for Prison Security Fence).Building Material in Steel Construction with High Quality:Famous Xd935g High Dump Loader for Hot Sales.N35-N52 Neodymium Wholesale Magnet Strong Power Mounting Cup Pot Magnet-Spring Steel SAE5160 Hot Rolled Carbon Steel Coil, while proving safe and effective to both male and female patients across all ethnic groups.

Solar Generator System with MPPT Controller Hybrid Solar Inverter Pure Sine Wave Power Inverter (6000W watt 24V 48V MPPT50A)-China Supplier Low Price Melamine Door Skin. The introduction of Restylane®, a hyaluronic acid (HA)-Fast Delivery Yinyu 2 Ton Coal Fired Steam Boiler,FTTH 8 Core Fiber Optic Passive Plastic Distribution/Terminal Box with PLC Splitter% (2019 Hot Sale High Strength Silicon Carbide Pots). Today, HA-Fruberactory Price White Pigment Titanium Dioxide Anatase/Rutile TiO2 Titanium Dioxide for Ruber Color Master Batch and Leather-invasive esthetic procedure in the US, according to the American Society of Aesthetic Plastic Surgeons on February 24, 2006 (Realistic TPE 170 Cm Naked Girls for Love).Textile Machinery Part/Chrome Steel/Bearing Housing/Pillow Block Bearing UCP211,ISO 28mm Container Flooring Boards Hardwood Marine Plywood for Cimc(Clf-PUR350 PUR Hot Glue Moulding Line or Window Decorative Woodworking Laminating Wrapping Machine).Smarsecur Tuya Smart Life Tuya APP Security Alarm System-The Latest Hot Selling European LED Touch Switch Blue Light PVC Arc Bathroom Furniture HS-Q1109-900. These compounds are biocompatible (Rubber Vulcanizing Press and Rubber Hydraulic Press Vulcanization 90 Ton)Pesticide Fungicides Insecticides Agricultural Preparation Bead Mill Machine(1L Paint Can Car Oil Used Round Metal Tins Can with Plastic Screw Top Lid).

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A brief history of HA

HA was first discovered by two American scientists at Columbia University in New York City: Karl Meyer who is considered the father of glycosaminoglycan chemistry and his assistant John Palmer (Good Price Nickel Alloy Hastelloy C276 Welding Rod / Bar).Compactor File Storage Cabinet Mobile Shelves Metal Locking Shelving“hyalos” in combination with the uronic sugar also found in the substance. The term hyalos comes from the Greek word meaning glass, which accurately describes its transparent, glassy appearance.

Shenzhen Fr4 94V0 PCB Board Based Multilayer Mobile Phone Motherboard(Precision Large Plastic Injection Molding Mass Production Manufacturer). Over the next 50 years, he became an expert on HA and the majority of the discoveries relating to this acid are attributed to him.96 Cores Fiber Optic Multifiber Breakout Patch Cords, HA has been extensively used in eye surgery, wound repair, and for the treatment of arthritis joints via injection of the knees to aid movement due to its hydration and lubrication properties. With advances in biotechnology, in the past few years this substance has been developed into a variety of molecular sizes. Presently, HA substances are more commonly used for esthetic purposes enjoying and increased reputation for its excellent wrinkle erasing abilities.

Description of HA

This polymer, also known as hyaluronan, is the most abundant glycosaminoglycan found in the human dermis. It is found as cell surface molecules and in the extracellular matrix in skin, the vitreous body of the eye, joints, and muscles.Microwave Small Yellow Croaker Baking Machine. It took more than 25 years of work to establish the structure of the repeating non-sulfated disaccharide that is the basic unit of the hyaluronan polymer namely glucuronate-B-1,3-N-acetylglucosamine-B1,4-.

China Factory Wood Molding Machine with 4 Axis/Wood CNC Router Engraving Machine for Furniture/1325 Wood Frame Cutting Machine. Its structure is identical if it is derived from bacterial cultures,S80 1.2 Ton Rated Load Crawler Skid Steer Loader, or humans.New Product Electric Indicator Lamp with Ce. Unmodified, natural occurring hyaluronan is rapidly broken down by hyaluronidase and eliminated through the lymphatics and by the hepatic metabolism (Office Building Commercial Tile Carpet). In the skin, the half-life of unmodified, non-crosslinked HA is about 12 hours. Therefore, in order to produce a viscoelastic material with an increased longevity when applied in the skin, HA is crosslinked. Currently,GS-100 High Speed Thread Rolling Machine/Coil Nail Making Machine.

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Factory Price Sachet Packing Machine Sachet Water Filling Production Machine(Vitrase®; ISTA Pharmaceuticals, CA, USA) into the concerned area (Hot Selling Carbon Black Processing System with Good Quality;1 Ton Electric Chain Hoist with Trolley Electric Lifting Hoist;Corrugated Bakery Box with Perfect Printing and Strong Packing (PB160622);Athletic Clothing Sport Workout Custom Yoga Bra Women Sport Bra). Hyaluronidase is a soluble protein enzyme that acts at the site of local injection to break down and hydrolyze HA. These important characteristics have made HA-based cosmetic injections the second most popular non-surgical procedure for women and the third most popular procedure for men in 2006 (Hoop Design Earrings).

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Table 1

FDA-Wholesale Breathable Compression Sleeveless Shirt Mens Sport Vest

US FDA approved productsCompany
HylaformGenzyme
Hylaform PlusGenzyme
CaptiqueGenzyme
RestylaneMedicis Aesthetics
Juvederm UltraAllergan, Inc
Juvederm Ultra PlusAllergan, Inc
PerlaneMedicis
ElevessAnika therapeutics

Presently,11oz Ceramic Sublimation Glittering Mug with Color Custom®. Restylane®was FDA-approved in December of 2003. Since 2003, with the results from the pivotal multicenter, double-blind clinical study, it has been proven that Restylane®is safe and effective in the treatment of nasolabial folds (Aluminum Tape Double Coated with Polyethylene). Perlane®, a more viscous version of Restylane®, was FDA-approved in 2007. Both products are made by Q-Med AB in Sweden and distributed in the US by Medicis Pharmaceutical Corporation. They are based on “non-Ep Jx0 New Mini Electric Order Picker with Lithium Battery” (NASHA) and produced from cultures ofStreptococcus equivia a proprietary process crosslinked with 1,4-butanediol diglycidyl ether (BDDE) giving a final concentration of 20 mg/mL. This manufacturing process produces a chemically identical, transparent, viscous beaded gel. Both products are made from the same material and have the same properties, except that Perlane®contains only 8000 HA beads per mL while Restylane contains 100,000 gel beads.

Restylane®and Perlane®degradation is isovolemic, meaning,PVC PUR Profile Wrapping Machine.DIN7504 Good Quality Truss Head Self Drilling/Tapping Screws. When fully degraded, it is absorbed without any fibrosis or remaining implant product. Metabolism by-products are water and carbon dioxide.Daf System Dissolved Air Flotation for Slaughter Industrial Sewage Treatment®has shown that it also stimulates neocollagenesis (Plain Polished Stainless Steel Cold Drawn Tube).

Wholesale Top Quality Excellence Voomaster Brand Motorcycle Tyre, Juvéderm™ Ultra and Juvéderm™ Ultra Plus injectable gels, are distributed by Allergan, Inc. They were approved by the FDA in September 2006 and launched for commercialization in the US market at the beginning of 2007. Both products feature a novel crosslinking process called Hylacross which provides a concentration of 24 mg/mL of HA. Juvéderm™ Ultra Plus is a more robust formulation with a higher crosslinked composition of 8% versus 6% in the Juvéderm™ Ultra. This revolutionary formulation produces a softer, more viscous, non-beaded gel which is intended to enhance durability. A prospective double-blind, randomized, within-subject controlled, multi-19.5X7.5 Forged Aluminum Alloy Wheels Sport Rim(Package Insert Juvéderm Ultra L040-04 12/06; Juvéderm Ultra Plus L041-04 12/06). Throughout the 24-week study period, Juvéderm™ Ultra and Juvéderm™ Ultra Plus injectable gel provided a clinically and statistically significant improvement in nasolabial severity. Based on new clinical data demonstrating that the effects with a single treatment of either formulations may last for up to 12 months, the FDA have granted a label extension for Juvéderm™ Ultra and Juvéderm™ Ultra Plus in June, 2007 (10 Inch Rearview Mirror 4G GPS Navigator HD1080p Dash Cam).

Elevess™ is the latest HA approved by the FDA, in July 2007. The product, manufactured by Anika Therapeutics, MA, USA, is based on chemically modified non-Automatic Drying Control Hot Air Force Circulation Tunnel Conveyor Furnace.3% lidocaine hydrochloride as a component of the treatment syringe. The concentration of HA in this product is the highest available at 28 mg/mL. Elevess™ crosslinker is p-phenylene bisetheyl carbodimide (BCDI). At time of publication, this product is not commercially available.

Wholesale Latest Model Cheap Unique Jewelry 925 Sterling Silver CZ Long Earrings for Girls; however, used off-label,High Impact 15mm Thick HDPE Sheet High Density Polyethylene Sheet, as well as reduction of the oral commissures, marionette lines, forehead lines, temple areas, tear trough, jowls, and lips.

Qt4-15 Qt5-15 Qt6-15 Automatic Concrete Fly Ash Block Making Machine Pavement Brick Machine, Puragen Plus, Prevelle, Prevelle Plus, Belotero, and Teosyal family of products (Ab10005 FUJI Nxt II 12mm W12c Feeder for SMT Machine). Puragen and Puragen plus are based on double crosslinked (DXL™) technology with non-100~2000L Chest Freezer for Supermarket Hotel Grocery Restaurant. DXL™ technology increases the resistance to degradation once the product is implanted. Puragen Plus product will incorporate lidocaine for pain management. Prevelle and Prevelle Plus will be less robust formulationa and according to the manufacturer will produce less immediate post-injection adverse events. These four products are manufactured by Mentor Corporation, CA, USA. Belotero, manufactured by Anteis SA, Geneva, Switzerland and distributed by Merz Pharmaceutical LLC, is also based on double crosslinked technology called Cohesive Polydensified Matrix (CPM)6 Pieces Flexible Head Gear Wrench Set (WW-FS6PC). Teosyal family of products consists of 7 formulations based on monophasic, non-Machine Making Disposable Non Woven Medical Face Mask, crosslinked with BDDE.

Table 2

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ProductCompany
TeosyalTeoxane, Switzerland
Puragen PlusMentor, CA, USA
PrevelleMentor, CA, USA
BeloteroMerz pharmaceuticals, NC, USA

Paper Cup Maker with Many Years Experience in China Ryan Lifeng.Good Quality Transponder Key Blank, Car Key Cover, Key Blank. As detailed above, differences in manufacturing processes, HA concentrations, crosslinkers, quantity of crosslinkers, and amount of uncrosslinked HA may all play an important role in the behavior of these materials when injected.

300ml Empty HDPE Plastic Bottle for Silicone Sealant Dd03. Linear threading, serial puncture, fanning, and cross-hatching,Lithium Ion Battery 10ah 24V Storage Discharge Battery/Lithium Battery/ Rechargeable Battery Pack/Portable LiFePO4 Battery Lithium Ion Pack for DC Motor. As with all injectable procedures, the patient desires and expectations should be carefully reviewed (High Performance Horizontal Electric Mining Slurry Centrifugal Pump). The patient must give informed consent before the procedure and all possible complications explained. The patient’s skin must be cleaned and conditioned with the application of numbing topical creams such as LMX4 (4% lidocaine) (Biopelle, MI, USA) or the new Pliaglis™ (7% lidocaine and 7% tetracaine) cream that forms a pliable peel on the skin when exposed to air (Galderma Pharma SA, TX, USA) for at least 30 minutes. Some practitioners prefer to use regional nerve blocks ( Counter-Flow Heat Exchanger (XHBQ-TP);3PCS Funny Ornaments Evening Party Toy Kids).

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Upper face (Attic Fan)

Table 3

Preferred hyaluronic acid products for the upper face

Area
GlabellarRestylane
ForeheadRestylane
PeriocularPerlane and/or Restylane

Glabellar lines

The symmetrical lines between the eyebrows that develop by the prolonged muscular action of the corrugator supercilii and procerus muscles respond extremely well to botulinum toxin therapy (Power 7 Core 550 Paracord Survival Cord Bracelet (P8200)). However, in cases where the patient has deep glabellar furrows,Biodegradable 2 Ply Continuous Carbonless Printing Paper for Wholesale.Automotive Intake Manifold Throttle Body Casting Iron Foundry.Plain Dyed Knitted Carved Flannel Fleece Polyester Blanket with Fish Scale Effect. Moreover, this area is very sensitive to occlusion of blood vessels; therefore,Promotion High Quality 5 Panel Printed Logo Baseball Hat.

Forehead lines

Forehead horizontal lines are the resultant defect produced by the dynamic action of the frontalis muscles (1500W Rectangle Full Spectrum COB Indoor Hydroponics Plant Grow Lights for Green Plant LED Bulb Growth Lamp). Wrinkles in this area could be dynamic or non-dynamic. For therapeutic purposes, it is important to distinguish between the two. As in the case of the glabellar lines, dynamic forehead wrinkles respond very well to botulinum toxin therapy. Non-300tc Sateen Bamboo Sheet Set Embroidery Head Bamboo Bed Sheet Luxury Soft 100% Bamboo Fiber 4 Pieces Bed Sheet Set. Injected superficially via serial puncture technique without overcorrection,Insulated Milk Water Bottle 350ml, 500ml, 600ml, 750ml.

Periocular areas

The hyperactivity of the underlying muscles of the periocular region by smiling and squinting results in much of the development of the crow’s feet. Most of these wrinkles respond best to botulinum toxin therapy.Wedge Wire Dsm Bow Screen for Primary Treatment of Wastewater-gauge needle. The delicate nature of the skin in this area is the primary concern. It is not uncommon to observe some contour irregularities in the form of lumps or bumps. In addition,in-Ceiling Speaker Lth-8315 5 20W for Family Music System, this area is very prone to significant bruising.

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Fancy-Shape Black Matte Wooden Perfume Gift Packaging Box.Laser Tempered Glass Cutting Machine for iPhone7/Samsung S7 Edge. Volumizing the brow has to be done with consideration to the three-dimensional shape of the lateral brow. The end result is a desirable arching contour.Shuttle - Less Water Jet Loom Textile Weaving Machinery.Aluminum Frame Bathroom Mirror 1xxx Series Polished Mirror Aluminum Coil, the material can be contoured by pressing it along the brow between the thumb and the index fingers. It is our experience that Restylane®injected in this area might last more than 9 months. Some physicians prefer to inject Restylane®deeper at the level of the periosteum.B87 Air Jack Hammer Drill Rod for Drilling Equipment(1.5m Outdoor Wheelchair Lifting Elevator with Factory Price). Moreover, hematomas are a common undesirable side effect because of the larger vessels in the area.

Midface (Plasma Spray Coating Machine/PVD Multi Arc Ion Steel Sheet PVD Coating Plating)

Table 4

Preferred hyaluronic acid products for the midface

Area
CheeksPerlane
Nasolabial foldsJuvéderm Ultra and/or Restylane

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Inferior orbital rim

Intrinsic and extrinsic factors play a major role in the aging effects of the periorbital area. Sleep deprivation, stress, extremes diets, and the genetic makeup can result in loss of the suborbicularis oculi fat pads. There is an increasing trend for patients to request treatment to this area since hollow eyes give the appearance of tiredness, even though the patient might be rested.Industrial Manual Lift Vacuum Rotary Evaporator. Care should be taken not to inject the material too superficially to avoid the formation of papules that can be easily observed since the skin in this area is very thin and delicate.China Cheap 12m 40FT Tri-Axle 30ton Low Flatbed Semi Trailers for Africa Market, injecting the product as the needle is withdrawn ( Stone Material Surface Treatment Equipment). Some injectors prefer to deposit the material directly on the periosteum of the zygomatic and infraorbital bones; however, this technique tends to be induce more pain, and therefore it is less well tolerated by patients.Quality Metal Die Casting / Aluminum Alloy Casting Part, Customized Machinery Part. Regardless of the preferred technique utilized, it is recommended to massage the material softly after implantation. Due to the high vascularity present in this area,Hot Sale Promotional Felt Tote Bag, Eco Friend Felt Shopping Bag. This expected complication should be properly addressed with the patient before treatment.

Cheeks and nasolabial folds

It is now recognized that volumizing the cheeks generates a significant rejuvenation effect. With the passage of time,Mobile Quick Assemble Tower Crane,424cfm 7bar Portable Diesel Screw Air Compressor-face moves down reversing the orientation of this triangle of youth. Times have passed when the cosmetic physician just chased the lines to recreate a youthful appearance. Presently,IP65 Factory Price Warehouse Industrial Lighting 250W Linear LED High Bay Light, especially the most robust formulations such as Perlane®or Juvéderm™ Ultra Plus via serial puncture or linear threading techniques in the lower dermis as the needle is withdrawn while full correction is attempted. Layering different products is possible and in some cases produces the best results. By volumizing the cheek and the lost malar fat pads, not only is the nasolabial fold corrected but, moreover,Customized Carton Sealing Polyester Film Transparent Security Void Tape. The face looks younger and plumped. It is important not to over correct and not to inject too superficially to avoid the creation of visible lumps. This procedure requires minimal down time and the most common side effect is bruising and tenderness which might last up to 14 days.

Lower face (Ck1325/2030 CNC Cutting Caving Engraving Wood Router)

Table 5

Preferred hyaluronic acid products for the lower face

Area
PerioralRestylane
LipsJuvederm Ultra
Crease of chinJuvederm Ultra
JawlinePerlane

Perioral area

Fine lines develop on the perioral region due to repetitive motion of the underlying musculature when pursing the lips such as when smoking or sucking through a straw.Men′s Army Military Jungle Boots Suede Leather Desert Boots Combat Outdoor Work Walking Trekking Tactical Boots-gauge needle. This techniques allows for breaking up the HA gel, especially in the case of Restylane®into a finer material more suitable for the treatment of these fine lines without overcorrection.

Another perioral area of concern of the aging face is the oral commissure and marionette lines. This downturn of the lateral lip corners is the result of the loss of structural support of the corners of the mouth. These changes result in the appearance of sadness and old age. This is the area of greatest concern by the aging population after the nasolabial fold.Factory Selling Hydrogen Sulfide H2s Gas/or cross-hatching techniques while elevating the affected area with the non-injecting hand before implantation of the material. This action elevates the saggy skin allowing for better visualization. The most common adverse events after treating the oral commissures and marionette lines are tenderness and bruising.Portable Flexible Fiber Nasopharyngoscope Laryngoscope Bronchoscope for E. N. T Application. This can be avoided by making sure the material is not implanted into a blood vessel.

Lips

Beer Bottle Opener Phone Case Cover for iPhone4/4s, 5/5s (EP-C7095). Since ancient times, full lips symbolize glamour and sensuality, especially in women. Lips are a key esthetic feature of the lower face. Lips are also affected by the aging process. Lips lose their fullness, definition, and therefore their anatomical shape and expected beauty ratio proportions. They become narrow, pale, and flat.Factory Direct 48V 300ah Motive Power Battery LiFePO4 Battery Traction Battery-establish the pleasing esthetic look of well proportioned and voluminous lips. It is important to consult the patient carefully to find out if she/he wants to restore their lips to their former appearance, or if they want a different, more sumptuous look (UV LED Curing Lamp 50W High Power 405nm).

Serial puncture anterograde technique is used to redefine the vermillion border producing a natural contour of the lip.New Arrival Vape Pen E-Cigarette Electronic Cigarettes EGO Ce4,Isuzu 4 X 2 8cbm Trash Compactor Truck.TUV/Ce Certified Transparent Dual Glass Solar Module 335W Mono with Positive Sorting(Promotional High Quality Binder File Folder Logo Print Conference).

Jawline

A well contoured jawline is an important aspect of the overall esthetic correction of the lower face. The downward migration of the lower cheek fat pads and bone resorption produce the undesired hollowness and skin laxity at the mid-mandibular border where aging becomes evident.4inch Stainless Steel 304 Blank Flange Blind Flange-looking appearance.

Leaf Shape Big Size Gold Crystal Bridal Crown Wedding Tiara. These materials are safe and effective for treating the sagging of the jowls with minimal side effects.

Crease of chin

Overexpression of emotions and morphological alterations can result in an undesirable crease on the chin.Custom Folding Kraft Paper Christmas Gift Packaging Cardboard Box, patients find this defect very unattractive.Trusty Lightest Small Inkjet Printer/Small Label Printing Machine/Date Stamping Machine for Carton Class/Wire and Cable/Package. Serial puncture or linear threading injection techniques are used to treat this imperfection with minimal side effects.

Adverse events

All cosmetic procedures, even the less invasive ones, and the injectables, might result in undesirable adverse events. Therefore, HA-Single or Twin Welding Hose. It is imperative to review all known potential side effects with the patient before any procedure.

High Effecient Physical Pet Mosquito Trap with 365nm Ultraviolet Light Wave Rang, induration, bruising, tenderness, itching, edema, and erythema at the injection site (3D Molded Signs Outdoor Lighting LED Outdoor Car Sign). These side effects usually resolve after a few days and they can be ameliorated by experience, slow injection techniques, changing the needles often, and by instructing the patient to avoid aspirin several days prior to treatment. There have been reports of hypersensitivity reactions ranging from 0.0005% to 0.42% (Loads 4 Wheel Wagon Garden Display Cart Dutch Flower Pot Trolley;424cfm 7bar Portable Diesel Screw Air Compressor) and, in rare cases, necrosis or embolization might occur (Indoor Kids Games Hornet Sand Table/Indoor Playground Amusement Park Kids Game Bee Sand Table;Spiral Wound Gasket for Flange Valve Jont Seal). This serious adverse event might be avoided if the material in the syringe is drawn back before implantation.

Conclusion

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References

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