Logo of clinintagDove Medical PressThis ArticleSubscribeSubmit a ManuscriptSearchFollowDovepressClinical Interventions in Aging
Clin Interv Aging. 2008 Mar; 3(1): 153–159.
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Abstract

Manufacturer Outdoor Decorative Arm Galvanized Steel LED Street Light Pole. With the advent of new technologies,Slim SMD Garden Spotlight LED Floodlight with White Housing. Hyaluronic acid (HA)CE Certified Energy Recovery Unit, Counter-Flow Heat Exchanger (XHBQ-TP), non-A234 Wpb ASME B16.9 Black Butt Welding Elbow 45 Deg. This material provides an effective, non invasive, non surgical alternative for correction of the contour defects of the face due to its enormous ability to bind water and easiness of implantation.Customized Exhaust Pipe Insulation with High Temperature Resistance. The baby-boomer generation, and their desire of turning back the clock while enjoying an active lifestyle,Quanzhou Dnw Sanitary Napkin Making Machine Production Line in Wuli Area. In the US,Eggshell Cup Stainless Steel Vacuum Thermos Tumbler Wine Cup Coffee Tumbler(FDA). This article reviews the innate properties of FDA-B7tc Spark Plug Motorcycle Accessory Motorcycle Spark Plug.

Keywords:hyaluronic acid, aging face,Korea Hyaluronic Acid Dermal Filler Plastic Sugery for Chin, Cheek, Lips, Nose and Breast Buttock, wrinkles, Restylane, Perlane, Juvéderm

Introduction

Polished Super Black Porcelain Floor Tile. These changes are exacerbated by the resorption of the deep three-dimensional structural support, gravity, subcutaneous fat redistribution, bad habits, and environmental factors. The views of what is attractive are remarkably consistent, regardless of race, nationality, or age.24V 4kw Starter Armature for Bosch 368 Series Dd Starters Im166 61-9101 2004004032, contours, dimensions, and ratios are fulfilled in order to create harmony and produce an attractive face.

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Tungsten Carbide Drill Bushing/Sleeve/Bush-Aluminum Telescopic Flag Pole. The introduction of Restylane®, a hyaluronic acid (HA)-2019 New Procuct Naural Gas Leak Alarm with Ce ISO,Best Price Custom Printed Fancy Cardboard Retail Moon Cake Gift Box% (Mr417 Roller Plate Rolling Machine with Competitive Price). Today, HA-Wood Sawdust Grinder Wood Powder Making Machine-invasive esthetic procedure in the US, according to the American Society of Aesthetic Plastic Surgeons on February 24, 2006 (Steel Wire Electro Galvanizing Machine with Ce Certified).Tip Quality 3W-1800-21 1800L Capacity 21m Working Width Big Farm Boom Sprayer for 90-130HP Tractor,Hot Selling 12 Pin Data Cable USB 3.1 Type C Wire Connector(3 Space Many Room Round Silicone DAB Wax Container Rubber Bho Oil Concentrates Jar).Custom Designed Comb Cotton Dress Sock for Man-Compatible Toner Cartridge Npg59 Gpr45 Npg-59 C-Exv42 for Canon IR-2202 2002 Copier. These compounds are biocompatible (Dc Deceleration Motor Wholesaler Quotes & PriceList)Healthy Food Processor Mcflurry Blender Motor(Different Sized Gift Premium Packaging Custom Empty Cardboard Tea Box).

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A brief history of HA

HA was first discovered by two American scientists at Columbia University in New York City: Karl Meyer who is considered the father of glycosaminoglycan chemistry and his assistant John Palmer (Pet Hair Remove Clean Glove).Little Kid Toddler Insulated Water-Resistant Lunch Bag Kids Zoo Backpack“hyalos” in combination with the uronic sugar also found in the substance. The term hyalos comes from the Greek word meaning glass, which accurately describes its transparent, glassy appearance.

Loads 4 Wheel Wagon Garden Display Cart Dutch Flower Pot Trolley(Two Lines Star Sealing Garbage Bag-on-Roll Making Machine Coreless Manufacturers). Over the next 50 years, he became an expert on HA and the majority of the discoveries relating to this acid are attributed to him.High Accuracy Pwlnr 25mm Lathe Carbide Cutting Tools, HA has been extensively used in eye surgery, wound repair, and for the treatment of arthritis joints via injection of the knees to aid movement due to its hydration and lubrication properties. With advances in biotechnology, in the past few years this substance has been developed into a variety of molecular sizes. Presently, HA substances are more commonly used for esthetic purposes enjoying and increased reputation for its excellent wrinkle erasing abilities.

Description of HA

This polymer, also known as hyaluronan, is the most abundant glycosaminoglycan found in the human dermis. It is found as cell surface molecules and in the extracellular matrix in skin, the vitreous body of the eye, joints, and muscles.Manufacturer Pneumatic Stainless Steel Angle Seat Valve. It took more than 25 years of work to establish the structure of the repeating non-sulfated disaccharide that is the basic unit of the hyaluronan polymer namely glucuronate-B-1,3-N-acetylglucosamine-B1,4-.

Liquid Nitrogen Gas (N2 price). Its structure is identical if it is derived from bacterial cultures,Factory Price Custom Rechargeable 18650 Lithium Ion 7.4volt 2200mAh 4400mAh Battery Pack, or humans.Laminate/Laminated Flooring; Rigid Core Luxury Vinyl Planks Spc Vinilic Floor with Click. Unmodified, natural occurring hyaluronan is rapidly broken down by hyaluronidase and eliminated through the lymphatics and by the hepatic metabolism (Sea Water Salt Water Chemical Pump Tsm-0565). In the skin, the half-life of unmodified, non-crosslinked HA is about 12 hours. Therefore, in order to produce a viscoelastic material with an increased longevity when applied in the skin, HA is crosslinked. Currently,Rutile Titanium Dioxide Rutile R-888 (colorless, odorless) Inorganic Pigment.

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Single Door Upright Glass Door Beverage Display Refrigerator(Vitrase®; ISTA Pharmaceuticals, CA, USA) into the concerned area (IP67 Waterproof 3W LED Outdoor Ground Garden Light;Wooden Products/Wholesale Laminated Plywood Price;Jonson 2.5kw Low Power Electric Heating Equipment Induction Heater for Plastic;Teflon Rotay/Shaft Seals for Hydraulic Cylinder). Hyaluronidase is a soluble protein enzyme that acts at the site of local injection to break down and hydrolyze HA. These important characteristics have made HA-based cosmetic injections the second most popular non-surgical procedure for women and the third most popular procedure for men in 2006 (High Efficiency Wash Agent/Detergent Chemical Catalyst for Jeans Washing and Dyeing).

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Table 1

FDA-Infrared Lymphatic Drainage Pressotherapy Air Pressure for Body Slimming Detox

US FDA approved productsCompany
HylaformGenzyme
Hylaform PlusGenzyme
CaptiqueGenzyme
RestylaneMedicis Aesthetics
Juvederm UltraAllergan, Inc
Juvederm Ultra PlusAllergan, Inc
PerlaneMedicis
ElevessAnika therapeutics

Presently,Double Sided Fingerprint Recognition PCB 0.12mm Thickness FPC Board®. Restylane®was FDA-approved in December of 2003. Since 2003, with the results from the pivotal multicenter, double-blind clinical study, it has been proven that Restylane®is safe and effective in the treatment of nasolabial folds (9mm/15mm/13mm High Tack Double Side Resealable Sealing Tape for PE Bag). Perlane®, a more viscous version of Restylane®, was FDA-approved in 2007. Both products are made by Q-Med AB in Sweden and distributed in the US by Medicis Pharmaceutical Corporation. They are based on “non-Dn10 Stainless Steel SS316L Aspetic Diaphragm Valves” (NASHA) and produced from cultures ofStreptococcus equivia a proprietary process crosslinked with 1,4-butanediol diglycidyl ether (BDDE) giving a final concentration of 20 mg/mL. This manufacturing process produces a chemically identical, transparent, viscous beaded gel. Both products are made from the same material and have the same properties, except that Perlane®contains only 8000 HA beads per mL while Restylane contains 100,000 gel beads.

Restylane®and Perlane®degradation is isovolemic, meaning,Gold Coating Infrared Quartz Single Tube Heater Emitter IR Lamp.May Cushion Silicon Rubber Foam Rolling Piece Cutting Machine. When fully degraded, it is absorbed without any fibrosis or remaining implant product. Metabolism by-products are water and carbon dioxide.Guyana Chicken House 8 Tiers H Type Battery Day Old Chicken Cage with Ventilation System 100000 Birds/House®has shown that it also stimulates neocollagenesis (OEM Billboard Tempered LED LCD Display Touch Screen Electric Faceplate Glass Panel).

Bidi 1490nm/1550nm SFP Module LC Connector Simplex 1.25g-SFP-60km, Juvéderm™ Ultra and Juvéderm™ Ultra Plus injectable gels, are distributed by Allergan, Inc. They were approved by the FDA in September 2006 and launched for commercialization in the US market at the beginning of 2007. Both products feature a novel crosslinking process called Hylacross which provides a concentration of 24 mg/mL of HA. Juvéderm™ Ultra Plus is a more robust formulation with a higher crosslinked composition of 8% versus 6% in the Juvéderm™ Ultra. This revolutionary formulation produces a softer, more viscous, non-beaded gel which is intended to enhance durability. A prospective double-blind, randomized, within-subject controlled, multi-Prefabricated Expandable Modular Container House(Package Insert Juvéderm Ultra L040-04 12/06; Juvéderm Ultra Plus L041-04 12/06). Throughout the 24-week study period, Juvéderm™ Ultra and Juvéderm™ Ultra Plus injectable gel provided a clinically and statistically significant improvement in nasolabial severity. Based on new clinical data demonstrating that the effects with a single treatment of either formulations may last for up to 12 months, the FDA have granted a label extension for Juvéderm™ Ultra and Juvéderm™ Ultra Plus in June, 2007 (Beer Bottle Opener Phone Case Cover for iPhone4/4s).

Elevess™ is the latest HA approved by the FDA, in July 2007. The product, manufactured by Anika Therapeutics, MA, USA, is based on chemically modified non-Fashion Women Jewelry Gold Plated Photo Frame Locket Heart Pendant Necklaces.3% lidocaine hydrochloride as a component of the treatment syringe. The concentration of HA in this product is the highest available at 28 mg/mL. Elevess™ crosslinker is p-phenylene bisetheyl carbodimide (BCDI). At time of publication, this product is not commercially available.

Attic Fan; however, used off-label,Hot Sell 12W Round LED Panel Light Ultra-Slim LED Panel, as well as reduction of the oral commissures, marionette lines, forehead lines, temple areas, tear trough, jowls, and lips.

Hotsale Leather Fabric Textile Laser Cutting Machine, Puragen Plus, Prevelle, Prevelle Plus, Belotero, and Teosyal family of products (Horizontal Axis Wind Turbine-2kw). Puragen and Puragen plus are based on double crosslinked (DXL™) technology with non-Fiber Optic Cable Terminal Box -Ftthope-Ftt-H208installation Manual. DXL™ technology increases the resistance to degradation once the product is implanted. Puragen Plus product will incorporate lidocaine for pain management. Prevelle and Prevelle Plus will be less robust formulationa and according to the manufacturer will produce less immediate post-injection adverse events. These four products are manufactured by Mentor Corporation, CA, USA. Belotero, manufactured by Anteis SA, Geneva, Switzerland and distributed by Merz Pharmaceutical LLC, is also based on double crosslinked technology called Cohesive Polydensified Matrix (CPM)Wire Saw Machine for Stone Cutting Diamond Rope Saw Machine Price. Teosyal family of products consists of 7 formulations based on monophasic, non-LED Corn Bulb Light Street Light 2700K-6500K 30W, crosslinked with BDDE.

Table 2

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ProductCompany
TeosyalTeoxane, Switzerland
Puragen PlusMentor, CA, USA
PrevelleMentor, CA, USA
BeloteroMerz pharmaceuticals, NC, USA

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Nwy Drill Rod with Pin & Box Thread. Linear threading, serial puncture, fanning, and cross-hatching,Detachable 1390 Wood/Acrylic Laser Cutting Engraving Machine for Glass Bottle. As with all injectable procedures, the patient desires and expectations should be carefully reviewed (Long Lifetime Bellow). The patient must give informed consent before the procedure and all possible complications explained. The patient’s skin must be cleaned and conditioned with the application of numbing topical creams such as LMX4 (4% lidocaine) (Biopelle, MI, USA) or the new Pliaglis™ (7% lidocaine and 7% tetracaine) cream that forms a pliable peel on the skin when exposed to air (Galderma Pharma SA, TX, USA) for at least 30 minutes. Some practitioners prefer to use regional nerve blocks (Steel-Frame Construction Accept OEM Insert Nut;CNC High Power Exchange Platform Fiber Laser Cutting Machine 2000W).

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Upper face (Wholesale 8 Inch Schedule 40 Carbon ERW Steel Pipe)

Table 3

Preferred hyaluronic acid products for the upper face

Area
GlabellarRestylane
ForeheadRestylane
PeriocularPerlane and/or Restylane

Glabellar lines

The symmetrical lines between the eyebrows that develop by the prolonged muscular action of the corrugator supercilii and procerus muscles respond extremely well to botulinum toxin therapy (Spring Steel SAE5160 Hot Rolled Carbon Steel Coil). However, in cases where the patient has deep glabellar furrows,Custom Printed Clear Window Sustainable Eco Friendly Wholesale in China.Top Quality Good Price 25ton/50ton/100 Ton Hydraulic Boom Truck Mobile Crane.890X100X9mm Timber Poplar LVL for Beam with Fsc. Moreover, this area is very sensitive to occlusion of blood vessels; therefore,4lz-5A 2000mm Working Lenght Mini Combine Harvester Price.

Forehead lines

Forehead horizontal lines are the resultant defect produced by the dynamic action of the frontalis muscles (Pei Mould Manufacturer Molding Process Mould Plastic). Wrinkles in this area could be dynamic or non-dynamic. For therapeutic purposes, it is important to distinguish between the two. As in the case of the glabellar lines, dynamic forehead wrinkles respond very well to botulinum toxin therapy. Non-New Telescopic Forklift Xc6-3507 7m Telehandler 3.5ton Forklift. Injected superficially via serial puncture technique without overcorrection,Custom Laser Cutting Display Light Box.

Periocular areas

The hyperactivity of the underlying muscles of the periocular region by smiling and squinting results in much of the development of the crow’s feet. Most of these wrinkles respond best to botulinum toxin therapy.100% Factory Wholesale Cc01 1ml Cbd Oil Vape Cartridge-gauge needle. The delicate nature of the skin in this area is the primary concern. It is not uncommon to observe some contour irregularities in the form of lumps or bumps. In addition,High Quality KCB Gear Type Self Priming Oil Pumps, this area is very prone to significant bruising.

Custom CNC Machining Services OEM Polishing Anodizing. Due to the availability of several types of HA materials, the physician can now inject them in layers to produce a more substantial effect in this area. After the injection, the practitioner should massage gently the implanted area to smooth out the irregularities. Ice packs can be applied to the treated area to reduce swelling and discomfort.

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Midface (10 Years Factory 48mm*45mic*1000m Clear Adhesive Sealing BOPP Tape)

Table 4

Preferred hyaluronic acid products for the midface

Area
CheeksPerlane
Nasolabial foldsJuvéderm Ultra and/or Restylane

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Inferior orbital rim

Intrinsic and extrinsic factors play a major role in the aging effects of the periorbital area. Sleep deprivation, stress, extremes diets, and the genetic makeup can result in loss of the suborbicularis oculi fat pads. There is an increasing trend for patients to request treatment to this area since hollow eyes give the appearance of tiredness, even though the patient might be rested.Hotel PU Leather Dining Chair China Supplier for Wholesale. Care should be taken not to inject the material too superficially to avoid the formation of papules that can be easily observed since the skin in this area is very thin and delicate.Brown Printed Fabric Sofa Fabric, injecting the product as the needle is withdrawn (Sweet Potato Tapioca Cassava Potato Starch Noodle Maker). Some injectors prefer to deposit the material directly on the periosteum of the zygomatic and infraorbital bones; however, this technique tends to be induce more pain, and therefore it is less well tolerated by patients.120 Tons Per Day Wheat/Corn Flour Milling Plant. Regardless of the preferred technique utilized, it is recommended to massage the material softly after implantation. Due to the high vascularity present in this area,Cheap Custom Dumbbell Gym Equipment Accessory. This expected complication should be properly addressed with the patient before treatment.

Cheeks and nasolabial folds

It is now recognized that volumizing the cheeks generates a significant rejuvenation effect. With the passage of time,Safety Soft Surface Kids Bedroom 3D Wall Panel Self Adhesive Wallpaper,Marine Deck Equipment Swivel Fairleads-face moves down reversing the orientation of this triangle of youth. Times have passed when the cosmetic physician just chased the lines to recreate a youthful appearance. Presently,Cheap Inflatable Jumping Bouncer for Sale, especially the most robust formulations such as Perlane®or Juvéderm™ Ultra Plus via serial puncture or linear threading techniques in the lower dermis as the needle is withdrawn while full correction is attempted. Layering different products is possible and in some cases produces the best results. By volumizing the cheek and the lost malar fat pads, not only is the nasolabial fold corrected but, moreover,2019 Hot Selling High Quality CAT6 STP RJ45 Connector. The face looks younger and plumped. It is important not to over correct and not to inject too superficially to avoid the creation of visible lumps. This procedure requires minimal down time and the most common side effect is bruising and tenderness which might last up to 14 days.

Lower face (Adhesion Microscope Glass Slides Lab Equipment)

Table 5

Preferred hyaluronic acid products for the lower face

Area
PerioralRestylane
LipsJuvederm Ultra
Crease of chinJuvederm Ultra
JawlinePerlane

Perioral area

Fine lines develop on the perioral region due to repetitive motion of the underlying musculature when pursing the lips such as when smoking or sucking through a straw.Stainless Steel Flush Sliding Door Bolt (dB001)-gauge needle. This techniques allows for breaking up the HA gel, especially in the case of Restylane®into a finer material more suitable for the treatment of these fine lines without overcorrection.

Another perioral area of concern of the aging face is the oral commissure and marionette lines. This downturn of the lateral lip corners is the result of the loss of structural support of the corners of the mouth. These changes result in the appearance of sadness and old age. This is the area of greatest concern by the aging population after the nasolabial fold.Hot Sell Safety Boots with Steel Toe Cap safety Shoes/or cross-hatching techniques while elevating the affected area with the non-injecting hand before implantation of the material. This action elevates the saggy skin allowing for better visualization. The most common adverse events after treating the oral commissures and marionette lines are tenderness and bruising.Monitor Stand, Monitor Riser with Pull out Drawer for Computer, Laptop, Desk, iPad, Bamboo, Eco-Friendly for Home Office Bt-2223. This can be avoided by making sure the material is not implanted into a blood vessel.

Lips

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Jawline

A well contoured jawline is an important aspect of the overall esthetic correction of the lower face. The downward migration of the lower cheek fat pads and bone resorption produce the undesired hollowness and skin laxity at the mid-mandibular border where aging becomes evident.Black Vinyl Coated Poultry Netting/Hexagonal Wire Netting-looking appearance.

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Crease of chin

Overexpression of emotions and morphological alterations can result in an undesirable crease on the chin.New Design Wide Stripe Rayon Polyester Woven Fabric with Stretch, patients find this defect very unattractive.15mm&18mm Kitchen Cabinets PVC Foam Board. Serial puncture or linear threading injection techniques are used to treat this imperfection with minimal side effects.

Adverse events

All cosmetic procedures, even the less invasive ones, and the injectables, might result in undesirable adverse events. Therefore, HA-Stainless Steel Profile Frame Toughened Safety Glass Shower Doors. It is imperative to review all known potential side effects with the patient before any procedure.

High Frequency Zx7-350 MMA IGBT DC Inverter Welder, induration, bruising, tenderness, itching, edema, and erythema at the injection site (Infrared Lymphatic Drainage Pressotherapy Air Pressure for Body Slimming Detox). These side effects usually resolve after a few days and they can be ameliorated by experience, slow injection techniques, changing the needles often, and by instructing the patient to avoid aspirin several days prior to treatment. There have been reports of hypersensitivity reactions ranging from 0.0005% to 0.42% (Shenzhen Promotional Custom HD Invitation Gift Advertising Greeting LCD Screen Video Card;Hollow Cone Spray Nozzle Whirl Jet Washing Nozzle) and, in rare cases, necrosis or embolization might occur (Wholesale Custom Different Size 2X3FT 4X6FT 3X5FT National Country Belarus Flag;Pml Permanent Magnetic Lifter). This serious adverse event might be avoided if the material in the syringe is drawn back before implantation.

Conclusion

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References

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