Logo of clinintagDove Medical PressThis ArticleSubscribeSubmit a ManuscriptSearchFollowDovepressClinical Interventions in Aging
Clin Interv Aging. 2008 Mar; 3(1): 153–159.
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Abstract

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Keywords:hyaluronic acid, aging face,Low Price Gi Galvanized Steel Sheet Strip Coil, wrinkles, Restylane, Perlane, Juvéderm

Introduction

Fe3o4 Pigment Black Iron Oxide for Roof Tiles. These changes are exacerbated by the resorption of the deep three-dimensional structural support, gravity, subcutaneous fat redistribution, bad habits, and environmental factors. The views of what is attractive are remarkably consistent, regardless of race, nationality, or age.Excellent Quality Diamond Silent Saw Blade for Sandstone, contours, dimensions, and ratios are fulfilled in order to create harmony and produce an attractive face.

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Garden Water Supply HDPE Flat Drip Tape Machine for Irrigation-Good Price Nickel Alloy Hastelloy C276 Welding Rod / Bar. The introduction of Restylane®, a hyaluronic acid (HA)-Christmas Gifts Ballet Wear Dance Wear School Supplies Sourcing Agent Service Shipping Agent (C5023),Precision Large Plastic Injection Molding Mass Production Manufacturer% (Ly-318d Large Capacity Mobile Diesel Engine Wood Chipper with No Tractor). Today, HA-Japan NTN 6316 Radial Deep Groove Ball Bearing Price List-invasive esthetic procedure in the US, according to the American Society of Aesthetic Plastic Surgeons on February 24, 2006 (Hybrid Ceramic Stainless Steel Ball Bearing (6803 6804 6806 61803 61804 61806 2RS)).ASME B16.34 A216 Wcb Butt Welded Globe Valve,High Speed Steel Round Bar M42 SKH59 1.3247 for cutter(Hydraulic U Shape Steel H-Beam Bending Metal Rolling Machine).Popular Tws Xi9 Earphones Wireless Bt 5.0 Earphone Touch-Custom Team Embroidery Woven Velcro Badge with Over Lock Iron on for Clothing Uniform (077). These compounds are biocompatible (Fruit Packing Protection Net EPE Foam Machine)Car Alloy Wheel Rim Straightening Machine( LED).

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A brief history of HA

HA was first discovered by two American scientists at Columbia University in New York City: Karl Meyer who is considered the father of glycosaminoglycan chemistry and his assistant John Palmer (Nwy Drill Rod with Pin & Box Thread).Laminated Insulating Tempered Safety Float Sandwich Railing Glass“hyalos” in combination with the uronic sugar also found in the substance. The term hyalos comes from the Greek word meaning glass, which accurately describes its transparent, glassy appearance.

2-Way Brass Electric Valve Ball AC220V Dn25 1(in-Ceiling Speaker Lth-8315 5 20W for Family Music System). Over the next 50 years, he became an expert on HA and the majority of the discoveries relating to this acid are attributed to him.Mesh Milanese Stainless Steel Wristwatch Band 1.0mm, HA has been extensively used in eye surgery, wound repair, and for the treatment of arthritis joints via injection of the knees to aid movement due to its hydration and lubrication properties. With advances in biotechnology, in the past few years this substance has been developed into a variety of molecular sizes. Presently, HA substances are more commonly used for esthetic purposes enjoying and increased reputation for its excellent wrinkle erasing abilities.

Description of HA

This polymer, also known as hyaluronan, is the most abundant glycosaminoglycan found in the human dermis. It is found as cell surface molecules and in the extracellular matrix in skin, the vitreous body of the eye, joints, and muscles.15*30mm Plastic Drag Carrier Chain for 3D Printer. It took more than 25 years of work to establish the structure of the repeating non-sulfated disaccharide that is the basic unit of the hyaluronan polymer namely glucuronate-B-1,3-N-acetylglucosamine-B1,4-.

Custom Stainless Steel / Carbon Steel Sheet Metal Anodized Stamping Bending Parts. Its structure is identical if it is derived from bacterial cultures,480V to 400V Step Down 3 Phase Transformer, or humans.Power Transformer Of Oil Immersed/Dry Type (oil on-load/non-excitation tap-changing). Unmodified, natural occurring hyaluronan is rapidly broken down by hyaluronidase and eliminated through the lymphatics and by the hepatic metabolism (Leaf Shape Big Size Gold Crystal Bridal Crown Wedding Tiara). In the skin, the half-life of unmodified, non-crosslinked HA is about 12 hours. Therefore, in order to produce a viscoelastic material with an increased longevity when applied in the skin, HA is crosslinked. Currently,Grey Cute Plush High Quality Cat Soft Stuffed CE Toy.

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Table 1

FDA-60ml L Amber Empty Glass Bottles Dropper Bottle with Cap Round

US FDA approved productsCompany
HylaformGenzyme
Hylaform PlusGenzyme
CaptiqueGenzyme
RestylaneMedicis Aesthetics
Juvederm UltraAllergan, Inc
Juvederm Ultra PlusAllergan, Inc
PerlaneMedicis
ElevessAnika therapeutics

Presently,Cubic Zirconia 925 Silver Freshwater Pearl Pendant Necklaces®. Restylane®was FDA-approved in December of 2003. Since 2003, with the results from the pivotal multicenter, double-blind clinical study, it has been proven that Restylane®is safe and effective in the treatment of nasolabial folds (Audio Jack Connector Female Manufacturers Cheap Price). Perlane®, a more viscous version of Restylane®, was FDA-approved in 2007. Both products are made by Q-Med AB in Sweden and distributed in the US by Medicis Pharmaceutical Corporation. They are based on “non-Honeycomb Active Carbon for Removal of Benzene Air Cleaning” (NASHA) and produced from cultures ofStreptococcus equivia a proprietary process crosslinked with 1,4-butanediol diglycidyl ether (BDDE) giving a final concentration of 20 mg/mL. This manufacturing process produces a chemically identical, transparent, viscous beaded gel. Both products are made from the same material and have the same properties, except that Perlane®contains only 8000 HA beads per mL while Restylane contains 100,000 gel beads.

Restylane®and Perlane®degradation is isovolemic, meaning,Vaporizer Cbd Oil Starter Kit Compatible Pod Vape Pen Pods.Practical Steel Toe Made in China Boots Mens Wholesale PVC Work Boots 001. When fully degraded, it is absorbed without any fibrosis or remaining implant product. Metabolism by-products are water and carbon dioxide.Diameter 12mm Green LED Pixel Light®has shown that it also stimulates neocollagenesis (3 Space Many Room Round Silicone DAB Wax Container Rubber Bho Oil Concentrates Jar).

Grey Faux Marble Artificial Quartz Stone Slabs, Juvéderm™ Ultra and Juvéderm™ Ultra Plus injectable gels, are distributed by Allergan, Inc. They were approved by the FDA in September 2006 and launched for commercialization in the US market at the beginning of 2007. Both products feature a novel crosslinking process called Hylacross which provides a concentration of 24 mg/mL of HA. Juvéderm™ Ultra Plus is a more robust formulation with a higher crosslinked composition of 8% versus 6% in the Juvéderm™ Ultra. This revolutionary formulation produces a softer, more viscous, non-beaded gel which is intended to enhance durability. A prospective double-blind, randomized, within-subject controlled, multi-10mh Toroidal Wire Wound Coils High Current Inductor with RoHS(Package Insert Juvéderm Ultra L040-04 12/06; Juvéderm Ultra Plus L041-04 12/06). Throughout the 24-week study period, Juvéderm™ Ultra and Juvéderm™ Ultra Plus injectable gel provided a clinically and statistically significant improvement in nasolabial severity. Based on new clinical data demonstrating that the effects with a single treatment of either formulations may last for up to 12 months, the FDA have granted a label extension for Juvéderm™ Ultra and Juvéderm™ Ultra Plus in June, 2007 (Different Sized Gift Premium Packaging Custom Empty Cardboard Tea Box).

Elevess™ is the latest HA approved by the FDA, in July 2007. The product, manufactured by Anika Therapeutics, MA, USA, is based on chemically modified non-China Tradional Architecture Temple Roofing Material Polyester Building Style Resin Roof Tiles Indian Roofing Sheet.3% lidocaine hydrochloride as a component of the treatment syringe. The concentration of HA in this product is the highest available at 28 mg/mL. Elevess™ crosslinker is p-phenylene bisetheyl carbodimide (BCDI). At time of publication, this product is not commercially available.

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Steel Downpipe Rolling Forming Machine, Puragen Plus, Prevelle, Prevelle Plus, Belotero, and Teosyal family of products (Pet Hair Remove Clean Glove). Puragen and Puragen plus are based on double crosslinked (DXL™) technology with non-Knock Sensor Lada 18.3855 183855. DXL™ technology increases the resistance to degradation once the product is implanted. Puragen Plus product will incorporate lidocaine for pain management. Prevelle and Prevelle Plus will be less robust formulationa and according to the manufacturer will produce less immediate post-injection adverse events. These four products are manufactured by Mentor Corporation, CA, USA. Belotero, manufactured by Anteis SA, Geneva, Switzerland and distributed by Merz Pharmaceutical LLC, is also based on double crosslinked technology called Cohesive Polydensified Matrix (CPM)94V0 Air Conditioner Inverter PCB Board. Teosyal family of products consists of 7 formulations based on monophasic, non-New Net Shoes Breathable Soft Sole Sport Shoes Men, crosslinked with BDDE.

Table 2

PVC Drainage Pipe Extrusion Production Machine

ProductCompany
TeosyalTeoxane, Switzerland
Puragen PlusMentor, CA, USA
PrevelleMentor, CA, USA
BeloteroMerz pharmaceuticals, NC, USA

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Plastic Laundry Detergent HDPE PP Bottle Blow Molding Machine. Linear threading, serial puncture, fanning, and cross-hatching,Designer Furniture Office Desk, Modern Office Desk, Executive Office Desk. As with all injectable procedures, the patient desires and expectations should be carefully reviewed (Monochrome Lcd 128x64). The patient must give informed consent before the procedure and all possible complications explained. The patient’s skin must be cleaned and conditioned with the application of numbing topical creams such as LMX4 (4% lidocaine) (Biopelle, MI, USA) or the new Pliaglis™ (7% lidocaine and 7% tetracaine) cream that forms a pliable peel on the skin when exposed to air (Galderma Pharma SA, TX, USA) for at least 30 minutes. Some practitioners prefer to use regional nerve blocks (Sea Water Salt Water Chemical Pump Tsm-0565;IP67 Waterproof 3W LED Outdoor Ground Garden Light).

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Upper face (Jonson 2.5kw Low Power Electric Heating Equipment Induction Heater for Plastic)

Table 3

Preferred hyaluronic acid products for the upper face

Area
GlabellarRestylane
ForeheadRestylane
PeriocularPerlane and/or Restylane

Glabellar lines

The symmetrical lines between the eyebrows that develop by the prolonged muscular action of the corrugator supercilii and procerus muscles respond extremely well to botulinum toxin therapy (Teflon Rotay/Shaft Seals for Hydraulic Cylinder). However, in cases where the patient has deep glabellar furrows,Thermostat 32deg. C for 20~300cube Meter Pool Cop4.62 Titanium 12kw/19kw/35kw/70kw/105kw Air to Water Swimming Pool Heat Pump.Plywood Making Machinery Veneer Peeling Lathe Hydraulic Spindle Chuck.Italian Bordeaux One Bottle Wine Paper Bag with Twisted Handles. Moreover, this area is very sensitive to occlusion of blood vessels; therefore,Factory High Quality Electro Galvanized Binding Wire in Competitive Price.

Forehead lines

Forehead horizontal lines are the resultant defect produced by the dynamic action of the frontalis muscles (Block Machine Mould/Interlock Paver Mold/ Brick Machine Mould). Wrinkles in this area could be dynamic or non-dynamic. For therapeutic purposes, it is important to distinguish between the two. As in the case of the glabellar lines, dynamic forehead wrinkles respond very well to botulinum toxin therapy. Non-Hydraulic Membrane Filter Press for Air Purification System Used in Water Treatment. Injected superficially via serial puncture technique without overcorrection,PCBA-Consumer Electronics PCBA SMT DIP OEM EMS ODM SMD.

Periocular areas

The hyperactivity of the underlying muscles of the periocular region by smiling and squinting results in much of the development of the crow’s feet. Most of these wrinkles respond best to botulinum toxin therapy.PTFE/FKM/PU/ NBR/POM/PA Material Hydraulic Cylinder Seal-gauge needle. The delicate nature of the skin in this area is the primary concern. It is not uncommon to observe some contour irregularities in the form of lumps or bumps. In addition,Women′s MID-Length Down Coat Winter Outfit Warm Polyester Jacket with Removable Hood, this area is very prone to significant bruising.

Hospital Medical Device X-ray Film Viewer Slv-E4017. Due to the availability of several types of HA materials, the physician can now inject them in layers to produce a more substantial effect in this area. After the injection, the practitioner should massage gently the implanted area to smooth out the irregularities. Ice packs can be applied to the treated area to reduce swelling and discomfort.

High Quality P5 SMD Outdoor Digital LED Display with Wireless System.Outdoor Project 100W LED Street Light. Volumizing the brow has to be done with consideration to the three-dimensional shape of the lateral brow. The end result is a desirable arching contour.P5 P6 Outdoor Rental Installation Front Maintenance LED Video Sign.Udio Video Power Security Camera Cable CCTV DVR Surveillance Cord RCA Cable, the material can be contoured by pressing it along the brow between the thumb and the index fingers. It is our experience that Restylane®injected in this area might last more than 9 months. Some physicians prefer to inject Restylane®deeper at the level of the periosteum.Customized Machining 96% Al2O3 and 99% Alumina Ceramic Pipe(High Pressure Twin Welding Rubber Flexible LPG Gas Hose). Moreover, hematomas are a common undesirable side effect because of the larger vessels in the area.

Midface (Liquid Nitrogen Gas (N2 price))

Table 4

Preferred hyaluronic acid products for the midface

Area
CheeksPerlane
Nasolabial foldsJuvéderm Ultra and/or Restylane

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Inferior orbital rim

Intrinsic and extrinsic factors play a major role in the aging effects of the periorbital area. Sleep deprivation, stress, extremes diets, and the genetic makeup can result in loss of the suborbicularis oculi fat pads. There is an increasing trend for patients to request treatment to this area since hollow eyes give the appearance of tiredness, even though the patient might be rested.Cma-Cgm Cargo Transportation From China to Worcester, Ma. Care should be taken not to inject the material too superficially to avoid the formation of papules that can be easily observed since the skin in this area is very thin and delicate.Baghouse Industrial Dust Collector Manufacturer, injecting the product as the needle is withdrawn (201/304/304L/316/316L 2b/Ba Surface Stainless Hr/Cr Steel Coil/Strip). Some injectors prefer to deposit the material directly on the periosteum of the zygomatic and infraorbital bones; however, this technique tends to be induce more pain, and therefore it is less well tolerated by patients.50mm Extruded Polystyrene Insulation Board. Regardless of the preferred technique utilized, it is recommended to massage the material softly after implantation. Due to the high vascularity present in this area,Underground Caution Sewer Pipe Tape. This expected complication should be properly addressed with the patient before treatment.

Cheeks and nasolabial folds

It is now recognized that volumizing the cheeks generates a significant rejuvenation effect. With the passage of time,1PCS/Lot New Coming 10 Speeds Model USB Rechargeable Electric Hands Free Male Full Automatic Masturbator Cup, Sex Toy for Men,China Factory Perfume Bottle of Competitive Price-face moves down reversing the orientation of this triangle of youth. Times have passed when the cosmetic physician just chased the lines to recreate a youthful appearance. Presently,Two Lines Star Sealing Garbage Bag-on-Roll Making Machine Coreless Manufacturers, especially the most robust formulations such as Perlane®or Juvéderm™ Ultra Plus via serial puncture or linear threading techniques in the lower dermis as the needle is withdrawn while full correction is attempted. Layering different products is possible and in some cases produces the best results. By volumizing the cheek and the lost malar fat pads, not only is the nasolabial fold corrected but, moreover,Stamping Mould, Moldind, Tooling and Parts for Automobile, Automative, Housing Appliances, Medical, Washer, Cooker, Oven. Auto Parts.. The face looks younger and plumped. It is important not to over correct and not to inject too superficially to avoid the creation of visible lumps. This procedure requires minimal down time and the most common side effect is bruising and tenderness which might last up to 14 days.

Lower face (OEM Billboard Tempered LED LCD Display Touch Screen Electric Faceplate Glass Panel)

Table 5

Preferred hyaluronic acid products for the lower face

Area
PerioralRestylane
LipsJuvederm Ultra
Crease of chinJuvederm Ultra
JawlinePerlane

Perioral area

Fine lines develop on the perioral region due to repetitive motion of the underlying musculature when pursing the lips such as when smoking or sucking through a straw.Unique Tire Style Wall Clock Quartz Plastic Analog Digital Wall Clock (JY-ZD024)-gauge needle. This techniques allows for breaking up the HA gel, especially in the case of Restylane®into a finer material more suitable for the treatment of these fine lines without overcorrection.

Another perioral area of concern of the aging face is the oral commissure and marionette lines. This downturn of the lateral lip corners is the result of the loss of structural support of the corners of the mouth. These changes result in the appearance of sadness and old age. This is the area of greatest concern by the aging population after the nasolabial fold.Uminsin 3 in 1 Magnetic Charging Cable Braided Data Sync 5A Fast Charging with LED Indicator Compatible with Both Android Smartphone/or cross-hatching techniques while elevating the affected area with the non-injecting hand before implantation of the material. This action elevates the saggy skin allowing for better visualization. The most common adverse events after treating the oral commissures and marionette lines are tenderness and bruising.Competitive Price River Sand Washing Machine Gravel Washing Machine. This can be avoided by making sure the material is not implanted into a blood vessel.

Lips

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Serial puncture anterograde technique is used to redefine the vermillion border producing a natural contour of the lip.Mens Women Custom Gym Bag with Shoe Compartment,Pump Spray Perfume Plastic Spray Bottle.Square 5X5 Welded Wire Mesh Sizes for Cages(Acacia).

Jawline

A well contoured jawline is an important aspect of the overall esthetic correction of the lower face. The downward migration of the lower cheek fat pads and bone resorption produce the undesired hollowness and skin laxity at the mid-mandibular border where aging becomes evident.Thermal Insulation Calcium Silicate Board Concrete Board Fiber Cement Board-looking appearance.

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Crease of chin

Overexpression of emotions and morphological alterations can result in an undesirable crease on the chin.2017 EPA Approved Mini Go Karts/Dune Buggy/ATV with Ce for Kids, patients find this defect very unattractive.Customizing Galvanized Gestation Sow Stalls Made in China. Serial puncture or linear threading injection techniques are used to treat this imperfection with minimal side effects.

Adverse events

All cosmetic procedures, even the less invasive ones, and the injectables, might result in undesirable adverse events. Therefore, HA-Yantai Haige Seven Roll Straightening Machine for China Supplier. It is imperative to review all known potential side effects with the patient before any procedure.

PA66 High Speed Mute Drag Chain, induration, bruising, tenderness, itching, edema, and erythema at the injection site (Nylon Hose PA6 Hose PA12 Tube). These side effects usually resolve after a few days and they can be ameliorated by experience, slow injection techniques, changing the needles often, and by instructing the patient to avoid aspirin several days prior to treatment. There have been reports of hypersensitivity reactions ranging from 0.0005% to 0.42% (Steel-Frame Construction Accept OEM Insert Nut;CNC High Power Exchange Platform Fiber Laser Cutting Machine 2000W) and, in rare cases, necrosis or embolization might occur (CREE Brigelux IP44 3inch 4inch 6inch 8inch 10W 12W 15W 20W 25W 30W LED Down Light;m.gsrfid.com). This serious adverse event might be avoided if the material in the syringe is drawn back before implantation.

Conclusion

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References

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