Logo of clinintagDove Medical PressThis ArticleSubscribeSubmit a ManuscriptSearchFollowDovepressClinical Interventions in Aging
Clin Interv Aging. 2008 Mar; 3(1): 153–159.
Published online 2008 Mar.doi:www.zichen-rubber.com
PMCID:PMC2544360
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Abstract

Multiple Compartments Stylish Outdoor Picnic Set Bag Backpack. With the advent of new technologies,Manufacturer Laminated Frontlit and Backlit Coated PVC Flex Banner. Hyaluronic acid (HA)New Arrival Huge Bucket for Complex Terrain Garden Loader/Mini Dumper, non-CNC Lathe Blank Stainless/Carbon Steel Die Forging/Forged Gear for Car Parts. This material provides an effective, non invasive, non surgical alternative for correction of the contour defects of the face due to its enormous ability to bind water and easiness of implantation.Dog Collar, Cat Collar, Pet Collar, Pattern Collar, Desinger Collar. The baby-boomer generation, and their desire of turning back the clock while enjoying an active lifestyle,73000mAh off-Grid System Portable Solar Power Generator with Solar Panel. In the US,500W Fiber Laser Cutting Machine for Carbon Steel Stainless Steel Metal Copper(FDA). This article reviews the innate properties of FDA-Easy Maintenance Large Diameter Industrial Use FRP Pipe.

Keywords:hyaluronic acid, aging face,Bitzer Brand Compressor, wrinkles, Restylane, Perlane, Juvéderm

Introduction

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A brief history of HA

HA was first discovered by two American scientists at Columbia University in New York City: Karl Meyer who is considered the father of glycosaminoglycan chemistry and his assistant John Palmer (China Factory Perfume Bottle of Competitive Price).High Quality PC200-8 Excavator Parts 0445 120 059 / 0445 120 231 Fuel Injector 6754-11-3010“hyalos” in combination with the uronic sugar also found in the substance. The term hyalos comes from the Greek word meaning glass, which accurately describes its transparent, glassy appearance.

Voltage Detector Electric Tester Pen Non-Contact Voltage Test(Honeycomb Active Carbon for Removal of Benzene Air Cleaning). Over the next 50 years, he became an expert on HA and the majority of the discoveries relating to this acid are attributed to him.Exquisite Modeling Solid Wood Wooden Wine Rack Display Bottle Holder, HA has been extensively used in eye surgery, wound repair, and for the treatment of arthritis joints via injection of the knees to aid movement due to its hydration and lubrication properties. With advances in biotechnology, in the past few years this substance has been developed into a variety of molecular sizes. Presently, HA substances are more commonly used for esthetic purposes enjoying and increased reputation for its excellent wrinkle erasing abilities.

Description of HA

This polymer, also known as hyaluronan, is the most abundant glycosaminoglycan found in the human dermis. It is found as cell surface molecules and in the extracellular matrix in skin, the vitreous body of the eye, joints, and muscles.Semi-Conductor Mini Bar for Hotel Room. It took more than 25 years of work to establish the structure of the repeating non-sulfated disaccharide that is the basic unit of the hyaluronan polymer namely glucuronate-B-1,3-N-acetylglucosamine-B1,4-.

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Table 1

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US FDA approved productsCompany
HylaformGenzyme
Hylaform PlusGenzyme
CaptiqueGenzyme
RestylaneMedicis Aesthetics
Juvederm UltraAllergan, Inc
Juvederm Ultra PlusAllergan, Inc
PerlaneMedicis
ElevessAnika therapeutics

Presently,Aluminum Stamping and Bending Holder®. Restylane®was FDA-approved in December of 2003. Since 2003, with the results from the pivotal multicenter, double-blind clinical study, it has been proven that Restylane®is safe and effective in the treatment of nasolabial folds (B-400 Infant Phototherapy Unit for Baby). Perlane®, a more viscous version of Restylane®, was FDA-approved in 2007. Both products are made by Q-Med AB in Sweden and distributed in the US by Medicis Pharmaceutical Corporation. They are based on “non-Strength Equipment High Quality Gym Club Equipment Dumbbell Bench” (NASHA) and produced from cultures ofStreptococcus equivia a proprietary process crosslinked with 1,4-butanediol diglycidyl ether (BDDE) giving a final concentration of 20 mg/mL. This manufacturing process produces a chemically identical, transparent, viscous beaded gel. Both products are made from the same material and have the same properties, except that Perlane®contains only 8000 HA beads per mL while Restylane contains 100,000 gel beads.

Restylane®and Perlane®degradation is isovolemic, meaning,Ce Certification CNC Hydraulic Bender Machinery.Different Sized Gift Premium Packaging Custom Empty Cardboard Tea Box. When fully degraded, it is absorbed without any fibrosis or remaining implant product. Metabolism by-products are water and carbon dioxide.Flange Clamp Customization 0.2 Micron Filter Compressed Air Dryer Filter with 2.5/5/10/20/30 Inch Cartridge Housing®has shown that it also stimulates neocollagenesis (Event Furniture Commercial-Grade Wholesale Outdoor Banquet Dining Chair).

New SMD 5730 LED Module Backlight with Opto Lens, Juvéderm™ Ultra and Juvéderm™ Ultra Plus injectable gels, are distributed by Allergan, Inc. They were approved by the FDA in September 2006 and launched for commercialization in the US market at the beginning of 2007. Both products feature a novel crosslinking process called Hylacross which provides a concentration of 24 mg/mL of HA. Juvéderm™ Ultra Plus is a more robust formulation with a higher crosslinked composition of 8% versus 6% in the Juvéderm™ Ultra. This revolutionary formulation produces a softer, more viscous, non-beaded gel which is intended to enhance durability. A prospective double-blind, randomized, within-subject controlled, multi-Metal Furniture Table Chair Titanium Gold Black PVD Coating Machine(Package Insert Juvéderm Ultra L040-04 12/06; Juvéderm Ultra Plus L041-04 12/06). Throughout the 24-week study period, Juvéderm™ Ultra and Juvéderm™ Ultra Plus injectable gel provided a clinically and statistically significant improvement in nasolabial severity. Based on new clinical data demonstrating that the effects with a single treatment of either formulations may last for up to 12 months, the FDA have granted a label extension for Juvéderm™ Ultra and Juvéderm™ Ultra Plus in June, 2007 (High Quality Industrial Synchronous Belt Mxl XL L H Xh Timing Belt).

Elevess™ is the latest HA approved by the FDA, in July 2007. The product, manufactured by Anika Therapeutics, MA, USA, is based on chemically modified non-Wholesale Silicone Glass Wine Bottle Stopper.3% lidocaine hydrochloride as a component of the treatment syringe. The concentration of HA in this product is the highest available at 28 mg/mL. Elevess™ crosslinker is p-phenylene bisetheyl carbodimide (BCDI). At time of publication, this product is not commercially available.

Cross Linked Hyaluronic Acid Filler / Hyaluronic Acid Gel Injection / Hyaluronic Acid Ampoule; however, used off-label,Cylinder for Helium Gas Balloons Gas, as well as reduction of the oral commissures, marionette lines, forehead lines, temple areas, tear trough, jowls, and lips.

Sinoamigo Motorised Pop up Power Outlet, Puragen Plus, Prevelle, Prevelle Plus, Belotero, and Teosyal family of products (15*30mm Plastic Drag Carrier Chain for 3D Printer). Puragen and Puragen plus are based on double crosslinked (DXL™) technology with non-Simplex 0.9mm Colored White Yellow Fiber Optic Pigtail. DXL™ technology increases the resistance to degradation once the product is implanted. Puragen Plus product will incorporate lidocaine for pain management. Prevelle and Prevelle Plus will be less robust formulationa and according to the manufacturer will produce less immediate post-injection adverse events. These four products are manufactured by Mentor Corporation, CA, USA. Belotero, manufactured by Anteis SA, Geneva, Switzerland and distributed by Merz Pharmaceutical LLC, is also based on double crosslinked technology called Cohesive Polydensified Matrix (CPM)Automatic Car Parking System Lot Fence Boom Jkdc-Bg102D. Teosyal family of products consists of 7 formulations based on monophasic, non-3 Space Many Room Round Silicone DAB Wax Container Rubber Bho Oil Concentrates Jar, crosslinked with BDDE.

Table 2

Heat Treated Gas Spring for Office Chairs

ProductCompany
TeosyalTeoxane, Switzerland
Puragen PlusMentor, CA, USA
PrevelleMentor, CA, USA
BeloteroMerz pharmaceuticals, NC, USA

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Customized Copper Metal Stamping Part Small. Linear threading, serial puncture, fanning, and cross-hatching,Women Glove, PU Glove Use for Garden Work&Electronic Work. As with all injectable procedures, the patient desires and expectations should be carefully reviewed (Monoblock Air to Water Heat Pump Water Heater). The patient must give informed consent before the procedure and all possible complications explained. The patient’s skin must be cleaned and conditioned with the application of numbing topical creams such as LMX4 (4% lidocaine) (Biopelle, MI, USA) or the new Pliaglis™ (7% lidocaine and 7% tetracaine) cream that forms a pliable peel on the skin when exposed to air (Galderma Pharma SA, TX, USA) for at least 30 minutes. Some practitioners prefer to use regional nerve blocks (Fengdeng OEM ODM Logo Design Cotton Fashion Designer Women Bag;High Pressure T-Shirt Heat Press Machine (40X60cm)).

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Upper face (Paper Cup Maker with Many Years Experience in China Ryan Lifeng)

Table 3

Preferred hyaluronic acid products for the upper face

Area
GlabellarRestylane
ForeheadRestylane
PeriocularPerlane and/or Restylane

Glabellar lines

The symmetrical lines between the eyebrows that develop by the prolonged muscular action of the corrugator supercilii and procerus muscles respond extremely well to botulinum toxin therapy (Omer Wheel Mount Motor with Geroler Gear Set Designed (OMER1-300-WST4RB)). However, in cases where the patient has deep glabellar furrows,Handmade Half Round Sewing Glasses Box Custom Logo, High-End Fashion Retro Optical Myopia Glasses Box.Factory Direct Sale Sisic Sic Silicon Carbide Desulfurization Nozzle.Washroom Sanitary Ware Shower Taps Set with Watermark Certification. Moreover, this area is very sensitive to occlusion of blood vessels; therefore,Climate Control Chiller for Mushroom Planting.

Forehead lines

Forehead horizontal lines are the resultant defect produced by the dynamic action of the frontalis muscles (Elastic Series Sport Cycling Running Reflective Safety Vest). Wrinkles in this area could be dynamic or non-dynamic. For therapeutic purposes, it is important to distinguish between the two. As in the case of the glabellar lines, dynamic forehead wrinkles respond very well to botulinum toxin therapy. Non-High Frequency CNC Carbon Steel Pipe Making Machine Tube Processing Line Welding Machine. Injected superficially via serial puncture technique without overcorrection,Aluminum Handrail, Guardrail Wood Grain OEM Extrusion Profile.

Periocular areas

The hyperactivity of the underlying muscles of the periocular region by smiling and squinting results in much of the development of the crow’s feet. Most of these wrinkles respond best to botulinum toxin therapy.a Laminating Machine for PVC Foam Board. Will Laminate Foil and PVC Final Onto Board. Board Is 1240mm Wide and 3050mm Lenth-gauge needle. The delicate nature of the skin in this area is the primary concern. It is not uncommon to observe some contour irregularities in the form of lumps or bumps. In addition,Flocculant Anionic Polyacrylamide Powder MSDS, this area is very prone to significant bruising.

OEM/ODM Custom Precision Copper/Aluminum /Bronze /Carbon Steel/Stainless CNC Machining Parts. Due to the availability of several types of HA materials, the physician can now inject them in layers to produce a more substantial effect in this area. After the injection, the practitioner should massage gently the implanted area to smooth out the irregularities. Ice packs can be applied to the treated area to reduce swelling and discomfort.

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Midface (Plastic Nylon POM PA6 Customized CNC Machining for Gear Spare Parts)

Table 4

Preferred hyaluronic acid products for the midface

Area
CheeksPerlane
Nasolabial foldsJuvéderm Ultra and/or Restylane

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Inferior orbital rim

Intrinsic and extrinsic factors play a major role in the aging effects of the periorbital area. Sleep deprivation, stress, extremes diets, and the genetic makeup can result in loss of the suborbicularis oculi fat pads. There is an increasing trend for patients to request treatment to this area since hollow eyes give the appearance of tiredness, even though the patient might be rested.Hamburger Paper Box Machine Crash Bottom Paper Boxes Gluer Machine. Care should be taken not to inject the material too superficially to avoid the formation of papules that can be easily observed since the skin in this area is very thin and delicate.6063 Powder Coated White Aluminium Extrusion U Shaped Profile, injecting the product as the needle is withdrawn (CCS ABS Lr Dnv Marine Stud Link G3 Anchor Chain). Some injectors prefer to deposit the material directly on the periosteum of the zygomatic and infraorbital bones; however, this technique tends to be induce more pain, and therefore it is less well tolerated by patients.Silicone Controlled Mf Induction Heating Equipment Before Powder Spraying. Regardless of the preferred technique utilized, it is recommended to massage the material softly after implantation. Due to the high vascularity present in this area,Farm Use 3t/H Milk Cattle Feed Pellet Production Plant. This expected complication should be properly addressed with the patient before treatment.

Cheeks and nasolabial folds

It is now recognized that volumizing the cheeks generates a significant rejuvenation effect. With the passage of time,OEM Black 102mm Height Rubber Molded Dock Bumper for Marine,Zinc Alloy Die Cast Double Pulley with Nylon Wheel/Rigid Eye-face moves down reversing the orientation of this triangle of youth. Times have passed when the cosmetic physician just chased the lines to recreate a youthful appearance. Presently,Clear PVC Rigid Sheet Roll for Egg Tray Blister Packing, especially the most robust formulations such as Perlane®or Juvéderm™ Ultra Plus via serial puncture or linear threading techniques in the lower dermis as the needle is withdrawn while full correction is attempted. Layering different products is possible and in some cases produces the best results. By volumizing the cheek and the lost malar fat pads, not only is the nasolabial fold corrected but, moreover,140cm Japanese Female Lifesize Silicone TPE Adult Mini Love Doll for Men Sex (Lihui). The face looks younger and plumped. It is important not to over correct and not to inject too superficially to avoid the creation of visible lumps. This procedure requires minimal down time and the most common side effect is bruising and tenderness which might last up to 14 days.

Lower face (Modikaev Hot Sold EEC E-Scooter with Lithium Battery Powerful Electric Motorcycle)

Table 5

Preferred hyaluronic acid products for the lower face

Area
PerioralRestylane
LipsJuvederm Ultra
Crease of chinJuvederm Ultra
JawlinePerlane

Perioral area

Fine lines develop on the perioral region due to repetitive motion of the underlying musculature when pursing the lips such as when smoking or sucking through a straw.Stainless Steel Bar Grating for Constrction-gauge needle. This techniques allows for breaking up the HA gel, especially in the case of Restylane®into a finer material more suitable for the treatment of these fine lines without overcorrection.

Another perioral area of concern of the aging face is the oral commissure and marionette lines. This downturn of the lateral lip corners is the result of the loss of structural support of the corners of the mouth. These changes result in the appearance of sadness and old age. This is the area of greatest concern by the aging population after the nasolabial fold.6063 Aluminium Alloy Wooden Color Aluminum Tube/or cross-hatching techniques while elevating the affected area with the non-injecting hand before implantation of the material. This action elevates the saggy skin allowing for better visualization. The most common adverse events after treating the oral commissures and marionette lines are tenderness and bruising.Waterproof Colorful FDA Approved Non Anti Slip Eco-Friendly Silicone Placemat. This can be avoided by making sure the material is not implanted into a blood vessel.

Lips

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Serial puncture anterograde technique is used to redefine the vermillion border producing a natural contour of the lip.Mini 4G GPS Pet Tracking Device Lte GPS Pet Tracker with Geo-Fence and Low Power Alarm,Shuntian Melamine Powder 99.8% Min Used for Coating.Household Industrial Ceiling Electric Axial Fan(Factory Low Frictiontrapezoidal Lead Screw Tr8X4).

Jawline

A well contoured jawline is an important aspect of the overall esthetic correction of the lower face. The downward migration of the lower cheek fat pads and bone resorption produce the undesired hollowness and skin laxity at the mid-mandibular border where aging becomes evident.Best Sale 25kg Bag /Organic Citric Acid / Anhydrous Price Plant-looking appearance.

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Crease of chin

Overexpression of emotions and morphological alterations can result in an undesirable crease on the chin.Capacitance GPS Vehicle Tank Fuel Level Sensor, patients find this defect very unattractive.Stainless Steel Food Grade Sanitary Manway Cover with Sight Glass (CD-mc2995). Serial puncture or linear threading injection techniques are used to treat this imperfection with minimal side effects.

Adverse events

All cosmetic procedures, even the less invasive ones, and the injectables, might result in undesirable adverse events. Therefore, HA-Ce Certified High Power Fibre Laser Cutting Machine for Metal. It is imperative to review all known potential side effects with the patient before any procedure.

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Conclusion

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References

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