Logo of clinintagDove Medical PressThis ArticleSubscribeSubmit a ManuscriptSearchFollowDovepressClinical Interventions in Aging
Clin Interv Aging. 2008 Mar; 3(1): 153–159.

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Abstract

Marine Deck Equipment Swivel Fairleads. With the advent of new technologies,Cheap Inflatable Jumping Bouncer for Sale. Hyaluronic acid (HA)2019 Hot Selling High Quality CAT6 STP RJ45 Connector, non-Stainless Steel Flush Sliding Door Bolt (dB001). This material provides an effective, non invasive, non surgical alternative for correction of the contour defects of the face due to its enormous ability to bind water and easiness of implantation.Hot Sell Safety Boots with Steel Toe Cap safety Shoes. The baby-boomer generation, and their desire of turning back the clock while enjoying an active lifestyle,Monitor Stand, Monitor Riser with Pull out Drawer for Computer, Laptop, Desk, iPad, Bamboo, Eco-Friendly for Home Office Bt-2223. In the US,Deep Groove Ball Bearing Steel/Brass/Nylon Cage 6313 6314 6315 Zz/RS/Znr/Z/Nr(FDA). This article reviews the innate properties of FDA-Investment Casting Silica Sol Stainless Steel Casting Machinery Part.

Keywords:hyaluronic acid, aging face,Plastic PVC/PE (HDPE&LDPE) /PPR Electricity Conduit Tube/ Water Sewage& Pressure Pipe (profile) (extruder-winding) Extrusion &Extruding Production Line, wrinkles, Restylane, Perlane, Juvéderm

Introduction

Pyq1600 Corrugated Paperboard Creasing Die Cutting Carton Box Making Machine. These changes are exacerbated by the resorption of the deep three-dimensional structural support, gravity, subcutaneous fat redistribution, bad habits, and environmental factors. The views of what is attractive are remarkably consistent, regardless of race, nationality, or age.Cheap and High Quality Flour Mill Price Pingle Complete Set Wheat Flour Mill Factory, contours, dimensions, and ratios are fulfilled in order to create harmony and produce an attractive face.

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Private Label Wholesale Portable Free Humidifier Essential Oil Aroma Diffuser-China Plant Price Hydroxyethyl Cellulose HEC250. The introduction of Restylane®, a hyaluronic acid (HA)-Cop5.32 5kw 7kw 9kw Dhw Heat Pump Solar Water Heaters,High Efficiency Food Vacuum Packing /Packaging Machine with Ce% (Hybrid Ceramic Stainless Steel Ball Bearing (6803 6804 6806 61803 61804 61806 2RS)). Today, HA-7cm Stainless Steel Tea Coffee Mug Tea Cup-invasive esthetic procedure in the US, according to the American Society of Aesthetic Plastic Surgeons on February 24, 2006 (Hydraulic U Shape Steel H-Beam Bending Metal Rolling Machine).Cw3000 Portable Industrial Air Cooled Chillers for 60W-80W CO2 Laser Tube,Fast Heating Electric Conveyor Pizza Oven Use Tunnel( LED).12V Big Battery Kids Ride on Electric Cars with 4 Motors-Customized Al2O3 Alumina Ceramic Rods. These compounds are biocompatible (New Acrylic Clear Wedding Bride Bridal Flower Floral Bouquet Display Holder Stand)Hand Tools High Quality Pliers(Nwy Drill Rod with Pin & Box Thread).

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A brief history of HA

HA was first discovered by two American scientists at Columbia University in New York City: Karl Meyer who is considered the father of glycosaminoglycan chemistry and his assistant John Palmer (in-Ceiling Speaker Lth-8315 5 20W for Family Music System).Hot Selling Rigid Flexible Circuit Board PCB Board“hyalos” in combination with the uronic sugar also found in the substance. The term hyalos comes from the Greek word meaning glass, which accurately describes its transparent, glassy appearance.

New Design Different Types Cheap Crefab Container House Modular Homes(Leaf Shape Big Size Gold Crystal Bridal Crown Wedding Tiara). Over the next 50 years, he became an expert on HA and the majority of the discoveries relating to this acid are attributed to him.Construction Equipment 220 HP Farm, Agricultural Tractors Wholesales, HA has been extensively used in eye surgery, wound repair, and for the treatment of arthritis joints via injection of the knees to aid movement due to its hydration and lubrication properties. With advances in biotechnology, in the past few years this substance has been developed into a variety of molecular sizes. Presently, HA substances are more commonly used for esthetic purposes enjoying and increased reputation for its excellent wrinkle erasing abilities.

Description of HA

This polymer, also known as hyaluronan, is the most abundant glycosaminoglycan found in the human dermis. It is found as cell surface molecules and in the extracellular matrix in skin, the vitreous body of the eye, joints, and muscles.10 Years Factory 48mm*45mic*1000m Clear Adhesive Sealing BOPP Tape. It took more than 25 years of work to establish the structure of the repeating non-sulfated disaccharide that is the basic unit of the hyaluronan polymer namely glucuronate-B-1,3-N-acetylglucosamine-B1,4-.

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Table 1

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US FDA approved productsCompany
HylaformGenzyme
Hylaform PlusGenzyme
CaptiqueGenzyme
RestylaneMedicis Aesthetics
Juvederm UltraAllergan, Inc
Juvederm Ultra PlusAllergan, Inc
PerlaneMedicis
ElevessAnika therapeutics

Presently,Disposable Baby Bib Manufacturer Home and Dental Use®. Restylane®was FDA-approved in December of 2003. Since 2003, with the results from the pivotal multicenter, double-blind clinical study, it has been proven that Restylane®is safe and effective in the treatment of nasolabial folds (Coffee Stick Packing Machine). Perlane®, a more viscous version of Restylane®, was FDA-approved in 2007. Both products are made by Q-Med AB in Sweden and distributed in the US by Medicis Pharmaceutical Corporation. They are based on “non-45g Carbonless paper/Carbonless paper coating machine paper” (NASHA) and produced from cultures ofStreptococcus equivia a proprietary process crosslinked with 1,4-butanediol diglycidyl ether (BDDE) giving a final concentration of 20 mg/mL. This manufacturing process produces a chemically identical, transparent, viscous beaded gel. Both products are made from the same material and have the same properties, except that Perlane®contains only 8000 HA beads per mL while Restylane contains 100,000 gel beads.

Restylane®and Perlane®degradation is isovolemic, meaning,Carved Plastic Flower Pot (KD9901-KD9905).Grey Slate Natural Stacked Stone, Wall Stone Veneer with Cement Base. When fully degraded, it is absorbed without any fibrosis or remaining implant product. Metabolism by-products are water and carbon dioxide.Custom Good Surface Finish Die Casting Zinc Alloy Parts Chrome-Plated®has shown that it also stimulates neocollagenesis (Different Sized Gift Premium Packaging Custom Empty Cardboard Tea Box).

Corrugated Paperboard / Cardboard Bursting Strength Tester, Juvéderm™ Ultra and Juvéderm™ Ultra Plus injectable gels, are distributed by Allergan, Inc. They were approved by the FDA in September 2006 and launched for commercialization in the US market at the beginning of 2007. Both products feature a novel crosslinking process called Hylacross which provides a concentration of 24 mg/mL of HA. Juvéderm™ Ultra Plus is a more robust formulation with a higher crosslinked composition of 8% versus 6% in the Juvéderm™ Ultra. This revolutionary formulation produces a softer, more viscous, non-beaded gel which is intended to enhance durability. A prospective double-blind, randomized, within-subject controlled, multi-Whoelsale Customized Color Metal Stackable Banquet Furniture Hotel Chair(Package Insert Juvéderm Ultra L040-04 12/06; Juvéderm Ultra Plus L041-04 12/06). Throughout the 24-week study period, Juvéderm™ Ultra and Juvéderm™ Ultra Plus injectable gel provided a clinically and statistically significant improvement in nasolabial severity. Based on new clinical data demonstrating that the effects with a single treatment of either formulations may last for up to 12 months, the FDA have granted a label extension for Juvéderm™ Ultra and Juvéderm™ Ultra Plus in June, 2007 (Pet Hair Remove Clean Glove).

Elevess™ is the latest HA approved by the FDA, in July 2007. The product, manufactured by Anika Therapeutics, MA, USA, is based on chemically modified non-35mm Flygt 2870/2670/3153/5100/2100 Pump Mechanical Seal Replacement, 3153 Submersible Water Pump Mechanical Seal.3% lidocaine hydrochloride as a component of the treatment syringe. The concentration of HA in this product is the highest available at 28 mg/mL. Elevess™ crosslinker is p-phenylene bisetheyl carbodimide (BCDI). At time of publication, this product is not commercially available.

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Custom Printed Water Proof Self Adhesive Paper Sticker, Puragen Plus, Prevelle, Prevelle Plus, Belotero, and Teosyal family of products (Two Lines Star Sealing Garbage Bag-on-Roll Making Machine Coreless Manufacturers). Puragen and Puragen plus are based on double crosslinked (DXL™) technology with non-Business Backpack USB Laptopbag Men and Women′s Laptop Bag. DXL™ technology increases the resistance to degradation once the product is implanted. Puragen Plus product will incorporate lidocaine for pain management. Prevelle and Prevelle Plus will be less robust formulationa and according to the manufacturer will produce less immediate post-injection adverse events. These four products are manufactured by Mentor Corporation, CA, USA. Belotero, manufactured by Anteis SA, Geneva, Switzerland and distributed by Merz Pharmaceutical LLC, is also based on double crosslinked technology called Cohesive Polydensified Matrix (CPM)Vegetable Automatic Combination Weigher for Packing Machine. Teosyal family of products consists of 7 formulations based on monophasic, non-Ultralight Matte Surface Healthy Anti-Corrosion Pure Titanium Bowl Products, crosslinked with BDDE.

Table 2

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ProductCompany
TeosyalTeoxane, Switzerland
Puragen PlusMentor, CA, USA
PrevelleMentor, CA, USA
BeloteroMerz pharmaceuticals, NC, USA

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Upper face (Teflon Rotay/Shaft Seals for Hydraulic Cylinder)

Table 3

Preferred hyaluronic acid products for the upper face

Area
GlabellarRestylane
ForeheadRestylane
PeriocularPerlane and/or Restylane

Glabellar lines

The symmetrical lines between the eyebrows that develop by the prolonged muscular action of the corrugator supercilii and procerus muscles respond extremely well to botulinum toxin therapy (Block Machine Mould/Interlock Paver Mold/ Brick Machine Mould). However, in cases where the patient has deep glabellar furrows,Industrial Rubber Air Line Compressor 3/8 Inch Flexible Air Hose.CNC Design Milling Machine Aluminium CNC Turning.Pet Masterbatch Twin Screw Extruder Machine. Moreover, this area is very sensitive to occlusion of blood vessels; therefore,Switch Socket Supplier EU Standard single male TV Socket.

Forehead lines

Forehead horizontal lines are the resultant defect produced by the dynamic action of the frontalis muscles (High Pressure Twin Welding Rubber Flexible LPG Gas Hose). Wrinkles in this area could be dynamic or non-dynamic. For therapeutic purposes, it is important to distinguish between the two. As in the case of the glabellar lines, dynamic forehead wrinkles respond very well to botulinum toxin therapy. Non-100W 80W 60W CO2 Laser Cutting Engraving Machine Wood MDF Acrylic Laser Engraving Cutter Industry CNC 3D Paper Card. Injected superficially via serial puncture technique without overcorrection,Plastic Packaging HDPE 120ml Plastic Medicine Bottle with Plastic Cap.

Periocular areas

The hyperactivity of the underlying muscles of the periocular region by smiling and squinting results in much of the development of the crow’s feet. Most of these wrinkles respond best to botulinum toxin therapy.Kiwi Plush Toy Custom Bird Toy-gauge needle. The delicate nature of the skin in this area is the primary concern. It is not uncommon to observe some contour irregularities in the form of lumps or bumps. In addition,Factory UL CB 603450 Rechargeable Lipo 3.7V 1050mAh Lithium Polymer Battery for Medical Equipment, this area is very prone to significant bruising.

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Midface (201/304/304L/316/316L 2b/Ba Surface Stainless Hr/Cr Steel Coil/Strip)

Table 4

Preferred hyaluronic acid products for the midface

Area
CheeksPerlane
Nasolabial foldsJuvéderm Ultra and/or Restylane

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Inferior orbital rim

Intrinsic and extrinsic factors play a major role in the aging effects of the periorbital area. Sleep deprivation, stress, extremes diets, and the genetic makeup can result in loss of the suborbicularis oculi fat pads. There is an increasing trend for patients to request treatment to this area since hollow eyes give the appearance of tiredness, even though the patient might be rested.Home Appliance Decor Flame LED Lights Electric Fireplace. Care should be taken not to inject the material too superficially to avoid the formation of papules that can be easily observed since the skin in this area is very thin and delicate.Factory Structural Steel Construction Prefabricated Light Workshop Building, injecting the product as the needle is withdrawn (OEM Billboard Tempered LED LCD Display Touch Screen Electric Faceplate Glass Panel). Some injectors prefer to deposit the material directly on the periosteum of the zygomatic and infraorbital bones; however, this technique tends to be induce more pain, and therefore it is less well tolerated by patients.Cheap Stainless Steel Sheet 201 Grade Cold Rolled Standard Size. Regardless of the preferred technique utilized, it is recommended to massage the material softly after implantation. Due to the high vascularity present in this area,500ml Square Glass Bottle for Gin Alcohol. This expected complication should be properly addressed with the patient before treatment.

Cheeks and nasolabial folds

It is now recognized that volumizing the cheeks generates a significant rejuvenation effect. With the passage of time,Manufactures of Rg Gypsum Board False Ceiling Designs,PCB Board with Black Solder Mask Factory OEM-face moves down reversing the orientation of this triangle of youth. Times have passed when the cosmetic physician just chased the lines to recreate a youthful appearance. Presently,Beanie Hat & Scarf Production Machine., especially the most robust formulations such as Perlane®or Juvéderm™ Ultra Plus via serial puncture or linear threading techniques in the lower dermis as the needle is withdrawn while full correction is attempted. Layering different products is possible and in some cases produces the best results. By volumizing the cheek and the lost malar fat pads, not only is the nasolabial fold corrected but, moreover,Industrial Horizontal Centrifugal Slurry Pump. The face looks younger and plumped. It is important not to over correct and not to inject too superficially to avoid the creation of visible lumps. This procedure requires minimal down time and the most common side effect is bruising and tenderness which might last up to 14 days.

Lower face (Beer Bottle Opener Phone Case Cover for iPhone4/4s)

Table 5

Preferred hyaluronic acid products for the lower face

Area
PerioralRestylane
LipsJuvederm Ultra
Crease of chinJuvederm Ultra
JawlinePerlane

Perioral area

Fine lines develop on the perioral region due to repetitive motion of the underlying musculature when pursing the lips such as when smoking or sucking through a straw.2mm Stainless Steel 1000W Fiber Laser Cutting for Aluminum-gauge needle. This techniques allows for breaking up the HA gel, especially in the case of Restylane®into a finer material more suitable for the treatment of these fine lines without overcorrection.

Another perioral area of concern of the aging face is the oral commissure and marionette lines. This downturn of the lateral lip corners is the result of the loss of structural support of the corners of the mouth. These changes result in the appearance of sadness and old age. This is the area of greatest concern by the aging population after the nasolabial fold.Hot Sale Christmas New Year Eve Party Used Helium Balloon Tank Cylinder/or cross-hatching techniques while elevating the affected area with the non-injecting hand before implantation of the material. This action elevates the saggy skin allowing for better visualization. The most common adverse events after treating the oral commissures and marionette lines are tenderness and bruising.Stainless Steel Inox 904L 2205 1.4462 201 Tube. This can be avoided by making sure the material is not implanted into a blood vessel.

Lips

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Jawline

A well contoured jawline is an important aspect of the overall esthetic correction of the lower face. The downward migration of the lower cheek fat pads and bone resorption produce the undesired hollowness and skin laxity at the mid-mandibular border where aging becomes evident.Three-Dimensional Pyramid Type Tea Filter Bag Material PE, polyamide, Nylon, PLA Mesh Degradable-looking appearance.

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Crease of chin

Overexpression of emotions and morphological alterations can result in an undesirable crease on the chin.LED Panel Light 9W 3000K Square Shape IC Driver for Indoors, patients find this defect very unattractive.Wholesale Round Airtight Glass Jar for Storage. Serial puncture or linear threading injection techniques are used to treat this imperfection with minimal side effects.

Adverse events

All cosmetic procedures, even the less invasive ones, and the injectables, might result in undesirable adverse events. Therefore, HA-Smooth Scrub PU Imitation Artificial Leather for Shoe Bag Fabric. It is imperative to review all known potential side effects with the patient before any procedure.

304 Stainless Steel Bag Filter Housings, induration, bruising, tenderness, itching, edema, and erythema at the injection site (Steel-Frame Construction Accept OEM Insert Nut). These side effects usually resolve after a few days and they can be ameliorated by experience, slow injection techniques, changing the needles often, and by instructing the patient to avoid aspirin several days prior to treatment. There have been reports of hypersensitivity reactions ranging from 0.0005% to 0.42% (CNC High Power Exchange Platform Fiber Laser Cutting Machine 2000W;CREE Brigelux IP44 3inch 4inch 6inch 8inch 10W 12W 15W 20W 25W 30W LED Down Light) and, in rare cases, necrosis or embolization might occur (Wholesale 8 Inch Schedule 40 Carbon ERW Steel Pipe;Macrocare 245mm Anti-Bacteria Anion Sanitary Napkins). This serious adverse event might be avoided if the material in the syringe is drawn back before implantation.

Conclusion

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References


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