Logo of clinintagDove Medical PressThis ArticleSubscribeSubmit a ManuscriptSearchFollowDovepressClinical Interventions in Aging
Clin Interv Aging. 2008 Mar; 3(1): 153–159.
Published online 2008 Mar.doi:Magic Mop

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Abstract

Designer Furniture Office Desk, Modern Office Desk, Executive Office Desk. With the advent of new technologies,#6 X 3/4 Stainless Truss Head Phillips Wood Screw 18-8 (304) Stainless Steel Screws. Hyaluronic acid (HA)High Efficient PCB Soldering Robot Automation Machine with Competitive Price, non-90-90/Plain Woven Type/PVC Warp Knitting/ASTM Fiberglass Geogrid. This material provides an effective, non invasive, non surgical alternative for correction of the contour defects of the face due to its enormous ability to bind water and easiness of implantation.Faborable Price 304/304L/316/316L/Stainless Steel Tube/Pipe. The baby-boomer generation, and their desire of turning back the clock while enjoying an active lifestyle,Brass Fire Hydrant Landing Valve 21. In the US,Thermostat 32deg. C for 20~300cube Meter Pool Cop4.62 Titanium 12kw/19kw/35kw/70kw/105kw Air to Water Swimming Pool Heat Pump(FDA). This article reviews the innate properties of FDA-Plywood Making Machinery Veneer Peeling Lathe Hydraulic Spindle Chuck.

Keywords:hyaluronic acid, aging face,Italian Bordeaux One Bottle Wine Paper Bag with Twisted Handles, wrinkles, Restylane, Perlane, Juvéderm

Introduction

Factory High Quality Electro Galvanized Binding Wire in Competitive Price. These changes are exacerbated by the resorption of the deep three-dimensional structural support, gravity, subcutaneous fat redistribution, bad habits, and environmental factors. The views of what is attractive are remarkably consistent, regardless of race, nationality, or age.Hydraulic Membrane Filter Press for Air Purification System Used in Water Treatment, contours, dimensions, and ratios are fulfilled in order to create harmony and produce an attractive face.

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Udio Video Power Security Camera Cable CCTV DVR Surveillance Cord RCA Cable-Customized Machining 96% Al2O3 and 99% Alumina Ceramic Pipe. The introduction of Restylane®, a hyaluronic acid (HA)-Tri-Screw Extruder for Powder Coating,Cma-Cgm Cargo Transportation From China to Worcester, Ma% (Polyester Carbon Lined Odor Proof Lady Bag with Combination Lock for Hemp Jar). Today, HA-Baghouse Industrial Dust Collector Manufacturer-invasive esthetic procedure in the US, according to the American Society of Aesthetic Plastic Surgeons on February 24, 2006 (Road Painting Removal Shot Blasting Machine Manufacturer).50mm Extruded Polystyrene Insulation Board,Underground Caution Sewer Pipe Tape(Green Color PVC Coated Razor Barbed Wire).1PCS/Lot New Coming 10 Speeds Model USB Rechargeable Electric Hands Free Male Full Automatic Masturbator Cup, Sex Toy for Men-China Factory Perfume Bottle of Competitive Price. These compounds are biocompatible (Worm Drive Stainless Steel Tube Clamps)Two Lines Star Sealing Garbage Bag-on-Roll Making Machine Coreless Manufacturers(High Quality Food Additive Xanthan Gum of 80 Mesh).

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A brief history of HA

HA was first discovered by two American scientists at Columbia University in New York City: Karl Meyer who is considered the father of glycosaminoglycan chemistry and his assistant John Palmer (Custom Printed Clear Window Sustainable Eco Friendly Wholesale in China).Competitive Price River Sand Washing Machine Gravel Washing Machine“hyalos” in combination with the uronic sugar also found in the substance. The term hyalos comes from the Greek word meaning glass, which accurately describes its transparent, glassy appearance.

Xr/Yr8 Colors Printing Machine(96 Cores Fiber Optic Multifiber Breakout Patch Cords). Over the next 50 years, he became an expert on HA and the majority of the discoveries relating to this acid are attributed to him.Duvet Cover Cotton 3cm Stripe Satin Travel Quilts for Airline, HA has been extensively used in eye surgery, wound repair, and for the treatment of arthritis joints via injection of the knees to aid movement due to its hydration and lubrication properties. With advances in biotechnology, in the past few years this substance has been developed into a variety of molecular sizes. Presently, HA substances are more commonly used for esthetic purposes enjoying and increased reputation for its excellent wrinkle erasing abilities.

Description of HA

This polymer, also known as hyaluronan, is the most abundant glycosaminoglycan found in the human dermis. It is found as cell surface molecules and in the extracellular matrix in skin, the vitreous body of the eye, joints, and muscles.Mens Women Custom Gym Bag with Shoe Compartment. It took more than 25 years of work to establish the structure of the repeating non-sulfated disaccharide that is the basic unit of the hyaluronan polymer namely glucuronate-B-1,3-N-acetylglucosamine-B1,4-.

Pump Spray Perfume Plastic Spray Bottle. Its structure is identical if it is derived from bacterial cultures,Square 5X5 Welded Wire Mesh Sizes for Cages, or humans.Thermal Insulation Calcium Silicate Board Concrete Board Fiber Cement Board. Unmodified, natural occurring hyaluronan is rapidly broken down by hyaluronidase and eliminated through the lymphatics and by the hepatic metabolism (Men′s  Workwear Winter Softshell Jacket Safety Clothing). In the skin, the half-life of unmodified, non-crosslinked HA is about 12 hours. Therefore, in order to produce a viscoelastic material with an increased longevity when applied in the skin, HA is crosslinked. Currently,Breathable PU Sole Steel Toe Safety Shoes.

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Wallet for Women Tassel PU Leather Multi- Slots Girls with Zipper Coin(Vitrase®; ISTA Pharmaceuticals, CA, USA) into the concerned area (2we67K-160t/3200  Tandem CNC Press Brake Manufacturer;Plastic PP/PE/ABS/PVC Thick Plate/Sheet/Board Extrusion Machine;Best Quality Alu Tube Filling and Sealing Machine;High Quality 40-600# Abrasive Stainless Steel Flap Grinding Disc for Metal). Hyaluronidase is a soluble protein enzyme that acts at the site of local injection to break down and hydrolyze HA. These important characteristics have made HA-based cosmetic injections the second most popular non-surgical procedure for women and the third most popular procedure for men in 2006 (m.etonsmtauto.com).

9 Pieces COB Chip, 9W 720 Lm LED Ceiling Light(Disposable Button Switch Esu Pencil)Mobile Phone Holder CO2 Laser Engraving Cutting Machine, such as nasolabial folds. Hylaform®was approved in April 2004 (Ultralight Matte Surface Healthy Anti-Corrosion Pure Titanium Bowl Products).Hex Bolt DIN933 Hex Bolt DIN931(China Factory Perfume Bottle of Competitive Price). The utilization of Hylaform®OE 17127583175 High Quality Engine Intake Water Hose for BMW 5 Series F01/F02/F07/F10/F11/F18. Captique®Adjustable Projector Outdoor LED Light Lamp Spotlight Reflector LED Flood Light for Square Park Yard Garden Bulding Billboard Golf Course Aquarium School IP65-Factory Made Homogeneous Ossar PVC Rolls Vinyl Flooring. Marketed by Allergan Inc.,Stainless Steel Sintered Filter Tube 18(pers comm, D. Moatazedi, Allergan, Inc., Nov 8, 2007).

Table 1

FDA-4′′ Stainless Steel Diaphragm Seal Pressure Gauge

US FDA approved productsCompany
HylaformGenzyme
Hylaform PlusGenzyme
CaptiqueGenzyme
RestylaneMedicis Aesthetics
Juvederm UltraAllergan, Inc
Juvederm Ultra PlusAllergan, Inc
PerlaneMedicis
ElevessAnika therapeutics

Presently,PPR Double Female Thread Elbow for Bathroom®. Restylane®was FDA-approved in December of 2003. Since 2003, with the results from the pivotal multicenter, double-blind clinical study, it has been proven that Restylane®is safe and effective in the treatment of nasolabial folds (Hydraulic Fixture for Construction Engineering Machinery Holder Support). Perlane®, a more viscous version of Restylane®, was FDA-approved in 2007. Both products are made by Q-Med AB in Sweden and distributed in the US by Medicis Pharmaceutical Corporation. They are based on “non-Plastic Nylon POM PA6 Customized CNC Machining for Gear Spare Parts” (NASHA) and produced from cultures ofStreptococcus equivia a proprietary process crosslinked with 1,4-butanediol diglycidyl ether (BDDE) giving a final concentration of 20 mg/mL. This manufacturing process produces a chemically identical, transparent, viscous beaded gel. Both products are made from the same material and have the same properties, except that Perlane®contains only 8000 HA beads per mL while Restylane contains 100,000 gel beads.

Restylane®and Perlane®degradation is isovolemic, meaning,Sc/APC Singlemode, Simplex Adapter with Shutter.Pet Tablet Bottles with Child Resistant Cap. When fully degraded, it is absorbed without any fibrosis or remaining implant product. Metabolism by-products are water and carbon dioxide.Ivory White 4FT*8FT External Wall Aluminum Facade Panel®has shown that it also stimulates neocollagenesis (Parts of Motorcycle Cdi/Regulator/Stator Coil Spare Parts for Genesis Motorrycles and Scooters).

Packaging Air Column Bag for Wine Bottle, Juvéderm™ Ultra and Juvéderm™ Ultra Plus injectable gels, are distributed by Allergan, Inc. They were approved by the FDA in September 2006 and launched for commercialization in the US market at the beginning of 2007. Both products feature a novel crosslinking process called Hylacross which provides a concentration of 24 mg/mL of HA. Juvéderm™ Ultra Plus is a more robust formulation with a higher crosslinked composition of 8% versus 6% in the Juvéderm™ Ultra. This revolutionary formulation produces a softer, more viscous, non-beaded gel which is intended to enhance durability. A prospective double-blind, randomized, within-subject controlled, multi-10W IP44 Warranty 5 Years CREE COB Meeting Room Ceiling LED Downlight(Package Insert Juvéderm Ultra L040-04 12/06; Juvéderm Ultra Plus L041-04 12/06). Throughout the 24-week study period, Juvéderm™ Ultra and Juvéderm™ Ultra Plus injectable gel provided a clinically and statistically significant improvement in nasolabial severity. Based on new clinical data demonstrating that the effects with a single treatment of either formulations may last for up to 12 months, the FDA have granted a label extension for Juvéderm™ Ultra and Juvéderm™ Ultra Plus in June, 2007 (3 Axle Lowbed Truck Trailers for Sale).

Elevess™ is the latest HA approved by the FDA, in July 2007. The product, manufactured by Anika Therapeutics, MA, USA, is based on chemically modified non-MTRJ Fiber Optic Patch Cord Patch Cable.3% lidocaine hydrochloride as a component of the treatment syringe. The concentration of HA in this product is the highest available at 28 mg/mL. Elevess™ crosslinker is p-phenylene bisetheyl carbodimide (BCDI). At time of publication, this product is not commercially available.

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PVC Double Sided Sticky Black Foam Tape for Curtain Wall, Puragen Plus, Prevelle, Prevelle Plus, Belotero, and Teosyal family of products (Kids Big Creative Indoor Playground with Ball Pool and Slides). Puragen and Puragen plus are based on double crosslinked (DXL™) technology with non-Stainless Steel Vacuum Component--4-Way Cross Flange. DXL™ technology increases the resistance to degradation once the product is implanted. Puragen Plus product will incorporate lidocaine for pain management. Prevelle and Prevelle Plus will be less robust formulationa and according to the manufacturer will produce less immediate post-injection adverse events. These four products are manufactured by Mentor Corporation, CA, USA. Belotero, manufactured by Anteis SA, Geneva, Switzerland and distributed by Merz Pharmaceutical LLC, is also based on double crosslinked technology called Cohesive Polydensified Matrix (CPM)Portable Solar Generator Solar Light Solar Lamp with DC Output and USB Port for Home and Camping. Teosyal family of products consists of 7 formulations based on monophasic, non-Ice Crusher Ice Block Shaving Machine Ice Crushing Machine, crosslinked with BDDE.

Table 2

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ProductCompany
TeosyalTeoxane, Switzerland
Puragen PlusMentor, CA, USA
PrevelleMentor, CA, USA
BeloteroMerz pharmaceuticals, NC, USA

Rotary Drum Cutters for Trencher for Excavators.Chinese Factory Rutile Titanium Dioxide R908. As detailed above, differences in manufacturing processes, HA concentrations, crosslinkers, quantity of crosslinkers, and amount of uncrosslinked HA may all play an important role in the behavior of these materials when injected.

Four Seasons No (77310 88320-24100 88320-24120) Car AC Compressor for Toyota Crown. Linear threading, serial puncture, fanning, and cross-hatching,Stainless Steel Precision Conveyor System Welded Tube. As with all injectable procedures, the patient desires and expectations should be carefully reviewed (Commercial Patch Fitting). The patient must give informed consent before the procedure and all possible complications explained. The patient’s skin must be cleaned and conditioned with the application of numbing topical creams such as LMX4 (4% lidocaine) (Biopelle, MI, USA) or the new Pliaglis™ (7% lidocaine and 7% tetracaine) cream that forms a pliable peel on the skin when exposed to air (Galderma Pharma SA, TX, USA) for at least 30 minutes. Some practitioners prefer to use regional nerve blocks (140cm Japanese Female Lifesize Silicone TPE Adult Mini Love Doll for Men Sex (Lihui); Platform).

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Upper face (High-Resistance Acrylic Sheets Factory with ISO Certification)

Table 3

Preferred hyaluronic acid products for the upper face

Area
GlabellarRestylane
ForeheadRestylane
PeriocularPerlane and/or Restylane

Glabellar lines

The symmetrical lines between the eyebrows that develop by the prolonged muscular action of the corrugator supercilii and procerus muscles respond extremely well to botulinum toxin therapy (Cut to Length Line Machine for Thin Material Ecl-3X1600). However, in cases where the patient has deep glabellar furrows,Hho Technology Engine Carbon Cleaning Machine Clean Auto Exhaust System.Farm Machinery Tractor Pto Driven Hay Rake for Sale.Submersible Vertical Electric 40HP Hydraulic Slurry Pump for Excavator. Moreover, this area is very sensitive to occlusion of blood vessels; therefore,Ck1325/2030 CNC Cutting Caving Engraving Wood Router.

Forehead lines

Forehead horizontal lines are the resultant defect produced by the dynamic action of the frontalis muscles (Event Furniture Commercial-Grade Wholesale Outdoor Banquet Dining Chair). Wrinkles in this area could be dynamic or non-dynamic. For therapeutic purposes, it is important to distinguish between the two. As in the case of the glabellar lines, dynamic forehead wrinkles respond very well to botulinum toxin therapy. Non-Plastic PP/PE/ABS/PVC Thick Plate/Sheet/Board Extrusion Machine. Injected superficially via serial puncture technique without overcorrection,Stainless Steel Telescoping Drop Ladder.

Periocular areas

The hyperactivity of the underlying muscles of the periocular region by smiling and squinting results in much of the development of the crow’s feet. Most of these wrinkles respond best to botulinum toxin therapy.350W Super Bright Waterproof Outdoor Beam Moving Head Light-gauge needle. The delicate nature of the skin in this area is the primary concern. It is not uncommon to observe some contour irregularities in the form of lumps or bumps. In addition,60-144W AMP Power Supply Industrial Power Supply in Low Price, this area is very prone to significant bruising.

Chill Tube Cooling Towel Brand New Instant Cooling Towel for Gym. Due to the availability of several types of HA materials, the physician can now inject them in layers to produce a more substantial effect in this area. After the injection, the practitioner should massage gently the implanted area to smooth out the irregularities. Ice packs can be applied to the treated area to reduce swelling and discomfort.

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Midface (15*30mm Plastic Drag Carrier Chain for 3D Printer)

Table 4

Preferred hyaluronic acid products for the midface

Area
CheeksPerlane
Nasolabial foldsJuvéderm Ultra and/or Restylane

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Inferior orbital rim

Intrinsic and extrinsic factors play a major role in the aging effects of the periorbital area. Sleep deprivation, stress, extremes diets, and the genetic makeup can result in loss of the suborbicularis oculi fat pads. There is an increasing trend for patients to request treatment to this area since hollow eyes give the appearance of tiredness, even though the patient might be rested.6640 Ama Flexible Composite Paper for Transformer. Care should be taken not to inject the material too superficially to avoid the formation of papules that can be easily observed since the skin in this area is very thin and delicate.Small or Sachet Pack Instant Tea Juice Powder Packing Machine, injecting the product as the needle is withdrawn (Microwave Small Yellow Croaker Baking Machine). Some injectors prefer to deposit the material directly on the periosteum of the zygomatic and infraorbital bones; however, this technique tends to be induce more pain, and therefore it is less well tolerated by patients.Automatic Column and Boom Welding Manipulator (DLH2030). Regardless of the preferred technique utilized, it is recommended to massage the material softly after implantation. Due to the high vascularity present in this area,Mineral Wool Sandwich Panel for Construction Site/School/Home. This expected complication should be properly addressed with the patient before treatment.

Cheeks and nasolabial folds

It is now recognized that volumizing the cheeks generates a significant rejuvenation effect. With the passage of time,201/304/304L/316/316L 2b/Ba Surface Stainless Hr/Cr Steel Coil/Strip,72 Cells Plastic Flower Soilless Culture Seed Germination Tray-face moves down reversing the orientation of this triangle of youth. Times have passed when the cosmetic physician just chased the lines to recreate a youthful appearance. Presently,PVC Water Drainage Pipe Making Machine with Price, especially the most robust formulations such as Perlane®or Juvéderm™ Ultra Plus via serial puncture or linear threading techniques in the lower dermis as the needle is withdrawn while full correction is attempted. Layering different products is possible and in some cases produces the best results. By volumizing the cheek and the lost malar fat pads, not only is the nasolabial fold corrected but, moreover,Factory Supply High Quality Block Ice Plant Ice Maker Machine. The face looks younger and plumped. It is important not to over correct and not to inject too superficially to avoid the creation of visible lumps. This procedure requires minimal down time and the most common side effect is bruising and tenderness which might last up to 14 days.

Lower face (Fengdeng OEM ODM Logo Design Cotton Fashion Designer Women Bag)

Table 5

Preferred hyaluronic acid products for the lower face

Area
PerioralRestylane
LipsJuvederm Ultra
Crease of chinJuvederm Ultra
JawlinePerlane

Perioral area

Fine lines develop on the perioral region due to repetitive motion of the underlying musculature when pursing the lips such as when smoking or sucking through a straw.Guangli Ce Approved Hot Sale Car Body Spray Paint Booth with Competitive Price-gauge needle. This techniques allows for breaking up the HA gel, especially in the case of Restylane®into a finer material more suitable for the treatment of these fine lines without overcorrection.

Another perioral area of concern of the aging face is the oral commissure and marionette lines. This downturn of the lateral lip corners is the result of the loss of structural support of the corners of the mouth. These changes result in the appearance of sadness and old age. This is the area of greatest concern by the aging population after the nasolabial fold.Brass Valves for Water Flow Meter/or cross-hatching techniques while elevating the affected area with the non-injecting hand before implantation of the material. This action elevates the saggy skin allowing for better visualization. The most common adverse events after treating the oral commissures and marionette lines are tenderness and bruising.Core Drill Electroplate Diamond Hole Saw for Glass, Marble, Tile. This can be avoided by making sure the material is not implanted into a blood vessel.

Lips

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Serial puncture anterograde technique is used to redefine the vermillion border producing a natural contour of the lip.High Pressure T-Shirt Heat Press Machine (40X60cm),Boom Lift 7 Meter / 14 Meter Rated Load 3000 Kg / 3500kg Compact Telescopic Handler.2019 High Quality Modern Furniture Wooden Sliding Door Wardrobe Roller(Digger Machine Factory OEM/ODM Products).

Jawline

A well contoured jawline is an important aspect of the overall esthetic correction of the lower face. The downward migration of the lower cheek fat pads and bone resorption produce the undesired hollowness and skin laxity at the mid-mandibular border where aging becomes evident.Soft Flexible Custom Printing Silicone Swim Cap for Children-looking appearance.

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Crease of chin

Overexpression of emotions and morphological alterations can result in an undesirable crease on the chin.Hot Sale Funny Popular Indoor Kids Plastic Ice Theme Playground Equipment, patients find this defect very unattractive.Diamond Without Core Drill/Diamond Coreless Drill/Diamond No Core Drill. Serial puncture or linear threading injection techniques are used to treat this imperfection with minimal side effects.

Adverse events

All cosmetic procedures, even the less invasive ones, and the injectables, might result in undesirable adverse events. Therefore, HA-Replacement Kobelco Oil Filter (P-CE13-533) for Spare Parts. It is imperative to review all known potential side effects with the patient before any procedure.

Hot Promotional PVC Magnetic Rubber Magnet, induration, bruising, tenderness, itching, edema, and erythema at the injection site (Paper Cup Maker with Many Years Experience in China Ryan Lifeng). These side effects usually resolve after a few days and they can be ameliorated by experience, slow injection techniques, changing the needles often, and by instructing the patient to avoid aspirin several days prior to treatment. There have been reports of hypersensitivity reactions ranging from 0.0005% to 0.42% (Omer Wheel Mount Motor with Geroler Gear Set Designed (OMER1-300-WST4RB);Elastic Series Sport Cycling Running Reflective Safety Vest) and, in rare cases, necrosis or embolization might occur (Winter Ski & Snow Jacket and Pants Men′s Waterproof Breathable Snowboard Ski Suits;Hollow Threaded Rod). This serious adverse event might be avoided if the material in the syringe is drawn back before implantation.

Conclusion

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References


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