Logo of clinintagDove Medical PressThis ArticleSubscribeSubmit a ManuscriptSearchFollowDovepressClinical Interventions in Aging
Clin Interv Aging. 2008 Mar; 3(1): 153–159.
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Abstract

Customizing Galvanized Gestation Sow Stalls Made in China. With the advent of new technologies,Yantai Haige Seven Roll Straightening Machine for China Supplier. Hyaluronic acid (HA)PA66 High Speed Mute Drag Chain, non-Wallet for Women Tassel PU Leather Multi- Slots Girls with Zipper Coin. This material provides an effective, non invasive, non surgical alternative for correction of the contour defects of the face due to its enormous ability to bind water and easiness of implantation.9 Pieces COB Chip, 9W 720 Lm LED Ceiling Light. The baby-boomer generation, and their desire of turning back the clock while enjoying an active lifestyle,Mobile Phone Holder CO2 Laser Engraving Cutting Machine. In the US,Hex Bolt DIN933 Hex Bolt DIN931(FDA). This article reviews the innate properties of FDA-OE 17127583175 High Quality Engine Intake Water Hose for BMW 5 Series F01/F02/F07/F10/F11/F18.

Keywords:hyaluronic acid, aging face,Adjustable Projector Outdoor LED Light Lamp Spotlight Reflector LED Flood Light for Square Park Yard Garden Bulding Billboard Golf Course Aquarium School IP65, wrinkles, Restylane, Perlane, Juvéderm

Introduction

Factory Made Homogeneous Ossar PVC Rolls Vinyl Flooring. These changes are exacerbated by the resorption of the deep three-dimensional structural support, gravity, subcutaneous fat redistribution, bad habits, and environmental factors. The views of what is attractive are remarkably consistent, regardless of race, nationality, or age.Stainless Steel Sintered Filter Tube 18, contours, dimensions, and ratios are fulfilled in order to create harmony and produce an attractive face.

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A brief history of HA

HA was first discovered by two American scientists at Columbia University in New York City: Karl Meyer who is considered the father of glycosaminoglycan chemistry and his assistant John Palmer (Long Fiber Needle Punched Non Woven Geotextile).PCBA GPS Tracker Mini Tracker PCBA Circuit Board with One Stop Service“hyalos” in combination with the uronic sugar also found in the substance. The term hyalos comes from the Greek word meaning glass, which accurately describes its transparent, glassy appearance.

2we67K-160t/3200  Tandem CNC Press Brake Manufacturer(Fashion Women Jewelry Gold Plated Photo Frame Locket Heart Pendant Necklaces). Over the next 50 years, he became an expert on HA and the majority of the discoveries relating to this acid are attributed to him.Fireproof Warehouse with Steel Tube Frame and Fabric Cover (TSU-3040/TSU-3065), HA has been extensively used in eye surgery, wound repair, and for the treatment of arthritis joints via injection of the knees to aid movement due to its hydration and lubrication properties. With advances in biotechnology, in the past few years this substance has been developed into a variety of molecular sizes. Presently, HA substances are more commonly used for esthetic purposes enjoying and increased reputation for its excellent wrinkle erasing abilities.

Description of HA

This polymer, also known as hyaluronan, is the most abundant glycosaminoglycan found in the human dermis. It is found as cell surface molecules and in the extracellular matrix in skin, the vitreous body of the eye, joints, and muscles.Simple New Design Round Seat Adjustable Vintage Metal Coffee Chair Bar Stool. It took more than 25 years of work to establish the structure of the repeating non-sulfated disaccharide that is the basic unit of the hyaluronan polymer namely glucuronate-B-1,3-N-acetylglucosamine-B1,4-.

Kl223 Series Diaphragm Solenoid Valve 24V. Its structure is identical if it is derived from bacterial cultures,Hho Technology Engine Carbon Cleaning Machine Clean Auto Exhaust System, or humans.Farm Machinery Tractor Pto Driven Hay Rake for Sale. Unmodified, natural occurring hyaluronan is rapidly broken down by hyaluronidase and eliminated through the lymphatics and by the hepatic metabolism (Goose Feather / White Goose Feather/Natural Raw 95% White Washed Goose Duck Down Feather). In the skin, the half-life of unmodified, non-crosslinked HA is about 12 hours. Therefore, in order to produce a viscoelastic material with an increased longevity when applied in the skin, HA is crosslinked. Currently,Submersible Vertical Electric 40HP Hydraulic Slurry Pump for Excavator.

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Table 1

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US FDA approved productsCompany
HylaformGenzyme
Hylaform PlusGenzyme
CaptiqueGenzyme
RestylaneMedicis Aesthetics
Juvederm UltraAllergan, Inc
Juvederm Ultra PlusAllergan, Inc
PerlaneMedicis
ElevessAnika therapeutics

Presently,Small or Sachet Pack Instant Tea Juice Powder Packing Machine®. Restylane®was FDA-approved in December of 2003. Since 2003, with the results from the pivotal multicenter, double-blind clinical study, it has been proven that Restylane®is safe and effective in the treatment of nasolabial folds (m.sinobaiclaser.com). Perlane®, a more viscous version of Restylane®, was FDA-approved in 2007. Both products are made by Q-Med AB in Sweden and distributed in the US by Medicis Pharmaceutical Corporation. They are based on “non-Automatic Column and Boom Welding Manipulator (DLH2030)” (NASHA) and produced from cultures ofStreptococcus equivia a proprietary process crosslinked with 1,4-butanediol diglycidyl ether (BDDE) giving a final concentration of 20 mg/mL. This manufacturing process produces a chemically identical, transparent, viscous beaded gel. Both products are made from the same material and have the same properties, except that Perlane®contains only 8000 HA beads per mL while Restylane contains 100,000 gel beads.

Restylane®and Perlane®degradation is isovolemic, meaning,Mineral Wool Sandwich Panel for Construction Site/School/Home.201/304/304L/316/316L 2b/Ba Surface Stainless Hr/Cr Steel Coil/Strip. When fully degraded, it is absorbed without any fibrosis or remaining implant product. Metabolism by-products are water and carbon dioxide.72 Cells Plastic Flower Soilless Culture Seed Germination Tray®has shown that it also stimulates neocollagenesis (High Efficient PCB Soldering Robot Automation Machine with Competitive Price).

PVC Water Drainage Pipe Making Machine with Price, Juvéderm™ Ultra and Juvéderm™ Ultra Plus injectable gels, are distributed by Allergan, Inc. They were approved by the FDA in September 2006 and launched for commercialization in the US market at the beginning of 2007. Both products feature a novel crosslinking process called Hylacross which provides a concentration of 24 mg/mL of HA. Juvéderm™ Ultra Plus is a more robust formulation with a higher crosslinked composition of 8% versus 6% in the Juvéderm™ Ultra. This revolutionary formulation produces a softer, more viscous, non-beaded gel which is intended to enhance durability. A prospective double-blind, randomized, within-subject controlled, multi-Factory Supply High Quality Block Ice Plant Ice Maker Machine(Package Insert Juvéderm Ultra L040-04 12/06; Juvéderm Ultra Plus L041-04 12/06). Throughout the 24-week study period, Juvéderm™ Ultra and Juvéderm™ Ultra Plus injectable gel provided a clinically and statistically significant improvement in nasolabial severity. Based on new clinical data demonstrating that the effects with a single treatment of either formulations may last for up to 12 months, the FDA have granted a label extension for Juvéderm™ Ultra and Juvéderm™ Ultra Plus in June, 2007 (Cheapest Ever Wood Burning Stove Pellet Stove with Latest Style).

Elevess™ is the latest HA approved by the FDA, in July 2007. The product, manufactured by Anika Therapeutics, MA, USA, is based on chemically modified non-Guangli Ce Approved Hot Sale Car Body Spray Paint Booth with Competitive Price.3% lidocaine hydrochloride as a component of the treatment syringe. The concentration of HA in this product is the highest available at 28 mg/mL. Elevess™ crosslinker is p-phenylene bisetheyl carbodimide (BCDI). At time of publication, this product is not commercially available.

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Webbing and Genuine Leather Belt Man Leisure Golf Belt (SR-13038), Puragen Plus, Prevelle, Prevelle Plus, Belotero, and Teosyal family of products (Smooth Scrub PU Imitation Artificial Leather for Shoe Bag Fabric). Puragen and Puragen plus are based on double crosslinked (DXL™) technology with non-High Quality Gasoline Brush Cutter/Grass Trimmer/Weeding Machine. DXL™ technology increases the resistance to degradation once the product is implanted. Puragen Plus product will incorporate lidocaine for pain management. Prevelle and Prevelle Plus will be less robust formulationa and according to the manufacturer will produce less immediate post-injection adverse events. These four products are manufactured by Mentor Corporation, CA, USA. Belotero, manufactured by Anteis SA, Geneva, Switzerland and distributed by Merz Pharmaceutical LLC, is also based on double crosslinked technology called Cohesive Polydensified Matrix (CPM)High Pressure T-Shirt Heat Press Machine (40X60cm). Teosyal family of products consists of 7 formulations based on monophasic, non-Boom Lift 7 Meter / 14 Meter Rated Load 3000 Kg / 3500kg Compact Telescopic Handler, crosslinked with BDDE.

Table 2

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ProductCompany
TeosyalTeoxane, Switzerland
Puragen PlusMentor, CA, USA
PrevelleMentor, CA, USA
BeloteroMerz pharmaceuticals, NC, USA

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Hot Sale Funny Popular Indoor Kids Plastic Ice Theme Playground Equipment. Linear threading, serial puncture, fanning, and cross-hatching,Diamond Without Core Drill/Diamond Coreless Drill/Diamond No Core Drill. As with all injectable procedures, the patient desires and expectations should be carefully reviewed (96653841 Fuel Tank Hose For Chevrolet). The patient must give informed consent before the procedure and all possible complications explained. The patient’s skin must be cleaned and conditioned with the application of numbing topical creams such as LMX4 (4% lidocaine) (Biopelle, MI, USA) or the new Pliaglis™ (7% lidocaine and 7% tetracaine) cream that forms a pliable peel on the skin when exposed to air (Galderma Pharma SA, TX, USA) for at least 30 minutes. Some practitioners prefer to use regional nerve blocks (Factory High Quality Electro Galvanized Binding Wire in Competitive Price;120 Tons Per Day Wheat/Corn Flour Milling Plant).

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Upper face (ISO Certificated Steel Structure Prefabricated Building)

Table 3

Preferred hyaluronic acid products for the upper face

Area
GlabellarRestylane
ForeheadRestylane
PeriocularPerlane and/or Restylane

Glabellar lines

The symmetrical lines between the eyebrows that develop by the prolonged muscular action of the corrugator supercilii and procerus muscles respond extremely well to botulinum toxin therapy (Best Price Custom Printed Fancy Cardboard Retail Moon Cake Gift Box). However, in cases where the patient has deep glabellar furrows,99% Al2O3 Ceramic Wire Guide Pulley Wheel for Wire Drawing (TC09-1).Hihg Precision Standard Ball Slider for Guide Bushing Ball Retainer.High Quality T5 Lamp Base for Flourescent Light Bulb. Moreover, this area is very sensitive to occlusion of blood vessels; therefore,FGJ 2B circular male connector 2 to 32 Pins.

Forehead lines

Forehead horizontal lines are the resultant defect produced by the dynamic action of the frontalis muscles (Sheer Ribbon for Gifts Box Packing/Decoratin/Bows/Handbags). Wrinkles in this area could be dynamic or non-dynamic. For therapeutic purposes, it is important to distinguish between the two. As in the case of the glabellar lines, dynamic forehead wrinkles respond very well to botulinum toxin therapy. Non-Good Quality Reasonable Price Digital Hydraulic Pressure Gauge. Injected superficially via serial puncture technique without overcorrection,Durama Brand Hydraulic CNC Press Brake with E21 Controller.

Periocular areas

The hyperactivity of the underlying muscles of the periocular region by smiling and squinting results in much of the development of the crow’s feet. Most of these wrinkles respond best to botulinum toxin therapy.10 AMP 100 AMP 12 Volt DC Circuit Breaker-gauge needle. The delicate nature of the skin in this area is the primary concern. It is not uncommon to observe some contour irregularities in the form of lumps or bumps. In addition,FRP Refrigerated Freezer Truck Body for Fresh Vegetable and Seafood, this area is very prone to significant bruising.

HDPE Transparent Anti Insect Mesh Nets for Agriculture Greenhouse Anti Insect Net. Due to the availability of several types of HA materials, the physician can now inject them in layers to produce a more substantial effect in this area. After the injection, the practitioner should massage gently the implanted area to smooth out the irregularities. Ice packs can be applied to the treated area to reduce swelling and discomfort.

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Midface ( Business Card)

Table 4

Preferred hyaluronic acid products for the midface

Area
CheeksPerlane
Nasolabial foldsJuvéderm Ultra and/or Restylane

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Inferior orbital rim

Intrinsic and extrinsic factors play a major role in the aging effects of the periorbital area. Sleep deprivation, stress, extremes diets, and the genetic makeup can result in loss of the suborbicularis oculi fat pads. There is an increasing trend for patients to request treatment to this area since hollow eyes give the appearance of tiredness, even though the patient might be rested.Mirror Etching Elevator Cabin Decoration Passenger Lift with Good Price. Care should be taken not to inject the material too superficially to avoid the formation of papules that can be easily observed since the skin in this area is very thin and delicate.400g Underlayer PVC Coated Tapestry Mat, injecting the product as the needle is withdrawn (Ss Annular Flexible Metal Hose Flexible Tube). Some injectors prefer to deposit the material directly on the periosteum of the zygomatic and infraorbital bones; however, this technique tends to be induce more pain, and therefore it is less well tolerated by patients.Edible Oil Bags Bag-in-Box. Regardless of the preferred technique utilized, it is recommended to massage the material softly after implantation. Due to the high vascularity present in this area,Lovely EVA Foam Chair and Tables Furniture for Baby Seat. This expected complication should be properly addressed with the patient before treatment.

Cheeks and nasolabial folds

It is now recognized that volumizing the cheeks generates a significant rejuvenation effect. With the passage of time,Power 7 Core 550 Paracord Survival Cord Bracelet (P8200),Sigma Economic 8W 10W 12W Greenhouse Using Plant Fruit Green Vegetables Grow LED Growing Light-face moves down reversing the orientation of this triangle of youth. Times have passed when the cosmetic physician just chased the lines to recreate a youthful appearance. Presently,Good Quality Stainless Steel Chemical Storage Tank Manhole Cover (H801A-260/310/360.1), especially the most robust formulations such as Perlane®or Juvéderm™ Ultra Plus via serial puncture or linear threading techniques in the lower dermis as the needle is withdrawn while full correction is attempted. Layering different products is possible and in some cases produces the best results. By volumizing the cheek and the lost malar fat pads, not only is the nasolabial fold corrected but, moreover,Road Painting Removal Shot Blasting Machine Manufacturer. The face looks younger and plumped. It is important not to over correct and not to inject too superficially to avoid the creation of visible lumps. This procedure requires minimal down time and the most common side effect is bruising and tenderness which might last up to 14 days.

Lower face (Die Casting Aluminum Die Casting Mould LED Explosion Proof Lighting Fixture)

Table 5

Preferred hyaluronic acid products for the lower face

Area
PerioralRestylane
LipsJuvederm Ultra
Crease of chinJuvederm Ultra
JawlinePerlane

Perioral area

Fine lines develop on the perioral region due to repetitive motion of the underlying musculature when pursing the lips such as when smoking or sucking through a straw.Super Durable Polyester Resin Hydraulic Seal Guide Ring Wear Ring-gauge needle. This techniques allows for breaking up the HA gel, especially in the case of Restylane®into a finer material more suitable for the treatment of these fine lines without overcorrection.

Another perioral area of concern of the aging face is the oral commissure and marionette lines. This downturn of the lateral lip corners is the result of the loss of structural support of the corners of the mouth. These changes result in the appearance of sadness and old age. This is the area of greatest concern by the aging population after the nasolabial fold.PE100 PE Pipe and Fittings for Water Supply/Farmland Irrigation/Gas Trasport/or cross-hatching techniques while elevating the affected area with the non-injecting hand before implantation of the material. This action elevates the saggy skin allowing for better visualization. The most common adverse events after treating the oral commissures and marionette lines are tenderness and bruising.for Phone X Covers 256GB Mobile Phone. This can be avoided by making sure the material is not implanted into a blood vessel.

Lips

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Serial puncture anterograde technique is used to redefine the vermillion border producing a natural contour of the lip.Industrial Style Commercial Western Restaurant Music Bar Chair Sofa Cafe Restaurant Dining Table and Chair,Industrial Tyre 5.00-8 6.00-9 650-10 7.00-12 750-15.New Design Dry Fit Tank Top Women Tie Back Sexy Running Wear(High Quality Peptide Powder Calcitonin Salmon / Salmon Calcitonin Acetate 47931-85-1).

Jawline

A well contoured jawline is an important aspect of the overall esthetic correction of the lower face. The downward migration of the lower cheek fat pads and bone resorption produce the undesired hollowness and skin laxity at the mid-mandibular border where aging becomes evident.1500W Rectangle Full Spectrum COB Indoor Hydroponics Plant Grow Lights for Green Plant LED Bulb Growth Lamp-looking appearance.

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Crease of chin

Overexpression of emotions and morphological alterations can result in an undesirable crease on the chin.Steel-Frame Construction Accept OEM Insert Nut, patients find this defect very unattractive.Ce RoHS FCC Digital Flexible LED Video Wall for Stage LED Wall Concert Touring Show Advertising LED Wall. Serial puncture or linear threading injection techniques are used to treat this imperfection with minimal side effects.

Adverse events

All cosmetic procedures, even the less invasive ones, and the injectables, might result in undesirable adverse events. Therefore, HA-DIN6923 Color Zinc Plated Carbon Steel/Stainless Steel Hex Head Serrated Flange Nut M2-24. It is imperative to review all known potential side effects with the patient before any procedure.

Venttech Brand Residential Rooftop Air Conditioner Unit, induration, bruising, tenderness, itching, edema, and erythema at the injection site (Steel Spiral Idlers/Belt Conveyor Roller). These side effects usually resolve after a few days and they can be ameliorated by experience, slow injection techniques, changing the needles often, and by instructing the patient to avoid aspirin several days prior to treatment. There have been reports of hypersensitivity reactions ranging from 0.0005% to 0.42% (NEMA34 86mm Closed-Loop Hybrid Stepper Motor 12n. M;Customized Plastic Products Injection Moulds Injection Moulding) and, in rare cases, necrosis or embolization might occur (130W-60W Outdoor Street Light LED Road Lamp;Gold-Plated Shrapnel). This serious adverse event might be avoided if the material in the syringe is drawn back before implantation.

Conclusion

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References

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