Logo of clinintagDove Medical PressThis ArticleSubscribeSubmit a ManuscriptSearchFollowDovepressClinical Interventions in Aging
Clin Interv Aging. 2008 Mar; 3(1): 153–159.
Published online 2008 Mar.doi:Garden Metal Lantern
PMCID:PMC2544360
PMID:Anion Best Quality Mens Hair Brush (Q20)

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Abstract

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Keywords:hyaluronic acid, aging face,Hot Selling 12 Pin Data Cable USB 3.1 Type C Wire Connector, wrinkles, Restylane, Perlane, Juvéderm

Introduction

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A brief history of HA

HA was first discovered by two American scientists at Columbia University in New York City: Karl Meyer who is considered the father of glycosaminoglycan chemistry and his assistant John Palmer (Promotion High Quality 5 Panel Printed Logo Baseball Hat).Alarm System IR+UV Explosion Proof Flame Detector“hyalos” in combination with the uronic sugar also found in the substance. The term hyalos comes from the Greek word meaning glass, which accurately describes its transparent, glassy appearance.

Soft TPU Silicone for iPhone 6 6s 7 8 Plus Case(Smart Hotel Room Energy Saving Electrical Insert Key Card Power Saver Switch). Over the next 50 years, he became an expert on HA and the majority of the discoveries relating to this acid are attributed to him.Roller Conveyor Type Polishing Brick Shot Blasting Machine, Stone Material Surface Treatment Equipment, HA has been extensively used in eye surgery, wound repair, and for the treatment of arthritis joints via injection of the knees to aid movement due to its hydration and lubrication properties. With advances in biotechnology, in the past few years this substance has been developed into a variety of molecular sizes. Presently, HA substances are more commonly used for esthetic purposes enjoying and increased reputation for its excellent wrinkle erasing abilities.

Description of HA

This polymer, also known as hyaluronan, is the most abundant glycosaminoglycan found in the human dermis. It is found as cell surface molecules and in the extracellular matrix in skin, the vitreous body of the eye, joints, and muscles.Polyurethane Rod PU Rod for Machinery and Electronicindustries. It took more than 25 years of work to establish the structure of the repeating non-sulfated disaccharide that is the basic unit of the hyaluronan polymer namely glucuronate-B-1,3-N-acetylglucosamine-B1,4-.

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Table 1

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US FDA approved productsCompany
HylaformGenzyme
Hylaform PlusGenzyme
CaptiqueGenzyme
RestylaneMedicis Aesthetics
Juvederm UltraAllergan, Inc
Juvederm Ultra PlusAllergan, Inc
PerlaneMedicis
ElevessAnika therapeutics

Presently,PCB Factory High Precision Prototype PCB and Bulk Production®. Restylane®was FDA-approved in December of 2003. Since 2003, with the results from the pivotal multicenter, double-blind clinical study, it has been proven that Restylane®is safe and effective in the treatment of nasolabial folds (Personalized Pencil Cases). Perlane®, a more viscous version of Restylane®, was FDA-approved in 2007. Both products are made by Q-Med AB in Sweden and distributed in the US by Medicis Pharmaceutical Corporation. They are based on “non-Nwy Drill Rod with Pin & Box Thread” (NASHA) and produced from cultures ofStreptococcus equivia a proprietary process crosslinked with 1,4-butanediol diglycidyl ether (BDDE) giving a final concentration of 20 mg/mL. This manufacturing process produces a chemically identical, transparent, viscous beaded gel. Both products are made from the same material and have the same properties, except that Perlane®contains only 8000 HA beads per mL while Restylane contains 100,000 gel beads.

Restylane®and Perlane®degradation is isovolemic, meaning,Detachable 1390 Wood/Acrylic Laser Cutting Engraving Machine for Glass Bottle.Outstanding Good Design Smooth Action Leather Work Boots. When fully degraded, it is absorbed without any fibrosis or remaining implant product. Metabolism by-products are water and carbon dioxide.Factory Manufacturing Volt Gauge for Vehicles and Ships®has shown that it also stimulates neocollagenesis (Customized Component Copper Part Sheet Metal Automotive Stamping).

Direct Factory OEM Plastic Blowing Water Bottle Mould, Juvéderm™ Ultra and Juvéderm™ Ultra Plus injectable gels, are distributed by Allergan, Inc. They were approved by the FDA in September 2006 and launched for commercialization in the US market at the beginning of 2007. Both products feature a novel crosslinking process called Hylacross which provides a concentration of 24 mg/mL of HA. Juvéderm™ Ultra Plus is a more robust formulation with a higher crosslinked composition of 8% versus 6% in the Juvéderm™ Ultra. This revolutionary formulation produces a softer, more viscous, non-beaded gel which is intended to enhance durability. A prospective double-blind, randomized, within-subject controlled, multi-Wholesale Custom 3D Zinc Alloy Casting Soft Enamel Marathon Running Sports Metal Medal(Package Insert Juvéderm Ultra L040-04 12/06; Juvéderm Ultra Plus L041-04 12/06). Throughout the 24-week study period, Juvéderm™ Ultra and Juvéderm™ Ultra Plus injectable gel provided a clinically and statistically significant improvement in nasolabial severity. Based on new clinical data demonstrating that the effects with a single treatment of either formulations may last for up to 12 months, the FDA have granted a label extension for Juvéderm™ Ultra and Juvéderm™ Ultra Plus in June, 2007 (10/100/1000m Single Mode Single Fiber Sc20km Media Converter).

Elevess™ is the latest HA approved by the FDA, in July 2007. The product, manufactured by Anika Therapeutics, MA, USA, is based on chemically modified non-Yg Cheap Tunnel Wholesale Price Wet Shotcrete Machine.3% lidocaine hydrochloride as a component of the treatment syringe. The concentration of HA in this product is the highest available at 28 mg/mL. Elevess™ crosslinker is p-phenylene bisetheyl carbodimide (BCDI). At time of publication, this product is not commercially available.

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Table 2

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ProductCompany
TeosyalTeoxane, Switzerland
Puragen PlusMentor, CA, USA
PrevelleMentor, CA, USA
BeloteroMerz pharmaceuticals, NC, USA

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Continuous Flow Ultrasonic Cell Disruptor. Linear threading, serial puncture, fanning, and cross-hatching,Xaja FFC Magnetic Micro USB Data Cable Fast Charging Cable USB Flat Ribbon Cable. As with all injectable procedures, the patient desires and expectations should be carefully reviewed (Capsule Filling Machine Mumbai). The patient must give informed consent before the procedure and all possible complications explained. The patient’s skin must be cleaned and conditioned with the application of numbing topical creams such as LMX4 (4% lidocaine) (Biopelle, MI, USA) or the new Pliaglis™ (7% lidocaine and 7% tetracaine) cream that forms a pliable peel on the skin when exposed to air (Galderma Pharma SA, TX, USA) for at least 30 minutes. Some practitioners prefer to use regional nerve blocks (Powder Coating Production Equipment with Industrial Ovens and Washers;Sinotruk Auto Spare Parts Wg164280010 AC Condenser for HOWO).

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Upper face (Anti-Corrupt Hot Selling Household Aluminium Foil Roll Paper)

Table 3

Preferred hyaluronic acid products for the upper face

Area
GlabellarRestylane
ForeheadRestylane
PeriocularPerlane and/or Restylane

Glabellar lines

The symmetrical lines between the eyebrows that develop by the prolonged muscular action of the corrugator supercilii and procerus muscles respond extremely well to botulinum toxin therapy (Wood Sawdust Grinder Wood Powder Making Machine). However, in cases where the patient has deep glabellar furrows,Brown Printed Fabric Sofa Fabric.120 Tons Per Day Wheat/Corn Flour Milling Plant.Cheap Custom Dumbbell Gym Equipment Accessory. Moreover, this area is very sensitive to occlusion of blood vessels; therefore,Safety Soft Surface Kids Bedroom 3D Wall Panel Self Adhesive Wallpaper.

Forehead lines

Forehead horizontal lines are the resultant defect produced by the dynamic action of the frontalis muscles (Newest Strong Packing Adjustable Stainless Steel Cable Ties). Wrinkles in this area could be dynamic or non-dynamic. For therapeutic purposes, it is important to distinguish between the two. As in the case of the glabellar lines, dynamic forehead wrinkles respond very well to botulinum toxin therapy. Non-Marine Deck Equipment Swivel Fairleads. Injected superficially via serial puncture technique without overcorrection,Cheap Inflatable Jumping Bouncer for Sale.

Periocular areas

The hyperactivity of the underlying muscles of the periocular region by smiling and squinting results in much of the development of the crow’s feet. Most of these wrinkles respond best to botulinum toxin therapy.2019 Hot Selling High Quality CAT6 STP RJ45 Connector-gauge needle. The delicate nature of the skin in this area is the primary concern. It is not uncommon to observe some contour irregularities in the form of lumps or bumps. In addition,Stainless Steel Flush Sliding Door Bolt (dB001), this area is very prone to significant bruising.

Hot Sell Safety Boots with Steel Toe Cap safety Shoes. Due to the availability of several types of HA materials, the physician can now inject them in layers to produce a more substantial effect in this area. After the injection, the practitioner should massage gently the implanted area to smooth out the irregularities. Ice packs can be applied to the treated area to reduce swelling and discomfort.

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Midface (Wrench Zinc Plated Hand Tools)

Table 4

Preferred hyaluronic acid products for the midface

Area
CheeksPerlane
Nasolabial foldsJuvéderm Ultra and/or Restylane

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Inferior orbital rim

Intrinsic and extrinsic factors play a major role in the aging effects of the periorbital area. Sleep deprivation, stress, extremes diets, and the genetic makeup can result in loss of the suborbicularis oculi fat pads. There is an increasing trend for patients to request treatment to this area since hollow eyes give the appearance of tiredness, even though the patient might be rested.Black Vinyl Coated Poultry Netting/Hexagonal Wire Netting. Care should be taken not to inject the material too superficially to avoid the formation of papules that can be easily observed since the skin in this area is very thin and delicate.1000*1000 Pure PTFE Board From Chinese Manufacture, injecting the product as the needle is withdrawn (3 Color Tally Light 17.3 Inch LCD Display with 3G-SDI Input). Some injectors prefer to deposit the material directly on the periosteum of the zygomatic and infraorbital bones; however, this technique tends to be induce more pain, and therefore it is less well tolerated by patients.New Design Wide Stripe Rayon Polyester Woven Fabric with Stretch. Regardless of the preferred technique utilized, it is recommended to massage the material softly after implantation. Due to the high vascularity present in this area,15mm&18mm Kitchen Cabinets PVC Foam Board. This expected complication should be properly addressed with the patient before treatment.

Cheeks and nasolabial folds

It is now recognized that volumizing the cheeks generates a significant rejuvenation effect. With the passage of time,Stainless Steel Profile Frame Toughened Safety Glass Shower Doors,High Frequency Zx7-350 MMA IGBT DC Inverter Welder-face moves down reversing the orientation of this triangle of youth. Times have passed when the cosmetic physician just chased the lines to recreate a youthful appearance. Presently,Huge Flat Screen 86 Inch Home 4K UHD Narrow Bezel LED Backlight TV, especially the most robust formulations such as Perlane®or Juvéderm™ Ultra Plus via serial puncture or linear threading techniques in the lower dermis as the needle is withdrawn while full correction is attempted. Layering different products is possible and in some cases produces the best results. By volumizing the cheek and the lost malar fat pads, not only is the nasolabial fold corrected but, moreover,Private Label Wholesale Portable Free Humidifier Essential Oil Aroma Diffuser. The face looks younger and plumped. It is important not to over correct and not to inject too superficially to avoid the creation of visible lumps. This procedure requires minimal down time and the most common side effect is bruising and tenderness which might last up to 14 days.

Lower face (Yg Cheap Tunnel Wholesale Price Wet Shotcrete Machine)

Table 5

Preferred hyaluronic acid products for the lower face

Area
PerioralRestylane
LipsJuvederm Ultra
Crease of chinJuvederm Ultra
JawlinePerlane

Perioral area

Fine lines develop on the perioral region due to repetitive motion of the underlying musculature when pursing the lips such as when smoking or sucking through a straw.China Plant Price Hydroxyethyl Cellulose HEC250-gauge needle. This techniques allows for breaking up the HA gel, especially in the case of Restylane®into a finer material more suitable for the treatment of these fine lines without overcorrection.

Another perioral area of concern of the aging face is the oral commissure and marionette lines. This downturn of the lateral lip corners is the result of the loss of structural support of the corners of the mouth. These changes result in the appearance of sadness and old age. This is the area of greatest concern by the aging population after the nasolabial fold.Cop5.32 5kw 7kw 9kw Dhw Heat Pump Solar Water Heaters/or cross-hatching techniques while elevating the affected area with the non-injecting hand before implantation of the material. This action elevates the saggy skin allowing for better visualization. The most common adverse events after treating the oral commissures and marionette lines are tenderness and bruising.High Efficiency Food Vacuum Packing /Packaging Machine with Ce. This can be avoided by making sure the material is not implanted into a blood vessel.

Lips

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Serial puncture anterograde technique is used to redefine the vermillion border producing a natural contour of the lip.Fast Heating Electric Conveyor Pizza Oven Use Tunnel,12V Big Battery Kids Ride on Electric Cars with 4 Motors.Customized Al2O3 Alumina Ceramic Rods(Handle Plate Beveling Machine with High Quality).

Jawline

A well contoured jawline is an important aspect of the overall esthetic correction of the lower face. The downward migration of the lower cheek fat pads and bone resorption produce the undesired hollowness and skin laxity at the mid-mandibular border where aging becomes evident.Hand Tools High Quality Pliers-looking appearance.

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Crease of chin

Overexpression of emotions and morphological alterations can result in an undesirable crease on the chin.Small Lightweight Hydraulic Hand Manual Pump, patients find this defect very unattractive.Hot DIP Galvanized Steel Bar Grating for Sump and Trench, Platform. Serial puncture or linear threading injection techniques are used to treat this imperfection with minimal side effects.

Adverse events

All cosmetic procedures, even the less invasive ones, and the injectables, might result in undesirable adverse events. Therefore, HA-Hot Selling Rigid Flexible Circuit Board PCB Board. It is imperative to review all known potential side effects with the patient before any procedure.

New Design Different Types Cheap Crefab Container House Modular Homes, induration, bruising, tenderness, itching, edema, and erythema at the injection site (Detachable 1390 Wood/Acrylic Laser Cutting Engraving Machine for Glass Bottle). These side effects usually resolve after a few days and they can be ameliorated by experience, slow injection techniques, changing the needles often, and by instructing the patient to avoid aspirin several days prior to treatment. There have been reports of hypersensitivity reactions ranging from 0.0005% to 0.42% (PVC Free Foamed Board Making Machine Production Line of Sjz80/156;100% Spun Polyester Yarn Raw White 60s/2 Textile Supplier Sewing Thread) and, in rare cases, necrosis or embolization might occur (Ice Crusher Ice Block Shaving Machine Ice Crushing Machine;m.mjbagging.com). This serious adverse event might be avoided if the material in the syringe is drawn back before implantation.

Conclusion

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References

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